Taurolithocholic acid (BioDeep_00000398032)
Main id: BioDeep_00000003426
natural product Bile acids BioNovoGene_Lab2019
代谢物信息卡片
Taurolithocholic acid
化学式: C26H45NO5S (483.3018)
中文名称: 牛磺石胆酸
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 35.16%
分子结构信息
SMILES: C(C4O)CC(C1([H])2)(C([H])(C4)CCC1(C([H])(C3)C(C)(C([H])(C(C)CCC(=O)NCCS(O)(=O)=O)C3)CC2)[H])C
InChI: InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
D013501 - Surface-Active Agents > D003902 - Detergents
The bile acid taurine conjugate of lithocholic acid.
KEIO_ID T072
同义名列表
2 个代谢物同义名
数据库引用编号
57 个数据库交叉引用编号
- ChEBI: CHEBI:36259
- KEGG: C02592
- PubChem: 439763
- ChEMBL: CHEMBL408701
- MeSH: Taurolithocholic Acid
- CAS: 516-90-5
- MoNA: CCMSLIB00005435494
- MoNA: CCMSLIB00005435495
- MoNA: CCMSLIB00005435496
- MoNA: CCMSLIB00005435588
- MoNA: CCMSLIB00005435589
- MoNA: CCMSLIB00005435590
- MoNA: CCMSLIB00005435591
- MoNA: CCMSLIB00005435592
- MoNA: MoNA038815
- MoNA: MoNA038725
- MoNA: MoNA038683
- MoNA: MoNA038303
- MoNA: MoNA038152
- MoNA: MoNA038094
- MoNA: MoNA036774
- MoNA: MoNA036771
- MoNA: MoNA036768
- MoNA: MoNA036570
- MoNA: MoNA036565
- MoNA: MoNA036564
- MoNA: MoNA036379
- MoNA: MoNA036377
- MoNA: MoNA036376
- MoNA: MoNA035385
- MoNA: MoNA035384
- MoNA: MoNA035380
- MoNA: MoNA035031
- MoNA: MoNA035030
- MoNA: MoNA035029
- MoNA: MoNA034655
- MoNA: MoNA034654
- MoNA: MoNA034652
- MoNA: MoNA032677
- MoNA: MoNA032673
- MoNA: MoNA032672
- MoNA: MoNA032650
- MoNA: MoNA032649
- MoNA: MoNA032646
- MoNA: KO001957
- MoNA: KO001956
- MoNA: KO001955
- MoNA: KO001954
- MetaboLights: MTBLC36259
- ChEBI: CHEBI:17179
- PubChem: 5584
- LipidMAPS: LMST05040003
- 3DMET: B01591
- NIKKAJI: J337.752K
- RefMet: Taurolithocholic acid
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-581
- KNApSAcK: 17179
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 654 - Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Siyu Wu, Lorenzo Romero-Ramírez, Jörg Mey. Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow-derived macrophages under inflammatory stress.
Journal of cellular physiology.
2022 02; 237(2):1455-1470. doi:
10.1002/jcp.30619. [PMID: 34705285] - Ali Nakhi, Henry L Wong, Melissa Weldy, Alexander Khoruts, Michael J Sadowsky, Peter I Dosa. Structural modifications that increase gut restriction of bile acid derivatives.
RSC medicinal chemistry.
2021 Mar; 12(3):394-405. doi:
10.1039/d0md00425a. [PMID: 34046622] - Francesca De Faveri, Michael Chvanov, Svetlana Voronina, Danielle Moore, Liam Pollock, Lee Haynes, Muhammad Awais, Alison J Beckett, Ulrike Mayer, Robert Sutton, David N Criddle, Ian A Prior, Tom Wileman, Alexei V Tepikin. LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells.
Autophagy.
2020 07; 16(7):1314-1331. doi:
10.1080/15548627.2019.1679514. [PMID: 31651224] - Fengfeng Mao, Teng Liu, Xinfeng Hou, Hanqing Zhao, Wenhui He, Cong Li, Zhiyi Jing, Jianhua Sui, Fengchao Wang, Xiaohui Liu, Jun Han, Christoph H Borchers, Jian-She Wang, Wenhui Li. Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency.
The Journal of biological chemistry.
2019 08; 294(31):11853-11862. doi:
10.1074/jbc.ra118.007179. [PMID: 31201272] - Issey Takehara, Nobuaki Watanabe, Daiki Mori, Osamu Ando, Hiroyuki Kusuhara. Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion.
Journal of pharmaceutical sciences.
2019 08; 108(8):2756-2764. doi:
10.1016/j.xphs.2019.03.021. [PMID: 30905707] - Ali Nakhi, Connor M McDermott, Kristen L Stoltz, Kristen John, Jon E Hawkinson, Elizabeth A Ambrose, Alexander Khoruts, Michael J Sadowsky, Peter I Dosa. 7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
Journal of medicinal chemistry.
2019 07; 62(14):6824-6830. doi:
10.1021/acs.jmedchem.9b00770. [PMID: 31268316] - Hannah M Eggink, Lauren L Tambyrajah, Rosa van den Berg, Isabel M Mol, Jose K van den Heuvel, Martijn Koehorst, Albert K Groen, Anita Boelen, Andries Kalsbeek, Johannes A Romijn, Patrick C N Rensen, Sander Kooijman, Maarten R Soeters. Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice.
The Journal of endocrinology.
2018 02; 236(2):85-97. doi:
10.1530/joe-17-0503. [PMID: 29233934] - Thomas R Kolodecik, Anamika M Reed, Kimie Date, Christine A Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V Desir, Fred S Gorelick. The serum protein renalase reduces injury in experimental pancreatitis.
The Journal of biological chemistry.
2017 12; 292(51):21047-21059. doi:
10.1074/jbc.m117.789776. [PMID: 29042438] - Se Won Park, Cynthia R L Webster, Mohammed S Anwer. Mechanism of inhibition of taurolithocholate-induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate.
Physiological reports.
2017 Dec; 5(23):. doi:
10.14814/phy2.13529. [PMID: 29192063] - Shishuai Meng, Hao Wang, Dongbo Xue, Weihui Zhang. Screening and validation of differentially expressed extracellular miRNAs in acute pancreatitis.
Molecular medicine reports.
2017 Nov; 16(5):6412-6418. doi:
10.3892/mmr.2017.7374. [PMID: 28849189] - Wei Huang, Andrea C Haynes, Rajarshi Mukherjee, Li Wen, Diane Latawiec, Alexei V Tepikin, David N Criddle, Rab K Prinjha, Nicholas Smithers, Robert Sutton. Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2017 Sep; 17(5):689-697. doi:
10.1016/j.pan.2017.06.005. [PMID: 28648518] - Wei Huang, Matthew C Cane, Rajarshi Mukherjee, Peter Szatmary, Xiaoying Zhang, Victoria Elliott, Yulin Ouyang, Michael Chvanov, Diane Latawiec, Li Wen, David M Booth, Andrea C Haynes, Ole H Petersen, Alexei V Tepikin, David N Criddle, Robert Sutton. Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release.
Gut.
2017 02; 66(2):301-313. doi:
10.1136/gutjnl-2015-309363. [PMID: 26642860] - Guoxiang Xie, Xiaoning Wang, Fengjie Huang, Aihua Zhao, Wenlian Chen, Jingyu Yan, Yunjing Zhang, Sha Lei, Kun Ge, Xiaojiao Zheng, Jiajian Liu, Mingming Su, Ping Liu, Wei Jia. Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis.
International journal of cancer.
2016 10; 139(8):1764-75. doi:
10.1002/ijc.30219. [PMID: 27273788] - Christopher M Schonhoff, Se Won Park, Cynthia R L Webster, M Sawkat Anwer. p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2.
American journal of physiology. Gastrointestinal and liver physiology.
2016 06; 310(11):G999-G1005. doi:
10.1152/ajpgi.00005.2016. [PMID: 27012769] - Wei Huang, Nicole Cash, Li Wen, Peter Szatmary, Rajarshi Mukherjee, Jane Armstrong, Michael Chvanov, Alexei V Tepikin, Michael P Murphy, Robert Sutton, David N Criddle. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis.
Mediators of inflammation.
2015; 2015(?):901780. doi:
10.1155/2015/901780. [PMID: 25878403] - Xingguo Cheng, Youcai Zhang, Curtis D Klaassen. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum.
The Journal of pharmacology and experimental therapeutics.
2014 Oct; 351(1):105-13. doi:
10.1124/jpet.114.216796. [PMID: 25034404] - Carlos A Penno, Stuart A Morgan, Adam J Rose, Stephan Herzig, Gareth G Lavery, Alex Odermatt. 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.
Molecular metabolism.
2014 Aug; 3(5):554-64. doi:
10.1016/j.molmet.2014.04.008. [PMID: 25061560] - Ana C S Carvalho, Rhamon B Sousa, Álvaro Xavier Franco, José Victor Gomes Costa, Luara Manuela Neves, Ronaldo A Ribeiro, Robert Sutton, David N Criddle, Pedro M G Soares, Marcellus H L P de Souza. Protective effects of fucoidan, a P- and L-selectin inhibitor, in murine acute pancreatitis.
Pancreas.
2014 Jan; 43(1):82-7. doi:
10.1097/mpa.0b013e3182a63b9d. [PMID: 24177139] - Zhong-Ze Fang, Rong-Rong He, Yun-Feng Cao, Naoki Tanaka, Changtao Jiang, Kristopher W Krausz, Yunpeng Qi, Pei-Pei Dong, Chun-Zhi Ai, Xiao-Yu Sun, Mo Hong, Guang-Bo Ge, Frank J Gonzalez, Xiao-Chi Ma, Hong-Zhi Sun. A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders.
Journal of lipid research.
2013 Dec; 54(12):3334-44. doi:
10.1194/jlr.m040519. [PMID: 24115227] - Christopher M Schonhoff, Cynthia R L Webster, M Sawkat Anwer. Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH-NTCP Cells.
Hepatology (Baltimore, Md.).
2013 Jul; 58(1):284-92. doi:
10.1002/hep.26333. [PMID: 23424156] - Tsutomu Matsubara, Naoki Tanaka, Misako Sato, Dong Wook Kang, Kristopher W Krausz, Kathleen C Flanders, Kazuo Ikeda, Hans Luecke, Lalage M Wakefield, Frank J Gonzalez. TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury.
Journal of lipid research.
2012 Dec; 53(12):2698-707. doi:
10.1194/jlr.m031773. [PMID: 23034213] - Youcai Zhang, Iván L Csanaky, Xingguo Cheng, Lois D Lehman-McKeeman, Curtis D Klaassen. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Jun; 127(2):451-62. doi:
10.1093/toxsci/kfs123. [PMID: 22461449] - Laia Tolosa, Sandra Pinto, M Teresa Donato, Agustín Lahoz, José V Castell, J Enrique O'Connor, M José Gómez-Lechón. Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 May; 127(1):187-98. doi:
10.1093/toxsci/kfs083. [PMID: 22331495] - Daniela Küllenberg, Lenka A Taylor, Michael Schneider, Ulrich Massing. Health effects of dietary phospholipids.
Lipids in health and disease.
2012 Jan; 11(?):3. doi:
10.1186/1476-511x-11-3. [PMID: 22221489] - Tiangang Li, John Y L Chiang. Bile Acid signaling in liver metabolism and diseases.
Journal of lipids.
2012; 2012(?):754067. doi:
10.1155/2012/754067. [PMID: 21991404] - Rima Kaddurah-Daouk, Rebecca A Baillie, Hongjie Zhu, Zhao-Bang Zeng, Michelle M Wiest, Uyen Thao Nguyen, Katie Wojnoonski, Steven M Watkins, Miles Trupp, Ronald M Krauss. Enteric microbiome metabolites correlate with response to simvastatin treatment.
PloS one.
2011; 6(10):e25482. doi:
10.1371/journal.pone.0025482. [PMID: 22022402] - Jocelyn Trottier, Andrzej Białek, Patrick Caron, Robert J Straka, Piotr Milkiewicz, Olivier Barbier. Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting.
PloS one.
2011; 6(7):e22094. doi:
10.1371/journal.pone.0022094. [PMID: 21760958] - Youcai Zhang, Curtis D Klaassen. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.
Journal of lipid research.
2010 Nov; 51(11):3230-42. doi:
10.1194/jlr.m007641. [PMID: 20671298] - Lorena Fuentes-Broto, Francisco J Miana-Mena, Eduardo Piedrafita, César Berzosa, Enrique Martínez-Ballarín, Francisco A García-Gil, Russel J Reiter, Joaquín J García. Melatonin protects against taurolithocholic-induced oxidative stress in rat liver.
Journal of cellular biochemistry.
2010 Aug; 110(5):1219-25. doi:
10.1002/jcb.22636. [PMID: 20564217] - Zélia Velez, Peter C Hubbard, Kevin Welham, Joerg D Hardege, Eduardo N Barata, Adelino V M Canário. Identification, release and olfactory detection of bile salts in the intestinal fluid of the Senegalese sole (Solea senegalensis).
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology.
2009 Jul; 195(7):691-8. doi:
10.1007/s00359-009-0444-5. [PMID: 19415298] - Bao-Zhu Yu, Rajani Kaimal, Shi Bai, Khalid A El Sayed, Suren A Tatulian, Rafael J Apitz, Mahendra K Jain, Ruitang Deng, Otto G Berg. Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.
Journal of natural products.
2009 Jan; 72(1):24-8. doi:
10.1021/np8004453. [PMID: 19102680] - Anne K Green, Rebecca C Stratton, Paul E Squires, Alec W M Simpson. Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by stimulating net plasma membrane Ca2+ efflux.
The Journal of biological chemistry.
2007 Nov; 282(47):34542-54. doi:
10.1074/jbc.m707115200. [PMID: 17893148] - Julia V Gerasimenko, Sarah E Flowerdew, Svetlana G Voronina, Tatiana K Sukhomlin, Alexei V Tepikin, Ole H Petersen, Oleg V Gerasimenko. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.
The Journal of biological chemistry.
2006 Dec; 281(52):40154-63. doi:
10.1074/jbc.m606402200. [PMID: 17074764] - Anand Balakrishnan, Stephen A Wring, James E Polli. Interaction of native bile acids with human apical sodium-dependent bile acid transporter (hASBT): influence of steroidal hydroxylation pattern and C-24 conjugation.
Pharmaceutical research.
2006 Jul; 23(7):1451-9. doi:
10.1007/s11095-006-0219-4. [PMID: 16783481] - Roland Reinehr, Stephan Becker, Verena Keitel, Andrea Eberle, Susanne Grether-Beck, Dieter Häussinger. Bile salt-induced apoptosis involves NADPH oxidase isoform activation.
Gastroenterology.
2005 Dec; 129(6):2009-31. doi:
10.1053/j.gastro.2005.09.023. [PMID: 16344068] - Makoto Sasaki, Hiroshi Suzuki, Jun Aoki, Kousei Ito, Peter J Meier, Yuichi Sugiyama. Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2.
Molecular pharmacology.
2004 Sep; 66(3):450-9. doi:
10.1124/mol.66.3.. [PMID: 15322236] - DebraLynn Mims, David Hercules. Quantification of bile acids directly from plasma by MALDI-TOF-MS.
Analytical and bioanalytical chemistry.
2004 Mar; 378(5):1322-6. doi:
10.1007/s00216-003-2475-z. [PMID: 14747894] - F A Crocenzi, A D Mottino, E J Sánchez Pozzi, J M Pellegrino, E A Rodríguez Garay, P Milkiewicz, M Vore, R Coleman, M G Roma. Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat.
Gut.
2003 Aug; 52(8):1170-7. doi:
10.1136/gut.52.8.1170. [PMID: 12865277] - Dirk Graf, Roland Reinehr, Anna Kordelia Kurz, Richard Fischer, Dieter Häussinger. Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms.
Archives of biochemistry and biophysics.
2003 Jul; 415(1):34-42. doi:
10.1016/s0003-9861(03)00224-8. [PMID: 12801510] - Astrid Barth, Gottwalt Klinger, Michael Rost. Influence of ethinyloestradiol propanolsulphonate on serum bile acids in healthy volunteers.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2003 Jun; 54(5-6):381-6. doi:
10.1078/0940-2993-00274. [PMID: 12877349] - Markéta Smídková, Marcela Spundová, Zdenek Marecek, Gustav Entlicher. Effect of drugs on cholesterol crystallization in an artificial bile model and relation of this effect to drug binding to albumin.
Fundamental & clinical pharmacology.
2003 Jun; 17(3):331-9. doi:
10.1046/j.1472-8206.2003.00157.x. [PMID: 12803572] - Hirotaka Kitada, Masaaki Miyata, Toshifumi Nakamura, Aki Tozawa, Wataru Honma, Miki Shimada, Kiyoshi Nagata, Christopher J Sinal, Grace L Guo, Frank J Gonzalez, Yasushi Yamazoe. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.
The Journal of biological chemistry.
2003 May; 278(20):17838-44. doi:
10.1074/jbc.m210634200. [PMID: 12637555] - Noam Zelcer, Glen Reid, Peter Wielinga, Annemieke Kuil, Ingrid van der Heijden, John D Schuetz, Piet Borst. Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).
The Biochemical journal.
2003 Apr; 371(Pt 2):361-7. doi:
10.1042/bj20021886. [PMID: 12523936] - DebraLynn Mims, David Hercules. Quantification of bile acids directly from urine by MALDI-TOF-MS.
Analytical and bioanalytical chemistry.
2003 Mar; 375(5):609-16. doi:
10.1007/s00216-003-1771-y. [PMID: 12638043] - Kunrong Cheng, Sandeep Khurana, Ying Chen, Richard H Kennedy, Piotr Zimniak, Jean-Pierre Raufman. Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist.
The Journal of pharmacology and experimental therapeutics.
2002 Oct; 303(1):29-35. doi:
10.1124/jpet.102.036376. [PMID: 12235229] - Dirk Graf, Anna Kordelia Kurz, Roland Reinehr, Richard Fischer, Gerald Kircheis, Dieter Häussinger. Prevention of bile acid-induced apoptosis by betaine in rat liver.
Hepatology (Baltimore, Md.).
2002 Oct; 36(4 Pt 1):829-39. doi:
10.1053/jhep.2002.35536. [PMID: 12297830] - R Gebhardt. Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves.
Planta medica.
2002 Sep; 68(9):776-9. doi:
10.1055/s-2002-34417. [PMID: 12357385] - Dirk Graf, Anna Kordelia Kurz, Richard Fischer, Roland Reinehr, Dieter Häussinger. Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner.
Gastroenterology.
2002 May; 122(5):1411-27. doi:
10.1053/gast.2002.32976. [PMID: 11984527] - Yuji Tanaka, Yoshinao Kobayashi, Esteban C Gabazza, Kunihiro Higuchi, Toshinori Kamisako, Makoto Kuroda, Keisuke Takeuchi, Motoh Iwasa, Masahiko Kaito, Yukihiko Adachi. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice.
American journal of physiology. Gastrointestinal and liver physiology.
2002 Apr; 282(4):G656-62. doi:
10.1152/ajpgi.00383.2001. [PMID: 11897625] - Makoto Sasaki, Hiroshi Suzuki, Kousei Ito, Takaaki Abe, Yuichi Sugiyama. Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2).
The Journal of biological chemistry.
2002 Feb; 277(8):6497-503. doi:
10.1074/jbc.m109081200. [PMID: 11748225] - R Gebhardt. Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites.
Medical science monitor : international medical journal of experimental and clinical research.
2001 May; 7 Suppl 1(?):316-20. doi:
". [PMID: 12211745] - C Zhang, S B Brown, T J Hara. Biochemical and physiological evidence that bile acids produced and released by lake char (Salvelinus namaycush) function as chemical signals.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2001 Mar; 171(2):161-71. doi:
10.1007/s003600000170. [PMID: 11302533] - K Fadden, M J Hill, E Latymer, G Low, R W Owen. Steroid metabolism along the gastrointestinal tract of the cannulated pig.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
1999 Feb; 8(1):35-40. doi:
10.1097/00008469-199902000-00005. [PMID: 10091041] - U Bolder, W E Thasler, A F Hofmann, K W Jauch. [Hepatocellular transport of bile acids and organic anions in infection and SIRS--evidence for different mechanisms for regulating membrane transport proteins].
Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress.
1998; 115(Suppl I):391-6. doi:
NULL. [PMID: 14518282] - M Heijn, J H Hooijberg, G L Scheffer, G Szabó, H V Westerhoff, J Lankelma. Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.
Biochimica et biophysica acta.
1997 May; 1326(1):12-22. doi:
10.1016/s0005-2736(97)00003-5. [PMID: 9188796] - H J Verkade, M A de Bruijn, M A Brink, H Talsma, R J Vonk, F Kuipers, A K Groen. Interactions between organic anions, micelles and vesicles in model bile systems.
The Biochemical journal.
1996 Dec; 320 ( Pt 3)(?):917-23. doi:
10.1042/bj3200917. [PMID: 9003381] - G J Beukeveld, G In 't Veld, R Havinga, A K Groen, B G Wolthers, F Kuipers. Relationship between biliary lipid and protoporphyrin secretion; potential role of mdr2 P-glycoprotein in hepatobiliary organic anion transport.
Journal of hepatology.
1996 Mar; 24(3):343-52. doi:
10.1016/s0168-8278(96)80015-8. [PMID: 8778203] - A Dietrich, W Dieminger, S MacNelly, W Gerok, G Kurz. Synthesis and applicability of a photolabile 7,7-azi analogue of 3-sulfated taurine-conjugated bile salts.
Journal of lipid research.
1995 Aug; 36(8):1729-44. doi:
. [PMID: 7595094] - A Dietrich, W Dieminger, K Fuchte, G H Stoll, E Schlitz, W Gerok, G Kurz. Functional significance of interaction of H-FABP with sulfated and nonsulfated taurine-conjugated bile salts in rat liver.
Journal of lipid research.
1995 Aug; 36(8):1745-55. doi:
". [PMID: 7595095] - G M Möckel, S Gorti, R K Tandon, T Tanaka, M C Carey. Microscope laser light-scattering spectroscopy of vesicles within canaliculi of rat hepatocyte couplets.
The American journal of physiology.
1995 Jul; 269(1 Pt 1):G73-84. doi:
10.1152/ajpgi.1995.269.1.g73. [PMID: 7631803] - M G Roma, G L Penalva, R M Agüero, E A Rodríguez Garay. Hepatic transport of organic anions in taurolithocholate-induced cholestasis in rats.
Journal of hepatology.
1994 May; 20(5):603-10. doi:
10.1016/s0168-8278(05)80347-2. [PMID: 8071536] - A B Duguay, G L Plaa. Plasma concentrations in methyl isobutyl ketone-potentiated experimental cholestasis after inhalation or oral administration.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1993 Aug; 21(2):222-7. doi:
10.1006/faat.1993.1092. [PMID: 8405785] - Y Adachi, H Kobayashi, M Shouji, M Kitano, Y Okuyama, T Yamamoto. Functional integrity of hepatocyte canalicular membrane transport of taurocholate and bilirubin diglucuronide in Eisai hyperbilirubinuria rats.
Life sciences.
1993; 52(9):777-84. doi:
10.1016/0024-3205(93)90075-e. [PMID: 8437507] - R A Marinelli, M G Roma, J M Pellegrino, E A Rodríguez Garay. Taurolithocholate-induced inhibition of biliary lipid and protein excretion in the rat.
Biochimica et biophysica acta.
1992 Apr; 1125(1):44-8. doi:
10.1016/0005-2760(92)90153-m. [PMID: 1567906] - J M Little, P Zimniak, A Radominska, P Lehman, R Lester. Urinary excretion of lithocholic acid and its conjugates by the bile duct-ligated rat.
Hepatology (Baltimore, Md.).
1991 Oct; 14(4 Pt 1):690-5. doi:
10.1016/0270-9139(91)90059-5. [PMID: 1916672] - H J Verkade, M J Wolbers, R Havinga, D R Uges, R J Vonk, F Kuipers. The uncoupling of biliary lipid from bile acid secretion by organic anions in the rat.
Gastroenterology.
1990 Nov; 99(5):1485-92. doi:
10.1016/0016-5085(90)91180-e. [PMID: 2210257] - F Kuipers, M Enserink, R Havinga, A B van der Steen, M J Hardonk, J Fevery, R J Vonk. Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat.
The Journal of clinical investigation.
1988 May; 81(5):1593-9. doi:
10.1172/jci113493. [PMID: 3366909] - J Van Eldere, J Robben, P Caenepeel, H Eyssen. Influence of a cecal volume-reducing intestinal microflora on the excretion and entero-hepatic circulation of steroids and bile acids.
Journal of steroid biochemistry.
1988 Jan; 29(1):33-9. doi:
10.1016/0022-4731(88)90373-1. [PMID: 2831434] - F Gratton, A M Weber, B Tuchweber, R Morazain, C C Roy, I M Yousef. Effect of chronic administration of taurolithocholate on bile formation and liver ultrastructure in the rat.
Liver.
1987 Jun; 7(3):130-7. doi:
10.1111/j.1600-0676.1987.tb00332.x. [PMID: 3613882] - R Utili, L E Adinolfi, G B Gaeta, M F Tripodi, D Alvaro. Effect of endotoxin tolerance on drug hepatotoxicity: amelioration of taurolithocholate cholestasis in the perfused rat liver.
Digestion.
1987; 36(2):74-80. doi:
10.1159/000199402. [PMID: 3552808] - N Tavoloni, H R Wyssbrod, M J Jones. Permeability characteristics of the guinea pig biliary apparatus.
Hepatology (Baltimore, Md.).
1986 Nov; 6(6):1369-81. doi:
10.1002/hep.1840060625. [PMID: 2431992] - P Bonazzi, G Novelli, R Galeazzi. The interaction of rifamycin-SV with the hepatic transport and sulfation of taurolithocolic acid in rats.
Pharmacological research communications.
1986 Aug; 18(8):675-85. doi:
10.1016/0031-6989(86)90110-4. [PMID: 3763675] - B D Schirmer, W J Kortz, R J Miller, K G Christian, E Hayes, R S Jones. Glucagon lowers canine biliary cholesterol output at physiologic doses.
Digestive diseases and sciences.
1986 Mar; 31(3):297-304. doi:
10.1007/bf01318122. [PMID: 3512201] - H Suzuki, M Hamada, F Kato. Metabolism of lithocholic and chenodeoxycholic acids in the squirrel monkey.
Gastroenterology.
1985 Sep; 89(3):631-6. doi:
10.1016/0016-5085(85)90461-5. [PMID: 4018504] - W R Berry, G Kirshenbaum, C Hoilien, M Le, J Reichen. Taurolithocholate increases heme catabolism and alters the clearance of antipyrine in the rat.
Gastroenterology.
1985 Feb; 88(2):397-402. doi:
10.1016/0016-5085(85)90498-6. [PMID: 3965329] - J Schölmerich, M S Becher, K Schmidt, R Schubert, B Kremer, S Feldhaus, W Gerok. Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties--studies on isolated hepatocytes and lipid membrane vesicles.
Hepatology (Baltimore, Md.).
1984 Jul; 4(4):661-6. doi:
10.1002/hep.1840040416. [PMID: 6745854] - U Mathis, G Karlaganis, R Preisig. Monohydroxy bile salt sulfates: tauro-3 beta-hydroxy-5-cholenoate-3-sulfate induces intrahepatic cholestasis in rats.
Gastroenterology.
1983 Sep; 85(3):674-81. doi:
. [PMID: 6873614] - W Jung, R Gebhardt, H Robenek. Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. II. Taurolithocholate-induced alterations of canalicular morphology and of the distribution of filipin-cholesterol complexes.
European journal of cell biology.
1982 Nov; 29(1):77-82. doi:
. [PMID: 7151828] - A K Batta, S Shefer, G Salen. Thin-layer chromatographic separation of conjugates of ursodeoxycholic acid from those of litho-, chenodeoxy-, deoxy-, and cholic acids.
Journal of lipid research.
1981 May; 22(4):712-4. doi:
". [PMID: 7276746] - L J Chen. Bile salt sulfotransferase.
Methods in enzymology.
1981; 77(?):213-8. doi:
10.1016/s0076-6879(81)77028-9. [PMID: 6948990] - B Arborgh, A Eklund, A Norman, B Strandvik. Urinary bile acid excretion in correlation to liver histopathology in cystic fibrosis.
Scandinavian journal of gastroenterology.
1980; 15(1):73-80. doi:
10.3109/00365528009181435. [PMID: 7367826] - J Reichen, G Paumgartner. Inhibition of hepatic Na +, K + -adenosinetriphosphatase in taurolithocholate-induced cholestasis in the rat.
Experientia.
1979 Sep; 35(9):1186-8. doi:
10.1007/bf01963278. [PMID: 226396] - R Drew, B G Piestly. Effect of chlorpromazine and erythromycin on bile salt-induced cholestasis in the rat.
Pharmacology.
1979; 18(4):202-9. doi:
10.1159/000137253. [PMID: 572556] - K J Hammerman, L J Chen, A Fernandez-Corugedo, D L Earnest. Sex differences in hepatic sulfation of taurolithocholate in the rat.
Gastroenterology.
1978 Dec; 75(6):1021-5. doi:
10.1016/0016-5085(78)90069-0. [PMID: 710853] - B Shaikh, N J Pontzer, J E Molina, M I Kelsey. Separation and detection of uv-absorbing derivatives of fecal bile acid metabolites by high-performance liquid chromatography.
Analytical biochemistry.
1978 Mar; 85(1):47-55. doi:
10.1016/0003-2697(78)90272-5. [PMID: 629396]
