Osmundacetone (BioDeep_00000396853)

   

PANOMIX_OTCML-2023


代谢物信息卡片


3-Buten-2-one, 4-(3,4-dihydroxyphenyl)-, (3E)-

化学式: C10H10O3 (178.062991)
中文名称: 紫萁酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 82.86%

分子结构信息

SMILES: CC(/C=C/C1=CC=C(O)C(O)=C1)=O
InChI: InChI=1S/C10H10O3/c1-7(11)2-3-8-4-5-9(12)10(13)6-8/h2-6,12-13H,1H3/b3-2+

描述信息

(E)-3,4-Dihydroxybenzylideneacetone is a natural product found in Inonotus obliquus, Peltigera dolichorrhiza, and Phellinus igniarius with data available.
(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress[1].
(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress[1].
(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress[1].

同义名列表

12 个代谢物同义名

3-Buten-2-one, 4-(3,4-dihydroxyphenyl)-, (3E)-; (3E)-4-(3,4-DIHYDROXYPHENYL)BUT-3-EN-2-ONE; (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one; (E)-3,4-Dihydroxybenzylideneacetone, 97\\%; (E)-3,4-Dihydroxybenzylideneacetone,97\\%; 3-Buten-2-one, 4-(3,4-dihydroxyphenyl)-; 4-(3,4-Dihydroxyphenyl)but-3-en-2-one; (E)-3,4-Dihydroxybenzylideneacetone; (E)-3,4-ihydroxybenzylidenecetone; (E)-Osmundacetone; Osmundacetone; ZN-2



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Chen Ke, Changhan Chen, Ming Yang, Hao Chen, Liqun Li, Youhui Ke. Osmundacetone Inhibits Angiogenesis of Infantile Hemangiomas through Inducing Caspases and Reducing VEGFR2/MMP2. Anti-cancer agents in medicinal chemistry. 2023 Nov; ?(?):. doi: 10.2174/0118715206273410231103100600. [PMID: 37957872]
  • Yue Yang, Pingya He, Yuhao Hou, Zhicheng Liu, Xiaoping Zhang, Ning Li. Osmundacetone modulates mitochondrial metabolism in non-small cell lung cancer cells by hijacking the glutamine/glutamate/α-KG metabolic axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 100(?):154075. doi: 10.1016/j.phymed.2022.154075. [PMID: 35413646]
  • Hao Wu, Yijia Cao, Jiaqi Wang, Runhua Liu, Yu Sun, Chenning Zhang, Yikun Sun. Pharmacokinetic and metabolic profiling studies of osmundacetone in rats by UPLC-MS/MS and UPLC-QE-Orbitrap-HRMS. Biomedical chromatography : BMC. 2022 Jan; 36(1):e5251. doi: 10.1002/bmc.5251. [PMID: 34606105]
  • Tuy An Trinh, Young Hye Seo, Sungyoul Choi, Jun Lee, Ki Sung Kang. Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. Biomolecules. 2021 02; 11(2):. doi: 10.3390/biom11020328. [PMID: 33671577]
  • Young Hye Seo, Tuy An Trinh, Seung Mok Ryu, Hyo Seon Kim, Goya Choi, Byeong Cheol Moon, Sang Hee Shim, Dae Sik Jang, Dongho Lee, Ki Sung Kang, Jun Lee. Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death. Journal of natural products. 2020 10; 83(10):3149-3155. doi: 10.1021/acs.jnatprod.0c00756. [PMID: 32991171]
  • Yan-Ni Shi, Zheng-Chao Tu, Xin-Long Wang, Yong-Ming Yan, Ping Fang, Zhi-Li Zuo, Bo Hou, Tong-Hua Yang, Yong-Xian Cheng. Bioactive compounds from the insect Aspongopus chinensis. Bioorganic & medicinal chemistry letters. 2014 Nov; 24(22):5164-9. doi: 10.1016/j.bmcl.2014.09.083. [PMID: 25442305]
  • Namphung Vongvanich, Prasat Kittakoop, Panarat Charoenchai, Sutichai Intamas, Kanlayanee Sriklung, Yodhathai Thebtaranonth. Antiplasmodial, antimycobacterial, and cytotoxic principles from Camchaya calcarea. Planta medica. 2006 Dec; 72(15):1427-30. doi: 10.1055/s-2006-951711. [PMID: 17089326]
  • Chisako Yamagami, Miki Akamatsu, Noriko Motohashi, Shogo Hamada, Takao Tanahashi. Quantitative structure-activity relationship studies for antioxidant hydroxybenzalacetones by quantum chemical- and 3-D-QSAR(CoMFA) analyses. Bioorganic & medicinal chemistry letters. 2005 Jun; 15(11):2845-50. doi: 10.1016/j.bmcl.2005.03.087. [PMID: 15911266]