dimethylthiourea (BioDeep_00000397423)

 

Secondary id: BioDeep_00000866614

PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1/C3H8N2S/c1-4-3(6)5-2/h1-2H3,(H2,4,5,6

化学式: C3H8N2S (104.0408168)
中文名称: 1,3-二甲基硫脲, N,N-二甲基硫脲
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 81.91%

分子结构信息

SMILES: CNC(=S)NC
InChI: InChI=1S/C3H8N2S/c1-4-3(6)5-2/h1-2H3,(H2,4,5,6)

描述信息

D000975 - Antioxidants > D016166 - Free Radical Scavengers
D020011 - Protective Agents > D000975 - Antioxidants
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (?OH) and blocks ?OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including ?OH scavenging and anti-inflammatory action[1][2].
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (?OH) and blocks ?OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including ?OH scavenging and anti-inflammatory action[1][2].

同义名列表

32 个代谢物同义名

InChI=1/C3H8N2S/c1-4-3(6)5-2/h1-2H3,(H2,4,5,6; 4-04-00-00217 (Beilstein Handbook Reference); doi:10.14272/VLCDUOXHFNUCKK-UHFFFAOYSA-N.1; 10.14272/VLCDUOXHFNUCKK-UHFFFAOYSA-N.1; (Z)-N,N-dimethylcarbamimidothioic acid; Urea, 1,3-dimethyl-2-thio-; N,N-Dimethylthiourea, 99\\%; N,N-DIMETHYLTHIOUREA [MI]; UREA,1,3-DIMETHYL,2-THIO; 1,3-Dimethylisothiourea; 1,3-dimethyl-2-thiourea; Thiourea, N,N-dimethyl-; Urea,3-dimethyl-2-thio-; 1,3-dimethyl-thiourea; 1,3-dimethylthio urea; 1,3-dimethyl thiourea; Dimethylthiocarbamide; N, N-Dimethylthiourea; sym-Dimethylthiourea; N,N-Dimethylthiourea; 1-3-Dimethylthiourea; Thiourea,N-dimethyl-; 1,3-dimethylthiourea; Dimethyl-2-thiourea; dimethylthiourea; UNII-8P30PMD17W; Tox21_301391; (CH3NH)2CS; 8P30PMD17W; AI3-16377; DMTU; N,N'-Dimethylthiourea



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wei-Qing Li, Jia-Yu Li, Yi-Fei Zhang, Wen-Qi Luo, Yi Dou, Song Yu. Effect of Reactive Oxygen Scavenger N,N'-Dimethylthiourea (DMTU) on Seed Germination and Radicle Elongation of Maize. International journal of molecular sciences. 2023 Oct; 24(21):. doi: 10.3390/ijms242115557. [PMID: 37958543]
  • Yanyan Zhang, Xin Fu, Yiqing Feng, Xiaowei Zhang, Huangai Bi, Xizhen Ai. Abscisic Acid Mediates Salicylic Acid Induced Chilling Tolerance of Grafted Cucumber by Activating H2O2 Biosynthesis and Accumulation. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232416057. [PMID: 36555697]
  • Ilaria Fraudentali, Chiara Pedalino, Paraskevi Tavladoraki, Riccardo Angelini, Alessandra Cona. A New Player in Jasmonate-Mediated Stomatal Closure: The Arabidopsis thaliana Copper Amine Oxidase β. Cells. 2021 12; 10(12):. doi: 10.3390/cells10123399. [PMID: 34943906]
  • Yu Xiao, Lulu Zhang, Heting Zhang, Hongyu Feng, Zhe Li, Huiping Chen. Interaction between endogenous H2O2 and OsVPE3 in the GA-induced PCD of rice aleurone layers. Plant cell reports. 2021 Apr; 40(4):691-705. doi: 10.1007/s00299-021-02665-w. [PMID: 33559721]
  • X Wang, J Zhang, J Song, M Huang, J Cai, Q Zhou, T Dai, D Jiang. Abscisic acid and hydrogen peroxide are involved in drought priming-induced drought tolerance in wheat (Triticum aestivum L.). Plant biology (Stuttgart, Germany). 2020 Nov; 22(6):1113-1122. doi: 10.1111/plb.13143. [PMID: 32530558]
  • Mengmeng Han, Baoyuan Wang, Guilong Song, Shengqing Shi. Comparative study of alleviation effects of DMTU and PCIB on root growth inhibition in two tall fescue varieties under cadmium stress. Ecotoxicology and environmental safety. 2020 Jun; 196(?):110528. doi: 10.1016/j.ecoenv.2020.110528. [PMID: 32240865]
  • Lijuan Liu, Lin Huang, Xianyong Lin, Chengliang Sun. Hydrogen peroxide alleviates salinity-induced damage through enhancing proline accumulation in wheat seedlings. Plant cell reports. 2020 May; 39(5):567-575. doi: 10.1007/s00299-020-02513-3. [PMID: 32025801]
  • Yingying Zhao, Yihua Zhang, Feijie Liu, Ren Wang, Liqin Huang, Wenbiao Shen. Hydrogen peroxide is involved in methane-induced tomato lateral root formation. Plant cell reports. 2019 Mar; 38(3):377-389. doi: 10.1007/s00299-019-02372-7. [PMID: 30617541]
  • Muhammad Arfan, Da-Wei Zhang, Li-Juan Zou, Shi-Shuai Luo, Wen-Rong Tan, Tong Zhu, Hong-Hui Lin. Hydrogen Peroxide and Nitric Oxide Crosstalk Mediates Brassinosteroids Induced Cold Stress Tolerance in Medicago truncatula. International journal of molecular sciences. 2019 Jan; 20(1):. doi: 10.3390/ijms20010144. [PMID: 30609774]
  • Roberto Biondi, Stefano Brancorsini, Giulia Poli, Maria Giulia Egidi, Enrico Capodicasa, Livio Bottiglieri, Sandro Gerli, Eleonora Brillo, Gian Carlo Di Renzo, Dragos Cretoiu, Romeo Micu, Nicolae Suciu. Detection and scavenging of hydroxyl radical via D-phenylalanine hydroxylation in human fluids. Talanta. 2018 May; 181(?):172-181. doi: 10.1016/j.talanta.2017.12.084. [PMID: 29426497]
  • Xiaohui Wang, Xianjuan Dong, Yingying Feng, Xiao Liu, Jinling Wang, Zhongxiu Zhang, Jun Li, Yunfang Zhao, Shepo Shi, Pengfei Tu. H2O2 and NADPH oxidases involve in regulation of 2-(2-phenylethyl)chromones accumulation during salt stress in Aquilaria sinensis calli. Plant science : an international journal of experimental plant biology. 2018 Apr; 269(?):1-11. doi: 10.1016/j.plantsci.2018.01.002. [PMID: 29606206]
  • Q M Chen, Y Yu, C M Lin, N Cui, J Y Zhao, T F Song, H Y Fan. Glucohexaose-induced protein phosphatase 2C regulates cell redox status of cucumber seedling. Journal of biosciences. 2018 Mar; 43(1):117-126. doi: 10.1007/s12038-018-9738-5. [PMID: 29485120]
  • Yoshiji Ohta, Koji Yashiro, Takashi Kobayashi, Kazuo Inui, Junji Yoshino. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundamental & clinical pharmacology. 2017 Jun; 31(3):319-328. doi: 10.1111/fcp.12268. [PMID: 28107553]
  • Changhua Zhu, Na Yang, Zhengfei Guo, Meng Qian, Lijun Gan. An ethylene and ROS-dependent pathway is involved in low ammonium-induced root hair elongation in Arabidopsis seedlings. Plant physiology and biochemistry : PPB. 2016 Aug; 105(?):37-44. doi: 10.1016/j.plaphy.2016.04.002. [PMID: 27074220]
  • Qien Li, Zhaofeng Wang, Yanning Zhao, Xiaochen Zhang, Shuaijun Zhang, Letao Bo, Yao Wang, Yingfeng Ding, Lizhe An. Putrescine protects hulless barley from damage due to UV-B stress via H2S- and H2O2-mediated signaling pathways. Plant cell reports. 2016 May; 35(5):1155-68. doi: 10.1007/s00299-016-1952-8. [PMID: 26910861]
  • Yu V Karpets, Yu E Kolupaev, T O Yastreb. SIGNAL MEDIATORS AT INDUCTION OF HEAT RESISTANCE OF WHEAT PLANTLETS BY SHORT-TERM HEATING. Ukrainian biochemical journal. 2015 Nov; 87(6):104-12. doi: 10.15407/ubj87.06.104. [PMID: 27025064]
  • Onur Cil, Cristina Esteva-Font, Sadik Taskin Tas, Tao Su, Sujin Lee, Marc O Anderson, Mert Ertunc, Alan S Verkman. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney international. 2015 Aug; 88(2):311-20. doi: 10.1038/ki.2015.138. [PMID: 25993324]
  • Sandip A Ghuge, Andrea Carucci, Renato A Rodrigues-Pousada, Alessandra Tisi, Stefano Franchi, Paraskevi Tavladoraki, Riccardo Angelini, Alessandra Cona. The Apoplastic Copper AMINE OXIDASE1 Mediates Jasmonic Acid-Induced Protoxylem Differentiation in Arabidopsis Roots. Plant physiology. 2015 Jun; 168(2):690-707. doi: 10.1104/pp.15.00121. [PMID: 25883242]
  • Baoyun Qian, Xia Li, Xiaolong Liu, Man Wang. Improved oxidative tolerance in suspension-cultured cells of C4-pepctransgenic rice by H2O2 and Ca(2+) under PEG-6000. Journal of integrative plant biology. 2015 Jun; 57(6):534-49. doi: 10.1111/jipb.12283. [PMID: 25231250]
  • Cristina Esteva-Font, Puay-Wah Phuan, Sujin Lee, Tao Su, Marc O Anderson, A S Verkman. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters. Biochimica et biophysica acta. 2015 May; 1848(5):1075-80. doi: 10.1016/j.bbamem.2015.01.004. [PMID: 25613743]
  • Kilani Ben Rejeb, Maâli Benzarti, Ahmed Debez, Christophe Bailly, Arnould Savouré, Chedly Abdelly. NADPH oxidase-dependent H2O2 production is required for salt-induced antioxidant defense in Arabidopsis thaliana. Journal of plant physiology. 2015 Feb; 174(?):5-15. doi: 10.1016/j.jplph.2014.08.022. [PMID: 25462961]
  • Jisheng Li, Honglei Jia, Jue Wang, Qianhua Cao, Zichao Wen. Hydrogen sulfide is involved in maintaining ion homeostasis via regulating plasma membrane Na+/H+ antiporter system in the hydrogen peroxide-dependent manner in salt-stress Arabidopsis thaliana root. Protoplasma. 2014 Jul; 251(4):899-912. doi: 10.1007/s00709-013-0592-x. [PMID: 24318675]
  • Jing Zhang, Xiaohui Duan, Fan Ding, HaiZhen Ma, Tengguo Zhang, Yingli Yang. Salinity induced the changes of root growth and antioxidative responses in two wheat cultivars. Protoplasma. 2014 Jul; 251(4):771-80. doi: 10.1007/s00709-013-0579-7. [PMID: 24318673]
  • Josefin Axelsson, Anna Rippe, Kristinn Sverrisson, Bengt Rippe. Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. American journal of physiology. Renal physiology. 2013 Aug; 305(3):F237-43. doi: 10.1152/ajprenal.00154.2013. [PMID: 23657856]
  • Satoru Mitazaki, Midori Hashimoto, Yui Matsuhashi, Shigeyoshi Honma, Miwako Suto, Naho Kato, Osamu Nakagawasai, Koichi Tan-No, Kouichi Hiraiwa, Makoto Yoshida, Sumiko Abe. Interleukin-6 modulates oxidative stress produced during the development of cisplatin nephrotoxicity. Life sciences. 2013 Apr; 92(12):694-700. doi: 10.1016/j.lfs.2013.01.026. [PMID: 23384965]
  • Guangjie Li, Baohai Li, Gangqiang Dong, Xiaoyu Feng, Herbert J Kronzucker, Weiming Shi. Ammonium-induced shoot ethylene production is associated with the inhibition of lateral root formation in Arabidopsis. Journal of experimental botany. 2013 Mar; 64(5):1413-25. doi: 10.1093/jxb/ert019. [PMID: 23382554]
  • Wei Yang, Changhua Zhu, Xiaoling Ma, Guijun Li, Lijun Gan, Denny Ng, Kai Xia. Hydrogen peroxide is a second messenger in the salicylic acid-triggered adventitious rooting process in mung bean seedlings. PloS one. 2013; 8(12):e84580. doi: 10.1371/journal.pone.0084580. [PMID: 24386397]
  • Iu E Kolupaev, A I Oboznyĭ. [Participation of the active oxygen forms in the induction of ascorbate peroxidase and guaiacol peroxidase under heat hardening of wheat seedlings]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2012 Nov; 84(6):131-8. doi: ". [PMID: 23387278]
  • O Cil, M Ertunc, R Onur. The diuretic effect of urea analog dimethylthiourea in female Wistar rats. Human & experimental toxicology. 2012 Oct; 31(10):1050-5. doi: 10.1177/0960327112459205. [PMID: 23023029]
  • Shohana Parvin, Ok Ran Lee, Gayathri Sathiyaraj, Altanzul Khorolragchaa, Yu-Jin Kim, Balusamy Sri Renuka Devi, Deok-Chun Yang. Interrelationship between calmodulin (CaM) and H2O2 in abscisic acid-induced antioxidant defense in the seedlings of Panax ginseng. Molecular biology reports. 2012 Jul; 39(7):7327-38. doi: 10.1007/s11033-012-1564-5. [PMID: 22307798]
  • Jinglong Jiang, Miao Su, Liyan Wang, Chengjin Jiao, Zhengxi Sun, Wei Cheng, Fengmin Li, Chongying Wang. Exogenous hydrogen peroxide reversibly inhibits root gravitropism and induces horizontal curvature of primary root during grass pea germination. Plant physiology and biochemistry : PPB. 2012 Apr; 53(?):84-93. doi: 10.1016/j.plaphy.2012.01.017. [PMID: 22342943]
  • Yuan-Ting Hsu, Tse-Min Lee. Modulation of gene expression of carotene biosynthesis-related protein by photosynthetic electron transport for the acclimation of intertidal macroalga Ulva fasciata to hypersalinity and excess light. Physiologia plantarum. 2012 Mar; 144(3):225-37. doi: 10.1111/j.1399-3054.2011.01547.x. [PMID: 22122736]
  • Samir Mandal, Sudip Mukherjee, Kaustav Dutta Chowdhury, Avik Sarkar, Kankana Basu, Soumosish Paul, Debasish Karmakar, Mahasweta Chatterjee, Tuli Biswas, Gobinda Chandra Sadhukhan, Gargi Sen. S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead. Biochimica et biophysica acta. 2012 Jan; 1820(1):9-23. doi: 10.1016/j.bbagen.2011.09.019. [PMID: 22033380]
  • Onur Cil, Mert Ertunc, Kadri Safak Gucer, Fatih Ozaltin, Alper Bektas Iskit, Rustu Onur. Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical. Renal failure. 2012; 34(2):211-20. doi: 10.3109/0886022x.2011.643389. [PMID: 22229548]
  • El-Sayed M El-Sayed, Abdel-Aziz H Abdel-Aziz, Samira Saleh, Ahmed S Saad. The chemopreventive effect of dimethylthiourea against carmustine-induced myelotoxicity in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Sep; 49(9):1965-9. doi: 10.1016/j.fct.2011.05.007. [PMID: 21620922]
  • Maik Böhmer, Julian I Schroeder. Quantitative transcriptomic analysis of abscisic acid-induced and reactive oxygen species-dependent expression changes and proteomic profiling in Arabidopsis suspension cells. The Plant journal : for cell and molecular biology. 2011 Jul; 67(1):105-18. doi: 10.1111/j.1365-313x.2011.04579.x. [PMID: 21426425]
  • Mingzhu Wu, Jingjing Huang, Sheng Xu, Tengfang Ling, Yanjie Xie, Wenbiao Shen. Haem oxygenase delays programmed cell death in wheat aleurone layers by modulation of hydrogen peroxide metabolism. Journal of experimental botany. 2011 Jan; 62(1):235-48. doi: 10.1093/jxb/erq261. [PMID: 20797999]
  • Toby K McGovern, William S Powell, Brian J Day, Carl W White, Karuthapillai Govindaraju, Harry Karmouty-Quintana, Normand Lavoie, Ju Jing Tan, James G Martin. Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma. Respiratory research. 2010 Oct; 11(?):138. doi: 10.1186/1465-9921-11-138. [PMID: 20925946]
  • Lichao Hou, Keliang Xie, Mingzhe Qin, Daorong Peng, Shirong Ma, Lei Shang, Nan Li, Shuzhi Li, Genlin Ji, Yan Lu, Lize Xiong. Effects of reactive oxygen species scavenger on the protective action of 100\% oxygen treatment against sterile inflammation in mice. Shock (Augusta, Ga.). 2010 Jun; 33(6):646-54. doi: 10.1097/shk.0b013e3181c1b5d4. [PMID: 19789462]
  • V Mohan Murali Achary, Brahma B Panda. Aluminium-induced DNA damage and adaptive response to genotoxic stress in plant cells are mediated through reactive oxygen intermediates. Mutagenesis. 2010 Mar; 25(2):201-9. doi: 10.1093/mutage/gep063. [PMID: 19955331]
  • Shang-Pin Liu, Chien-Yu Chang, Wen-Hung Huang, Yaw-Syan Fu, David Chao, Hung-Tu Huang. Dimethylthiourea pretreatment inhibits endotoxin-induced compound exocytosis in goblet cells and plasma leakage of rat small intestine. Journal of electron microscopy. 2010; 59(2):127-39. doi: 10.1093/jmicro/dfp049. [PMID: 19825851]
  • Xiao-Yue Chen, Xiao Ding, Sheng Xu, Ren Wang, Wei Xuan, Ze-Yu Cao, Jian Chen, Hong-Hong Wu, Mao-Bing Ye, Wen-Biao Shen. Endogenous hydrogen peroxide plays a positive role in the upregulation of heme oxygenase and acclimation to oxidative stress in wheat seedling leaves. Journal of integrative plant biology. 2009 Oct; 51(10):951-60. doi: 10.1111/j.1744-7909.2009.00869.x. [PMID: 19778405]
  • Beibei Xue, Aying Zhang, Mingyi Jiang. Involvement of polyamine oxidase in abscisic acid-induced cytosolic antioxidant defense in leaves of maize. Journal of integrative plant biology. 2009 Mar; 51(3):225-34. doi: 10.1111/j.1744-7909.2008.00766.x. [PMID: 19261065]
  • Wen-Hung Huang, Wei-Ban Chang, Shang-Pin Liu, Jen-Tai Lin, Yaw-Syan Fu, Min-Chi Chang, Hung-Tu Huang. Inhibitory effect of dimethylthiourea on rat urinary bladder inflammation produced by 6-hydroxydopamine application. Autonomic neuroscience : basic & clinical. 2009 Jan; 145(1-2):44-9. doi: 10.1016/j.autneu.2008.11.003. [PMID: 19059812]
  • Takayuki Tsuji, Akihiko Kato, Hideo Yasuda, Takehiko Miyaji, Jinghui Luo, Yukitoshi Sakao, Hideaki Ito, Yoshihide Fujigaki, Akira Hishida. The dimethylthiourea-induced attenuation of cisplatin nephrotoxicity is associated with the augmented induction of heat shock proteins. Toxicology and applied pharmacology. 2009 Jan; 234(2):202-8. doi: 10.1016/j.taap.2008.09.031. [PMID: 18992762]
  • Kuo Tung Hung, Deng Guo Cheng, Yi Ting Hsu, Ching Huei Kao. Abscisic acid-induced hydrogen peroxide is required for anthocyanin accumulation in leaves of rice seedlings. Journal of plant physiology. 2008 Aug; 165(12):1280-7. doi: 10.1016/j.jplph.2007.10.008. [PMID: 18160127]
  • N A G Santos, C S Catão Bezerra, N M Martins, C Curti, M L P Bianchi, A C Santos. Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Cancer chemotherapy and pharmacology. 2008 Jan; 61(1):145-55. doi: 10.1007/s00280-007-0459-y. [PMID: 17396264]
  • Neife Aparecida Guinaim dos Santos, Nádia Maria Martins, Carlos Curti, Maria de Lourdes Pires Bianchi, Antonio Cardozo dos Santos. Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats. Chemico-biological interactions. 2007 Dec; 170(3):177-86. doi: 10.1016/j.cbi.2007.07.014. [PMID: 17850778]
  • Kuo Tung Hung, Ching Huei Kao. The participation of hydrogen peroxide in methyl jasmonate-induced NH(4)(+) accumulation in rice leaves. Journal of plant physiology. 2007 Nov; 164(11):1469-79. doi: 10.1016/j.jplph.2006.10.005. [PMID: 17215059]
  • Qiu-Hong Pan, Yan-Jun Zhang, Yan-Yan Liu, Yan-Fang Zhang, Wei-Dong Huang. [Changes in H2O2 and salicylic acid contents as well as plasma membrane H+-ATPase activity and their relations in pea leaves during thermotolerance induction]. Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology. 2007 Oct; 33(5):425-34. doi: NULL. [PMID: 17960046]
  • Liyu Xing, Daniel G Remick. Mechanisms of oxidant regulation of monocyte chemotactic protein 1 production in human whole blood and isolated mononuclear cells. Shock (Augusta, Ga.). 2007 Aug; 28(2):178-85. doi: 10.1097/shk.0b013e3180311cf4. [PMID: 17529908]
  • Su-Lan Liao, Yen-Chuan Ou, Shih-Yun Chen, An-Na Chiang, Chun-Jung Chen. Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes. Neurochemistry international. 2007 Jun; 50(7-8):905-15. doi: 10.1016/j.neuint.2006.09.016. [PMID: 17084486]
  • Pei-Xuan Wang, Paul W Sanders. Immunoglobulin light chains generate hydrogen peroxide. Journal of the American Society of Nephrology : JASN. 2007 Apr; 18(4):1239-45. doi: 10.1681/asn.2006111299. [PMID: 17360948]
  • Qi Li, Xiang-dong Zhou. [Upstream signaling pathway of neutrophil elastase-induced mucous hypersecretion]. Zhonghua yi xue za zhi. 2007 Jan; 87(5):348-52. doi: NULL. [PMID: 17456367]
  • C B Marshall, J W Pippin, R D Krofft, S J Shankland. Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney international. 2006 Dec; 70(11):1962-73. doi: 10.1038/sj.ki.5001965. [PMID: 17035936]
  • Prosper M'Bemba-Meka, Nicole Lemieux, Saroj K Chakrabarti. Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel subsulfide-induced human lymphocyte death in vitro. The Science of the total environment. 2006 Oct; 369(1-3):21-34. doi: 10.1016/j.scitotenv.2006.04.007. [PMID: 16780931]
  • Samarjit Das, Peter Der, Utpal Raychaudhuri, Nilanjana Maulik, Dipak K Das. The effect of Euryale ferox (Makhana), an herb of aquatic origin, on myocardial ischemic reperfusion injury. Molecular and cellular biochemistry. 2006 Sep; 289(1-2):55-63. doi: 10.1007/s11010-006-9147-1. [PMID: 16628469]
  • Andrea Kramer, Mabel van den Hoven, Angelique Rops, Tessa Wijnhoven, Lambert van den Heuvel, Joost Lensen, Toin van Kuppevelt, Harry van Goor, Johan van der Vlag, Gerjan Navis, Jo H M Berden. Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system. Journal of the American Society of Nephrology : JASN. 2006 Sep; 17(9):2513-20. doi: 10.1681/asn.2006020184. [PMID: 16899518]
  • Yasuhiro Masubuchi, Mamiko Kawasaki, Toshiharu Horie. Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats. Archives of toxicology. 2006 Jun; 80(6):347-53. doi: 10.1007/s00204-006-0079-z. [PMID: 16485119]
  • Martin F Bek, Michael Bayer, Barbara Müller, Stefan Greiber, Detlef Lang, Albrecht Schwab, Christian August, Erik Springer, Rolf Rohrbach, Tobias B Huber, Thomas Benzing, Hermann Pavenstädt. Expression and function of C/EBP homology protein (GADD153) in podocytes. The American journal of pathology. 2006 Jan; 168(1):20-32. doi: 10.2353/ajpath.2006.040774. [PMID: 16400006]
  • T Sudhakar Babu, Sridevi Tripuranthakam, Bruce M Greenberg. Biochemical responses of the aquatic higher plant Lemna gibba to a mixture of copper and 1,2-dihydroxyanthraquinone: synergistic toxicity via reactive oxygen species. Environmental toxicology and chemistry. 2005 Dec; 24(12):3030-6. doi: 10.1897/05-073r.1. [PMID: 16445081]
  • Takaaki Oteki, Sohji Nagase, Hidekatsu Yokoyama, Hiroaki Ohya, Takao Akatsuka, Mika Tada, Atsushi Ueda, Aki Hirayama, Akio Koyama. Normalizing renal reducing ability prevents adriamycin-induced proteinuria. Biochemical and biophysical research communications. 2005 Nov; 337(1):48-51. doi: 10.1016/j.bbrc.2005.08.266. [PMID: 16171782]
  • Prosper M'Bemba-Meka, Nicole Lemieux, Saroj K Chakrabarti. Nickel compound-induced DNA single-strand breaks in chromosomal and nuclear chromatin in human blood lymphocytes in vitro: role of oxidative stress and intracellular calcium. Mutation research. 2005 Oct; 586(2):124-37. doi: 10.1016/j.mrgentox.2005.06.001. [PMID: 16099703]
  • Mario Governa, Monica Amati, Ivana Fenoglio, Matteo Valentino, Sabrina Coloccini, Lucia Bolognini, Gian Carlo Botta, Monica Emanuelli, Francesca Pierella, Anna Rita Volpe, Paola Astolfi, Marco Carmignani, Bice Fubini. Variability of biological effects of silicas: different degrees of activation of the fifth component of complement by amorphous silicas. Toxicology and applied pharmacology. 2005 Oct; 208(1):68-77. doi: 10.1016/j.taap.2005.01.019. [PMID: 16164962]
  • Prosper M'Bemba-Meka, Nicole Lemieux, Saroj K Chakrabarti. Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulfate-induced human lymphocyte death in vitro. Chemico-biological interactions. 2005 Sep; 156(1):69-80. doi: 10.1016/j.cbi.2005.07.004. [PMID: 16125158]
  • Yoshiko Kawai, Yuka Kohda, Takaaki Kodawara, Munekazu Gemba. Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1). The Journal of toxicological sciences. 2005 Aug; 30(3):157-63. doi: 10.2131/jts.30.157. [PMID: 16141650]
  • Ganesan Ramesh, W Brian Reeves. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. American journal of physiology. Renal physiology. 2005 Jul; 289(1):F166-74. doi: 10.1152/ajprenal.00401.2004. [PMID: 15701814]
  • Miriam Galbusera, Simona Buelli, Sara Gastoldi, Daniela Macconi, Stefania Angioletti, Cristian Testa, Giuseppe Remuzzi, Marina Morigi. Activation of porcine endothelium in response to xenogeneic serum causes thrombosis independently of platelet activation. Xenotransplantation. 2005 Mar; 12(2):110-20. doi: 10.1111/j.1399-3089.2005.00203.x. [PMID: 15693841]
  • Kuo Tung Hung, Ching Huei Kao. Hydrogen peroxide is necessary for abscisic acid-induced senescence of rice leaves. Journal of plant physiology. 2004 Dec; 161(12):1347-57. doi: 10.1016/j.jplph.2004.05.011. [PMID: 15658805]
  • Aditi A Kapasi, Salvatore A Coscia, Manish P Pandya, Pravin C Singhal. Morphine modulates HIV-1 gp160-induced murine macrophage and human monocyte apoptosis by disparate ways. Journal of neuroimmunology. 2004 Mar; 148(1-2):86-96. doi: 10.1016/j.jneuroim.2003.11.015. [PMID: 14975589]
  • T Sudhakar Babu, Tariq A Akhtar, Mark A Lampi, Sridevi Tripuranthakam, D George Dixon, Bruce M Greenberg. Similar stress responses are elicited by copper and ultraviolet radiation in the aquatic plant Lemna gibba: implication of reactive oxygen species as common signals. Plant & cell physiology. 2003 Dec; 44(12):1320-9. doi: 10.1093/pcp/pcg160. [PMID: 14701927]
  • Su Mi Baek, Chae Hwa Kwon, Jae Ho Kim, Jae Suk Woo, Jin Sup Jung, Yong Keun Kim. Differential roles of hydrogen peroxide and hydroxyl radical in cisplatin-induced cell death in renal proximal tubular epithelial cells. The Journal of laboratory and clinical medicine. 2003 Sep; 142(3):178-86. doi: 10.1016/s0022-2143(03)00111-2. [PMID: 14532906]
  • Kazuhiko Tsuruya, Masanori Tokumoto, Toshiharu Ninomiya, Makoto Hirakawa, Kohsuke Masutani, Masatomo Taniguchi, Kyoichi Fukuda, Hidetoshi Kanai, Hideki Hirakata, Mitsuo Iida. Antioxidant ameliorates cisplatin-induced renal tubular cell death through inhibition of death receptor-mediated pathways. American journal of physiology. Renal physiology. 2003 Aug; 285(2):F208-18. doi: 10.1152/ajprenal.00311.2002. [PMID: 12684229]
  • Ramez Labib, Rita Turkall, Mohamed S Abdel-Rahman. Endotoxin potentiates cocaine-mediated hepatotoxicity by nitric oxide and reactive oxygen species. International journal of toxicology. 2003 Jul; 22(4):305-16. doi: 10.1080/10915810305117. [PMID: 12933325]
  • Virginia Garretón, Jorge Carpinelli, Xavier Jordana, Loreto Holuigue. The as-1 promoter element is an oxidative stress-responsive element and salicylic acid activates it via oxidative species. Plant physiology. 2002 Nov; 130(3):1516-26. doi: 10.1104/pp.009886. [PMID: 12428016]
  • Marina Morigi, Daniela Macconi, Carla Zoja, Roberta Donadelli, Simona Buelli, Cristina Zanchi, Marina Ghilardi, Giuseppe Remuzzi. Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. Journal of the American Society of Nephrology : JASN. 2002 May; 13(5):1179-89. doi: NULL. [PMID: 11961005]
  • Mario Governa, Ivana Fenoglio, Monica Amati, Matteo Valentino, Lucia Bolognini, Sabrina Coloccini, Anna Rita Volpe, Marco Carmignani, Bice Fubini. Cleavage of the fifth component of human complement and release of a split product with C5a-like activity by crystalline silica through free radical generation and kallikrein activation. Toxicology and applied pharmacology. 2002 Mar; 179(3):129-36. doi: 10.1006/taap.2002.9351. [PMID: 11906242]
  • Stefan Greiber, Barbara Müller, Petra Daemisch, Hermann Pavenstädt. Reactive oxygen species alter gene expression in podocytes: induction of granulocyte macrophage-colony-stimulating factor. Journal of the American Society of Nephrology : JASN. 2002 Jan; 13(1):86-95. doi: 10.1681/asn.v13186. [PMID: 11752025]
  • Z Wu, L Qiu. Effect of nitric oxide on iron-mediated cytotoxicity in primary cultured renal proximal tubules. Cell biochemistry and function. 2001 Dec; 19(4):237-47. doi: 10.1002/cbf.921. [PMID: 11746204]
  • W Tian, H L Bonkovsky, S Shibahara, D M Cohen. Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells. American journal of physiology. Renal physiology. 2001 Nov; 281(5):F983-91. doi: 10.1152/ajprenal.0358.2000. [PMID: 11592956]
  • R Bruck, H Shirin, H Aeed, Z Matas, A Hochman, M Pines, Y Avni. Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers. Journal of hepatology. 2001 Oct; 35(4):457-64. doi: 10.1016/s0168-8278(01)00163-5. [PMID: 11682029]
  • U Pattanaik, K Prasad. Reactive oxygen species and endotoxic shock: effect of dimethylthiourea. Journal of cardiovascular pharmacology and therapeutics. 2001 Jul; 6(3):273-85. doi: 10.1177/107424840100600308. [PMID: 11584334]
  • M G Schlag, K A Harris, R F Potter. Role of leukocyte accumulation and oxygen radicals in ischemia-reperfusion-induced injury in skeletal muscle. American journal of physiology. Heart and circulatory physiology. 2001 Apr; 280(4):H1716-21. doi: 10.1152/ajpheart.2001.280.4.h1716. [PMID: 11247784]
  • V Sanwal, M Pandya, M Bhaskaran, N Franki, K Reddy, G Ding, A Kapasi, E Valderrama, P C Singhal. Puromycin aminonucleoside induces glomerular epithelial cell apoptosis. Experimental and molecular pathology. 2001 Feb; 70(1):54-64. doi: 10.1006/exmp.2000.2345. [PMID: 11170791]
  • Y Ding, H C Gonick, N D Vaziri, K Liang, L Wei. Lead-induced hypertension. III. Increased hydroxyl radical production. American journal of hypertension. 2001 Feb; 14(2):169-73. doi: 10.1016/s0895-7061(00)01248-6. [PMID: 11243309]
  • S Ueno, T Kashimoto, N Susa, Y Furukawa, M Ishii, K Yokoi, M Yasuno, Y F Sasaki, J Ueda, Y Nishimura, M Sugiyama. Detection of dichromate (VI)-induced DNA strand breaks and formation of paramagnetic chromium in multiple mouse organs. Toxicology and applied pharmacology. 2001 Jan; 170(1):56-62. doi: 10.1006/taap.2000.9081. [PMID: 11141356]
  • M Tanaka, T Miyazaki, S Tanigaki, K Kasai, K Minegishi, K Miyakoshi, H Ishimoto, Y Yoshimura. Participation of reactive oxygen species in PGF2alpha-induced apoptosis in rat luteal cells. Journal of reproduction and fertility. 2000 Nov; 120(2):239-45. doi: 10.1530/jrf.0.1200239. [PMID: 11058439]
  • A O El-Kadi, A M Bleau, I Dumont, H Maurice, P du Souich. Role of reactive oxygen intermediates in the decrease of hepatic cytochrome P450 activity by serum of humans and rabbits with an acute inflammatory reaction. Drug metabolism and disposition: the biological fate of chemicals. 2000 Sep; 28(9):1112-20. doi: . [PMID: 10950858]
  • C Harms, M Lautenschlager, A Bergk, D Freyer, M Weih, U Dirnagl, J R Weber, H Hörtnagl. Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2000 Sep; 14(12):1814-24. doi: 10.1096/fj.99-0899com. [PMID: 10973931]
  • R Sharma, A Khanna, M Sharma, V J Savin. Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals. Kidney international. 2000 Jul; 58(1):131-6. doi: 10.1046/j.1523-1755.2000.00148.x. [PMID: 10886557]
  • M Governa, M Amati, M Valentino, I Visonà, B Fubini, G C Botta, A R Volpe, M Carmignani. In vitro cleavage by asbestos fibers of the fifth component of human complement through free-radical generation and kallikrein activation. Journal of toxicology and environmental health. Part A. 2000 Apr; 59(7):539-52. doi: 10.1080/009841000156664. [PMID: 10777245]
  • H Wilms, F A Delano, G W Schmid-Schönbein. Mechanisms of parenchymal cell death in-vivo after microvascular hemorrhage. Microcirculation (New York, N.Y. : 1994). 2000 Feb; 7(1):1-11. doi: NULL. [PMID: 10708333]
  • Y L Lai, C F Lee. Mediators and oxygen radicals in hyperpnea-induced airway constriction of guinea pigs. Lung. 2000; 178(4):213-23. doi: 10.1007/s004080000025. [PMID: 10960556]
  • H Zhou, T Miyaji, A Kato, Y Fujigaki, K Sano, A Hishida. Attenuation of cisplatin-induced acute renal failure is associated with less apoptotic cell death. The Journal of laboratory and clinical medicine. 1999 Dec; 134(6):649-58. doi: 10.1016/s0022-2143(99)90106-3. [PMID: 10595794]
  • K Hamada, C A Goldsmith, L Kobzik. Increased airway hyperresponsiveness and inflammation in a juvenile mouse model of asthma exposed to air-pollutant aerosol. Journal of toxicology and environmental health. Part A. 1999 Oct; 58(3):129-43. doi: 10.1080/009841099157340. [PMID: 10522645]
  • H Kim, J Y Seo, K H Kim. Effects of mannitol and dimethylthiourea on helicobacter pylori-induced IL-8 production in gastric epithelial cells. Pharmacology. 1999 Oct; 59(4):201-11. doi: 10.1159/000028321. [PMID: 10474080]
  • R Bruck, H Aeed, H Shirin, Z Matas, L Zaidel, Y Avni, Z Halpern. The hydroxyl radical scavengers dimethylsulfoxide and dimethylthiourea protect rats against thioacetamide-induced fulminant hepatic failure. Journal of hepatology. 1999 Jul; 31(1):27-38. doi: 10.1016/s0168-8278(99)80160-3. [PMID: 10424280]
  • I Ranchon, J M Gorrand, J Cluzel, M T Droy-Lefaix, M Doly. Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract. Investigative ophthalmology & visual science. 1999 May; 40(6):1191-9. doi: ". [PMID: 10235553]
  • S C Lee, B G Kang, S E Oh. Induction of ascorbate peroxidase by ethylene and hydrogen peroxide during growth of cultured soybean cells. Molecules and cells. 1999 Apr; 9(2):166-71. doi: ". [PMID: 10340471]