2,4-Diaminobutyric acid (BioDeep_00000405531)

   

natural product


代谢物信息卡片


2,4-Diaminobutanoic acid

化学式: C4H10N2O2 (118.0742)
中文名称: 2,4-二氨基丁酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CN)C(C(=O)O)N
InChI: InChI=1S/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)

描述信息

A diamino acid that is butyric acid in which a hydrogen at position 2 and a hydrogen at position 4 are replaced by amino groups.

同义名列表

3 个代谢物同义名

2,4-Diaminobutanoic acid; 2,4-Diaminobutyric acid; 2,4-Diaminobutyric acid



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sea-Yong Kim, Per Hedberg, Monika Winder, Sara Rydberg. Evidence of 2,4-diaminobutyric acid (DAB) production as a defense mechanism in diatom Thalassiosira pseudonana. Aquatic toxicology (Amsterdam, Netherlands). 2022 Aug; 249(?):106210. doi: 10.1016/j.aquatox.2022.106210. [PMID: 35665646]
  • Kate Samardzic, Joel R Steele, Jake P Violi, Anne Colville, Simon M Mitrovic, Kenneth J Rodgers. Toxicity and bioaccumulation of two non-protein amino acids synthesised by cyanobacteria, β-N-Methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB), on a crop plant. Ecotoxicology and environmental safety. 2021 Jan; 208(?):111515. doi: 10.1016/j.ecoenv.2020.111515. [PMID: 33099142]
  • Le-Ni Sun, Dan-Dan Pan, Xiang-Wei Wu, En-Dong Yang, Ri-Mao Hua, Qing X Li. Leucobacter triazinivorans sp. nov., a s-triazine herbicide prometryn-degrading bacterium isolated from sludge. International journal of systematic and evolutionary microbiology. 2018 Jan; 68(1):204-210. doi: 10.1099/ijsem.0.002483. [PMID: 29139349]
  • Peter B Nunn, Geoffrey A Codd. Metabolic solutions to the biosynthesis of some diaminomonocarboxylic acids in nature: Formation in cyanobacteria of the neurotoxins 3-N-methyl-2,3-diaminopropanoic acid (BMAA) and 2,4-diaminobutanoic acid (2,4-DAB). Phytochemistry. 2017 Dec; 144(?):253-270. doi: 10.1016/j.phytochem.2017.09.015. [PMID: 29059579]
  • Yong Li, Wei Fang, Shou-Jiang Xie, Xuqi Yang, Lai-Fa Wang. Leucobacter corticis sp. nov., isolated from symptomatic bark of Populus × euramericana canker. International journal of systematic and evolutionary microbiology. 2017 Jul; 67(7):2248-2252. doi: 10.1099/ijsem.0.001934. [PMID: 28699860]
  • Wei Fang, Xia Li, Xiu-Mei Tan, Lai-Fa Wang, Chun-Gen Piao, Yong Li. Leucobacter populi sp. nov. isolated from a symptomatic bark of Populus × euramericana canker. International journal of systematic and evolutionary microbiology. 2016 Jun; 66(6):2254-2258. doi: 10.1099/ijsem.0.001020. [PMID: 26971343]
  • Jian-Rong Huang, Hong Ming, Shuai Li, Xiao-Lin Meng, Jian-Xin Zhang, Thi-Nhan Khieu, Zhong Tang, Wen-Jun Li, Guo-Xing Nie. Agromyces insulae sp. nov., an actinobacterium isolated from a soil sample. International journal of systematic and evolutionary microbiology. 2016 May; 66(5):2002-2007. doi: 10.1099/ijsem.0.000978. [PMID: 26883212]
  • Wei-An Lai, Shih-Yao Lin, Asif Hameed, Yi-Han Hsu, You-Cheng Liu, Hsuan-Ru Huang, Fo-Ting Shen, Chiu-Chung Young. Leucobacter zeae sp. nov., isolated from the rhizosphere of maize (Zea mays L.). International journal of systematic and evolutionary microbiology. 2015 Dec; 65(12):4734-4742. doi: 10.1099/ijsem.0.000640. [PMID: 26420495]
  • Juan Du, Hina Singh, Jung-Eun Yang, Chang Shik Yin, MooChang Kook, Hongshan Yu, Tae-Hoo Yi. Pseudoclavibacter terrae sp. nov. isolated from rhizosphere soil of Ophiopogon japonicus. International journal of systematic and evolutionary microbiology. 2015 Nov; 65(11):4202-4207. doi: 10.1099/ijsem.0.000560. [PMID: 26311346]
  • Audrey Combes, Saïda El Abdellaoui, Jérome Vial, Emmeline Lagrange, Valérie Pichon. Development of an analytical procedure for quantifying the underivatized neurotoxin β-N-methylamino-L-alanine in brain tissues. Analytical and bioanalytical chemistry. 2014 Jul; 406(19):4627-36. doi: 10.1007/s00216-014-7872-y. [PMID: 24858470]
  • Maitham Ahmed Al-Sammak, Kyle D Hoagland, David Cassada, Daniel D Snow. Co-occurrence of the cyanotoxins BMAA, DABA and anatoxin-a in Nebraska reservoirs, fish, and aquatic plants. Toxins. 2014 Jan; 6(2):488-508. doi: 10.3390/toxins6020488. [PMID: 24476710]
  • Maitham Ahmed Al-Sammak, Kyle D Hoagland, Daniel D Snow, David Cassada. Methods for simultaneous detection of the cyanotoxins BMAA, DABA, and anatoxin-a in environmental samples. Toxicon : official journal of the International Society on Toxinology. 2013 Dec; 76(?):316-25. doi: 10.1016/j.toxicon.2013.10.015. [PMID: 24140919]
  • Maria Hoernke, Christian Schwieger, Andreas Kerth, Alfred Blume. Binding of cationic pentapeptides with modified side chain lengths to negatively charged lipid membranes: Complex interplay of electrostatic and hydrophobic interactions. Biochimica et biophysica acta. 2012 Jul; 1818(7):1663-72. doi: 10.1016/j.bbamem.2012.03.001. [PMID: 22433675]
  • Sathiyaraj Srinivasan, Hyun Sook Kim, Myung Kyum Kim, Myungjin Lee. Pseudoclavibacter caeni sp. nov., isolated from sludge of a sewage disposal plant. International journal of systematic and evolutionary microbiology. 2012 Apr; 62(Pt 4):786-790. doi: 10.1099/ijs.0.028951-0. [PMID: 21571937]
  • Hang-Yeon Weon, Rangasamy Anandham, Tomohiko Tamura, Moriyuki Hamada, Soo-Jin Kim, Yi-Seul Kim, Ken-Ichiro Suzuki, Soon-Wo Kwon. Leucobacter denitrificans sp. nov., isolated from cow dung. Journal of microbiology (Seoul, Korea). 2012 Feb; 50(1):161-5. doi: 10.1007/s12275-012-1324-1. [PMID: 22367952]
  • Hyun-Jung Kim, Sang-Seob Lee. Leucobacter kyeonggiensis sp. nov., a new species isolated from dye waste water. Journal of microbiology (Seoul, Korea). 2011 Dec; 49(6):1044-9. doi: 10.1007/s12275-011-1548-5. [PMID: 22203572]
  • Ji-Hyun Yun, Seong Woon Roh, Min-Soo Kim, Mi-Ja Jung, Eun-Jin Park, Kee-Sun Shin, Young-Do Nam, Jin-Woo Bae. Leucobacter salsicius sp. nov., from a salt-fermented food. International journal of systematic and evolutionary microbiology. 2011 Mar; 61(Pt 3):502-506. doi: 10.1099/ijs.0.021360-0. [PMID: 20363927]
  • Reda E A Moghaieb, Akiko Nakamura, Hirofumi Saneoka, Kounosuke Fujita. Evaluation of salt tolerance in ectoine-transgenic tomato plants (Lycopersicon esculentum) in terms of photosynthesis, osmotic adjustment, and carbon partitioning. GM crops. 2011 Jan; 2(1):58-65. doi: 10.4161/gmcr.2.1.15831. [PMID: 21844699]
  • E Martin, N Lodders, U Jäckel, P Schumann, P Kämpfer. Leucobacter aerolatus sp. nov., from the air of a duck barn. International journal of systematic and evolutionary microbiology. 2010 Dec; 60(Pt 12):2838-2842. doi: 10.1099/ijs.0.021303-0. [PMID: 20081017]
  • Lynne A Oland, Nicholas J Gibson, Leslie P Tolbert. Localization of a GABA transporter to glial cells in the developing and adult olfactory pathway of the moth Manduca sexta. The Journal of comparative neurology. 2010 Mar; 518(6):815-38. doi: 10.1002/cne.22244. [PMID: 20058309]
  • Thomas Krüger, Bettina Mönch, Steven Oppenhäuser, Bernd Luckas. LC-MS/MS determination of the isomeric neurotoxins BMAA (beta-N-methylamino-L-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius. Toxicon : official journal of the International Society on Toxinology. 2010 Feb; 55(2-3):547-57. doi: 10.1016/j.toxicon.2009.10.009. [PMID: 19825383]
  • Undine Behrendt, Andreas Ulrich, Peter Schumann. Leucobacter tardus sp. nov., isolated from the phyllosphere of Solanum tuberosum L. International journal of systematic and evolutionary microbiology. 2008 Nov; 58(Pt 11):2574-8. doi: 10.1099/ijs.0.2008/001065-0. [PMID: 18984695]
  • Fubin Qiu, Ying Huang, Lei Sun, Xiaoxia Zhang, Zhiheng Liu, Wei Song. Leifsonia ginsengi sp. nov., isolated from ginseng root. International journal of systematic and evolutionary microbiology. 2007 Feb; 57(Pt 2):405-408. doi: 10.1099/ijs.0.64487-0. [PMID: 17267987]
  • Sandra M Leal, Nitin Kumar, Wendi S Neckameyer. GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport. Journal of neurobiology. 2004 Nov; 61(2):189-208. doi: 10.1002/neu.20061. [PMID: 15389689]
  • Yukio Iwashita, Tadashi Ogawa, Shigeru Goto, Masaru Nakanishi, Takeshi Goto, Seigo Kitano. Effective transfer of interleukin-12 gene to solid tumors using a novel gene delivery system, poly [D,L-2,4-diaminobutyric acid]. Cancer gene therapy. 2004 Feb; 11(2):103-8. doi: 10.1038/sj.cgt.7700669. [PMID: 14671674]
  • Sandra M Leal, Wendi S Neckameyer. Pharmacological evidence for GABAergic regulation of specific behaviors in Drosophila melanogaster. Journal of neurobiology. 2002 Feb; 50(3):245-61. doi: 10.1002/neu.10030. [PMID: 11810639]
  • Michael A Weiss, Zhuli Wan, Ming Zhao, Ying-Chi Chu, Satoe H Nakagawa, G Thomson Burke, Wenhua Jia, Rosanna Hellmich, Panayotis G Katsoyannis. Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor. Journal of molecular biology. 2002 Jan; 315(2):103-11. doi: 10.1006/jmbi.2001.5224. [PMID: 11779231]
  • Harald H Sitte, Ernst A Singer, Petra Scholze. Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1. British journal of pharmacology. 2002 Jan; 135(1):93-102. doi: 10.1038/sj.bjp.0704446. [PMID: 11786484]
  • L Panasci, A McQuillan, W Feindel. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer chemotherapy and pharmacology. 1988; 21(2):143-4. doi: 10.1007/bf00257361. [PMID: 3349563]
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  • R Roskoski. Comparison of DABA and GABA transport into plasma membrane vesicles derived from synaptosomes. Journal of neurochemistry. 1981 Feb; 36(2):544-50. doi: 10.1111/j.1471-4159.1981.tb01626.x. [PMID: 6162006]
  • H R PERKINS, C S CUMMINS. CHEMICAL STRUCTURE OF BACTERIAL CELL WALLS. ORNITHINE AND 2,4-DIAMINOBUTYRIC ACID AS COMPONENTS OF THE CELL WALLS OF PLANT PATHOGENIC CORYNEBACTERIA. Nature. 1964 Mar; 201(?):1105-7. doi: 10.1038/2011105a0. [PMID: 14152785]
  • R LALIBERTE, L BERLINGUET. [Preliminary studies of the effects of substituted 2,4-diaminobutyric acids in the rat]. Laval medical. 1962 Nov; 33(?):675-9. doi: NULL. [PMID: 13928187]