pristanic acid (BioDeep_00000405367)
代谢物信息卡片
(2S,6R,10R)-2,6,10,14-Tetramethylpentadecanoic acid
化学式: C19H38O2 (298.28716479999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C)CCCC(C)CCCC(C)CCCC(C)C)(=O)O
InChI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
描述信息
A branched, long-chain saturated fatty acid composed of pentadecanoic acid having methyl substituents at the 2-, 6-, 10- and 14-positions.
同义名列表
10 个代谢物同义名
pristanic acid; Pentadecanoic acid, 2,6,10,14-tetramethyl-; 2,6,10,14-tetramethyl-pentadecanoic acid; 2,6,10,14-Tetramethylpentadecanoic acid; (2S,6R,10R)-2,6,10,14-Tetramethylpentadecanoic acid; (2S,6R,10R)-2,6,10,14-Tetramethylpentadecanoate; 2,6,10,14-Tetramethylpentadecanoate; Pristanate:(2S,6R,10R)-pristanate; (2S,6R,10R)-Pristanic acid; (2S)-Pristanic acid
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:51340
- PubChem: 123929
- Metlin: METLIN5760
- ChEMBL: CHEMBL1316599
- LipidMAPS: LMPR0104010022
- CAS: 1189-37-3
- MoNA: HMDB0000795_ms_ms_1133
- MoNA: HMDB0000795_ms_ms_1132
- MoNA: HMDB0000795_ms_ms_1134
- MetaboLights: MTBLC51340
- RefMet: Pristanic acid
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maaike Blankestijn, Vincent W Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C Wolters, Ronald J A Wanders, Frédéric M Vaz, Markus Islinger, Folkert Kuipers, Bart van de Sluis, Albert K Groen, Henkjan J Verkade, Johan W Jonker. Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
Scientific reports.
2022 02; 12(1):2512. doi:
10.1038/s41598-022-06479-y. [PMID: 35169201] - Tomonori Nakanishi, Kazuhiro Kagamizono, Sayaka Yokoyama, Ryoji Suzuki, Hiroyuki Sakakibara, Laurie Erickson, Satoshi Kawahara. Effects of dietary phytol on tissue accumulation of phytanic acid and pristanic acid and on the tissue lipid profiles in mice.
Animal science journal = Nihon chikusan Gakkaiho.
2020 Jan; 91(1):e13424. doi:
10.1111/asj.13424. [PMID: 32618084] - Serena Mezzar, Evelyn De Schryver, Stanny Asselberghs, Els Meyhi, Petruta L Morvay, Myriam Baes, Paul P Van Veldhoven. Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2017 Sep; 1862(9):972-990. doi:
10.1016/j.bbalip.2017.06.004. [PMID: 28629946] - Katharina Herzog, Henk van Lenthe, Ronald J A Wanders, Frédéric M Vaz, Hans R Waterham, Sacha Ferdinandusse. Identification and diagnostic value of phytanoyl- and pristanoyl-carnitine in plasma from patients with peroxisomal disorders.
Molecular genetics and metabolism.
2017 07; 121(3):279-282. doi:
10.1016/j.ymgme.2017.05.003. [PMID: 28566232] - Michela Semeraro, Cristiano Rizzo, Sara Boenzi, Marco Cappa, Enrico Bertini, Giacomo Antonetti, Carlo Dionisi-Vici. A new multiplex method for the diagnosis of peroxisomal disorders allowing simultaneous determination of plasma very-long-chain fatty acids, phytanic, pristanic, docosahexaenoic and bile acids by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry.
2016 Jul; 458(?):159-64. doi:
10.1016/j.cca.2016.05.009. [PMID: 27189059] - Arthur Sorlin, Gilbert Briand, David Cheillan, Arnaud Wiedemann, Bettina Montaut-Verient, Emmanuelle Schmitt, François Feillet. Effect of l-Arginine in One Patient with Peroxisome Biogenesis Disorder due to PEX12 Deficiency.
Neuropediatrics.
2016 Jun; 47(3):179-81. doi:
10.1055/s-0036-1578798. [PMID: 26947510] - Sacha Ferdinandusse, Gerardo Jimenez-Sanchez, Janet Koster, Simone Denis, Carlo W Van Roermund, Irma Silva-Zolezzi, Ann B Moser, Wouter F Visser, Mine Gulluoglu, Ozlem Durmaz, Mubeccel Demirkol, Hans R Waterham, Gülden Gökcay, Ronald J A Wanders, David Valle. A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3.
Human molecular genetics.
2015 Jan; 24(2):361-70. doi:
10.1093/hmg/ddu448. [PMID: 25168382] - Estela Natacha Brandt Busanello, Vannessa Gonçalves Araujo Lobato, Ângela Zanatta, Clarissa Günther Borges, Anelise Miotti Tonin, Carolina Maso Viegas, Vanusa Manfredini, César Augusto João Ribeiro, Carmen Regla Vargas, Diogo Onofre Gomes de Souza, Moacir Wajner. Pristanic acid provokes lipid, protein, and DNA oxidative damage and reduces the antioxidant defenses in cerebellum of young rats.
Cerebellum (London, England).
2014 Dec; 13(6):751-9. doi:
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Cancer medicine.
2014 Dec; 3(6):1562-9. doi:
10.1002/cam4.319. [PMID: 25132681] - Catherine J Klein, Thomas G Havranek, Mary E Revenis, Zahra Hassanali, Louis M Scavo. Plasma fatty acids in premature infants with hyperbilirubinemia: before-and-after nutrition support with fish oil emulsion.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
2013 Feb; 28(1):87-94. doi:
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Orphanet journal of rare diseases.
2012 Nov; 7(?):90. doi:
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Klinicheskaia laboratornaia diagnostika.
2012 Mar; ?(3):16-8. doi:
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Journal of neuroscience research.
2012 Mar; 90(3):597-605. doi:
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Acta neuropathologica.
2011 Sep; 122(3):271-83. doi:
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Lipids in health and disease.
2011 Aug; 10(?):152. doi:
10.1186/1476-511x-10-152. [PMID: 21871076] - Nicol Kruska, Georg Reiser. Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40.
Neurobiology of disease.
2011 Aug; 43(2):465-72. doi:
10.1016/j.nbd.2011.04.020. [PMID: 21570468] - Louise B Werner, Lars I Hellgren, Marianne Raff, Søren K Jensen, Rikke A Petersen, Tue Drachmann, Tine Tholstrup. Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study.
Lipids in health and disease.
2011 Jun; 10(?):95. doi:
10.1186/1476-511x-10-95. [PMID: 21663648] - William B Rizzo. The role of fatty aldehyde dehydrogenase in epidermal structure and function.
Dermato-endocrinology.
2011 Apr; 3(2):91-9. doi:
10.4161/derm.3.2.14619. [PMID: 21695018] - Guilhian Leipnitz, Alexandre Umpierrez Amaral, Carolina Gonçalves Fernandes, Bianca Seminotti, Angela Zanatta, Lisiane Aurélio Knebel, Carmen Regla Vargas, Moacir Wajner. Pristanic acid promotes oxidative stress in brain cortex of young rats: a possible pathophysiological mechanism for brain damage in peroxisomal disorders.
Brain research.
2011 Mar; 1382(?):259-65. doi:
10.1016/j.brainres.2011.01.014. [PMID: 21241675] - Emily Helen Smith, Dimitar K Gavrilov, Devin Oglesbee, William D Freeman, Michael W Vavra, Dietrich Matern, Silvia Tortorelli. An adult onset case of alpha-methyl-acyl-CoA racemase deficiency.
Journal of inherited metabolic disease.
2010 Dec; 33 Suppl 3(?):S349-53. doi:
10.1007/s10545-010-9183-6. [PMID: 20821052] - Paul A Watkins, Ann B Moser, Cicely B Toomer, Steven J Steinberg, Hugo W Moser, Mazen W Karaman, Krishna Ramaswamy, Kimberly D Siegmund, D Rick Lee, John J Ely, Oliver A Ryder, Joseph G Hacia. Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions.
BMC physiology.
2010 Oct; 10(?):19. doi:
10.1186/1472-6793-10-19. [PMID: 20932325] - Ronald J A Wanders, Jos P N Ruiter, Lodewijk IJLst, Hans R Waterham, Sander M Houten. The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results.
Journal of inherited metabolic disease.
2010 Oct; 33(5):479-94. doi:
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Nuclear receptor signaling.
2010 Apr; 8(?):e002. doi:
10.1621/nrs.08002. [PMID: 20414453] - Lars I Hellgren. Phytanic acid--an overlooked bioactive fatty acid in dairy fat?.
Annals of the New York Academy of Sciences.
2010 Mar; 1190(?):42-9. doi:
10.1111/j.1749-6632.2009.05254.x. [PMID: 20388135] - Cindy Krause, Hendrik Rosewich, Jutta Gärtner. Rational diagnostic strategy for Zellweger syndrome spectrum patients.
European journal of human genetics : EJHG.
2009 Jun; 17(6):741-8. doi:
10.1038/ejhg.2008.252. [PMID: 19142205] - John T Mackie, Barbara P Atshaves, H Ross Payne, Avery L McIntosh, Friedhelm Schroeder, Ann B Kier. Phytol-induced hepatotoxicity in mice.
Toxicologic pathology.
2009 Feb; 37(2):201-8. doi:
10.1177/0192623308330789. [PMID: 19188468] - T Fiskerstrand, P Knappskog, J Majewski, R J Wanders, H Boman, L A Bindoff. A novel Refsum-like disorder that maps to chromosome 20.
Neurology.
2009 Jan; 72(1):20-7. doi:
10.1212/01.wnl.0000333664.90605.23. [PMID: 19005174] - Sian A Thompson, Jacqui Calvin, Sarah Hogg, Sacha Ferdinandusse, Ronald J A Wanders, Roger A Barker. Relapsing encephalopathy in a patient with α-methylacyl-CoA racemase deficiency.
BMJ case reports.
2009; 2009(?):. doi:
10.1136/bcr.08.2008.0814. [PMID: 21686617] - Osama Y Al-Dirbashi, Tomofumi Santa, Mohamed S Rashed, Zuhair Al-Hassnan, Nobuyuki Shimozawa, Aziza Chedrawi, Minnie Jacob, Manhal Al-Mokhadab. Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders.
Journal of lipid research.
2008 Aug; 49(8):1855-62. doi:
10.1194/jlr.d800019-jlr200. [PMID: 18441019] - Rosalba Carrozzo, Carlo Bellini, Simona Lucioli, Federica Deodato, Denise Cassandrini, Michela Cassanello, Ubaldo Caruso, Cristiano Rizzo, Teresa Rizza, Matteo L Napolitano, Ronald J A Wanders, Cornelis Jakobs, Claudio Bruno, Filippo M Santorelli, Carlo Dionisi-Vici, Eugenio Bonioli. Peroxisomal acyl-CoA-oxidase deficiency: two new cases.
American journal of medical genetics. Part A.
2008 Jul; 146A(13):1676-81. doi:
10.1002/ajmg.a.32298. [PMID: 18536048] - S A Thompson, J Calvin, S Hogg, S Ferdinandusse, R J A Wanders, R A Barker. Relapsing encephalopathy in a patient with alpha-methylacyl-CoA racemase deficiency.
Journal of neurology, neurosurgery, and psychiatry.
2008 Apr; 79(4):448-50. doi:
10.1136/jnnp.2007.129478. [PMID: 18032455] - Bing Song Zheng, Elin Rönnberg, Lenita Viitanen, Tiina A Salminen, Krister Lundgren, Thomas Moritz, Johan Edqvist. Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings.
Journal of experimental botany.
2008; 59(12):3485-99. doi:
10.1093/jxb/ern201. [PMID: 18687588] - Barbara P Atshaves, Avery L McIntosh, Danilo Landrock, H Ross Payne, John T Mackie, Nobuyo Maeda, Judith Ball, Friedhelm Schroeder, Ann B Kier. Effect of SCP-x gene ablation on branched-chain fatty acid metabolism.
American journal of physiology. Gastrointestinal and liver physiology.
2007 Mar; 292(3):G939-51. doi:
10.1152/ajpgi.00308.2006. [PMID: 17068117] - J Gloerich, D M van den Brink, J P N Ruiter, N van Vlies, F M Vaz, R J A Wanders, S Ferdinandusse. Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation.
Journal of lipid research.
2007 Jan; 48(1):77-85. doi:
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PPAR research.
2007; 2007(?):74364. doi:
10.1155/2007/74364. [PMID: 17389766] - Steven Huyghe, Henning Schmalbruch, Karel De Gendt, Guido Verhoeven, Florian Guillou, Paul P Van Veldhoven, Myriam Baes. Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice.
Endocrinology.
2006 May; 147(5):2228-36. doi:
10.1210/en.2005-1571. [PMID: 16484321] - H Rosewich, H R Waterham, R J A Wanders, S Ferdinandusse, M Henneke, D Hunneman, J Gärtner. Pitfall in metabolic screening in a patient with fatal peroxisomal beta-oxidation defect.
Neuropediatrics.
2006 Apr; 37(2):95-8. doi:
10.1055/s-2006-923943. [PMID: 16773508] - D S Roe, B Z Yang, C Vianey-Saban, E Struys, L Sweetman, C R Roe. Differentiation of long-chain fatty acid oxidation disorders using alternative precursors and acylcarnitine profiling in fibroblasts.
Molecular genetics and metabolism.
2006 Jan; 87(1):40-7. doi:
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Journal of lipid research.
2005 Apr; 46(4):716-26. doi:
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American journal of physiology. Cell physiology.
2005 Mar; 288(3):C543-58. doi:
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Journal of cardiovascular electrophysiology.
2004 Nov; 15(11):1310-6. doi:
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Neurology.
2004 Jul; 63(1):188-9. doi:
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The Journal of biological chemistry.
2004 May; 279(21):21841-8. doi:
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Journal of lipid research.
2004 May; 45(5):812-30. doi:
10.1194/jlr.m300408-jlr200. [PMID: 14993239] - David W Johnson, Minh-Uyen Trinh, Tomoyuki Oe. Measurement of plasma pristanic, phytanic and very long chain fatty acids by liquid chromatography-electrospray tandem mass spectrometry for the diagnosis of peroxisomal disorders.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Dec; 798(1):159-62. doi:
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Progress in lipid research.
2003 Sep; 42(5):359-76. doi:
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Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2003 Aug; 29(1):85-91. doi:
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Gastroenterology.
2003 Jan; 124(1):217-32. doi:
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Journal of lipid research.
2002 Mar; 43(3):438-44. doi:
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European journal of clinical investigation.
2001 Aug; 31(8):714-22. doi:
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Biochemical Society transactions.
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Biochemical Society transactions.
2001 May; 29(Pt 2):292-8. doi:
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Journal of lipid research.
2001 Jan; 42(1):137-41. doi:
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Journal of lipid research.
2000 Nov; 41(11):1801-7. doi:
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Biochemical Society transactions.
2000 Feb; 28(2):141-9. doi:
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Journal of lipid research.
1999 Feb; 40(2):260-6. doi:
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Journal of inherited metabolic disease.
1998 Oct; 21(7):753-60. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
1998 Aug; 713(2):281-7. doi:
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FEBS letters.
1998 Jun; 429(3):225-8. doi:
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Journal of lipid research.
1997 Oct; 38(10):2062-70. doi:
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Journal of inherited metabolic disease.
1997 Sep; 20(5):658-64. doi:
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Journal of pediatric orthopedics. Part B.
1997 Jan; 6(1):20-3. doi:
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The Journal of clinical investigation.
1996 Feb; 97(3):681-8. doi:
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Journal of inherited metabolic disease.
1996; 19(6):761-8. doi:
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Journal of inherited metabolic disease.
1995; 18 Suppl 1(?):76-83. doi:
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Journal of inherited metabolic disease.
1995; 18 Suppl 1(?):45-60. doi:
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The Journal of biological chemistry.
1994 Apr; 269(13):9514-20. doi:
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Journal of lipid research.
1993 Oct; 34(10):1755-64. doi:
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Clinical chemistry.
1993 Sep; 39(9):1904-6. doi:
10.1093/clinchem/39.9.1904. [PMID: 8375069] - H J ten Brink, D S Schor, R M Kok, F Stellaard, J Kneer, B T Poll-The, J M Saudubray, C Jakobs. In vivo study of phytanic acid alpha-oxidation in classic Refsum's disease and chondrodysplasia punctata.
Pediatric research.
1992 Nov; 32(5):566-70. doi:
10.1203/00006450-199211000-00016. [PMID: 1282700] - H Singh, M Brogan, D Johnson, A Poulos. Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts.
Journal of lipid research.
1992 Nov; 33(11):1597-605. doi:
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Journal of lipid research.
1992 Oct; 33(10):1449-57. doi:
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Journal of lipid research.
1992 Jan; 33(1):41-7. doi:
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Journal of inherited metabolic disease.
1991; 14(5):681-4. doi:
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Journal of inherited metabolic disease.
1991; 14(3):345-8. doi:
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European journal of pediatrics.
1988 Feb; 147(2):143-7. doi:
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