Apicidin (BioDeep_00000399694)

   

natural product Chemicals and Drugs


代谢物信息卡片


Apicidin _120249

化学式: C34H49N5O6 (623.3682653999999)
中文名称: 组蛋白脱乙酰酶抑制剂
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)CCCCC[C@@H]1N=C(O)[C@H]2CCCCN2C(=O)[C@H]([C@@H](C)CC)N=C(O)[C@H](Cc2cn(OC)c3ccccc23)N=C1O
InChI: InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1

描述信息

D004791 - Enzyme Inhibitors > D056572 - Histone Deacetylase Inhibitors
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity[1].
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity[1].

同义名列表

3 个代谢物同义名

Apicidin; Apicidin _120249; OSI 2040



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Markus Hartl, Magdalena Füßl, Paul J Boersema, Jan-Oliver Jost, Katharina Kramer, Ahmet Bakirbas, Julia Sindlinger, Magdalena Plöchinger, Dario Leister, Glen Uhrig, Greg Bg Moorhead, Jürgen Cox, Michael E Salvucci, Dirk Schwarzer, Matthias Mann, Iris Finkemeier. Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis. Molecular systems biology. 2017 10; 13(10):949. doi: 10.15252/msb.20177819. [PMID: 29061669]
  • Beom Soo Shin, Jürgen B Bulitta, Joseph P Balthasar, Minki Kim, Yohan Choi, Sun Dong Yoo. Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling. Cancer chemotherapy and pharmacology. 2011 Aug; 68(2):465-75. doi: 10.1007/s00280-010-1502-y. [PMID: 21069337]
  • Darren M Hutt, Christian A Olsen, Chris J Vickers, David Herman, Monica Chalfant, Ana Montero, Luke J Leman, Renner Burkle, Bruce E Maryanoff, William E Balch, M Reza Ghadiri. Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. ACS medicinal chemistry letters. 2011 Jul; 2(9):703-707. doi: 10.1021/ml200136e. [PMID: 21984958]
  • Beom Soo Shin, Jürgen B Bulitta, Deok Ki Hong, Hye Youn Kim, Min Ki Kim, Yohan Choi, Jong Bong Lee, Sang Wook Hwang, Mann Hyung Lee, Sun Dong Yoo. Population pharmacokinetics of a novel histone deacetylase inhibitor, cyclo{(2S)-2-amino-8-[(aminocarbonyl)hydrazono] decanoyl-1-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl} (SD-2007), and its metabolic conversion to apicidin after intravenous injection and oral administration in rats. Chemotherapy. 2011; 57(3):259-67. doi: 10.1159/000328027. [PMID: 21597290]
  • Philip Jones, Sergio Altamura, Raffaele De Francesco, Paola Gallinari, Armin Lahm, Petra Neddermann, Michael Rowley, Sergio Serafini, Christian Steinkühler. Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases. Bioorganic & medicinal chemistry letters. 2008 Mar; 18(6):1814-9. doi: 10.1016/j.bmcl.2008.02.025. [PMID: 18308563]
  • Beom Soo Shin, Eun Hye Park, Chi Ho Yoon, John Kim, Okpyo Zee, Sun Dong Yoo. In vitro investigation of the hepatic intrinsic clearance of apicidin, a histone deacetylase inhibitor, in mouse, rat, and human, with correction by nonspecific protein binding. Journal of toxicology and environmental health. Part A. 2005 Dec; 68(23-24):2207-18. doi: 10.1080/15287390500181992. [PMID: 16326434]
  • Beom Soo Shin, John Kim, Chi Ho Yoon, Chul Hwan Kim, Eun Hye Park, Jeung-Whan Han, Sun Dong Yoo. Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a pharmacokinetic study. Rapid communications in mass spectrometry : RCM. 2005; 19(3):408-14. doi: 10.1002/rcm.1805. [PMID: 15645510]
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