Physalin A (BioDeep_00000397351)
Secondary id: BioDeep_00000021396
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C28H30O10 (526.1839)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CC(C3(C45C1C(=O)C(O4)(C6C(CCC5(C(=O)O3)O)C7(C(=CC6O)CC=CC7=O)C)O)C)OC(=O)C2=C
InChI: InChI=1S/C28H30O10/c1-12-21(32)36-17-11-23(12,2)19-20(31)27(35)18-14(24(3)13(10-15(18)29)6-5-7-16(24)30)8-9-26(34)22(33)37-25(17,4)28(19,26)38-27/h5,7,10,14-15,17-19,29,34-35H,1,6,8-9,11H2,2-4H3/t14-,15+,17+,18-,19-,23+,24-,25-,26-,27+,28-/m0/s1
描述信息
Physalin A is a physalin.
CID 44577487 is a natural product found in Alkekengi officinarum var. franchetii, Physalis lagascae, and other organisms with data available.
同义名列表
3 个代谢物同义名
(1S,2S,3R,5R,6S,7R,14R,15S,18R,21S,22R)-5,7,18-trihydroxy-1,14,21-trimethyl-25-methylidene-4,20,23-trioxaheptacyclo[20.3.1.12,5.03,18.03,21.06,15.09,14]heptacosa-8,11-diene-13,19,24,27-tetrone; Physalin A; 5,7,18-trihydroxy-1,14,21-trimethyl-25-methylidene-4,20,23-trioxaheptacyclo[20.3.1.1^{2,5}.0^{3,18}.0^{3,21}.0^{6,15}.0^{9,14}]heptacosa-8,11-diene-13,19,24,27-tetrone
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:191715
- PubChem: 44577487
- Metlin: METLIN89525
- ChEMBL: CHEMBL504741
- MeSH: physalin A
- CAS: 23027-91-0
- medchemexpress: HY-N9942
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yang Li, Na Zhao, Tingting Zhang, Xinchi Feng. A Rapid and Sensitive LC-MS/MS Method for the Quantitation of Physalin A with Special Consideration to Chemical Stability in Rat Plasma: Application to a Pharmacokinetic Study.
Molecules (Basel, Switzerland).
2022 Oct; 27(21):. doi:
10.3390/molecules27217272. [PMID: 36364097] - Liying Wang, Jinpo Gu, Mingyue Zong, Qingran Zhang, Huixiang Li, Danna Li, Xiaofeng Mou, Pan Liu, Yanan Liu, Feng Qiu, Feng Zhao. Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway.
Journal of ethnopharmacology.
2021 Mar; 267(?):113490. doi:
10.1016/j.jep.2020.113490. [PMID: 33091501] - Yunliang Zheng, Meihua Lin, Xingjiang Hu, You Zhai, Qiao Zhang, Yan Lou, Jianzhong ShenTu, Lihua Wu. Simultaneous pharmacokinetics and stability studies of physalins in rat plasma and intestinal bacteria culture media using liquid chromatography with mass spectrometry.
Journal of separation science.
2018 Apr; 41(8):1781-1790. doi:
10.1002/jssc.201701089. [PMID: 29331063] - Hongxia Liu, Kai Wang, Guiyang Xia, Kun Wang, Liwei Chai, Paul Owusu Donkor, Liqin Ding, Feng Qiu. Two sulfonate metabolites of physalin A in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 Jan; 48(1):11-17. doi:
10.1080/00498254.2016.1271961. [PMID: 28001472] - Xinchi Feng, Hongxia Liu, Liwei Chai, Liqin Ding, Guixiang Pan, Feng Qiu. Metabolic profiles of physalin A in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Mar; 1046(?):102-109. doi:
10.1016/j.jchromb.2017.01.037. [PMID: 28157662] - Ning Kang, Jun-Feng Jian, Shi-Jie Cao, Qiang Zhang, Yi-Wei Mao, Yi-Yuan Huang, Yan-Fei Peng, Feng Qiu, Xiu-Mei Gao. Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway.
Molecular and cellular biochemistry.
2016 Apr; 415(1-2):145-55. doi:
10.1007/s11010-016-2686-1. [PMID: 27000859] - Fanfan Zhu, Chunyan Dai, Yufei Fu, Jacky F C Loo, Dajin Xia, Sizhi P Gao, Zhongjun Ma, Zhe Chen. Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling.
Oncotarget.
2016 Feb; 7(8):9462-76. doi:
10.18632/oncotarget.7051. [PMID: 26843613] - Hao He, Yong-Sheng Feng, Ling-He Zang, Wei-Wei Liu, Li-Qin Ding, Li-Xia Chen, Ning Kang, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu, Takashi Ikejima. Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Sep; 71(?):128-35. doi:
10.1016/j.fct.2014.06.007. [PMID: 24952311] - Hao He, Ling-He Zang, Yong-Sheng Feng, Li-Xia Chen, Ning Kang, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu, Takashi Ikejima. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.
Journal of ethnopharmacology.
2013 Jul; 148(2):544-55. doi:
10.1016/j.jep.2013.04.051. [PMID: 23684722]
