S-Allylcysteine (BioDeep_00000397403)

PANOMIX_OTCML-2023

代谢物信息卡片

S-Allyl-L-cysteine, United States Pharmacopeia (USP) Reference Standard

化学式: C6H11NO2S (161.0510466)
中文名称: S-烯丙基-L-半胱氨酸, S- 烯丙基-D-半胱氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCSCC(C(=O)O)N
InChI: InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1

描述信息

An S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity.
S-allylcysteine is an S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity. It has a role as a metabolite and an antineoplastic agent. It is a tautomer of a S-allylcysteine zwitterion.
See also: Garlic (part of).
C26170 - Protective Agent > C275 - Antioxidant
D000970 - Antineoplastic Agents
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.
S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.

同义名列表

37 个代谢物同义名

S-Allylcysteine; S-Allyl-L-cysteine, United States Pharmacopeia (USP) Reference Standard; (2R)-2-AMINO-3-(PROP-2-EN-1-YLSULFANYL) PROPANOIC ACID; (2R)-2-amino-3-prop-2-enylsulfanylpropanoic acid; S-ALLYL-L-CYSTEINE (CONSTITUENT OF GARLIC) [DSC]; S-ALLYL-L-CYSTEINE (CONSTITUENT OF GARLIC); (2R)-3-(ALLYLTHIO)-2-AMINOPROPANOIC ACID; (R)-3-(Allylthio)-2-aminopropanoic acid; (R)-3-(Allylthio)-2-aminopropanoicacid; (R)-ALLYLTHIO-2-AMINOPROPANOIC ACID; (R)-Allylthio-2-aminopropionic Acid; S-Allyl-L-cysteine, >=98\\% (HPLC); L-CYSTEINE, S-2-PROPEN-1-YL-; S-ALLYL-L-CYSTEINE [USP-RS]; L-Cysteine, S-2-propen-1-yl; S-ALLYL-L-CYSTEINE (USP-RS); ALANINE, 3-(ALLYLTHIO)-, L-; S-prop-2-en-1-yl-L-cysteine; ZFAHNWWNDFHPOH-YFKPBYRVSA-N; L-Cysteine, S-2-propenyl-; S-ALLYL-L-CYSTEINE [FHFI]; S-(2-PROPENYL)-L-CYSTEINE; S-2-propenyl-L-cysteine; 3-(ALLYLTHIO)-L-ALANINE; ALANINE, 3-(ALLYLTHIO)-; S-ALLYLCYSTEINE [INCI]; S-allyl-laevo-cysteine; (+)-S-ALLYLCYSTEINE; S-Allyl-L-cysteine; S-Allyl cysteine; UNII-81R3X99M15; allyl cysteine; allyl-cysteine; L-DEOXYALLIIN; DEOXYALLIIN; 81R3X99M15; I3L

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:74077
KEGG: C16759
PubChem: 9793905
ChEMBL: CHEMBL2048654
Wikipedia: S-Allylcysteine
MeSH: S-allylcysteine
ChemIDplus: 0021593771
KNApSAcK: C00037771
CAS: 21593-77-1
CAS: 770742-93-3
medchemexpress: HY-W013573
MetaboLights: MTBLC74077
PubChem: 96023283
PDB-CCD: I3L
NIKKAJI: J490.173H
RefMet: S-Allylcysteine

分类词条

Amino acids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

33090 - Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Hatice Kubra Sasmaz, Eda Adal, Pınar Kadiroğlu, Serkan Selli, Turkan Uzlasir, Hasim Kelebek. Optimization of complex coacervation parameters for the production of encapsulated black garlic using response surface methodology. Journal of food science. 2023 Oct; ?(?):. doi: 10.1111/1750-3841.16768. [PMID: 37786327]
José C E Serrano, Eva Castro-Boqué, Alicia García-Carrasco, María Inés Morán-Valero, Daniel González-Hedström, Marcelino Bermúdez-López, José Manuel Valdivielso, Alberto E Espinel, Manuel Portero-Otín. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. Nutrients. 2023 Aug; 15(17):. doi: 10.3390/nu15173691. [PMID: 37686723]
Tomoki Nishioka, Haruhisa Suga, Masafumi Shimizu. The Stimulation of Indigenous Bacterial Antagonists by γ-Glutamyl-S-Allyl-l-Cysteine Increases Soil Suppressiveness to Fusarium Wilt. Applied and environmental microbiology. 2022 12; 88(24):e0155422. doi: 10.1128/aem.01554-22. [PMID: 36445356]
Taku Mizutani, Ryotaro Hara, Takayuki Iihoshi, Shoko Kozono, Michiki Takeuchi, Makoto Hibi, Satomi Takahashi, Makoto Ueda, Jun Ogawa. Identification of tryptophanase from Escherichia coli for the synthesis of S-allyl-l-cysteine and related S-substituted cysteine derivatives. Journal of bioscience and bioengineering. 2022 Sep; 134(3):182-186. doi: 10.1016/j.jbiosc.2022.06.001. [PMID: 35764447]
Hajime Moteki, Masahiko Ogihara, Mitsutoshi Kimura. Cell proliferation effects of S-allyl-L-cysteine are associated with phosphorylation of janus kinase 2, insulin-like growth factor type-I receptor tyrosine kinase, and extracellular signal-regulated kinase 2 in primary cultures of adult rat hepatocytes. European journal of pharmacology. 2022 Jul; 927(?):175067. doi: 10.1016/j.ejphar.2022.175067. [PMID: 35654135]
Pin-Hua Chen, Chun-Han Chang, Wei-Sheng Lin, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan. S-Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL/6J Mice. Molecular nutrition & food research. 2022 04; 66(7):e2101077. doi: 10.1002/mnfr.202101077. [PMID: 35092643]
Ramkumar Samynathan, Umadevi Subramanian, Baskar Venkidasamy, Mohammad Ali Shariati, Ill-Min Chung, Muthu Thiruvengadam. S-Allylcysteine (SAC) Exerts Renoprotective Effects via Regulation of TGF- β1/Smad3 Pathway Mediated Matrix Remodeling in Chronic Renal Failure. Current pharmaceutical design. 2022; 28(8):661-670. doi: 10.2174/1381612828666220401114301. [PMID: 35366767]
Zubeyir Elmazoglu, Zehra Aydın Bek, Sanem Gulistan Sarıbaş, Candan Özoğul, Berna Goker, Berivan Bitik, Cem Nuri Aktekin, Çimen Karasu. S-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis via targeting RAGE, TLR4, JNK, and Nrf2 signaling: comparison with colchicine. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2021 10; 99(5):645-654. doi: 10.1139/bcb-2021-0004. [PMID: 33930279]
Syed Mohammed Basheeruddin Asdaq, Obulesu Challa, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani, Abdulrahman Hadi Almutiri, Majed Sadun Alshammari. Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113203. [PMID: 34071846]
Md Masud Rana, Kota Shiozawa, Katsuyuki Mukai, Katsuhiko Takayanagi, Koichi Eguchi, Halima Sultana, Yusuke Ohsaki, Michio Komai, Hitoshi Shirakawa. S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061697. [PMID: 33803601]
Mario Orozco-Morales, Norma Yanet Hernández-Pedro, Pedro Barrios-Bernal, Oscar Arrieta, Luz María Ruiz-Godoy, Michael Aschner, Abel Santamaría, Ana Laura Colín-González. S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-κB, and apoptosis. Anti-cancer drugs. 2021 02; 32(2):117-126. doi: 10.1097/cad.0000000000001015. [PMID: 33136700]
Carolina Y Reyes-Soto, Edgar Rangel-López, Sonia Galván-Arzate, Ana Laura Colín-González, Alejandro Silva-Palacios, Cecilia Zazueta, José Pedraza-Chaverri, Jair Ramírez, Anahí Chavarria, Isaac Túnez, Tao Ke, Michael Aschner, Abel Santamaría. S-Allylcysteine Protects Against Excitotoxic Damage in Rat Cortical Slices Via Reduction of Oxidative Damage, Activation of Nrf2/ARE Binding, and BDNF Preservation. Neurotoxicity research. 2020 Dec; 38(4):929-940. doi: 10.1007/s12640-020-00260-7. [PMID: 32813208]
Prachi Gupta, Vikas Dutt, Nirmaljeet Kaur, Priya Kalra, Sanjeev Gupta, Anita Dua, Rajesh Dabur, Vikram Saini, Ashwani Mittal. S-allyl cysteine: A potential compound against skeletal muscle atrophy. Biochimica et biophysica acta. General subjects. 2020 10; 1864(10):129676. doi: 10.1016/j.bbagen.2020.129676. [PMID: 32649980]
Murugan Sesha Subramanian, Giri Nandagopal Ms, Syafinaz Amin Nordin, Karuppiah Thilakavathy, Narcisse Joseph. Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184111. [PMID: 32916777]
Masakazu Hashimoto, Tsuyoshi Nakai, Teruaki Masutani, Keiko Unno, Yukihiro Akao. Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract. Nutrients. 2020 Jun; 12(6):. doi: 10.3390/nu12061834. [PMID: 32575593]
Patrycja Bronowicka-Adamska, Anna Bentke, Małgorzata Lasota, Maria Wróbel. Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis. International journal of molecular sciences. 2020 Feb; 21(3):. doi: 10.3390/ijms21031090. [PMID: 32041330]
Kazuki Kurihara, Hajime Moteki, Hideshi Natsume, Masahiko Ogihara, Mitsutoshi Kimura. The Enhancing Effects of S-Allylcysteine on Liver Regeneration Are Associated with Increased Expression of mRNAs Encoding IGF-1 and Its Receptor in Two-Thirds Partially Hepatectomized Rats. Biological & pharmaceutical bulletin. 2020; 43(11):1776-1784. doi: 10.1248/bpb.b20-00495. [PMID: 33132323]
A-Sung Lee, Sang-Hee Lee, Seunghyung Lee, Boo-Keun Yang. Effects of streptozotocin and S-allyl-L-cysteine on motility, plasma membrane integrity, and mitochondrial activity of boar spermatozoa. Tropical animal health and production. 2020 Jan; 52(1):437-444. doi: 10.1007/s11250-019-01983-2. [PMID: 31301041]
Carlos Daniel Gomez, Penélope Aguilera, Alma Ortiz-Plata, Felipe Nares López, María Elena Chánez-Cárdenas, Eugenia Flores-Alfaro, Martha Eugenia Ruiz-Tachiquín, Monica Espinoza-Rojo. Aged garlic extract and S-allylcysteine increase the GLUT3 and GCLC expression levels in cerebral ischemia. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2019 Dec; 28(12):1609-1614. doi: 10.17219/acem/110328. [PMID: 31851788]
Li-Jun Yue, Xi-Yu Zhu, Rui-Sha Li, Hui-Jing Chang, Bing Gong, Chong-Chong Tian, Chang Liu, Yun-Xing Xue, Qing Zhou, Tian-Shu Xu, Dong-Jin Wang. S‑allyl‑cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy. International journal of molecular medicine. 2019 Nov; 44(5):1943-1951. doi: 10.3892/ijmm.2019.4351. [PMID: 31573046]
V V Sathibabu Uddandrao, Parim Brahmanaidu, Ramavat Ravindarnaik, Pothani Suresh, S Vadivukkarasi, Ganapathy Saravanan. Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic rats. European journal of nutrition. 2019 Sep; 58(6):2425-2437. doi: 10.1007/s00394-018-1795-x. [PMID: 30062492]
Mohammad-Reza Khajevand-Khazaei, Shekoofe Azimi, Ladan Sedighnejad, Sepide Salari, Atefeh Ghorbanpour, Tourandokht Baluchnejadmojarad, Parvaneh Mohseni-Moghaddam, Safoura Khamse, Mehrdad Roghani. S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation. International immunopharmacology. 2019 Apr; 69(?):19-26. doi: 10.1016/j.intimp.2019.01.026. [PMID: 30665040]
Saddia Bano, Muhammad Asif Rasheed, Farrukh Jamil, Muhammad Ibrahim, Sumaira Kanwal. In Silico Identification of Novel Apolipoprotein E4 Inhibitor for Alzheimer's Disease Therapy. Current computer-aided drug design. 2019; 15(1):97-103. doi: 10.2174/1573409914666181008164209. [PMID: 30306878]
Preethi Johnson, Chitra Loganathan, Ancy Iruthayaraj, Kumaradhas Poomani, Palvannan Thayumanavan. S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity. Biochimie. 2018 Nov; 154(?):1-9. doi: 10.1016/j.biochi.2018.07.015. [PMID: 30059711]
Marisol Maya-López, María Verónica Mireles-García, Monserrat Ramírez-Toledo, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Abel Santamaría. Thallium-Induced Toxicity in Rat Brain Crude Synaptosomal/Mitochondrial Fractions is Sensitive to Anti-excitatory and Antioxidant Agents. Neurotoxicity research. 2018 04; 33(3):634-640. doi: 10.1007/s12640-017-9863-1. [PMID: 29313218]
B W Lembede, K H Erlwanger, P Nkomozepi, E Chivandi. Effect of neonatal orally administered S-allyl cysteine in high-fructose diet fed Wistar rats. Journal of developmental origins of health and disease. 2018 04; 9(2):160-171. doi: 10.1017/s2040174417000940. [PMID: 29151399]
Chitra Basu, Runa Sur. S-Allyl Cysteine Alleviates Hydrogen Peroxide Induced Oxidative Injury and Apoptosis through Upregulation of Akt/Nrf-2/HO-1 Signaling Pathway in HepG2 Cells. BioMed research international. 2018; 2018(?):3169431. doi: 10.1155/2018/3169431. [PMID: 30515391]
B M Escribano, E Luque, M Aguilar-Luque, M Feijóo, J Caballero-Villarraso, L A Torres, V Ramirez, F I García-Maceira, E Agüera, A Santamaria, I Túnez. Dose-dependent S-allyl cysteine ameliorates multiple sclerosis disease-related pathology by reducing oxidative stress and biomarkers of dysbiosis in experimental autoimmune encephalomyelitis. European journal of pharmacology. 2017 Nov; 815(?):266-273. doi: 10.1016/j.ejphar.2017.09.025. [PMID: 28939293]
Taehoon Park, Ju-Hee Oh, Joo Hyun Lee, Sang Cheol Park, Young Pyo Jang, Young-Joo Lee. Oral Administration of (S)-Allyl-l-Cysteine and Aged Garlic Extract to Rats: Determination of Metabolites and Their Pharmacokinetics. Planta medica. 2017 Nov; 83(17):1351-1360. doi: 10.1055/s-0043-111895. [PMID: 28561204]
S K Anandasadagopan, C Sundaramoorthy, A K Pandurangan, V Nagarajan, K Srinivasan, S Ganapasam. S-Allyl cysteine alleviates inflammation by modulating the expression of NF-κB during chromium (VI)-induced hepatotoxicity in rats. Human & experimental toxicology. 2017 Nov; 36(11):1186-1200. doi: 10.1177/0960327116680275. [PMID: 28988497]
Jia-Ning Syu, Mei-Due Yang, Shu-Yao Tsai, En-Pei Isabel Chiang, Shao-Chih Chiu, Che-Yi Chao, Raymond L Rodriguez, Feng-Yao Tang. S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis. Cell transplantation. 2017 10; 26(10):1636-1647. doi: 10.1177/0963689717724792. [PMID: 29251114]
Parim Brahmanaidu, V V Sathibabu Uddandrao, Vadivukkarasi Sasikumar, Ramavat Ravindar Naik, Suresh Pothani, Mustapha Sabana Begum, M Prasanna Rajeshkumar, Chandrasekar Varatharaju, Balaji Meriga, P Rameshreddy, A Kalaivani, Ganapathy Saravanan. Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine. Molecular and cellular biochemistry. 2017 Aug; 432(1-2):25-32. doi: 10.1007/s11010-017-2994-0. [PMID: 28258439]
Yue-E Sun, Wei-Dong Wang. Study on the interaction of bioactive compound S-allyl cysteine from garlic with serum albumin. Journal of food and drug analysis. 2017 04; 25(2):385-390. doi: 10.1016/j.jfda.2016.08.013. [PMID: 28911681]
Toshiaki Matsutomo, Mitsuyasu Ushijima, Yukihiro Kodera, Masashi Nakamoto, Miyuki Takashima, Naoaki Morihara, Koichi Tamura. Metabolomic study on the antihypertensive effect of S-1-propenylcysteine in spontaneously hypertensive rats using liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Mar; 1046(?):147-155. doi: 10.1016/j.jchromb.2017.01.029. [PMID: 28183044]
Mahboubeh Zarezadeh, Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Mehrdad Roghani. Garlic active constituent s-allyl cysteine protects against lipopolysaccharide-induced cognitive deficits in the rat: Possible involved mechanisms. European journal of pharmacology. 2017 Jan; 795(?):13-21. doi: 10.1016/j.ejphar.2016.11.051. [PMID: 27915041]
Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Zahra Ghasemi, Mehrdad Roghani. S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. European journal of pharmacology. 2017 Jan; 794(?):69-76. doi: 10.1016/j.ejphar.2016.11.033. [PMID: 27887948]
De-Cheng Tsai, Meng-Chieh Liu, Yi-Reng Lin, Mei-Fang Huang, Shih-Shin Liang. A novel reductive amination method with isotopic formaldehydes for the preparation of internal standard and standards for determining organosulfur compounds in garlic. Food chemistry. 2016 Apr; 197(Pt A):692-8. doi: 10.1016/j.foodchem.2015.11.022. [PMID: 26617005]
Isabel Denzer, Gerald Münch, Monika Pischetsrieder, Kristina Friedland. S-allyl-L-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress. Food chemistry. 2016 Mar; 194(?):843-8. doi: 10.1016/j.foodchem.2015.08.052. [PMID: 26471626]
Hirotaka Amano, Daichi Kazamori, Kenji Itoh. Pharmacokinetics of S-Allyl-l-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption. The Journal of nutrition. 2016 Feb; 146(2):456S-459S. doi: 10.3945/jn.114.201749. [PMID: 26764325]
Toshiaki Matsutomo, Yukihiro Kodera. Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection. The Journal of nutrition. 2016 Feb; 146(2):450S-455S. doi: 10.3945/jn.114.208520. [PMID: 26764330]
Marisol Orozco-Ibarra, Jorge Muñoz-Sánchez, Martín E Zavala-Medina, Benjamín Pineda, Roxana Magaña-Maldonado, Edgar Vázquez-Contreras, Perla D Maldonado, José Pedraza-Chaverri, María Elena Chánez-Cárdenas. Aged garlic extract and S-allylcysteine prevent apoptotic cell death in a chemical hypoxia model. Biological research. 2016 Feb; 49(?):7. doi: 10.1186/s40659-016-0067-6. [PMID: 26830333]
Naoko Yoshimoto, Misato Onuma, Shinya Mizuno, Yuka Sugino, Ryo Nakabayashi, Shinsuke Imai, Tadamitsu Tsuneyoshi, Shin-ichiro Sumi, Kazuki Saito. Identification of a flavin-containing S-oxygenating monooxygenase involved in alliin biosynthesis in garlic. The Plant journal : for cell and molecular biology. 2015 Sep; 83(6):941-51. doi: 10.1111/tpj.12954. [PMID: 26345717]
Ana Laura Colín-González, Hugo Becerríl, Bianca Rubí Flores-Reyes, Ismael Torres, Enrique Pinzón, Daniel Santamaría-Del Angel, Isaac Túnez, Iris Serratos, José Pedraza-Chaverrí, Abel Santamaría, Perla D Maldonado. Acute restraint stress reduces hippocampal oxidative damage and behavior in rats: Effect of S-allyl cysteine. Life sciences. 2015 Aug; 135(?):165-72. doi: 10.1016/j.lfs.2015.06.009. [PMID: 26135627]
Hirotaka Amano, Daichi Kazamori, Kenji Itoh, Yukihiro Kodera. Metabolism, excretion, and pharmacokinetics of S-allyl-L-cysteine in rats and dogs. Drug metabolism and disposition: the biological fate of chemicals. 2015 May; 43(5):749-55. doi: 10.1124/dmd.115.063230. [PMID: 25681129]
Sanghee Lee, Nae In Chang, Miyoung Yoo, Jung Hoon Choi, Dongbin Shin. Development and validation of S-allyl-L-cysteine in rat plasma using a mixed-mode reversed-phase and cation-exchange LC-ESI-MS/MS method: application to pharmacokinetic studies. Journal of chromatographic science. 2015 Jan; 53(1):54-9. doi: 10.1093/chromsci/bmu013. [PMID: 24668040]
B K Nirala, N K Gohil. Effect of garlic component s-allyl cysteine sulfoxide on glycated human serum albumin induced activation of endothelial cells: an in vitro study. European review for medical and pharmacological sciences. 2015; 19(11):2125-31. doi: NULL. [PMID: 26125278]
Dehong Tan, Yao Zhang, Lulu Chen, Ling Liu, Xuan Zhang, Zhaoxia Wu, Bing Bai, Shujuan Ji. Decreased glycation and structural protection properties of γ-glutamyl-S-allyl-cysteine peptide isolated from fresh garlic scales (Allium sativum L.). Natural product research. 2015; 29(23):2219-22. doi: 10.1080/14786419.2014.1003065. [PMID: 25631559]
Su-Chen Ho, Min-Sheng Su. Evaluating the anti-neuroinflammatory capacity of raw and steamed garlic as well as five organosulfur compounds. Molecules (Basel, Switzerland). 2014 Oct; 19(11):17697-714. doi: 10.3390/molecules191117697. [PMID: 25365295]
Tania Gómez-Sierra, Eduardo Molina-Jijón, Edilia Tapia, Rogelio Hernández-Pando, Wylly Ramsés García-Niño, Perla D Maldonado, José Luis Reyes, Diana Barrera-Oviedo, Ismael Torres, José Pedraza-Chaverri. S-allylcysteine prevents cisplatin-induced nephrotoxicity and oxidative stress. The Journal of pharmacy and pharmacology. 2014 Sep; 66(9):1271-81. doi: 10.1111/jphp.12263. [PMID: 24779924]
Reem Shouk, Aya Abdou, Kalidas Shetty, Dipayan Sarkar, Ali H Eid. Mechanisms underlying the antihypertensive effects of garlic bioactives. Nutrition research (New York, N.Y.). 2014 Feb; 34(2):106-15. doi: 10.1016/j.nutres.2013.12.005. [PMID: 24461311]
Pulla Reddy Avula, Syed Mohammed Asdaq, Mohammed Asad. Effect of aged garlic extract and s-allyl cysteine and their interaction with atenolol during isoproterenol induced myocardial toxicity in rats. Indian journal of pharmacology. 2014 Jan; 46(1):94-9. doi: 10.4103/0253-7613.125185. [PMID: 24550592]
Yong Pil Hwang, Hyung Gyun Kim, Jae Ho Choi, Minh Truong Do, Young Chul Chung, Tae Cheon Jeong, Hye Gwang Jeong. S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. The Journal of nutritional biochemistry. 2013 Aug; 24(8):1469-78. doi: 10.1016/j.jnutbio.2012.12.006. [PMID: 23465592]
Ganapathy Saravanan, Ponnusamy Ponmurugan, Mustapha Shabana Begum. Effect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2013 Apr; 27(2):143-7. doi: 10.1016/j.jtemb.2012.07.009. [PMID: 22981633]
Zahra Malekpour-Dehkordi, Ebrahim Javadi, Mahmood Doosti, Maliheh Paknejad, Mitra Nourbakhsh, Narguess Yassa, Siavash Gerayesh-Nejad, Ramin Heshmat. S-Allylcysteine, a garlic compound, increases ABCA1 expression in human THP-1 macrophages. Phytotherapy research : PTR. 2013 Mar; 27(3):357-61. doi: 10.1002/ptr.4713. [PMID: 22610793]
K Ried, O R Frank, N P Stocks. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. European journal of clinical nutrition. 2013 Jan; 67(1):64-70. doi: 10.1038/ejcn.2012.178. [PMID: 23169470]
Julio César Tobón-Velasco, Genaro Vázquez-Victorio, Marina Macías-Silva, Elvis Cuevas, Syed F Ali, Perla D Maldonado, María Eva González-Trujano, Antonio Cuadrado, José Pedraza-Chaverrí, Abel Santamaría. RETRACTED: S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Free radical biology & medicine. 2012 09; 53(5):1024-40. doi: 10.1016/j.freeradbiomed.2012.06.040. [PMID: 22781654]
Ganapathy Saravanan, Ponnusamy Ponmurugan. Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2012 Sep; 64(6):639-44. doi: 10.1016/j.etp.2010.12.007. [PMID: 21216577]
Man-Hui Pai, Yueh-Hsiung Kuo, En-Pei Isabel Chiang, Feng-Yao Tang. S-Allylcysteine inhibits tumour progression and the epithelial-mesenchymal transition in a mouse xenograft model of oral cancer. The British journal of nutrition. 2012 Jul; 108(1):28-38. doi: 10.1017/s0007114511005307. [PMID: 22011514]
Patrick Krumm, Teresa Giraldez, Diego Alvarez de la Rosa, Wolfgang G Clauss, Martin Fronius, Mike Althaus. Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). Bioorganic & medicinal chemistry. 2012 Jul; 20(13):3979-84. doi: 10.1016/j.bmc.2012.05.021. [PMID: 22668601]
Ganapathy Saravanan, Ponnusamy Ponmurugan. Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. Journal of diabetes and its complications. 2012 Jul; 26(4):280-5. doi: 10.1016/j.jdiacomp.2012.03.024. [PMID: 22541895]
Chan Wok Sohn, Hyunae Kim, Bo Ram You, Min Jee Kim, Hyo Jin Kim, Ji Yeon Lee, Dai-Eun Sok, Jin Hee Kim, Kun Jong Lee, Mee Ree Kim. High temperature- and high pressure-processed garlic improves lipid profiles in rats fed high cholesterol diets. Journal of medicinal food. 2012 May; 15(5):435-40. doi: 10.1089/jmf.2011.1922. [PMID: 22404600]
Mei-chin Mong, Mei-chin Yin. Nuclear factor κB-dependent anti-inflammatory effects of s-allyl cysteine and s-propyl cysteine in kidney of diabetic mice. Journal of agricultural and food chemistry. 2012 Mar; 60(12):3158-65. doi: 10.1021/jf3002685. [PMID: 22394022]
Mohammad Ashafaq, Mohd Moshahid Khan, Syed Shadab Raza, Ajmal Ahmad, Gulrana Khuwaja, Hayate Javed, Andleeb Khan, Farah Islam, M Saeed Siddiqui, Mohammed M Safhi, Fakhrul Islam. S-allyl cysteine mitigates oxidative damage and improves neurologic deficit in a rat model of focal cerebral ischemia. Nutrition research (New York, N.Y.). 2012 Feb; 32(2):133-43. doi: 10.1016/j.nutres.2011.12.014. [PMID: 22348462]
Samir Mandal, Sudip Mukherjee, Kaustav Dutta Chowdhury, Avik Sarkar, Kankana Basu, Soumosish Paul, Debasish Karmakar, Mahasweta Chatterjee, Tuli Biswas, Gobinda Chandra Sadhukhan, Gargi Sen. S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead. Biochimica et biophysica acta. 2012 Jan; 1820(1):9-23. doi: 10.1016/j.bbagen.2011.09.019. [PMID: 22033380]
Dolores Javier Sánchez-González, Enrique Méndez-Bolaina, Nayeli Isabel Trejo-Bahena. Platelet-rich plasma peptides: key for regeneration. International journal of peptides. 2012; 2012(?):532519. doi: 10.1155/2012/532519. [PMID: 22518192]
Harun Alp, Sefer Varol, Muhammet Murat Celik, Murat Altas, Osman Evliyaoglu, Orhan Tokgoz, Mehmet Halis Tanrıverdi, Ertugrul Uzar. Protective effects of beta glucan and gliclazide on brain tissue and sciatic nerve of diabetic rats induced by streptozosin. Experimental diabetes research. 2012; 2012(?):230342. doi: 10.1155/2012/230342. [PMID: 22291696]
Russell L Blaylock, Joseph Maroon. Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Surgical neurology international. 2012; 3(?):19. doi: 10.4103/2152-7806.92935. [PMID: 22439110]
Ana L Colín-González, Ricardo A Santana, Carlos A Silva-Islas, Maria E Chánez-Cárdenas, Abel Santamaría, Perla D Maldonado. The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Oxidative medicine and cellular longevity. 2012; 2012(?):907162. doi: 10.1155/2012/907162. [PMID: 22685624]
Patricia Rojas, Norma Serrano-García, Omar N Medina-Campos, José Pedraza-Chaverri, Perla D Maldonado, Elizabeth Ruiz-Sánchez. S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice. The Journal of nutritional biochemistry. 2011 Oct; 22(10):937-44. doi: 10.1016/j.jnutbio.2010.08.005. [PMID: 21190833]
Balmiki Ray, Neelima B Chauhan, Debomoy K Lahiri. Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. Journal of neurochemistry. 2011 May; 117(3):388-402. doi: 10.1111/j.1471-4159.2010.07145.x. [PMID: 21166677]
Elizabeth A Mazzio, Fran Close, Karam F A Soliman. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences. 2011 Jan; 12(1):506-69. doi: 10.3390/ijms12010506. [PMID: 21340000]
Ganapathy Saravanan, Ponnusamy Ponmurugan. Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. Chemico-biological interactions. 2011 Jan; 189(1-2):100-6. doi: 10.1016/j.cbi.2010.10.001. [PMID: 20951120]
B Ray, N B Chauhan, D K Lahiri. The "aged garlic extract:" (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD). Current medicinal chemistry. 2011; 18(22):3306-13. doi: 10.2174/092986711796504664. [PMID: 21728972]
Khalid Hussain, Zhari Ismail, Amirin Sadikun, Pazillah Ibrahim. Bioactive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):980760. doi: 10.1093/ecam/nep143. [PMID: 19770264]
Marcela Alejandra Vazquez-Prieto, Cecilia Rodriguez Lanzi, Carina Lembo, Claudio Rómulo Galmarini, Roberto Miguel Miatello. Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats. Journal of nutrition and metabolism. 2011; 2011(?):475216. doi: 10.1155/2011/475216. [PMID: 21876795]
G Saravanan, P Ponmurugan, G P Senthil Kumar, T Rajarajan. Antidiabetic effect of S-allylcysteine: Effect on plasma and tissue glycoproteins in experimental diabetes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Dec; 17(14):1086-9. doi: 10.1016/j.phymed.2010.04.008. [PMID: 20576413]
Ganapathy Saravanan, Ponnusamy Ponmurugan. Beneficial effect of S-allylcysteine (SAC) on blood glucose and pancreatic antioxidant system in streptozotocin diabetic rats. Plant foods for human nutrition (Dordrecht, Netherlands). 2010 Dec; 65(4):374-8. doi: 10.1007/s11130-010-0192-2. [PMID: 20839055]
S M Asdaq, M N Inamdar. Potential of garlic and its active constituent, S-allyl cysteine, as antihypertensive and cardioprotective in presence of captopril. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Nov; 17(13):1016-26. doi: 10.1016/j.phymed.2010.07.012. [PMID: 20739164]
Feng-Yao Tang, En-Pei Chiang, Man-Hui Pai. Consumption of S-allylcysteine inhibits the growth of human non-small-cell lung carcinoma in a mouse xenograft model. Journal of agricultural and food chemistry. 2010 Oct; 58(20):11156-64. doi: 10.1021/jf102539k. [PMID: 20866043]
Karin Ried, Oliver R Frank, Nigel P Stocks. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas. 2010 Oct; 67(2):144-50. doi: 10.1016/j.maturitas.2010.06.001. [PMID: 20594781]
Qian Wang, Xian-Li Wang, Hong-Rui Liu, Peter Rose, Yi-Zhun Zhu. Protective effects of cysteine analogues on acute myocardial ischemia: novel modulators of endogenous H(2)S production. Antioxidants & redox signaling. 2010 May; 12(10):1155-65. doi: 10.1089/ars.2009.2947. [PMID: 19842912]
Eric Block, A John Dane, Siji Thomas, Robert B Cody. Applications of direct analysis in real time mass spectrometry (DART-MS) in Allium chemistry. 2-propenesulfenic and 2-propenesulfinic acids, diallyl trisulfane S-oxide, and other reactive sulfur compounds from crushed garlic and other Alliums. Journal of agricultural and food chemistry. 2010 Apr; 58(8):4617-25. doi: 10.1021/jf1000106. [PMID: 20225897]
Diana Elinos-Calderón, Yolanda Robledo-Arratia, Verónica Pérez-De La Cruz, Perla D Maldonado, Sonia Galván-Arzate, José Pedraza-Chaverrí, Abel Santamaría. Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine. Journal of neural transmission (Vienna, Austria : 1996). 2010 Jan; 117(1):35-44. doi: 10.1007/s00702-009-0299-5. [PMID: 19866339]
Hiroji Shinkawa, Shigekazu Takemura, Yukiko Minamiyama, Shintaro Kodai, Takuma Tsukioka, Mayuko Osada-Oka, Shoji Kubo, Shigeru Okada, Shigefumi Suehiro. S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats. Osaka city medical journal. 2009 Dec; 55(2):61-9. doi: NULL. [PMID: 20088405]
Keary Cope, Harold Seifried, Rebecca Seifried, John Milner, Penny Kris-Etherton, Earl H Harrison. A gas chromatography-mass spectrometry method for the quantitation of N-nitrosoproline and N-acetyl-S-allylcysteine in human urine: application to a study of the effects of garlic consumption on nitrosation. Analytical biochemistry. 2009 Nov; 394(2):243-8. doi: 10.1016/j.ab.2009.07.035. [PMID: 19643074]
Qian Wang, Hong-Rui Liu, Qing Mu, Peter Rose, Yi Zhun Zhu. S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway. Journal of cardiovascular pharmacology. 2009 Aug; 54(2):139-46. doi: 10.1097/fjc.0b013e3181ac8e12. [PMID: 19546814]
Vinayagam Magendiramani, Syed Umesalma, Srinivasan Kalayarasan, Ponnuraj Nagendraprabhu, Jagadeesan Arunkumar, Ganapasam Sudhandiran. S-allylcysteine attenuates renal injury by altering the expressions of iNOS and matrix metallo proteinase-2 during cyclosporine-induced nephrotoxicity in Wistar rats. Journal of applied toxicology : JAT. 2009 Aug; 29(6):522-30. doi: 10.1002/jat.1437. [PMID: 19391111]
Fahim Atif, Seema Yousuf, Sandeep Kumar Agrawal. S-allyl L-cysteine diminishes cerebral ischemia-induced mitochondrial dysfunctions in hippocampus. Brain research. 2009 Apr; 1265(?):128-37. doi: 10.1016/j.brainres.2008.12.077. [PMID: 19401183]
Rachel M Novick, Adnan A Elfarra. Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes. Drug metabolism and disposition: the biological fate of chemicals. 2008 Dec; 36(12):2468-74. doi: 10.1124/dmd.108.021436. [PMID: 18775983]
Mannangatti Padmanabhan, Murugan Rajadurai, Ponnian Stanely Mainzen Prince. Preventive effect of S-allylcysteine on membrane-bound enzymes and glycoproteins in normal and isoproterenol-induced cardiac toxicity in male Wistar rats. Basic & clinical pharmacology & toxicology. 2008 Dec; 103(6):507-13. doi: 10.1111/j.1742-7843.2008.00244.x. [PMID: 19067678]
Chun-che Lin, Mei-chin Yin, Wen-hu Liu. Alleviative effects of s-allyl cysteine and s-ethyl cysteine on MCD diet-induced hepatotoxicity in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008 Nov; 46(11):3401-6. doi: 10.1016/j.fct.2008.08.010. [PMID: 18786595]
Kanchan Bhatia, Firoz Ahmad, Hina Rashid, Sheikh Raisuddin. Protective effect of S-allylcysteine against cyclophosphamide-induced bladder hemorrhagic cystitis in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008 Nov; 46(11):3368-74. doi: 10.1016/j.fct.2008.08.011. [PMID: 18786597]
Esperanza Garcia, Daniel Limon, Veronica Perez-De La Cruz, Magda Giordano, Mauricio Diaz-Muñoz, Perla D Maldonado, Maria Nieves Herrera-Mundo, Jose Pedraza-Chaverri, Abel Santamaria. Lipid peroxidation, mitochondrial dysfunction and neurochemical and behavioural deficits in different neurotoxic models: protective role of S-allylcysteine. Free radical research. 2008 Oct; 42(10):892-902. doi: 10.1080/10715760802506356. [PMID: 18985488]
Srinivasan Kalayarasan, Narayanan Sriram, Ananthasadagopan Sureshkumar, Ganapasam Sudhandiran. Chromium (VI)-induced oxidative stress and apoptosis is reduced by garlic and its derivative S-allylcysteine through the activation of Nrf2 in the hepatocytes of Wistar rats. Journal of applied toxicology : JAT. 2008 Oct; 28(7):908-19. doi: 10.1002/jat.1355. [PMID: 18548744]
Sabina Segoviano-Murillo, Dolores Javier Sánchez-González, Claudia María Martínez-Martínez, Cristino Cruz, Perla D Maldonado, José Pedraza-Chaverrí. S-allylcysteine ameliorates ischemia and reperfusion induced renal damage. Phytotherapy research : PTR. 2008 Jun; 22(6):836-40. doi: 10.1002/ptr.2396. [PMID: 18381751]
Amichand Dairam, Ronen Fogel, Santy Daya, Janice L Limson. Antioxidant and iron-binding properties of curcumin, capsaicin, and S-allylcysteine reduce oxidative stress in rat brain homogenate. Journal of agricultural and food chemistry. 2008 May; 56(9):3350-6. doi: 10.1021/jf0734931. [PMID: 18422331]
Sivapatham Sundaresan, Perumal Subramanian. Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine. Molecular and cellular biochemistry. 2008 Mar; 310(1-2):209-14. doi: 10.1007/s11010-007-9682-4. [PMID: 18185914]
Verónica Pérez-De La Cruz, Mina Konigsberg, José Pedraza-Chaverri, Nieves Herrera-Mundo, Mauricio Díaz-Muñoz, Julio Morán, Teresa Fortoul-van der Goes, Adrián Rondán-Zárate, Perla D Maldonado, Syed F Ali, Abel Santamaría. Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats. The European journal of neuroscience. 2008 Mar; 27(5):1075-85. doi: 10.1111/j.1460-9568.2008.06088.x. [PMID: 18364032]
Bc Mathew, Rs Biju. Neuroprotective effects of garlic a review. The Libyan journal of medicine. 2008 Mar; 3(1):23-33. doi: 10.4176/071110. [PMID: 21499478]