Perfluorooctanoic acid (BioDeep_00000397754)
Exogenous Industrial Pollutants
代谢物信息卡片
Perfluorooctanoic acid (PFOA)
化学式: C8HF15O2 (413.9737)
中文名称: 全氟辛酸
谱图信息:
最多检出来源 Homo sapiens(general) 55.88%
Reviewed
Last reviewed on 2024-08-07.
Cite this Page
Perfluorooctanoic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/perfluorooctanoic_acid (retrieved
2025-02-17) (BioDeep RN: BioDeep_00000397754). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(=O)(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O
InChI: InChI=1S/C8HF15O2/c9-2(10,1(24)25)3(11,12)4(13,14)5(15,16)6(17,18)7(19,20)8(21,22)23/h(H,24,25)
描述信息
Perfluorooctanoic acid is a fluoroalkanoic acid that is perfluorinated octanoic acid. It has a role as an environmental contaminant, a xenobiotic, a carcinogenic agent, a surfactant and an endocrine disruptor. It is functionally related to a perfluorooctane and an octanoic acid.
Perfluorooctanoic Acid (PFOA) can cause cancer according to The National Toxicology Program. It can cause developmental toxicity according to The Environmental Protection Agency (EPA).
Perfluorooctanoic acid (PFOA), also known as C8 and perfluorooctanoate, is a synthetic, stable perfluorinated carboxylic acid and fluorosurfactant. One industrial application is as a surfactant in the emulsion polymerization of fluoropolymers. It has been used in the manufacture of such prominent consumer goods as Teflon and Gore-Tex. PFOA has been manufactured since the 1940s in industrial quantities. It is also formed by the degradation of precursors such as some fluorotelomers. PFOA persists indefinitely in the environment. It is a toxicant and carcinogen in animals. PFOA has been detected in the blood of more than 98\% of the general US population in the low and sub-parts per billion range, and levels are higher in chemical plant employees and surrounding subpopulations. Exposure has been associated with increased cholesterol and uric acid levels, and recently higher serum levels of PFOA were found to be associated with increased risk of chronic kidney disease in the general United States population, consistent with earlier animal studies. This association was independent of confounders such as age, sex, race/ethnicity, body mass index, diabetes, hypertension, and serum cholesterol level. .
同义名列表
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:35549
- PubChem: 9554
- Metlin: METLIN96224
- ChEMBL: CHEMBL172988
- CAS: 335-67-1
- MoNA: AU594853
- MoNA: AU594852
- MoNA: AU594851
- MoNA: AU594850
- MoNA: AU240462
- MoNA: AU240460
- MoNA: AU240459
- MoNA: AU240458
- MoNA: AU240457
- MoNA: SM877354
- MoNA: EA271760
- MoNA: EA271759
- MoNA: EA271758
- MoNA: EA271757
- MoNA: EA271754
- MoNA: EA271753
- MoNA: EA271752
- MoNA: EA271751
- RefMet: Perfluorooctanoic acid
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Heidi Lahne, Doris Gerstner, Wolfgang Völkel, Wolfgang Schober, Bettina Aschenbrenner, Caroline Herr, Stefanie Heinze, Caroline Quartucci. Human biomonitoring follow-up study on PFOA contamination and investigation of possible influencing factors on PFOA exposure in a German population originally exposed to emissions from a fluoropolymer production plant.
International journal of hygiene and environmental health.
2024 Jun; 259(?):114387. doi:
10.1016/j.ijheh.2024.114387. [PMID: 38703464] - Qiuyue Shi, Xian Zhang, Xiaohui Liu, Changzhou Yan, Shaoyong Lu. Visualization of PFOA accumulation and its effects on phospholipid in zebrafish liver by MALDI Imaging.
Analytical and bioanalytical chemistry.
2024 Apr; 416(10):2493-2501. doi:
10.1007/s00216-024-05214-y. [PMID: 38451276] - Fengfeng Dong, Haijun Zhang, Nan Sheng, Jianglin Hu, Jiayin Dai, Yitao Pan. Nationwide distribution of perfluoroalkyl ether carboxylic acids in Chinese diets: An emerging concern.
Environment international.
2024 Apr; 186(?):108648. doi:
10.1016/j.envint.2024.108648. [PMID: 38615540] - Zhen Lin, Wei Zhou, Zhen Ke, Zhonghua Wu. Ecotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate on aquatic plant Vallisneria natans.
Environmental science and pollution research international.
2024 Apr; 31(18):26646-26664. doi:
10.1007/s11356-024-32705-3. [PMID: 38451456] - Fengling Li, Xiuqiong Gong, Yang Zhou, Qianqian Geng, Yanhua Jiang, Lin Yao, Meng Qu, Zhijun Tan. Integrated evidence of transcriptional, metabolic, and intestinal microbiota changes in Ruditapes philippinarum due to perfluorooctanoic acid-induced immunotoxicity.
The Science of the total environment.
2024 Mar; 916(?):170341. doi:
10.1016/j.scitotenv.2024.170341. [PMID: 38272093] - Si-Si Liu, Sheng-Ming Cheng, Qi-Si Cai, Guang-Guo Ying, Chang-Er Chen. Short-term mass loads of per- and polyfluoroalkyl substances in a wastewater treatment plant from South China.
Environmental science and pollution research international.
2024 Mar; 31(11):17417-17425. doi:
10.1007/s11356-024-32204-5. [PMID: 38337116] - Mia Sands, Xing Zhang, Arnon Gal, Mary Laws, Michael Spinella, Zeynep-Madak Erdogan, Joseph Irudayaraj. Comparative hepatotoxicity of novel lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice: Insights into epigenetic mechanisms and pathway-specific responses.
Environment international.
2024 Mar; 185(?):108556. doi:
10.1016/j.envint.2024.108556. [PMID: 38461777] - Erich Batzella, Isabella Rosato, Gisella Pitter, Filippo Da Re, Francesca Russo, Cristina Canova, Tony Fletcher. Determinants of PFOA Serum Half-Life after End of Exposure: A Longitudinal Study on Highly Exposed Subjects in the Veneto Region.
Environmental health perspectives.
2024 Feb; 132(2):27002. doi:
10.1289/ehp13152. [PMID: 38306197] - Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang. Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism.
The Journal of nutritional biochemistry.
2024 01; 123(?):109501. doi:
10.1016/j.jnutbio.2023.109501. [PMID: 37890710] - Qi Li, Yunxing Xiao, Weizhen Zhang, Shuang Li, Jing Liu, Yangjinzhi Yu, Yueling Wen, Yumiao Zhang, Ningfei Lei, Qianchao Wang. Single and combined toxicity effects of microplastics and perfluorooctanoic acid on submerged macrophytes and biofilms.
The Science of the total environment.
2023 Nov; 897(?):165370. doi:
10.1016/j.scitotenv.2023.165370. [PMID: 37423285] - Isaac A Adedara, Oluwatoyin O Abioye, Gbemisola T Oyedele, Cynthia N Ikeji, Blessing A Afolabi, Joao B T Rocha, Ebenezer O Farombi. Perfluorooctanoic acid induces behavioral impairment and oxidative injury in Nauphoeta cinerea nymphs.
Environmental science and pollution research international.
2023 Nov; 30(51):110340-110351. doi:
10.1007/s11356-023-30156-w. [PMID: 37783994] - Sashi Gadi, Suryakant Niture, Hieu Hoang, Qi Qi, Charles Hatcher, Xiaoyan Huang, Jamil Haider, Derek C Norford, TinChung Leung, Keith E Levine, Deepak Kumar. Deficiency of spns1 Exacerbates Per- and Polyfluoroalkyl Substances Mediated Hepatic Toxicity and Steatosis in Zebrafish (Danio rerio).
Toxicology.
2023 Oct; ?(?):153641. doi:
10.1016/j.tox.2023.153641. [PMID: 37806615] - Qi Li, Jiarui Jiang, Yiyang Lan, Shiyun Kang, Yixia Yang, Jiahui Zhang. Combined toxic effects of polypropylene and perfluorooctanoic acid on duckweed and periphytic microorganisms.
Environmental science and pollution research international.
2023 Oct; 30(50):108606-108616. doi:
10.1007/s11356-023-30006-9. [PMID: 37752396] - Hao Chen, Mirhan Kapidzic, Danielle Gantar, Sena Aksel, Justine Levan, Dimitri P Abrahamsson, Unurzul Jigmeddagva, Sanah Basrai, Ali San, Stephanie L Gaw, Tracey J Woodruff, Susan J Fisher, Joshua F Robinson. Perfluorooctanoic Acid Induces Transcriptomic Alterations in 2nd Trimester Human Cytotrophoblasts.
Toxicological sciences : an official journal of the Society of Toxicology.
2023 Sep; ?(?):. doi:
10.1093/toxsci/kfad097. [PMID: 37738295] - Zanina Ilieva, Patricia Hania, Roxana Suehring, Kimberley Gilbride, Rania Hamza. Impact of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) on secondary sludge microorganisms: removal, potential toxicity, and their implications on existing wastewater treatment regulations in Canada.
Environmental science. Processes & impacts.
2023 Sep; ?(?):. doi:
10.1039/d3em00202k. [PMID: 37674406] - Yonghua Wang, Xi Chen, Beibei Wang, Guanghua Lu, Jianchao Liu, Donghai Wu, Zhenhua Yan. Toxicity comparison of perfluorooctanoic acid (PFOA), hexafluoropropylene oxide dimer acid (HFPO-DA), and hexafluoropropylene oxide trimer acid (HFPO-TA) in zebrafish gut.
Aquatic toxicology (Amsterdam, Netherlands).
2023 Sep; 262(?):106655. doi:
10.1016/j.aquatox.2023.106655. [PMID: 37598522] - Wang Yang, Xi Ling, Shijun He, Haonan Cui, Zeyu Yang, Huihui An, Lihong Wang, Peng Zou, Qing Chen, Jinyi Liu, Lin Ao, Jia Cao. PPARα/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach.
Environment international.
2023 Aug; 178(?):108138. doi:
10.1016/j.envint.2023.108138. [PMID: 37572494] - Annelise K Gonzales, Sarah E Donaher, Bryanna D Wattier, Nicole E Martinez. Exposure of Lemna minor (common duckweed) to mixtures of uranium and perfluorooctanoic acid (PFOA).
Environmental toxicology and chemistry.
2023 Jul; ?(?):. doi:
10.1002/etc.5720. [PMID: 37477461] - Yan Zhang, Yang Li, Nana Gao, Yinglan Gong, Wanyu Shi, Xiaodan Wang. Transcriptome and Metabolome Analyses Reveal Perfluorooctanoic Acid-Induced Kidney Injury by Interfering with PPAR Signaling Pathway.
International journal of molecular sciences.
2023 Jul; 24(14):. doi:
10.3390/ijms241411503. [PMID: 37511261] - Lei Chen, Daijie Chen, Shunyi Zhou, Jieying Lin, Yun Liu, Xiongfei Huang, Qingqi Lin, Jean Louis Morel, Zhuobiao Ni, Shizhong Wang, Rongliang Qiu. New Insights into the Accumulation, Transport, and Distribution Mechanisms of Hexafluoropropylene Oxide Homologues, Important Alternatives to Perfluorooctanoic Acid, in Lettuce (Lactuca sativa L.).
Environmental science & technology.
2023 Jul; 57(26):9702-9712. doi:
10.1021/acs.est.2c09226. [PMID: 37314230] - Xuemin Zhang, Xijuan Ren, Weiqiang Sun, Nathan Griffin, Li Wang, Hui Liu. PFOA exposure induces aberrant glucose and lipid metabolism in the rat liver through the AMPK/mTOR pathway.
Toxicology.
2023 07; 493(?):153551. doi:
10.1016/j.tox.2023.153551. [PMID: 37236338] - Weiqiang Sun, Xuemin Zhang, Ying Qiao, Nathan Griffin, Hongxia Zhang, Li Wang, Hui Liu. Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish.
Ecotoxicology and environmental safety.
2023 Jul; 259(?):115020. doi:
10.1016/j.ecoenv.2023.115020. [PMID: 37201426] - Liang Yu, Zulin Hua, Xiaodong Liu, Luying Chen, Yuan Zhang, Yixin Ma, Yueyang Dong, Hongqin Xue. The addition of iron-carbon enhances the removal of perfluoroalkyl acids (PFAAs) in constructed wetlands.
Environmental pollution (Barking, Essex : 1987).
2023 Jun; 327(?):121534. doi:
10.1016/j.envpol.2023.121534. [PMID: 37001598] - Wataru Murase, Atsuhito Kubota, Atsuko Ikeda-Araki, Masaru Terasaki, Koji Nakagawa, Ryota Shizu, Kouichi Yoshinari, Hiroyuki Kojima. Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays.
Toxicology.
2023 Jun; ?(?):153577. doi:
10.1016/j.tox.2023.153577. [PMID: 37302725] - Phayong Thepaksorn, Pureum Lee, Yoko Shiwaku, Bo Zheng, Akio Koizumi, Kouji H Harada. Formation and Degradability of Per- and Polyfluoroalkyl Substances in River Soils around a Fluoropolymer-Manufacturing Plant in Osaka, Japan.
Archives of environmental contamination and toxicology.
2023 May; 84(4):427-435. doi:
10.1007/s00244-023-00998-z. [PMID: 37099060] - Jie Zhang, Qiutang Wang, Yujing Wang, Yang Xu, Wenchao Du, Hongyan Guo. Joint effects of CuO nanoparticles and perfluorooctanoic acid on cabbage (Brassica pekinensis L.).
Environmental science and pollution research international.
2023 May; 30(25):66745-66752. doi:
10.1007/s11356-023-26862-0. [PMID: 37099098] - Adesina A Babalola, Khadija A Mohammed, Adeboye A Olaseni, Gbemisola T Oyedele, Isaac A Adedara, Joao B T Rocha, Ebenezer O Farombi. Persistent oxidative injury and neurobehavioral impairment in adult male and female Nauphoeta cinerea exposed to perfluorooctanoic acid.
Environmental toxicology and pharmacology.
2023 Apr; 100(?):104135. doi:
10.1016/j.etap.2023.104135. [PMID: 37116629] - Charlotte B A Stoffels, Tina B Angerer, Hervé Robert, Nathalie Poupin, Laila Lakhal, Gilles Frache, Muriel Mercier-Bonin, Jean-Nicolas Audinot. Lipidomic Profiling of PFOA-Exposed Mouse Liver by Multi-Modal Mass Spectrometry Analysis.
Analytical chemistry.
2023 04; 95(16):6568-6576. doi:
10.1021/acs.analchem.2c05470. [PMID: 37027489] - Kailee E Hopkins, Melissa A McKinney, Robert J Letcher, Kim J Fernie. The influence of environmental and ecological factors on the accumulation and distribution of short- and long-chain perfluoroalkyl acids in a mid-trophic avian insectivore.
Environmental pollution (Barking, Essex : 1987).
2023 Mar; 321(?):121133. doi:
10.1016/j.envpol.2023.121133. [PMID: 36690292] - Mahmoud Abudayyak, Ecem Fatma Karaman, Zeynep Rana Guler, Sibel Ozden. Effects of perfluorooctanoic acid on endoplasmic reticulum stress and lipid metabolism-related genes in human pancreatic cells.
Environmental toxicology and pharmacology.
2023 Mar; 98(?):104083. doi:
10.1016/j.etap.2023.104083. [PMID: 36804611] - Xiaoxuan Wang, Weilan Zhang, Suman Lamichhane, Fugen Dou, Xingmao Ma. Effects of physicochemical properties and co-existing zinc agrochemicals on the uptake and phytotoxicity of PFOA and GenX in lettuce.
Environmental science and pollution research international.
2023 Mar; 30(15):43833-43842. doi:
10.1007/s11356-023-25435-5. [PMID: 36680712] - Yuan Yang, Guoqing Fu, Xueyi Zhao, Xiaoping Wu, Kaili Zhu, Shangyu Liu, Ding Yuan, Jie Wu, Ting Wang, Changcheng Zhang, Haixia Zhao. Perfluorooctanoic acid induces tight junction injury of Sertoli cells by blocking autophagic flux.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Mar; 173(?):113649. doi:
10.1016/j.fct.2023.113649. [PMID: 36736878] - Liam O'Hara, James G Longstaffe. 1 H-Nuclear Magnetic Resonance Metabolomics Analysis of Arabidopsis thaliana Exposed to Perfluorooctanoic Acid and Perfluoroctanesulfonic Acid.
Environmental toxicology and chemistry.
2023 03; 42(3):663-672. doi:
10.1002/etc.5547. [PMID: 36541334] - Zhiyi Yang, Lei Fu, Mengxi Cao, Fang Li, Jingguang Li, Zhiyu Chen, Ang Guo, Huifang Zhong, Wenbo Li, Yong Liang, Qian Luo. PFAS-induced lipidomic dysregulations and their associations with developmental toxicity in zebrafish embryos.
The Science of the total environment.
2023 Feb; 861(?):160691. doi:
10.1016/j.scitotenv.2022.160691. [PMID: 36473658] - Jun Xiao, Juan Huang, Ying Wang, Xiuwen Qian. The fate and behavior of perfluorooctanoic acid (PFOA) in constructed wetlands: Insights into potential removal and transformation pathway.
The Science of the total environment.
2023 Feb; 861(?):160309. doi:
10.1016/j.scitotenv.2022.160309. [PMID: 36403847] - Sujie Sun, Xue Li, Li Zhang, Zilin Zhong, Chao Chen, Yuhua Zuo, Yu Chen, Hongmei Hu, Fasheng Liu, Guanghua Xiong, Huiqiang Lu, Jianjun Chen, Jiayin Dai. Hexafluoropropylene oxide trimer acid (HFPO-TA) disturbs embryonic liver and biliary system development in zebrafish.
The Science of the total environment.
2023 Feb; 859(Pt 1):160087. doi:
10.1016/j.scitotenv.2022.160087. [PMID: 36372181] - Paula Pierozan, Marissa Kosnik, Oskar Karlsson. High-content analysis shows synergistic effects of low perfluorooctanoic acid (PFOS) and perfluorooctane sulfonic acid (PFOA) mixture concentrations on human breast epithelial cell carcinogenesis.
Environment international.
2023 Feb; 172(?):107746. doi:
10.1016/j.envint.2023.107746. [PMID: 36731186] - Styliani Fragki, Jochem Louisse, Bas Bokkers, Mirjam Luijten, Ad Peijnenburg, Deborah Rijkers, Aldert H Piersma, Marco J Zeilmaker. New approach methodologies: A quantitative in vitro to in vivo extrapolation case study with PFASs.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Feb; 172(?):113559. doi:
10.1016/j.fct.2022.113559. [PMID: 36535450] - Ying-Lin Wu, Qian Xiong, Ben Wang, You-Sheng Liu, Pei-Liang Zhou, Li-Xin Hu, Fang Liu, Guang-Guo Ying. Screening of structural and functional alterations in duckweed (Lemna minor) induced by per- and polyfluoroalkyl substances (PFASs) with FTIR spectroscopy.
Environmental pollution (Barking, Essex : 1987).
2023 Jan; 317(?):120671. doi:
10.1016/j.envpol.2022.120671. [PMID: 36436661] - Yonghua Wang, Shengnan Jiang, Beibei Wang, Xi Chen, Guanghua Lu. Comparison of developmental toxicity induced by PFOA, HFPO-DA, and HFPO-TA in zebrafish embryos.
Chemosphere.
2023 Jan; 311(Pt 1):136999. doi:
10.1016/j.chemosphere.2022.136999. [PMID: 36309054] - Hua-Ming Xiao, Shuai Zhao, Dilshad Hussain, Jian-Li Chen, Dan Luo, Fang Wei, Xian Wang. Fluoro-cotton assisted non-targeted screening of organic fluorine compounds from rice (Oryza sativa L.) grown in perfluoroalkyl substance polluted soil.
Environmental research.
2023 01; 216(Pt 4):114801. doi:
10.1016/j.envres.2022.114801. [PMID: 36375504] - Bryanna D Wattier, Annelise K Gonzales, Nicole E Martinez. Perfluorooctanoic acid uptake in the mustard species Brassica juncea.
Journal of environmental quality.
2023 Jan; 52(1):199-206. doi:
10.1002/jeq2.20431. [PMID: 36345599] - Qi Qi, Suryakant Niture, Sashi Gadi, Elena Arthur, John Moore, Keith E Levine, Deepak Kumar. Per- and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells.
Environmental toxicology.
2023 Jan; 38(1):225-242. doi:
10.1002/tox.23680. [PMID: 36251517] - Bei Gao, PengCheng Tu, Liang Chi, Weishou Shen, Nan Gao. Perfluorooctanoic Acid-Disturbed Serum and Liver Lipidome in C57BL/6 Mice.
Chemical research in toxicology.
2022 12; 35(12):2252-2259. doi:
10.1021/acs.chemrestox.2c00239. [PMID: 36484463] - Ping Zhang, Liangliang Sun, Fei Liu, Qingqing Gao, Ruting Wang, Qiong Ju, Jin Xu. Perfluorooctanoic acid and perfluorooctane sulfonic acid inhibit plant growth through the modulation of phytohormone signalling pathways: Evidence from molecular and genetic analysis in Arabidopsis.
The Science of the total environment.
2022 Dec; 851(Pt 2):158287. doi:
10.1016/j.scitotenv.2022.158287. [PMID: 36030856] - Xu Cheng, Yue Wei, Zefang Zhang, Fei Wang, Jia He, Ruixin Wang, Yali Xu, Mulatibieke Keerman, Shiyang Zhang, Ying Zhang, Jiao Bi, Jinqiu Yao, Meian He. Plasma PFOA and PFOS Levels, DNA Methylation, and Blood Lipid Levels: A Pilot Study.
Environmental science & technology.
2022 12; 56(23):17039-17051. doi:
10.1021/acs.est.2c04107. [PMID: 36374530] - Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim. Perfluoroalkyl substances and lipid concentrations in the blood: A systematic review of epidemiological studies.
The Science of the total environment.
2022 Dec; 850(?):158036. doi:
10.1016/j.scitotenv.2022.158036. [PMID: 35973530] - Brecht Attema, Aafke W F Janssen, Deborah Rijkers, Evert M van Schothorst, Guido J E J Hooiveld, Sander Kersten. Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice.
Molecular metabolism.
2022 12; 66(?):101602. doi:
10.1016/j.molmet.2022.101602. [PMID: 36115532] - Robin Lasters, Thimo Groffen, Marcel Eens, Dries Coertjens, Wouter A Gebbink, Jelle Hofman, Lieven Bervoets. Home-produced eggs: An important human exposure pathway of perfluoroalkylated substances (PFAS).
Chemosphere.
2022 Dec; 308(Pt 1):136283. doi:
10.1016/j.chemosphere.2022.136283. [PMID: 36075366] - Wenjing Tang, Yunyi Meng, Bin Yang, Dongyu He, Yan Li, Bojun Li, Zheming Shi, Changwei Zhao. Preparation of hollow-fiber nanofiltration membranes of high performance for effective removal of PFOA and high resistance to BSA fouling.
Journal of environmental sciences (China).
2022 Dec; 122(?):14-24. doi:
10.1016/j.jes.2021.10.004. [PMID: 35717080] - Steffen Kittlaus, Manfred Clara, Jos van Gils, Oliver Gabriel, Marianne Bertine Broer, Gerald Hochedlinger, Helene Trautvetter, Gerold Hepp, Jörg Krampe, Matthias Zessner, Ottavia Zoboli. Coupling a pathway-oriented approach with tailor-made monitoring as key to well-performing regionalized modelling of PFAS emissions and river concentrations.
The Science of the total environment.
2022 Nov; 849(?):157764. doi:
10.1016/j.scitotenv.2022.157764. [PMID: 35932866] - Matthew W Linakis, Paul Gustafson, Bruce C Allen, Annette M Bachand, Cynthia Van Landingham, Debra R Keast, Matthew P Longnecker. Is the cholesterol-perfluoroalkyl substance association confounded by dietary fiber intake?: a Bayesian analysis of NHANES data with adjustment for measurement error in fiber intake.
Environmental health : a global access science source.
2022 11; 21(1):114. doi:
10.1186/s12940-022-00923-2. [PMID: 36419083] - Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Nathan Griffin, Hui Liu, Li Wang. Rutin ameliorates perfluorooctanoic acid-induced testicular injury in mice by reducing oxidative stress and improving lipid metabolism.
Drug and chemical toxicology.
2022 Nov; ?(?):1-12. doi:
10.1080/01480545.2022.2145483. [PMID: 36373176] - Ting-An Lin, Chi-Wei Huang, Chia-Cheng Wei. Early-life perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) exposure cause obesity by disrupting fatty acids metabolism and enhancing triglyceride synthesis in Caenorhabditis elegans.
Aquatic toxicology (Amsterdam, Netherlands).
2022 Oct; 251(?):106274. doi:
10.1016/j.aquatox.2022.106274. [PMID: 36037606] - Erich Batzella, Maryam Zare Jeddi, Gisella Pitter, Francesca Russo, Tony Fletcher, Cristina Canova. Associations between Mixture of Perfluoroalkyl Substances and Lipid Profile in a Highly Exposed Adult Community in the Veneto Region.
International journal of environmental research and public health.
2022 09; 19(19):. doi:
10.3390/ijerph191912421. [PMID: 36231722] - Jane Kasten-Jolly, David A Lawrence. Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) modify in vitro mitogen- and antigen-induced human peripheral blood mononuclear cell (PBMC) responses.
Journal of toxicology and environmental health. Part A.
2022 Sep; 85(17):715-737. doi:
10.1080/15287394.2022.2075816. [PMID: 35611390] - Zefang Zhang, Fei Wang, Ying Zhang, Jinqiu Yao, Jiao Bi, Jia He, Shiyang Zhang, Yue Wei, Huan Guo, Xiaomin Zhang, Meian He. Associations of serum PFOA and PFOS levels with incident hypertension risk and change of blood pressure levels.
Environmental research.
2022 Sep; 212(Pt B):113293. doi:
10.1016/j.envres.2022.113293. [PMID: 35427595] - Lore Jane L Espartero, Miko Yamada, Judith Ford, Gary Owens, Tarl Prow, Albert Juhasz. Health-related toxicity of emerging per- and polyfluoroalkyl substances: Comparison to legacy PFOS and PFOA.
Environmental research.
2022 09; 212(Pt C):113431. doi:
10.1016/j.envres.2022.113431. [PMID: 35569538] - Jun Xiao, Juan Huang, Ying Wang, Xiuwen Qian, Meifang Cao. Evaluation of the ecological impacts of short- and long-chain perfluoroalkyl acids on constructed wetland systems: Perfluorobutyric acid and perfluorooctanoic acid.
Journal of hazardous materials.
2022 08; 435(?):128863. doi:
10.1016/j.jhazmat.2022.128863. [PMID: 35650717] - Burcu Ünlü Endirlik, Ayşe Eken, Hande Canpınar, Figen Öztürk, Aylin Gürbay. Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress.
Arhiv za higijenu rada i toksikologiju.
2022 Jul; 73(2):148-157. doi:
10.2478/aiht-2022-73-3629. [PMID: 35792765] - Ciara Chun Chen, Yihan Shi, Yanjie Zhu, Jiamin Zeng, Wei Qian, Shuang Zhou, Jie Ma, Ke Pan, Yuelu Jiang, Yi Tao, Xiaoshan Zhu. Combined toxicity of polystyrene microplastics and ammonium perfluorooctanoate to Daphnia magna: Mediation of intestinal blockage.
Water research.
2022 Jul; 219(?):118536. doi:
10.1016/j.watres.2022.118536. [PMID: 35550964] - Shui Cheung Edgar Leung, Pradeep Shukla, Dechao Chen, Ehsan Eftekhari, Hongjie An, Firuz Zare, Negareh Ghasemi, Dongke Zhang, Nam-Trung Nguyen, Qin Li. Emerging technologies for PFOS/PFOA degradation and removal: A review.
The Science of the total environment.
2022 Jun; 827(?):153669. doi:
10.1016/j.scitotenv.2022.153669. [PMID: 35217058] - Paola Berenice Ortiz-Sánchez, Ana L Roa-Espitia, Reyna Fierro, Aideé S López-Torres, Irma Jiménez-Morales, Iván Oseguera-López, Enrique O Hernández-González, Humberto González-Márquez. Perfluorooctane sulfonate and perfluorooctanoic acid induce plasma membrane dysfunction in boar spermatozoa during in vitro capacitation.
Reproductive toxicology (Elmsford, N.Y.).
2022 06; 110(?):85-96. doi:
10.1016/j.reprotox.2022.03.013. [PMID: 35364258] - Yachen Zhu, Hyeong-Moo Shin, Luohua Jiang, Scott M Bartell. Retrospective exposure reconstruction using approximate Bayesian computation: A case study on perfluorooctanoic acid and preeclampsia.
Environmental research.
2022 06; 209(?):112892. doi:
10.1016/j.envres.2022.112892. [PMID: 35149111] - Ling-Ling Xu, Yu-Kui Chen, Qin-Yao Zhang, Li-Jian Chen, Kai-Kai Zhang, Jia-Hao Li, Jia-Li Liu, Qi Wang, Xiao-Li Xie. Gestational exposure to GenX induces hepatic alterations by the gut-liver axis in maternal mice: A similar mechanism as PFOA.
The Science of the total environment.
2022 May; 820(?):153281. doi:
10.1016/j.scitotenv.2022.153281. [PMID: 35066053] - Tuan-Tuan Wang, Sai Wang, Shuai Shao, Xiao-Di Wang, Ding-Ying Wang, You-Sheng Liu, Cheng-Jun Ge, Guang-Guo Ying, Zhong-Bing Chen. Perfluorooctanoic acid (PFOA)-induced alterations of biomolecules in the wetland plant Alismaorientale.
The Science of the total environment.
2022 May; 820(?):153302. doi:
10.1016/j.scitotenv.2022.153302. [PMID: 35066035] - Yatao Du, Zhenzhen Cai, Guangdi Zhou, Wei Liang, Qiuhong Man, Weiye Wang. Perfluorooctanoic acid exposure increases both proliferation and apoptosis of human placental trophoblast cells mediated by ER stress-induced ROS or UPR pathways.
Ecotoxicology and environmental safety.
2022 May; 236(?):113508. doi:
10.1016/j.ecoenv.2022.113508. [PMID: 35427876] - Emily Marques, Marisa Pfohl, Wei Wei, Giuseppe Tarantola, Lucie Ford, Ogochukwu Amaeze, Jessica Alesio, Sangwoo Ryu, Xuelian Jia, Hao Zhu, Geoffrey D Bothun, Angela Slitt. Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes.
Toxicology and applied pharmacology.
2022 05; 442(?):115991. doi:
10.1016/j.taap.2022.115991. [PMID: 35337807] - Dong-Gyu Heo, Dong-Cheol Lee, Ye-Min Kwon, Mi-Ji Seol, Jun Sung Moon, Seung Min Chung, Ju-Hyun Kim. Simultaneous determination of perfluorooctanoic acid and perfluorooctanesulfonic acid in Korean sera using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Mar; 1192(?):123138. doi:
10.1016/j.jchromb.2022.123138. [PMID: 35114474] - Hui Liu, Weiqiang Sun, Yongbing Zhou, Nathan Griffin, Sam Faulkner, Li Wang. iTRAQ-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals perfluorooctanoic acid-induced lipid metabolism and urea cycle dysfunction.
Toxicology letters.
2022 Mar; 357(?):20-32. doi:
10.1016/j.toxlet.2021.12.016. [PMID: 34958885] - Wenxiang Zhang, Zheyi Liu, Ye Zhou, Can Lai, Binwen Sun, Min He, Ziyang Zhai, Jian Wang, Qi Wang, Xian Wang, Fangjun Wang, Yuanjiang Pan. Elucidating the molecular mechanisms of perfluorooctanoic acid-serum protein interactions by structural mass spectrometry.
Chemosphere.
2022 Mar; 291(Pt 2):132945. doi:
10.1016/j.chemosphere.2021.132945. [PMID: 34798108] - Yun Liu, Melissa N Eliot, George D Papandonatos, Karl T Kelsey, Ruby Fore, Scott Langevin, Jessie Buckley, Aimin Chen, Bruce P Lanphear, Kim M Cecil, Kimberly Yolton, Marie-France Hivert, Sharon K Sagiv, Andrea A Baccarelli, Emily Oken, Joseph M Braun. Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study.
Environmental health perspectives.
2022 03; 130(3):37005. doi:
10.1289/ehp10118. [PMID: 35266797] - Xiaojun Wei, Qian Wang, Chang Liu. Nanopore sensing of γ-cyclodextrin induced host-guest interaction to reverse the binding of perfluorooctanoic acid to human serum albumin.
Proteomics.
2022 03; 22(5-6):e2100058. doi:
10.1002/pmic.202100058. [PMID: 34648224] - Qingyu Huang, Lianzhong Luo, Xuejingping Han, Fuping Li, Xi Zhang, Meiping Tian. Low-dose perfluorooctanoic acid stimulates steroid hormone synthesis in Leydig cells: Integrated proteomics and metabolomics evidence.
Journal of hazardous materials.
2022 02; 424(Pt D):127656. doi:
10.1016/j.jhazmat.2021.127656. [PMID: 34774353] - Shan Huang, Matthew Sima, Ying Long, Courtney Messenger, Peter R Jaffé. Anaerobic degradation of perfluorooctanoic acid (PFOA) in biosolids by Acidimicrobium sp. strain A6.
Journal of hazardous materials.
2022 Feb; 424(Pt D):127699. doi:
10.1016/j.jhazmat.2021.127699. [PMID: 34799154] - Li Wang, Yongbing Zhou, Xinzhuang Ma, Weiqiang Sun, Hui Liu. Perfluorooctanoic acid-induced lipid metabolism disorder in SD rat liver and its effect on the expression of fatty acid metabolism-related proteins.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2022 Jan; 47(1):18-25. doi:
10.11817/j.issn.1672-7347.2022.210320. [PMID: 35545359] - Yanrong Su, Julia Santucci-Pereira, Nhi M Dang, Joice Kanefsky, Vishnuprabha Rahulkannan, Meardey Hillegass, Shalina Joshi, Hafsa Gurdogan, Zhen Chen, Vincent Bessonneau, Ruthann Rudel, Jennifer Ser-Dolansky, Sallie S Schneider, Jose Russo. Effects of Pubertal Exposure to Butyl Benzyl Phthalate, Perfluorooctanoic Acid, and Zeranol on Mammary Gland Development and Tumorigenesis in Rats.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031398. [PMID: 35163327] - Seyed Mohamad Sadegh Modaresi, Wei Wei, Marques Emily, Nicholas A DaSilva, Angela L Slitt. Per- and polyfluoroalkyl substances (PFAS) augment adipogenesis and shift the proteome in murine 3T3-L1 adipocytes.
Toxicology.
2022 01; 465(?):153044. doi:
10.1016/j.tox.2021.153044. [PMID: 34800597] - Dahai Zhu, Zhuyu Sun, Han Zhang, Ai Zhang, Yinyin Zhang, Andere Clement Miruka, Luxiang Zhu, Rui Li, Ying Guo, Yanan Liu. Reactive Nitrogen Species Generated by Gas-Liquid Dielectric Barrier Discharge for Efficient Degradation of Perfluorooctanoic Acid from Water.
Environmental science & technology.
2022 01; 56(1):349-360. doi:
10.1021/acs.est.1c06342. [PMID: 34936333] - Zhaoyang Li, Ying Zhang, Fei Wang, Ruixin Wang, Shiyang Zhang, Zefang Zhang, Peiwen Li, Jinqiu Yao, Jiao Bi, Jia He, Mulatibieke Keerman, Huan Guo, Xiaomin Zhang, Meian He. Associations between serum PFOA and PFOS levels and incident chronic kidney disease risk in patients with type 2 diabetes.
Ecotoxicology and environmental safety.
2022 Jan; 229(?):113060. doi:
10.1016/j.ecoenv.2021.113060. [PMID: 34890990] - Weiqiang Sun, Xinzhuang Ma, Yongbing Zhou, Li Wang, Hui Liu. [Effect of perfluorooctanoic acid on lipid accumulation in rat liver cells BRL-3A and its possible mechanism].
Wei sheng yan jiu = Journal of hygiene research.
2022 Jan; 51(1):107-112. doi:
10.19813/j.cnki.weishengyanjiu.2022.01.018. [PMID: 35341501] - Han Zhang, Pan Li, Ai Zhang, Zhuyu Sun, Jinxia Liu, Paul Héroux, Yanan Liu. Enhancing Interface Reactions by Introducing Microbubbles into a Plasma Treatment Process for Efficient Decomposition of PFOA.
Environmental science & technology.
2021 12; 55(23):16067-16077. doi:
10.1021/acs.est.1c01724. [PMID: 34751567] - Santosh Lamichhane, Heli Siljander, Daniel Duberg, Jarno Honkanen, Suvi M Virtanen, Matej Orešič, Mikael Knip, Tuulia Hyötyläinen. Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk.
Environment international.
2021 12; 157(?):106855. doi:
10.1016/j.envint.2021.106855. [PMID: 34500360] - Yan Zhang, Linchao Zhang, Jialu Bao, Liantao Liu, Xiaodan Wang. Perfluorooctanoic acid exposure in early pregnancy induces oxidative stress in mice uterus and liver.
Environmental science and pollution research international.
2021 Dec; 28(46):66355-66365. doi:
10.1007/s11356-021-15453-6. [PMID: 34331232] - Xuemin Feng, Xin Chen, Yi Yang, Liping Yang, Yumin Zhu, Guoqiang Shan, Lingyan Zhu, Shufeng Zhang. External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications.
Environment international.
2021 12; 157(?):106824. doi:
10.1016/j.envint.2021.106824. [PMID: 34411760] - Weixiao Cheng, Carla A Ng. Bayesian Refinement of the Permeability-Limited Physiologically Based Pharmacokinetic Model for Perfluorooctanoic Acid in Male Rats.
Chemical research in toxicology.
2021 11; 34(11):2298-2308. doi:
10.1021/acs.chemrestox.1c00193. [PMID: 34705448] - Xu Han, Lingling Meng, Gaoxin Zhang, Yingming Li, Yali Shi, Qinghua Zhang, Guibin Jiang. Exposure to novel and legacy per- and polyfluoroalkyl substances (PFASs) and associations with type 2 diabetes: A case-control study in East China.
Environment international.
2021 11; 156(?):106637. doi:
10.1016/j.envint.2021.106637. [PMID: 33993001] - Louise Dalsager, Tina Kold Jensen, Flemming Nielsen, Philippe Grandjean, Niels Bilenberg, Helle Raun Andersen. No association between maternal and child PFAS concentrations and repeated measures of ADHD symptoms at age 2½ and 5 years in children from the Odense Child Cohort.
Neurotoxicology and teratology.
2021 Nov; 88(?):107031. doi:
10.1016/j.ntt.2021.107031. [PMID: 34563660] - Siobán D Harlow, Michelle M Hood, Ning Ding, Bhramar Mukherjee, Antonia M Calafat, John F Randolph, Ellen B Gold, Sung Kyun Park. Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition.
The Journal of clinical endocrinology and metabolism.
2021 10; 106(11):e4427-e4437. doi:
10.1210/clinem/dgab476. [PMID: 34181018] - Sylvain De Guise, Milton Levin. Suppression of Th2 cytokines as a potential mechanism for reduced antibody response following PFOA exposure in female B6C3F1 mice.
Toxicology letters.
2021 Oct; 351(?):155-162. doi:
10.1016/j.toxlet.2021.09.002. [PMID: 34517056] - Takanobu Horikoshi, Tomoko Nishimura, Yoko Nomura, Toshiki Iwabuchi, Hiroaki Itoh, Takumi Takizawa, Kenji J Tsuchiya. Umbilical cord serum concentrations of perfluorooctane sulfonate, perfluorooctanoic acid, and the body mass index changes from birth to 5 1/2 years of age.
Scientific reports.
2021 10; 11(1):19789. doi:
10.1038/s41598-021-99174-3. [PMID: 34611219] - Emily S Marques, Juliana Agudelo, Emily M Kaye, Seyed Mohamad Sadegh Modaresi, Marisa Pfohl, Jitka Bečanová, Wei Wei, Marianne Polunas, Michael Goedken, Angela L Slitt. The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure.
Toxicology.
2021 10; 462(?):152921. doi:
10.1016/j.tox.2021.152921. [PMID: 34464680] - Randi Grønnestad, Silje Modahl Johanson, Mette H B Müller, Daniel Schlenk, Philip Tanabe, Åse Krøkje, Veerle L B Jaspers, Bjørn Munro Jenssen, Erik M Ræder, Jan L Lyche, Qingyang Shi, Augustine Arukwe. Effects of an environmentally relevant PFAS mixture on dopamine and steroid hormone levels in exposed mice.
Toxicology and applied pharmacology.
2021 10; 428(?):115670. doi:
10.1016/j.taap.2021.115670. [PMID: 34371090] - Pengyang Li, Zhiyong Xiao, Xiaocan Xie, Zhifang Li, Hongju Yang, Xiao Ma, Jiang Sun, Jiuyi Li. Perfluorooctanoic acid (PFOA) changes nutritional compositions in lettuce (Lactuca sativa) leaves by activating oxidative stress.
Environmental pollution (Barking, Essex : 1987).
2021 Sep; 285(?):117246. doi:
10.1016/j.envpol.2021.117246. [PMID: 33940231] - J J Schlezinger, T Hyötyläinen, T Sinioja, C Boston, H Puckett, J Oliver, W Heiger-Bernays, T F Webster. Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet.
Toxicology and applied pharmacology.
2021 09; 426(?):115644. doi:
10.1016/j.taap.2021.115644. [PMID: 34252412] - Jonathan Vibe Retbøll Christensen, Khushal Khan Bangash, Pál Weihe, Phillippe Grandjean, Flemming Nielsen, Tina Kold Jensen, Maria Skaalum Petersen. Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: A Faroese cohort study.
Reproductive toxicology (Elmsford, N.Y.).
2021 09; 104(?):52-57. doi:
10.1016/j.reprotox.2021.06.016. [PMID: 34182087] - Jessie P Buckley, Jordan R Kuiper, Bruce P Lanphear, Antonia M Calafat, Kim M Cecil, Aimin Chen, Yingying Xu, Kimberly Yolton, Heidi J Kalkwarf, Joseph M Braun. Associations of Maternal Serum Perfluoroalkyl Substances Concentrations with Early Adolescent Bone Mineral Content and Density: The Health Outcomes and Measures of the Environment (HOME) Study.
Environmental health perspectives.
2021 09; 129(9):97011. doi:
10.1289/ehp9424. [PMID: 34585601] - Aline de Souza Espindola Santos, Armando Meyer, Vanessa Emídio Dabkiewicz, Volney de Magalhães Câmara, Carmen Ildes Rodrigues Froes Asmus. Serum levels of perfluorooctanoic acid and perfluorooctane sulfonic acid in pregnant women: Maternal predictors and associations with birth outcomes in the PIPA Project.
The journal of obstetrics and gynaecology research.
2021 Sep; 47(9):3107-3118. doi:
10.1111/jog.14883. [PMID: 34111903] - Jaclyn A Janis, Sheryl L Rifas-Shiman, Shravanthi M Seshasayee, Sharon Sagiv, Antonia M Calafat, Diane R Gold, Brent A Coull, Clifford J Rosen, Emily Oken, Abby F Fleisch. Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Body Composition From Mid-Childhood to Early Adolescence.
The Journal of clinical endocrinology and metabolism.
2021 08; 106(9):e3760-e3770. doi:
10.1210/clinem/dgab187. [PMID: 33740056]
