bezafibrate (BioDeep_00000397718)

   


代谢物信息卡片


2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid

化学式: C19H20ClNO4 (361.1080790000001)
中文名称: 苯扎贝特
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(C(NCCc2ccc(OC(C(O)=O)(C)C)cc2)=O)ccc(Cl)cc1
InChI: InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AB - Fibrates
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4657; ORIGINAL_PRECURSOR_SCAN_NO 4655
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4682; ORIGINAL_PRECURSOR_SCAN_NO 4681
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4636; ORIGINAL_PRECURSOR_SCAN_NO 4635
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4660; ORIGINAL_PRECURSOR_SCAN_NO 4659
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4651; ORIGINAL_PRECURSOR_SCAN_NO 4650
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8993; ORIGINAL_PRECURSOR_SCAN_NO 8991
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9030; ORIGINAL_PRECURSOR_SCAN_NO 9028
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9048; ORIGINAL_PRECURSOR_SCAN_NO 9046
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9079; ORIGINAL_PRECURSOR_SCAN_NO 9078
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9087; ORIGINAL_PRECURSOR_SCAN_NO 9085
CONFIDENCE standard compound; INTERNAL_ID 559; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9094; ORIGINAL_PRECURSOR_SCAN_NO 9093
CONFIDENCE standard compound; INTERNAL_ID 2341
CONFIDENCE standard compound; INTERNAL_ID 8548
CONFIDENCE standard compound; INTERNAL_ID 4069
CONFIDENCE standard compound; EAWAG_UCHEM_ID 209
Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.

同义名列表

3 个代谢物同义名

bezafibrate; 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid; BM15075



数据库引用编号

65 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo. Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome. Heart and vessels. 2024 Jun; 39(6):486-495. doi: 10.1007/s00380-024-02363-z. [PMID: 38393377]
  • Yangyiyan Song, Wen Sun, Wenqiang Li, Wen Li. Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells. International immunopharmacology. 2023 Oct; 123(?):110751. doi: 10.1016/j.intimp.2023.110751. [PMID: 37567013]
  • Masako Iwasaki, Hitoshi Suzuki, Yukako Umezawa, Takeo Koshida, Midori Saito, Hiromitsu Fukuda, Hisatsugu Takahara, Keiichi Matsuzaki, Yusuke Suzuki. Efficacy and safety of pemafibrate in patients with chronic kidney disease: A retrospective study. Medicine. 2023 Feb; 102(7):e32818. doi: 10.1097/md.0000000000032818. [PMID: 36800602]
  • Caroline Santana Frientes, Marcelo Luis Marquezi, Juliana Monique Lino Aparecido, Marcelo Santin Cascapera, Patrícia Soares Rogeri, Antônio Herbert Lancha Junior. Effect of Menstrual Cycle Phase on Fuel Oxidation Post HIT in Women Reproductive Age: A Pilot Study. International journal of environmental research and public health. 2023 02; 20(4):. doi: 10.3390/ijerph20043148. [PMID: 36833845]
  • Hongyu Chen, Lu Tian, Xiangyu Sun, Rongliang Ma, Meiqin Zhang. New Horizons for Estimating the Time Since Deposition of Fingermarks: Combining Label-Free Physical Visualization and Electrochemical Characterization. Analytical chemistry. 2023 01; 95(2):889-897. doi: 10.1021/acs.analchem.2c03427. [PMID: 36537841]
  • Avigdor D Arad, Fred J DiMenna, Hannah D Kittrell, Harry R Kissileff, Jeanine B Albu. Whole body lipid oxidation during exercise is impaired with poor insulin sensitivity but not with obesity per se. American journal of physiology. Endocrinology and metabolism. 2022 Oct; 323(4):E366-E377. doi: 10.1152/ajpendo.00042.2022. [PMID: 35830686]
  • Bianca Seminotti, Morgana Brondani, Rafael Teixeira Ribeiro, Guilhian Leipnitz, Moacir Wajner. Disturbance of Mitochondrial Dynamics, Endoplasmic Reticulum-Mitochondria Crosstalk, Redox Homeostasis, and Inflammatory Response in the Brain of Glutaryl-CoA Dehydrogenase-Deficient Mice: Neuroprotective Effects of Bezafibrate. Molecular neurobiology. 2022 Aug; 59(8):4839-4853. doi: 10.1007/s12035-022-02887-3. [PMID: 35639256]
  • Akihiro Nakamura, Yuta Kagaya, Hiroki Saito, Masanori Kanazawa, Kenjiro Sato, Masanobu Miura, Masateru Kondo, Hideaki Endo. Efficacy and Safety of Pemafibrate Versus Bezafibrate to Treat Patients with Hypertriglyceridemia: A Randomized Crossover Study. Journal of atherosclerosis and thrombosis. 2022 Jun; ?(?):. doi: 10.5551/jat.63659. [PMID: 35768226]
  • Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Nícolas Manzke Glänzel, Leonardo de Moura Alvorcem, Morgana Brondani, Renata Britto, Mateus Grings, Vanessa Duarte Ortiz, Patrick Turck, Alex Sander da Rosa Araujo, Moacir Wajner, Guilhian Leipnitz. Antioxidant system disturbances and mitochondrial dysfunction induced by 3-methyglutaric acid in rat heart are prevented by bezafibrate. European journal of pharmacology. 2022 Jun; 924(?):174950. doi: 10.1016/j.ejphar.2022.174950. [PMID: 35430210]
  • David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Quetzalli Veloz Corona, Lulu Sanchez Reyes, Armando Valenzuela Peraza, Gerardo Barragán Mejía. Oseltamivir induces favorable response on oxidative damage in the brain of rats treated with Bezafibrate. The International journal of neuroscience. 2022 Jun; 132(6):574-581. doi: 10.1080/00207454.2020.1828882. [PMID: 32976735]
  • Yao Jiang, Andrew D Southam, Sandro Trova, Flavio Beke, Bader Alhazmi, Thomas Francis, Anshul Radotra, Alessandro di Maio, Mark T Drayson, Chris M Bunce, Farhat L Khanim. Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing. British journal of cancer. 2022 02; 126(2):275-286. doi: 10.1038/s41416-021-01570-z. [PMID: 34686779]
  • Xin Qiao, Yu-Yang Gao, Li-Xia Zheng, Xiao-Jing Ding, Ling-Wen Xu, Juan-Juan Hu, Wei-Zhen Gao, Jing-Yuan Xu. Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate. European journal of medicinal chemistry. 2021 Nov; 223(?):113730. doi: 10.1016/j.ejmech.2021.113730. [PMID: 34388483]
  • Nan Shen, Jielu Pan, Hongyu Miao, Haiyan Zhang, Lianjun Xing, Xiao Yu. Fibrates for the treatment of pruritus in primary biliary cholangitis: a systematic review and meta-analysis. Annals of palliative medicine. 2021 Jul; 10(7):7697-7705. doi: 10.21037/apm-21-1304. [PMID: 34353058]
  • Martin Lund, Kathrine G Andersen, Robert Heaton, Iain P Hargreaves, Niels Gregersen, Rikke K J Olsen. Bezafibrate activation of PPAR drives disturbances in mitochondrial redox bioenergetics and decreases the viability of cells from patients with VLCAD deficiency. Biochimica et biophysica acta. Molecular basis of disease. 2021 06; 1867(6):166100. doi: 10.1016/j.bbadis.2021.166100. [PMID: 33549744]
  • Joost Boeckmans, Alessandra Natale, Matthias Rombaut, Karolien Buyl, Brent Cami, Veerle De Boe, Anja Heymans, Vera Rogiers, Joery De Kock, Tamara Vanhaecke, Robim M Rodrigues. Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists. Cell biology and toxicology. 2021 04; 37(2):293-311. doi: 10.1007/s10565-020-09544-2. [PMID: 32613381]
  • Salwa A Ibrahim, Mervat Z Mohamed, Nashwa F El-Tahawy, Aly M Abdelrahman. Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats. Canadian journal of physiology and pharmacology. 2021 Mar; 99(3):313-320. doi: 10.1139/cjpp-2020-0159. [PMID: 32721217]
  • Juan M León-Martínez, Esperanza Martínez-Abundis, Manuel González-Ortiz, Karina G Pérez-Rubio. Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial. Journal of medicinal food. 2021 Feb; 24(2):111-115. doi: 10.1089/jmf.2020.0029. [PMID: 32397850]
  • Hideaki Shiraishi, Kenji Yamada, Kiyoshi Egawa, Mika Ishige, Fumihiro Ochi, Asami Watanabe, Sanae Kawakami, Kazuyo Kuzume, Kenji Watanabe, Koji Sameshima, Kiyotaka Nakamagoe, Akira Tamaoka, Naoko Asahina, Saki Yokoshiki, Keiko Kobayashi, Takashi Miyakoshi, Koji Oba, Toshiyuki Isoe, Hiroshi Hayashi, Seiji Yamaguchi, Norihiro Sato. Efficacy of bezafibrate for preventing myopathic attacks in patients with very long-chain acyl-CoA dehydrogenase deficiency. Brain & development. 2021 Feb; 43(2):214-219. doi: 10.1016/j.braindev.2020.07.019. [PMID: 32798077]
  • Elsemieke de Vries, Ruth Bolier, Jorn Goet, Albert Parés, Jef Verbeek, Marleen de Vree, Joost Drenth, Karel van Erpecum, Karin van Nieuwkerk, Frans van der Heide, Nahid Mostafavi, Jeltje Helder, Cyriel Ponsioen, Ronald Oude Elferink, Henk van Buuren, Ulrich Beuers. Fibrates for Itch (FITCH) in Fibrosing Cholangiopathies: A Double-Blind, Randomized, Placebo-Controlled Trial. Gastroenterology. 2021 02; 160(3):734-743.e6. doi: 10.1053/j.gastro.2020.10.001. [PMID: 33031833]
  • Jonathan J Sheard, Andrew D Southam, Hannah L MacKay, Max A Ellington, Martyn D Snow, Farhat L Khanim, Christopher M Bunce, William E Johnson. Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells. Bioscience reports. 2021 01; 41(1):. doi: 10.1042/bsr20202505. [PMID: 33289496]
  • Boris Zingerman, Danny Ziv, Netta Feder Krengel, Asher Korzets, Ilan Matok. Cessation of Bezafibrate in patients with chronic kidney disease improves renal function. Scientific reports. 2020 11; 10(1):19768. doi: 10.1038/s41598-020-76861-1. [PMID: 33188240]
  • Franck Peiretti, Roberta Montanari, Davide Capelli, Bernadette Bonardo, Cécilia Colson, Ez-Zoubir Amri, Marina Grimaldi, Patrick Balaguer, Keiichi Ito, Robert G Roeder, Giorgio Pochetti, Jean Michel Brunel. A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities. Journal of medicinal chemistry. 2020 11; 63(21):13124-13139. doi: 10.1021/acs.jmedchem.0c01555. [PMID: 33142057]
  • Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment. European journal of medicinal chemistry. 2020 Jul; 197(?):112311. doi: 10.1016/j.ejmech.2020.112311. [PMID: 32339855]
  • Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Nícolas Manzke Glänzel, Leonardo de Moura Alvorcem, Marina Rocha Frusciante, Carlos Severo Dutra Filho, Moacir Wajner, Guilhian Leipnitz. In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver. Biochimie. 2020 Apr; 171-172(?):187-196. doi: 10.1016/j.biochi.2020.03.007. [PMID: 32169667]
  • Keiko Takano, Chisato Saeki, Tsunekazu Oikawa, Akihisa Hidaka, Yusuke Mizuno, Jinya Ishida, Kazuki Takakura, Masanori Nakano, Yuichi Torisu, Katsushi Amano, Tomohisa Ishikawa, Mikio Zeniya, Akihito Tsubota, Masayuki Saruta. IgM response is a prognostic biomarker of primary biliary cholangitis treated with ursodeoxycholic acid and bezafibrate. Journal of gastroenterology and hepatology. 2020 Apr; 35(4):663-672. doi: 10.1111/jgh.14900. [PMID: 31677185]
  • Hannah Steele, Aurora Gomez-Duran, Angela Pyle, Sila Hopton, Jane Newman, Renae J Stefanetti, Sarah J Charman, Jehill D Parikh, Langping He, Carlo Viscomi, Djordje G Jakovljevic, Kieren G Hollingsworth, Alan J Robinson, Robert W Taylor, Leonardo Bottolo, Rita Horvath, Patrick F Chinnery. Metabolic effects of bezafibrate in mitochondrial disease. EMBO molecular medicine. 2020 03; 12(3):e11589. doi: 10.15252/emmm.201911589. [PMID: 32107855]
  • Ru Sun, Chengwu Shen, Shumaila Shafique, Omer Mustapha, Talib Hussain, Ikram Ullah Khan, Yasir Mehmood, Khaleeq Anwer, Yasser Shahzad, Abid Mehmood Yousaf. Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate. International journal of nanomedicine. 2020; 15(?):705-715. doi: 10.2147/ijn.s235146. [PMID: 32099359]
  • Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen, Daowen Wang. PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis. BMC cancer. 2019 Dec; 19(1):1166. doi: 10.1186/s12885-019-6379-5. [PMID: 31791289]
  • Akira Honda, Atsushi Tanaka, Tetsuji Kaneko, Atsumasa Komori, Masanori Abe, Mie Inao, Tadashi Namisaki, Naoaki Hashimoto, Kazuhito Kawata, Atsushi Takahashi, Masashi Ninomiya, Jong-Hon Kang, Mie Arakawa, Satoshi Yamagiwa, Satoru Joshita, Takeji Umemura, Ken Sato, Akira Kaneko, Kentaro Kikuchi, Jun Itakura, Takako Nomura, Keisuke Kakisaka, Hideki Fujii, Norifumi Kawada, Yasuhiro Takikawa, Tsutomu Masaki, Hiromasa Ohira, Satoshi Mochida, Hitoshi Yoshiji, Satoshi Iimuro, Yasushi Matsuzaki, Hajime Takikawa. Bezafibrate Improves GLOBE and UK-PBC Scores and Long-Term Outcomes in Patients With Primary Biliary Cholangitis. Hepatology (Baltimore, Md.). 2019 12; 70(6):2035-2046. doi: 10.1002/hep.30552. [PMID: 30737815]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Y H Chen, Z Zhan, P Hu, H Ren, M L Peng. [A new attempt with lipoprotein lipase agonists in the treatment of nonalcoholic steatohepatitis]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 2019 Jul; 27(7):533-540. doi: 10.3760/cma.j.issn.1007-3418.2019.07.011. [PMID: 31357780]
  • Zaza Iakobishvili, Tal Hasin, Robert Klempfner, Nir Shlomo, Ilan Goldenberg, Ronen Brenner, Ran Kornowski, Yariv Gerber. Association of Bezafibrate Treatment With Reduced Risk of Cancer in Patients With Coronary Artery Disease. Mayo Clinic proceedings. 2019 07; 94(7):1171-1179. doi: 10.1016/j.mayocp.2018.10.026. [PMID: 31272567]
  • Takashi Yamaguchi, Kohji Shirai, Daiji Nagayama, Shoko Nakamura, Rena Oka, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Yuta Sato, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Naomi Shimizu, Ichiro Tatsuno. Bezafibrate Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Hypertriglyceridemic Patients with Type 2 Diabetes Mellitus. Journal of atherosclerosis and thrombosis. 2019 Jul; 26(7):659-669. doi: 10.5551/jat.45799. [PMID: 30584220]
  • Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Mateus Struecker da Rosa, Nícolas Manzke Glänzel, Leonardo de Moura Alvorcem, Moacir Wajner, Guilhian Leipnitz. Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats. Neurotoxicity research. 2019 May; 35(4):809-822. doi: 10.1007/s12640-019-00019-9. [PMID: 30850947]
  • Patrícia Duarte, C Marisa R Almeida, Joana P Fernandes, Daniela Morais, Marta Lino, Carlos R Gomes, Maria F Carvalho, Ana P Mucha. Bioremediation of bezafibrate and paroxetine by microorganisms from estuarine sediment and activated sludge of an associated wastewater treatment plant. The Science of the total environment. 2019 Mar; 655(?):796-806. doi: 10.1016/j.scitotenv.2018.11.285. [PMID: 30577142]
  • Bernardo Duarte, Diogo Prata, Ana Rita Matos, Maria Teresa Cabrita, Isabel Caçador, João Carlos Marques, Henrique N Cabral, Patrick Reis-Santos, Vanessa F Fonseca. Ecotoxicity of the lipid-lowering drug bezafibrate on the bioenergetics and lipid metabolism of the diatom Phaeodactylum tricornutum. The Science of the total environment. 2019 Feb; 650(Pt 2):2085-2094. doi: 10.1016/j.scitotenv.2018.09.354. [PMID: 30290350]
  • Lauren R Waskowicz, Jin Zhou, Dustin J Landau, Elizabeth D Brooks, Andrea Lim, Zollie A Yavarow, Tsubasa Kudo, Haoyue Zhang, Yajun Wu, Stuart Grant, Sarah P Young, Bay Boon Huat, Paul M Yen, Dwight D Koeberl. Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. Human molecular genetics. 2019 01; 28(1):143-154. doi: 10.1093/hmg/ddy343. [PMID: 30256948]
  • Belisa Parmeggiani, Mateus Grings, Nevton Teixeira da Rosa-Junior, Renata Britto, Moacir Wajner, Guilhian Leipnitz. Bezafibrate Prevents Glycine-Induced Increase of Antioxidant Enzyme Activities in Rat Striatum. Molecular neurobiology. 2019 Jan; 56(1):29-38. doi: 10.1007/s12035-018-1074-0. [PMID: 29675575]
  • Sara Lemoinne, Albert Pares, Anna Reig, Karima Ben Belkacem, Astrid Donald Kemgang Fankem, Farid Gaouar, Raoul Poupon, Chantal Housset, Christophe Corpechot, Olivier Chazouillères. Primary sclerosing cholangitis response to the combination of fibrates with ursodeoxycholic acid: French-Spanish experience. Clinics and research in hepatology and gastroenterology. 2018 12; 42(6):521-528. doi: 10.1016/j.clinre.2018.06.009. [PMID: 30100231]
  • Suhaniya Samarasinghe, Parizad Avari, Karim Meeran, Jaimini Cegla. Management of hypertriglyceridaemic pancreatitis in the acute setting and review of literature. BMJ case reports. 2018 Nov; 11(1):. doi: 10.1136/bcr-2018-227594. [PMID: 30567142]
  • Joseph M Chambers, Shahram Jevin Poureetezadi, Amanda Addiego, Manuela Lahne, Rebecca A Wingert. ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny. eLife. 2018 11; 7(?):. doi: 10.7554/elife.40266. [PMID: 30475208]
  • Zaza Khuchua, Aleksandr I Glukhov, Arnold W Strauss, Sabzali Javadov. Elucidating the Beneficial Role of PPAR Agonists in Cardiac Diseases. International journal of molecular sciences. 2018 Nov; 19(11):. doi: 10.3390/ijms19113464. [PMID: 30400386]
  • Annette Wegner, Dragan Pavlovic, Sebastian Haußmann-Vopel, Christian Lehmann. Impact of lipid modulation on the intestinal microcirculation in experimental sepsis. Microvascular research. 2018 11; 120(?):41-46. doi: 10.1016/j.mvr.2018.05.009. [PMID: 29859746]
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