7-KETOCHOLESTEROL (BioDeep_00000405287)

Main id: BioDeep_00000018887

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


7-oxo-cholest-5-en-3beta-ol

化学式: C27H44O2 (400.3341124)
中文名称: 胆甾-3-羟基-5-烯-7-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2C(=O)C=C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,25+,26+,27-/m1/s1

描述信息

A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.
D004791 - Enzyme Inhibitors
7-Ketocholesterol, toxic oxysterol, inhibits the rate-limiting step in bile acid biosynthesis cholesterol 7 alpha-hydroxylase, as well as strongly inhibiting HMG-CoA reductase (the rate-limiting enzyme in cholesterol biosynthesis). 7-Ketocholesterol induces cell apoptosis[1].

同义名列表

3 个代谢物同义名

7-KETOCHOLESTEROL; 7-oxo-cholest-5-en-3beta-ol; 7-keto-5-cholesten-3B-ol



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

31 个相关的代谢反应过程信息。

Reactome(28)

BioCyc(0)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

72 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fangrui Xiu, Lara Console, Cesare Indiveri, Shanshan Su, Tong Wang, Michele Visentin. Effect of 7-ketocholesterol incorporation on substrate binding affinity and turnover rate of the organic cation transporter 2 (OCT2). Biochemical pharmacology. 2024 Feb; 220(?):116017. doi: 10.1016/j.bcp.2023.116017. [PMID: 38176620]
  • Tahir Mahmood, Joshua R Miles, Jessica Minnier, Hagai Tavori, Andrea E DeBarber, Sergio Fazio, Michael D Shapiro. Effect of PCSK9 inhibition on plasma levels of small dense low density lipoprotein-cholesterol and 7-ketocholesterol. Journal of clinical lipidology. 2024 Jan; 18(1):e50-e58. doi: 10.1016/j.jacl.2023.10.009. [PMID: 37923663]
  • Guoen Li, Hyun-Jung Park, Jae-Hee Suh, Hye-Seon Choi. 7-Ketocholesterol plays a key role in cholesterol-induced hepatitis via macrophage and neutrophil infiltration. The Journal of nutritional biochemistry. 2023 Dec; 125(?):109552. doi: 10.1016/j.jnutbio.2023.109552. [PMID: 38134972]
  • Sanchareeka Dey, Timothy Catchpole, Alison Takacs, Karl G Csaky. Investigating the effects of 7-ketocholesterol on retinal pigment epithelium bioenergetics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 Jul; 37(7):e23002. doi: 10.1096/fj.202300101r. [PMID: 37249566]
  • Imen Ghzaiel, Amira Zarrouk, Vivien Pires, Jean-Paul Pais de Barros, Sonia Hammami, Mohamed Ksila, Mohamed Hammami, Taoufik Ghrairi, Pierre Jouanny, Anne Vejux, Gérard Lizard. 7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes. The Journal of steroid biochemistry and molecular biology. 2023 Jun; 232(?):106345. doi: 10.1016/j.jsbmb.2023.106345. [PMID: 37286110]
  • Ana Pariente, Álvaro Pérez-Sala, Rodrigo Ochoa, Miriam Bobadilla, Ángela Villanueva-Martínez, Rafael Peláez, Ignacio M Larráyoz. Identification of 7-Ketocholesterol-Modulated Pathways and Sterculic Acid Protective Effect in Retinal Pigmented Epithelium Cells by Using Genome-Wide Transcriptomic Analysis. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087459. [PMID: 37108627]
  • Behnoush Nasr Zanjani, Afshin Samadi, Selen Yilmaz Isikhan, Incilay Lay, Sengul Beyaz, Asli Gelincik, Suna Buyukozturk, Nazli Arda. Plasma levels of oxysterols 7-ketocholesterol and cholestane-3β, 5α, 6β-triol in patients with allergic asthma. The Journal of asthma : official journal of the Association for the Care of Asthma. 2023 Feb; 60(2):288-297. doi: 10.1080/02770903.2022.2045310. [PMID: 35188447]
  • Ayami Saga, Masahiro Koseki, Kotaro Kanno, Jiuyang Chang, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Masumi Asaji, Katsunao Tanaka, Takashi Omatsu, Sae Nishihara, Yinghong Zhu, Kaori Ito, Hiroaki Hattori, Ikuyo Ichi, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Tohru Ohama, Shungo Hikoso, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata. A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232415855. [PMID: 36555497]
  • Imen Ghzaiel, Thomas Nury, Amira Zarrouk, Anne Vejux, Gérard Lizard. Oxiapoptophagy in Age-Related Diseases. Comment on Ouyang et al. 7-Ketocholesterol Induces Oxiapoptophagy and Inhibits Osteogenic Differentiation in MC3T3-E1 Cells. Cells 2022, 11, 2882. Cells. 2022 11; 11(22):. doi: 10.3390/cells11223612. [PMID: 36429041]
  • Leila Rezig, Imen Ghzaiel, Mohamed Ksila, Aline Yammine, Thomas Nury, Amira Zarrouk, Mohammad Samadi, Moncef Chouaibi, Anne Vejux, Gérard Lizard. Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases. Steroids. 2022 11; 187(?):109093. doi: 10.1016/j.steroids.2022.109093. [PMID: 36029811]
  • Sandra Soh, Wei-Yi Ong. Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells. Cells. 2022 01; 11(3):. doi: 10.3390/cells11030457. [PMID: 35159267]
  • Mei-Ling Cheng, Hsiang-Yu Tang, Pei-Ting Wu, Cheng-Hung Yang, Chi-Jen Lo, Jui-Fen Lin, Hung-Yao Ho. 7-Ketocholesterol Induces Lipid Metabolic Reprogramming and Enhances Cholesterol Ester Accumulation in Cardiac Cells. Cells. 2021 12; 10(12):. doi: 10.3390/cells10123597. [PMID: 34944104]
  • Ok-Joo Sul, Guoen Li, Ji-Eun Kim, Eun-Sook Kim, Hye-Seon Choi. 7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts. The Journal of nutritional biochemistry. 2021 10; 96(?):108783. doi: 10.1016/j.jnutbio.2021.108783. [PMID: 34023424]
  • Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Thomas Nury, Mohamed Ksila, Valerio Leoni, Balkiss Bouhaouala-Zahar, Sonia Hammami, Mohamed Hammami, John J Mackrill, Mohammad Samadi, Taoufik Ghrairi, Anne Vejux, Gérard Lizard. 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19. The Journal of steroid biochemistry and molecular biology. 2021 09; 212(?):105939. doi: 10.1016/j.jsbmb.2021.105939. [PMID: 34118414]
  • Alice Kilvington, Carlo Barnaba, Surender Rajasekaran, Mara L Laurens Leimanis, Ilce G Medina-Meza. Lipid profiling and dietary assessment of infant formulas reveal high intakes of major cholesterol oxidative product (7-ketocholesterol). Food chemistry. 2021 Aug; 354(?):129529. doi: 10.1016/j.foodchem.2021.129529. [PMID: 33761334]
  • Yu Li, Jordan S Orange. Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis. PLoS biology. 2021 08; 19(8):e3001328. doi: 10.1371/journal.pbio.3001328. [PMID: 34343168]
  • T Nury, A Yammine, I Ghzaiel, K Sassi, A Zarrouk, F Brahmi, M Samadi, S Rup-Jacques, D Vervandier-Fasseur, J P Pais de Barros, V Bergas, S Ghosh, M Majeed, A Pande, A Atanasov, S Hammami, M Hammami, J Mackrill, B Nasser, P Andreoletti, M Cherkaoui-Malki, A Vejux, G Lizard. Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases. Ageing research reviews. 2021 07; 68(?):101324. doi: 10.1016/j.arr.2021.101324. [PMID: 33774195]
  • Uğur Ünlütürk, Merve Savaş, Seda Hanife Oğuz, Afshin Samadi, Büşra Fırlatan, Deniz Yüce, İncilay Lay, Alper Gürlek. Oxysterol species generated by auto-oxidation in subclinical hypothyroidism. Clinical biochemistry. 2021 Jul; 93(?):73-79. doi: 10.1016/j.clinbiochem.2021.04.007. [PMID: 33861988]
  • Mason McComb, Richard W Browne, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Bianca Weinstock-Guttman, Jens Kuhle, Robert Zivadinov, Murali Ramanathan. The cholesterol autoxidation products, 7-ketocholesterol and 7β-hydroxycholesterol are associated with serum neurofilaments in multiple sclerosis. Multiple sclerosis and related disorders. 2021 May; 50(?):102864. doi: 10.1016/j.msard.2021.102864. [PMID: 33677412]
  • Sally Shuxian Koh, Samantha Chia-Yi Ooi, Natalie Man-Yin Lui, Cao Qiong, Leona Ting-Yuke Ho, Irwin Kee-Mun Cheah, Barry Halliwell, Deron R Herr, Wei-Yi Ong. Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury. Neuromolecular medicine. 2021 03; 23(1):184-198. doi: 10.1007/s12017-020-08620-4. [PMID: 33067719]
  • Xuan Kuo, Deron R Herr, Wei-Yi Ong. Anti-inflammatory and Cytoprotective Effect of Clinacanthus nutans Leaf But Not Stem Extracts on 7-Ketocholesterol Induced Brain Endothelial Cell Injury. Neuromolecular medicine. 2021 03; 23(1):176-183. doi: 10.1007/s12017-020-08621-3. [PMID: 33085066]
  • Christina Gkolfinopoulou, Faye Soukou, Ioannis Dafnis, Tahsin F Kellici, Despina Sanoudou, Thomas Mavromoustakos, Efstratios Stratikos, Angeliki Chroni. Structure-function analysis of naturally occurring apolipoprotein A-I L144R, A164S and L178P mutants provides insight on their role on HDL levels and cardiovascular risk. Cellular and molecular life sciences : CMLS. 2021 Feb; 78(4):1523-1544. doi: 10.1007/s00018-020-03583-y. [PMID: 32666307]
  • Xiaofei Wang, Yintao Li, Xuanyi Xia, Min Zhang, Chunmei Ge, Xiaoxiao Xia, Hourong Xiao, Shengmin Xu. Mutagenicity of 7-ketocholesterol in CHO cells: The role of lipid peroxidation. Toxicology. 2020 12; 446(?):152587. doi: 10.1016/j.tox.2020.152587. [PMID: 33017620]
  • Aline Yammine, Amira Zarrouk, Thomas Nury, Anne Vejux, Norbert Latruffe, Dominique Vervandier-Fasseur, Mohammad Samadi, John J Mackrill, Hélène Greige-Gerges, Lizette Auezova, Gérard Lizard. Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases. Cells. 2020 10; 9(11):. doi: 10.3390/cells9112346. [PMID: 33114025]
  • Aline Yammine, Thomas Nury, Anne Vejux, Norbert Latruffe, Dominique Vervandier-Fasseur, Mohammad Samadi, Hélène Greige-Gerges, Lizette Auezova, Gérard Lizard. Prevention of 7-Ketocholesterol-Induced Overproduction of Reactive Oxygen Species, Mitochondrial Dysfunction and Cell Death with Major Nutrients (Polyphenols, ω3 and ω9 Unsaturated Fatty Acids) of the Mediterranean Diet on N2a Neuronal Cells. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102296. [PMID: 32414101]
  • Ana Pariente, Álvaro Pérez-Sala, Rodrigo Ochoa, Rafael Peláez, Ignacio M Larráyoz. Genome-Wide Transcriptomic Analysis Identifies Pathways Regulated by Sterculic Acid in Retinal Pigmented Epithelium Cells. Cells. 2020 05; 9(5):. doi: 10.3390/cells9051187. [PMID: 32403229]
  • Neslihan Aksu, Afshin Samadi, Ahmet Yalçınkaya, Tuğçe Çetin, Burcu Eser, İncilay Lay, Türkan Nadir Öziş, Yeşim Öztaş, Suna Sabuncuoğlu. Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method. Molecular and cellular biochemistry. 2020 Apr; 467(1-2):117-125. doi: 10.1007/s11010-020-03706-w. [PMID: 32108278]
  • Anne Vejux, Dehbia Abed-Vieillard, Khadija Hajji, Amira Zarrouk, John J Mackrill, Shubhrima Ghosh, Thomas Nury, Aline Yammine, Mohamed Zaibi, Wafa Mihoubi, Habiba Bouchab, Boubker Nasser, Yaël Grosjean, Gérard Lizard. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochemical pharmacology. 2020 03; 173(?):113648. doi: 10.1016/j.bcp.2019.113648. [PMID: 31586589]
  • Alessandra Incani, Luisa Marras, Gabriele Serreli, Angela Ingianni, Raffaello Pompei, Monica Deiana, Fabrizio Angius. Human Herpesvirus 8 infection may contribute to oxidative stress in diabetes type 2 patients. BMC research notes. 2020 Feb; 13(1):75. doi: 10.1186/s13104-020-4935-3. [PMID: 32054515]
  • Sarmistha Saha, Elisabetta Profumo, Anna Rita Togna, Rachele Riganò, Luciano Saso, Brigitta Buttari. Lupeol Counteracts the Proinflammatory Signalling Triggered in Macrophages by 7-Keto-Cholesterol: New Perspectives in the Therapy of Atherosclerosis. Oxidative medicine and cellular longevity. 2020; 2020(?):1232816. doi: 10.1155/2020/1232816. [PMID: 33062133]
  • Jiuyang Chang, Masahiro Koseki, Ayami Saga, Kotaro Kanno, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Katsunao Tanaka, Masumi Asaji, Yinghong Zhu, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Ikuyo Ichi, Tohru Ohama, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata. Dietary Oxysterol, 7-Ketocholesterol Accelerates Hepatic Lipid Accumulation and Macrophage Infiltration in Obese Mice. Frontiers in endocrinology. 2020; 11(?):614692. doi: 10.3389/fendo.2020.614692. [PMID: 33776901]
  • Thomas Nury, Aline Yammine, Franck Menetrier, Amira Zarrouk, Anne Vejux, Gérard Lizard. 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Glial, Microglial and Neuronal Cells: Potential Role in Neurodegeneration : 7-ketocholesterol and 7β-hydroxycholesterol-Induced Peroxisomal Disorders and Neurodegeneration. Advances in experimental medicine and biology. 2020; 1299(?):31-41. doi: 10.1007/978-3-030-60204-8_3. [PMID: 33417205]
  • Priscila Calle, Angeles Muñoz, Anna Sola, Georgina Hotter. CPT1a gene expression reverses the inflammatory and anti-phagocytic effect of 7-ketocholesterol in RAW264.7 macrophages. Lipids in health and disease. 2019 Dec; 18(1):215. doi: 10.1186/s12944-019-1156-7. [PMID: 31823799]
  • William J Griffiths, Eylan Yutuc, Jonas Abdel-Khalik, Peter J Crick, Thomas Hearn, Alison Dickson, Brian W Bigger, Teresa Hoi-Yee Wu, Anu Goenka, Arunabha Ghosh, Simon A Jones, Douglas F Covey, Daniel S Ory, Yuqin Wang. Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free radical biology & medicine. 2019 11; 144(?):124-133. doi: 10.1016/j.freeradbiomed.2019.04.020. [PMID: 31009661]
  • Priscila Calle, Selene Torrico, Angeles Muñoz, Georgina Hotter. CPT1a downregulation protects against cholesterol-induced fibrosis in tubular epithelial cells by downregulating TGFβ-1 and inflammasome. Biochemical and biophysical research communications. 2019 10; 517(4):715-721. doi: 10.1016/j.bbrc.2019.07.121. [PMID: 31405564]
  • Ahmet Yalcinkaya, Afshin Samadi, Incilay Lay, Selma Unal, Suna Sabuncuoglu, Yesim Oztas. Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease. Scandinavian journal of clinical and laboratory investigation. 2019 Oct; 79(6):381-387. doi: 10.1080/00365513.2019.1627578. [PMID: 31187639]
  • Miquel Navas-Madroñal, Cristina Rodriguez, Modar Kassan, Joan Fité, José R Escudero, Laia Cañes, José Martínez-González, Mercedes Camacho, María Galán. Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm. Clinical science (London, England : 1979). 2019 07; 133(13):1421-1438. doi: 10.1042/cs20190399. [PMID: 31239294]
  • Kelly Fellows Maxwell, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Jesper Hagemeier, Richard W Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Murali Ramanathan. Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study. Journal of lipid research. 2019 07; 60(7):1190-1198. doi: 10.1194/jlr.m089664. [PMID: 31085627]
  • Tomasz Wielkoszyński, Jolanta Zalejska-Fiolka, Joanna K Strzelczyk, Aleksander J Owczarek, Armand Cholewka, Aneta Krawczyk, Agata Stanek. 5α,6α-Epoxyphytosterols and 5α,6α-Epoxycholesterol Increase Oxidative Stress in Rats on Low-Cholesterol Diet. Oxidative medicine and cellular longevity. 2019; 2019(?):1983975. doi: 10.1155/2019/1983975. [PMID: 31827670]
  • Nicholas J Hunt, Glen P Lockwood, Alessandra Warren, Hong Mao, Peter A G McCourt, David G Le Couteur, Victoria C Cogger. Manipulating fenestrations in young and old liver sinusoidal endothelial cells. American journal of physiology. Gastrointestinal and liver physiology. 2019 01; 316(1):G144-G154. doi: 10.1152/ajpgi.00179.2018. [PMID: 30285464]
  • Fatiha Brahmi, Anne Vejux, Randa Sghaier, Amira Zarrouk, Thomas Nury, Wiem Meddeb, Leila Rezig, Amira Namsi, Khouloud Sassi, Aline Yammine, Iham Badreddine, Dominique Vervandier-Fasseur, Khodir Madani, Lila Boulekbache-Makhlouf, Boubker Nasser, Gérard Lizard. Prevention of 7-ketocholesterol-induced side effects by natural compounds. Critical reviews in food science and nutrition. 2019; 59(19):3179-3198. doi: 10.1080/10408398.2018.1491828. [PMID: 29993272]
  • Thomas Nury, Randa Sghaier, Amira Zarrouk, Franck Ménétrier, Tugba Uzun, Valerio Leoni, Claudio Caccia, Wiem Meddeb, Amira Namsi, Khouloud Sassi, Wafa Mihoubi, Jean-Marc Riedinger, Mustapha Cherkaoui-Malki, Thibault Moreau, Anne Vejux, Gérard Lizard. Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol. Biochimie. 2018 Oct; 153(?):181-202. doi: 10.1016/j.biochi.2018.07.009. [PMID: 30031877]
  • Maryem Bezine, Sonia Maatoug, Rym Ben Khalifa, Meryam Debbabi, Amira Zarrouk, Yuqin Wang, William J Griffiths, Thomas Nury, Mohammad Samadi, Anne Vejux, Jérôme de Sèze, Thibault Moreau, Riadh Kharrat, Mohamed El Ayeb, Gérard Lizard. Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0). Biochimie. 2018 Oct; 153(?):56-69. doi: 10.1016/j.biochi.2018.02.008. [PMID: 29462682]
  • Yidan Sun, Susanne Kopp, Jasmin Strutz, Chaitanya Chakravarthi Gali, Martina Zandl-Lang, Elham Fanaee-Danesh, Andrijana Kirsch, Silvija Cvitic, Saša Frank, Richard Saffery, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck. Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 09; 1863(9):968-979. doi: 10.1016/j.bbalip.2018.05.005. [PMID: 29778664]
  • Stella M Lu, Gregory D Fairn. 7-Ketocholesterol impairs phagocytosis and efferocytosis via dysregulation of phosphatidylinositol 4,5-bisphosphate. Traffic (Copenhagen, Denmark). 2018 08; 19(8):591-604. doi: 10.1111/tra.12576. [PMID: 29693767]
  • Hsiang-Yu Tang, Chao-Hung Wang, Hung-Yao Ho, Pei-Ting Wu, Chun-Ling Hung, Cheng-Yu Huang, Pei-Ru Wu, Yung-Hsin Yeh, Mei-Ling Cheng. Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. Redox biology. 2018 04; 14(?):499-508. doi: 10.1016/j.redox.2017.10.020. [PMID: 29101899]
  • Yuqin Wang, William J Griffiths. Unravelling new pathways of sterol metabolism: lessons learned from in-born errors and cancer. Current opinion in clinical nutrition and metabolic care. 2018 03; 21(2):90-96. doi: 10.1097/mco.0000000000000442. [PMID: 29227331]
  • Yasuhiro Watanabe, Takashi Yamaguchi, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Rena Oka, Haruki Imamura, Yuta Sato, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Naomi Shimizu, Atsuhito Saiki, Ichiro Tatsuno. 7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy. Prostaglandins & other lipid mediators. 2018 01; 134(?):16-23. doi: 10.1016/j.prostaglandins.2017.11.002. [PMID: 29154978]
  • Erdi Sozen, Burak Yazgan, Ali Sahin, Umit Ince, Nesrin Kartal Ozer. High Cholesterol Diet-Induced Changes in Oxysterol and Scavenger Receptor Levels in Heart Tissue. Oxidative medicine and cellular longevity. 2018; 2018(?):8520746. doi: 10.1155/2018/8520746. [PMID: 30008986]
  • Monica Deiana, Simone Calfapietra, Alessandra Incani, Angela Atzeri, Daniela Rossin, Roberto Loi, Barbara Sottero, Noemi Iaia, Giuseppe Poli, Fiorella Biasi. Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. Free radical biology & medicine. 2017 12; 113(?):539-550. doi: 10.1016/j.freeradbiomed.2017.10.390. [PMID: 29102636]
  • Min Wang, Weiqing Long, Di Li, Duan Wang, Yuan Zhong, Di Mu, Jiayi Song, Min Xia. Plasma 7-ketocholesterol levels and the risk of incident cardiovascular events. Heart (British Cardiac Society). 2017 11; 103(22):1788-1794. doi: 10.1136/heartjnl-2016-310914. [PMID: 28490621]
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