Kikemanin (BioDeep_00000396465)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C20H23NO4 (341.16269980000004)
中文名称: 紫堇达明碱, 紫堇达明碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)OC
InChI: InChI=1S/C20H23NO4/c1-23-18-9-13-6-7-21-11-15-12(4-5-17(22)20(15)25-3)8-16(21)14(13)10-19(18)24-2/h4-5,9-10,16,22H,6-8,11H2,1-3H3/t16-/m0/s1
描述信息
Corydalmine is a natural product found in Stephania yunnanensis, Corydalis balansae, and other organisms with data available.
同义名列表
18 个代谢物同义名
(13aS)-2,3,9-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-10-ol; 6H-DIBENZO(A,G)QUINOLIZIN-10-OL, 5,8,13,13A-TETRAHYDRO-2,3,9-TRIMETHOXY-, (13AS)-; 6H-Dibenzo[a,g]quinolizin-10-ol,5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (13aS)-; 6H-Dibenzo(a,g)quinolizin-10-ol, 5,8,13,13a-tetrahydro-2,3,9-trimethoxy-, (S)-; 2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolin-10-ol; (13AS)-5,8,13,13A-TETRAHYDRO-2,3,9-TRIMETHOXY-6H-DIBENZO(A,G)QUINOLIZIN-10-OL; Kikemanine; L-Corydalmine; Schefferine; corydalmine, (13R-trans)-isomer; CORYDALMINE, (-)-; UNII-DV8DX4568D; (s)-corydalmine; (-)-corydalmine; (-)-KIKEMANINE; L-CORYDALMINE; Corydalmine; SCHEFFERINE; DV8DX4568D; Kikemanin
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 161665
- MeSH: corydalmine
- ChemIDplus: 0030413844
- CAS: 30413-84-4
- medchemexpress: HY-N2573
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Wen-Ling Dai, Yi-Ni Bao, Ji-Fa Fan, Shan-Shan Li, Wan-Li Zhao, Bo-Yang Yu, Ji-Hua Liu. Levo-corydalmine attenuates microglia activation and neuropathic pain by suppressing ASK1-p38 MAPK/NF-κB signaling pathways in rat spinal cord.
Regional anesthesia and pain medicine.
2020 03; 45(3):219-229. doi:
10.1136/rapm-2019-100875
. [PMID: 31898581] - Lin Zhou, Luyao Ao, Yunyi Yan, Chengyuan Li, Wanting Li, Anqi Ye, Jihua Liu, Yahui Hu, Weirong Fang, Yunman Li. Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2020 01; 17(1):340-355. doi:
10.1007/s13311-019-00784-7
. [PMID: 31617070] - Wen-Ling Dai, Xin-Tong Liu, Yi-Ni Bao, Bing Yan, Nan Jiang, Bo-Yang Yu, Ji-Hua Liu. Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
Experimental & molecular medicine.
2018 11; 50(11):1-12. doi:
10.1038/s12276-018-0175-1
. [PMID: 30429454] - Lin Zhou, Yahui Hu, Chengyuan Li, Yunyi Yan, Luyao Ao, Boyang Yu, Weirong Fang, Jihua Liu, Yunman Li. Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway.
Neuropharmacology.
2018 06; 135(?):34-47. doi:
10.1016/j.neuropharm.2018.03.004
. [PMID: 29518397] - Hongwei Zhang, Lan Gao, Menglin Shu, Jihua Liu, Boyang Yu. Development of a highly sensitive and specific ELISA method for the determination of l-corydalmine in SD rats with monoclonal antibody.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1073(?):163-169. doi:
10.1016/j.jchromb.2017.09.022
. [PMID: 29276980] - Wen-Ling Dai, Bing Yan, Nan Jiang, Juan-Juan Wu, Xiu-Feng Liu, Ji-Hua Liu, Bo-Yang Yu. Simultaneous inhibition of NMDA and mGlu1/5 receptors by levo-corydalmine in rat spinal cord attenuates bone cancer pain.
International journal of cancer.
2017 08; 141(4):805-815. doi:
10.1002/ijc.30780
. [PMID: 28500623] - Yahui Hu, Nandani Darshika Kodithuwakku, Lin Zhou, Chengyuan Li, Dan Han, Weirong Fang, Jihua Liu, Yunman Li. Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway.
Molecules (Basel, Switzerland).
2017 Jun; 22(6):. doi:
10.3390/molecules22060937
. [PMID: 28587280] - Inas A Abdallah, Peng Huang, Jing Liu, David Y Lee, Lee-Yuan Liu-Chen, Hazem E Hassan. Development and validation of a high performance liquid chromatography quantification method of levo-tetrahydropalmatine and its metabolites in plasma and brain tissues: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2017 Apr; 31(4):. doi:
10.1002/bmc.3850
. [PMID: 27606501] - De-Lan Yang, Wen-Li Mei, Yan-Bo Zeng, Zhi-Kai Guo, Dai-Jing Wei, Shou-Bai Liu, Qing-Huang Wang, Hao-Fu Dai. A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera.
Journal of Asian natural products research.
2013; 15(3):315-8. doi:
10.1080/10286020.2012.762641
. [PMID: 23418880]