EriocalyxinB (BioDeep_00000396425)
PANOMIX_OTCML-2023
代谢物信息卡片
(1S,2S,5R,8S,9S,10S,11R)-9,10-dihydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadec-13-ene-7,15-dione
化学式: C20H24O5 (344.1623654)
中文名称: 毛萼乙素
谱图信息:
最多检出来源 Astragalus membranaceus(otcml) 85.71%
分子结构信息
SMILES: CC1(C=CC(=O)C23C1C(C(C45C2CCC(C4)C(=C)C5=O)(OC3)O)O)C
InChI: InChI=1S/C20H24O5/c1-10-11-4-5-12-18-9-25-20(24,19(12,8-11)15(10)22)16(23)14(18)17(2,3)7-6-13(18)21/h6-7,11-12,14,16,23-24H,1,4-5,8-9H2,2-3H3/t11-,12+,14-,16+,18-,19+,20-/m1/s1
描述信息
Eriocalyxin B is a natural product found in Isodon eriocalyx with data available.
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Leilei Gou, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Pema Tenzin Puno, Clara Bik-San Lau. Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo.
Biochemical pharmacology.
2023 04; 210(?):115491. doi:
10.1016/j.bcp.2023.115491. [PMID: 36898414] - Ziqiang Yu, Yang Chen, Chaozhao Liang. Eriocalyxin B Induces Apoptosis and Autophagy Involving Akt/Mammalian Target of Rapamycin (mTOR) Pathway in Prostate Cancer Cells.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Nov; 25(?):8534-8543. doi:
10.12659/msm.917333. [PMID: 31714902] - Gang Du, Hai-Yan Gong, Ke-Na Feng, Qian-Qian Chen, Yan-Long Yang, Xiao-Li Fu, Shan Lu, Ying Zeng. Diterpene synthases facilitating production of the kaurane skeleton of eriocalyxin B in the medicinal plant Isodon eriocalyx.
Phytochemistry.
2019 Feb; 158(?):96-102. doi:
10.1016/j.phytochem.2018.11.015. [PMID: 30496917] - L Li, S L Zhao, G G L Yue, T P Wong, J X Pu, H D Sun, K P Fung, P C Leung, Q B Han, C B S Lau, P S Leung. Isodon eriocalyx and its bioactive component Eriocalyxin B enhance cytotoxic and apoptotic effects of gemcitabine in pancreatic cancer.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 May; 44(?):56-64. doi:
10.1016/j.phymed.2018.03.055. [PMID: 29895493] - Xunian Zhou, Grace Gar-Lee Yue, Andrew Man-Lok Chan, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Handong Sun, Jianxin Pu, Clara Bik-San Lau. Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer.
Biochemical pharmacology.
2017 10; 142(?):58-70. doi:
10.1016/j.bcp.2017.06.133. [PMID: 28669564] - Xunian Zhou, Grace Gar-Lee Yue, Minghua Liu, Zhili Zuo, Julia Kin-Ming Lee, Mingyue Li, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Handong Sun, Jianxin Pu, Clara Bik-San Lau. Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling.
Oncotarget.
2016 Dec; 7(50):82820-82835. doi:
10.18632/oncotarget.12652. [PMID: 27756875] - Xiaokui Yu, Li He, Peng Cao, Qiang Yu. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3.
PloS one.
2015; 10(5):e0128406. doi:
10.1371/journal.pone.0128406. [PMID: 26010889] - Ling-Mei Kong, Xu Deng, Zhi-Li Zuo, Han-Dong Sun, Qin-Shi Zhao, Yan Li. Identification and validation of p50 as the cellular target of eriocalyxin B.
Oncotarget.
2014 Nov; 5(22):11354-64. doi:
10.18632/oncotarget.2461. [PMID: 25404639] - Lin Li, Po Sing Leung. Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer.
The international journal of biochemistry & cell biology.
2014 Aug; 53(?):224-36. doi:
10.1016/j.biocel.2014.05.021. [PMID: 24875648] - Ying Lu, Bing Chen, Jun-Hong Song, Tao Zhen, Bai-Yan Wang, Xin Li, Ping Liu, Xin Yang, Qun-Ling Zhang, Xiao-Dong Xi, Sheng-Di Chen, Jian-Ping Zuo, Zhu Chen, Sai-Juan Chen. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells.
Proceedings of the National Academy of Sciences of the United States of America.
2013 Feb; 110(6):2258-63. doi:
10.1073/pnas.1222426110. [PMID: 23345445] - Z Wang, Q Yuan, J-H Sun, Z Cui, H-Y Chen, H Wu, J-x Chen. A validated HPLC method for the determination of eriocalyxin B in plasma and its application to pharmacokinetic studies.
Arzneimittel-Forschung.
2012 Dec; 62(12):666-9. doi:
10.1055/s-0032-1329986. [PMID: 23154887] - Lin Li, Grace G L Yue, Clara B S Lau, Handong Sun, Kwok Pui Fung, Ping Chung Leung, Quanbin Han, Po Sing Leung. Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways.
Toxicology and applied pharmacology.
2012 Jul; 262(1):80-90. doi:
10.1016/j.taap.2012.04.021. [PMID: 22561874] - Wei-Guang Wang, Xiao-Nian Li, Xue Du, Hai-Yan Wu, Xu Liu, Jia Su, Yan Li, Jian-Xin Pu, Han-Dong Sun. Laxiflorolides A and B, epimeric bishomoditerpene lactones from Isodon eriocalyx.
Journal of natural products.
2012 Jun; 75(6):1102-7. doi:
10.1021/np300106j. [PMID: 22624550] - Takuro Maruyama, Naoki Sugimoto, Masanori Kuroyanagi, Ik Hwi Kim, Hiroyuki Kamakura, Takeshi Kawasaki, Masao Fujita, Hiroshi Shimada, Yutaka Yamamoto, Atsuko Tada, Takeshi Yamazaki, Yukihiro Goda. Authentication and chemical study of isodonis herba and isodonis extracts.
Chemical & pharmaceutical bulletin.
2007 Nov; 55(11):1626-30. doi:
10.1248/cpb.55.1626. [PMID: 17978524] - Yu Zhao, Xue-Mei Niu, Li-Ping Qian, Ze-Yuan Liu, Qin-Shi Zhao, Han-Dong Sun. Synthesis and cytotoxicity of some new eriocalyxin B derivatives.
European journal of medicinal chemistry.
2007 Apr; 42(4):494-502. doi:
10.1016/j.ejmech.2006.11.004. [PMID: 17189663]