Oprea1_396152 (BioDeep_00000397200)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C15H10O4 (254.057906)
中文名称: 3,6-二羟基黄酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C=CC(=C3)O)O
InChI: InChI=1S/C15H10O4/c16-10-6-7-12-11(8-10)13(17)14(18)15(19-12)9-4-2-1-3-5-9/h1-8,16,18H
描述信息
3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation[1].
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数据库引用编号
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相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mariana Voicescu, Rodica Bandula. 3,6-diHydroxyflavone/bovine serum albumin interaction in cyclodextrin medium: absorption and emission monitoring.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Mar; 138(?):628-36. doi:
10.1016/j.saa.2014.11.093. [PMID: 25541401] - Oluseye A Ogunbayo, Francesco Michelangeli. Related flavonoids cause cooperative inhibition of the sarcoplasmic reticulum Ca²⁺ ATPase by multimode mechanisms.
The FEBS journal.
2014 Feb; 281(3):766-77. doi:
10.1111/febs.12621. [PMID: 24238016] - Chang Hui, Fu Yujie, Yuan Lijia, Yi Long, Xu Hongxia, Zhou Yong, Zhu Jundong, Zhang Qianyong, Mi Mantian. MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis.
Breast cancer research : BCR.
2012 May; 14(3):R80. doi:
10.1186/bcr3194. [PMID: 22616882] - Chu-Wen Yang, Chi-Lun Chang, Hsin-Chen Lee, Chin-Wen Chi, Jia-Ping Pan, Wen-Chin Yang. Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways.
BMC complementary and alternative medicine.
2012 Mar; 12(?):22. doi:
10.1186/1472-6882-12-22. [PMID: 22443687] - Mirza Bojić, Željko Debeljak, Marica Medić-Šarić, Maja Tomičić. Interference of selected flavonoid aglycons in platelet aggregation assays.
Clinical chemistry and laboratory medicine.
2012 Feb; 50(8):1403-8. doi:
10.1515/cclm-2011-0960. [PMID: 22868805] - Evangelia Vlachodimitropoulou, Paul A Sharp, Richard J Naftalin. Quercetin-iron chelates are transported via glucose transporters.
Free radical biology & medicine.
2011 Apr; 50(8):934-44. doi:
10.1016/j.freeradbiomed.2011.01.005. [PMID: 21238582] - Hui Chang, Hui Lin, Long Yi, Jundong Zhu, Yong Zhou, Mantian Mi, Qianyong Zhang. 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway.
European journal of pharmacology.
2010 Dec; 648(1-3):31-8. doi:
10.1016/j.ejphar.2010.08.020. [PMID: 20840847] - Oluseye A Ogunbayo, Robert M Harris, Rosemary H Waring, Christopher J Kirk, Francesco Michelangeli. Inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by flavonoids: a quantitative structure-activity relationship study.
IUBMB life.
2008 Dec; 60(12):853-8. doi:
10.1002/iub.132. [PMID: 18785622] - Hideki Kanho, Sayaka Yaoya, Tomio Itani, Takahisa Nakane, Nobuo Kawahara, Yoichi Takase, Kazuo Masuda, Masanori Kuroyanagi. Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives.
Bioscience, biotechnology, and biochemistry.
2004 Oct; 68(10):2032-9. doi:
10.1271/bbb.68.2032. [PMID: 15502347]