lanatoside C (BioDeep_00000398728)

Main id: BioDeep_00000230862

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


lanatoside C

化学式: C49H76O20 (984.4929695999999)
中文名称: 毛花苷C
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3CC(C5(C4(CCC5C6=CC(=O)OC6)O)C)O)C)O)OC7CC(C(C(O7)C)OC8CC(C(C(O8)C)OC9C(C(C(C(O9)CO)O)O)O)OC(=O)C)O
InChI: InChI=1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01A - Cardiac glycosides > C01AA - Digitalis glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D004071 - Digitalis Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.263
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71[1][2].
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71[1][2].

同义名列表

1 个代谢物同义名

lanatoside C



数据库引用编号

31 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jenny Felth, Linda Rickardson, Josefin Rosén, Malin Wickström, Mårten Fryknäs, Magnus Lindskog, Lars Bohlin, Joachim Gullbo. Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs. Journal of natural products. 2009 Nov; 72(11):1969-74. doi: 10.1021/np900210m. [PMID: 19894733]
  • A Tracqui, P Kintz, B Ludes, P Mangin. High-performance liquid chromatography-ionspray mass spectrometry for the specific determination of digoxin and some related cardiac glycosides in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1997 Apr; 692(1):101-9. doi: 10.1016/s0378-4347(96)00462-8. [PMID: 9187389]
  • Z A Khushbaktova, V N Syrov. [Comparative study of the effect of cycloartane and cardiac glycosides on various parameters of myocardial metabolism in animals]. Ukrainskii biokhimicheskii zhurnal (1978). 1993 May; 65(3):71-5. doi: ". [PMID: 8291144]
  • K Yoshimatsu, M Satake, K Shimomura, J I Sawada, T Terao. Determination of cardenolides in hairy root cultures of Digitalis lanata by enzyme-linked immunosorbent assay. Journal of natural products. 1990 Nov; 53(6):1498-502. doi: 10.1021/np50072a015. [PMID: 2089119]
  • P E Santos, S D Souza, L Freire-Maia, A P Almeida. Effects of crotoxin on the isolated guinea pig heart. Toxicon : official journal of the International Society on Toxinology. 1990; 28(2):215-24. doi: 10.1016/0041-0101(90)90415-4. [PMID: 2339436]
  • R Cristodorescu, G Deutsch, S Drăgan. Clinical utility of plasma digoxin measurements. Medecine interne. 1989 Jan; 27(1):25-32. doi: NULL. [PMID: 2749155]
  • P H Jiao, L Jin, Q Fang, L Xu, M Y Xie. [Clinical application of the determination of serum digoxin concentration]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 1986 Jun; 8(3):214-7. doi: NULL. [PMID: 2946462]
  • J Z Liao, Z M Wu, T P Kang, Z X Shi, L Z Guo, Y R Zhao, Z G Wang, Q C Hao. Effect of sheng mai san on left ventricular performance in coronary heart disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 1982 Mar; 2(1):57-62. doi: ". [PMID: 6765690]
  • H R Ochs, D J Greenblatt, J S Harmatz, G Bodem, H J Dengler. Clinical implications of serum digoxin concentrations. Klinische Wochenschrift. 1981 May; 59(10):501-7. doi: 10.1007/bf01696212. [PMID: 7241950]
  • V Gersl. [Effects of Coronilla varia Linné extract and lanatoside C in rabbits with experimental acute heart overloading in vivo]. Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum. 1980; 23(4):445-57. doi: ". [PMID: 6971482]
  • N A Gorchakova, I F Poliakova, K I Rubchinskaia, R D Samilova. [Action of isolanide in acute cardiac insufficiency in rats]. Farmakologiia i toksikologiia. 1977 Sep; 40(5):541-4. doi: ". [PMID: 923775]
  • M HUEDEPOHL, K LEDERBOGEN. [Clinical experiences with a lanatoside C preparation soluble in the small intestine]. Medizinische Klinik. 1962 May; 57(?):892-4. doi: ". [PMID: 14449711]
  • A MARTELLI. [Effects of the administration of lanatoside C in cardiocirculatory decompensation]. Gazzetta medica italiana. 1961 Jul; 120(?):250-5. doi: ". [PMID: 13767271]
  • S JOHN. [Saturation therapy with lanatoside C]. Munchener medizinische Wochenschrift (1950). 1961 Jun; 103(?):1228-33. doi: ". [PMID: 13790214]
  • O GIALLORETO, P P ALLARD, P DAVID. [Clinical trial of a new oral preparation of Lanatoside C ('Cedilanid Space Tab')]. L'union medicale du Canada. 1960 Dec; 89(?):1579-86. doi: ". [PMID: 13704996]
  • H BARFOD. [Lanatoside C therapy of cardiac insufficiency highly sensitive to glycosides]. Munchener medizinische Wochenschrift (1950). 1959 Apr; 101(16):716-7. doi: ". [PMID: 13656996]
  • H A BLAIR, A M WEDD. A comparison of effects of lanatoside C and digoxigenin on heart muscle. Archives internationales de pharmacodynamie et de therapie. 1956 Aug; 107(2):127-32. doi: ". [PMID: 13355484]
  • J TUZSON, G VASTAGH. [An unidentified glycosidic substance in lanatoside C preparations]. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. 1956 Apr; 289(4):203-7. doi: 10.1002/ardp.19562890406. [PMID: 13328073]
  • P DAVID, E S EDDIE. [Lanatoside C: indications and results]. L'union medicale du Canada. 1956 Mar; 85(3):271-82. doi: ". [PMID: 13325047]
  • H BUCHT, J EK, E VARNAUSKAS, L WERKO. Studies of the renal circulation and renal function in mitral valvular disease. IV. The effect of a single intravenous injection of lanatoside C. Cardiologia. 1956; 29(5):305-20. doi: 10.1159/000165615. [PMID: 13383483]
  • H BUCHT, J EK, L WERKO, E VARNAUSKAS. [Effect of lanatoside C on renal blood flow, diuresis and sodium excretion in mitral stenosis]. Nordisk medicin. 1955 Aug; 54(32):1248-51. doi: NULL. [PMID: 13253950]
  • L WERKO, H ELIASCH, B THOMASSON, E VARNAUSKAS. [Effects of lanatoside C on the pulmonary circulation in mitral valve defect]. Nordisk medicin. 1955 Apr; 53(14):568-71. doi: ". [PMID: 14384034]
  • B T BROWN, D RANGER, S E WRIGHT. The excretory products of lanatoside C and digitoxin in the rat. The Journal of pharmacology and experimental therapeutics. 1955 Mar; 113(3):353-8. doi: NULL. [PMID: 14368503]
  • C PULLE. [Lanatoside C, ther. of heart disease in pregnancy]. Minerva ginecologica. 1954 Apr; 6(8):264-70. doi: ". [PMID: 13185123]
  • S ZEEMAN, S HIRSCH, S BELLET. The effect of potassium depletion induced by desoxycorticosterone acetate on the lethal dose of lanatoside C in dogs: relationship of plasma levels, skeletal and cardiac muscle potassium content to the lethal dose. The American journal of the medical sciences. 1954 Jan; 227(1):65-73. doi: 10.1097/00000441-195401000-00009. [PMID: 13114216]
  • H PICHLER, S ZOLLNER. [Intravenous cedilanid therapy of tachycardiac auricular fibrillation in circulatory insufficiency]. Wiener medizinische Wochenschrift (1946). 1953 Sep; 103(35-36):663-6. doi: ". [PMID: 13103057]
  • I SASONYI. [Isolanid]. A Gyogyszeresz. 1953 May; 8(5):96. doi: ". [PMID: 24542667]
  • H DOROW, J BIALKOWSKI. [Peroral continous therapy of the chronic muscular cardiac insufficiency with lanatoside C]. Arztliche Wochenschrift. 1953 Feb; 8(7):162-5. doi: ". [PMID: 13057761]
  • L SOTTI, O RIONDATO. [Lanatoside C therapy of cardiac insufficiency]. Giornale di clinica medica. 1952 Jun; 33(6):617-34. doi: ". [PMID: 12989547]
  • R BINE, S S GEORGE, M FRIEDMAN. Renal excretion of Lanatoside C. in the rat. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1952 Mar; 79(3):513-4. doi: 10.3181/00379727-79-19429. [PMID: 14920478]
  • Z PNIAKOWSKA. [Effect of lanatoside C on circulatory insufficiency]. Polski tygodnik lekarski. 1952 Feb; 7(7-8):169-76. doi: ". [PMID: 14929733]
  • S HEDLUND. [Clinical investigations with cedilanid]. Cardiologia. 1952; 22(Suppl):1-88. doi: ". [PMID: 14916409]
  • V CORSI. [Effect of lanatoside C in patients with sinusal rhythm]. Cuore e circolazione. 1951 Dec; 35(6):358-69. doi: ". [PMID: 14905903]
  • O STORSTEIN. [Clinical investigation of effects of digitaline Nativelle and cedilanid]. Nordisk medicin. 1951 Mar; 45(13):470-4. doi: . [PMID: 14843518]
  • R BAGUENA CANDELA, V TORMO ALFONSO. [Rapid digitalization with digilanid and cedilanid]. Medicina espanola. 1951 Mar; 25(144):180-8. doi: ". [PMID: 14842436]
  • A HAHN, R BALZER, J PODKAMINER, M VODOPIVEE. [Use of cedilanid in severe diabetes mellitus]. Klinische Medizin; osterreichische Zeitschrift fur wissenschaftliche und praktische Medizin. 1951 Feb; 6(2):61-5. doi: ". [PMID: 14825681]
  • M FRIEDMAN, R BINE. Study of the rate of disappearance of a digitalis glycoside, lanatoside C, from the blood of man. The American journal of medicine. 1949 Mar; 6(3):387. doi: 10.1016/0002-9343(49)90180-1. [PMID: 18208196]
  • M Friedman, R Bine. A STUDY OF THE RATE OF DISAPPEARANCE OF A DIGITALIS GLYCOSIDE (LANATOSIDE C.) FROM THE BLOOD OF MAN. The Journal of clinical investigation. 1949 Jan; 28(1):32-4. doi: 10.1172/jci102049. [PMID: 16695656]
  • M FRIEDMAN, R BINE. The delay in the action of digitalis glycoside, lanatoside C. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1948 Apr; 67(4):533. doi: 10.3181/00379727-67-16365. [PMID: 18860008]
  • S P WISE. Lanatoside C (cedilanid). The New Orleans medical and surgical journal. 1946 Jul; 99(?):7-15. doi: ". [PMID: 20991535]