halofuginone hydrobromide (BioDeep_00000396326)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C16H18Br2ClN3O3 (492.9403348000001)
中文名称: 溴氯哌喹酮 氢溴酸盐, 哈洛夫酮溴酸盐, 常山酮溴酸盐, 卤夫酮溴酸盐, 氢溴酸卤夫酮
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 5.26%
分子结构信息
SMILES: C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br
InChI: /m0./s1
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
D006133 - Growth Substances > D006131 - Growth Inhibitors
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D04413
- PubChem: 400771
- ChEMBL: CHEMBL1969752
- CAS: 64924-67-0
- CAS: 57426-42-3
- medchemexpress: HY-N1584A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Junping Zhu, Jiaming Wei, Ye Lin, Yuanyuan Tang, Zhaoli Su, Liqing Li, Bin Liu, Xiong Cai. Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.
BMC complementary medicine and therapies.
2024 Feb; 24(1):105. doi:
10.1186/s12906-024-04397-2
. [PMID: 38413973] - Jiali Ni, Xiaoying Li, Xiaodi Tu, Haiyan Zhu, Shiqi Wang, Yayi Hou, Huan Dou. Halofuginone ameliorates systemic lupus erythematosus by targeting Blk in myeloid-derived suppressor cells.
International immunopharmacology.
2023 Jan; 114(?):109487. doi:
10.1016/j.intimp.2022.109487
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Drug discovery today.
2022 09; 27(9):2586-2592. doi:
10.1016/j.drudis.2022.05.020
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The Journal of pharmacology and experimental therapeutics.
2021 10; 379(1):33-40. doi:
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British journal of pharmacology.
2021 09; 178(17):3373-3394. doi:
10.1111/bph.15442
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Food chemistry.
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Nature communications.
2021 06; 12(1):3907. doi:
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Parasitology.
2021 04; 148(4):408-419. doi:
10.1017/s0031182020002267
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Journal of biosciences.
2020; 45(?):. doi:
10.1007/s12038-020-00042-5
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Biomolecules.
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Science signaling.
2019 11; 12(607):. doi:
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Journal of cellular physiology.
2019 08; 234(10):18970-18984. doi:
10.1002/jcp.28537
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Veterinary parasitology.
2019 May; 269(?):57-64. doi:
10.1016/j.vetpar.2019.04.008
. [PMID: 31079829] - Xiaojing Xia, Lei Wang, Xiaojian Zhang, Shan Wang, Lianchen Lei, Likun Cheng, Yanzhao Xu, Yawei Sun, Bolin Hang, Gaiping Zhang, YueYu Bai, JianHe Hu. Halofuginone-induced autophagy suppresses the migration and invasion of MCF-7 cells via regulation of STMN1 and p53.
Journal of cellular biochemistry.
2018 05; 119(5):4009-4020. doi:
10.1002/jcb.26559
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 May; 101(?):745-753. doi:
10.1016/j.biopha.2018.01.100
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Veterinary parasitology.
2018 Mar; 252(?):17-21. doi:
10.1016/j.vetpar.2018.01.018
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Molecular medicine reports.
2017 Sep; 16(3):3290-3298. doi:
10.3892/mmr.2017.7009
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Jun; 42(11):2042-2045. doi:
10.19540/j.cnki.cjcmm.20170224.006
. [PMID: 28822145] - Xin Hou, Jin Zhou, Rong Yang, Shanshan Liu, Mei Bi, Tong Liu, Chenling Fan, Haixia Guan, Weiping Teng, Zhongyan Shan, Yushu Li. Effect of Halofuginone on the Pathogenesis of Autoimmune Thyroid Disease in Different Mice Models.
Endocrine, metabolic & immune disorders drug targets.
2017; 17(2):141-148. doi:
10.2174/1871530317666170424101256
. [PMID: 28440200] - Weili Zhan, Yanhong Kang, Ning Chen, Chongshan Mao, Yi Kang, Jia Shang. Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation.
Drug design, development and therapy.
2017; 11(?):2947-2955. doi:
10.2147/dddt.s149623
. [PMID: 29066866] - Kivilcim Karadeniz Cerit, Berna Karakoyun, Meral Yüksel, Feriha Ercan, Halil Tuğtepe, Tolga E Dagli, Berrak Ç Yeğen. Halofuginone Alleviates Burn-Induced Hepatic and Renal Damage in Rats.
Journal of burn care & research : official publication of the American Burn Association.
2017 Jan; 38(1):e384-e394. doi:
10.1097/bcr.0000000000000400
. [PMID: 27388880] - Yang Chen, Weishuai Liu, Peng Wang, Hailing Hou, Ningbo Liu, Linlin Gong, Youyou Wang, Kai Ji, Lujun Zhao, Ping Wang. Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer.
Oncotarget.
2016 Nov; 7(44):71341-71352. doi:
10.18632/oncotarget.11217
. [PMID: 27533085] - Guoqing Chen, Ruihong Gong, Xianli Shi, Dajian Yang, Ge Zhang, Aiping Lu, Jianbo Yue, Zhaoxiang Bian. Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1.
Oncotarget.
2016 Aug; 7(31):50302-50314. doi:
10.18632/oncotarget.10367
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Schweizer Archiv fur Tierheilkunde.
2016 May; 158(5):341-50. doi:
10.17236/sat00062
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The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2016 Apr; 35(4):518-27. doi:
10.1016/j.healun.2015.12.003
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Zhongguo shi yan xue ye xue za zhi.
2015 Oct; 23(5):1488-92. doi:
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Oncotarget.
2015 Sep; 6(27):24148-62. doi:
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Science translational medicine.
2015 May; 7(288):288ra77. doi:
10.1126/scitranslmed.aaa3575
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Molecules (Basel, Switzerland).
2015 Jan; 20(1):573-94. doi:
10.3390/molecules20010573
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PloS one.
2015; 10(12):e0144735. doi:
10.1371/journal.pone.0144735
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Veterinary parasitology.
2014 May; 202(3-4):326-9. doi:
10.1016/j.vetpar.2014.02.027
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Scandinavian journal of immunology.
2014 Mar; 79(3):163-72. doi:
10.1111/sji.12144
. [PMID: 24383550] - Mei Ling Jin, Sun Young Park, Young Hun Kim, Geuntae Park, Sang Joon Lee. Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9.
International journal of oncology.
2014 Jan; 44(1):309-18. doi:
10.3892/ijo.2013.2157
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Veterinary parasitology.
2013 Oct; 197(1-2):59-67. doi:
10.1016/j.vetpar.2013.04.029
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Medical hypotheses.
2013 Apr; 80(4):357-9. doi:
10.1016/j.mehy.2013.01.001
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Journal of pediatric urology.
2013 Apr; 9(2):174-83. doi:
10.1016/j.jpurol.2012.01.015
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Nature.
2013 Feb; 494(7435):121-4. doi:
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PloS one.
2013; 8(12):e82232. doi:
10.1371/journal.pone.0082232
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The Journal of surgical research.
2012 Dec; 178(2):545-52. doi:
10.1016/j.jss.2012.07.053
. [PMID: 22901798] - Patricia Juárez, Khalid S Mohammad, Juan Juan Yin, Pierrick G J Fournier, Ryan C McKenna, Holly W Davis, Xiang H Peng, Maria Niewolna, Delphine Javelaud, John M Chirgwin, Alain Mauviel, Theresa A Guise. Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Cancer research.
2012 Dec; 72(23):6247-56. doi:
10.1158/0008-5472.can-12-1444
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British journal of haematology.
2012 Jun; 157(6):718-31. doi:
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Nature chemical biology.
2012 Feb; 8(3):311-7. doi:
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Science translational medicine.
2012 Jan; 4(118):118ra11. doi:
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The Veterinary record.
2011 May; 168(19):509. doi:
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Journal of endourology.
2011 Jan; 25(1):107-12. doi:
10.1089/end.2010.0514
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Preventive veterinary medicine.
2010 Sep; 96(3-4):143-51. doi:
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Cancer letters.
2010 Mar; 289(1):119-26. doi:
10.1016/j.canlet.2009.08.009
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Pancreas.
2009 May; 38(4):427-35. doi:
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Drug and chemical toxicology.
2009; 32(4):312-8. doi:
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Avian pathology : journal of the W.V.P.A.
2008 Oct; 37(5):521-6. doi:
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Veterinary journal (London, England : 1997).
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The Journal of surgical research.
2008 Jul; 148(1):7-12. doi:
10.1016/j.jss.2008.03.015
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European journal of pharmacology.
2007 Nov; 573(1-3):65-9. doi:
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Cell and tissue research.
2007 Apr; 328(1):153-66. doi:
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Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2007 Mar; 54(2):103-6. doi:
10.1111/j.1439-0442.2007.00871.x
. [PMID: 17305974] - Sydney Benchetrit, Shy Yarkoni, Mauro Rathaus, Marc Pines, Gloria Rashid, Joelle Bernheim, Jacques Bernheim. Halofuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats.
The Israel Medical Association journal : IMAJ.
2007 Jan; 9(1):30-4. doi:
NULL
. [PMID: 17274353] - M Lallemand, A Villeneuve, J Belda, P Dubreuil. Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves.
The Veterinary record.
2006 Nov; 159(20):672-6. doi:
10.1136/vr.159.20.672
. [PMID: 17099176] - M Leiba, L Cahalon, A Shimoni, O Lider, A Zanin-Zhorov, I Hecht, U Sela, I Vlodavsky, A Nagler. Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.
Journal of leukocyte biology.
2006 Aug; 80(2):399-406. doi:
10.1189/jlb.0705409
. [PMID: 16769768] - M J A de Jonge, H Dumez, J Verweij, S Yarkoni, D Snyder, D Lacombe, S Marréaud, T Yamaguchi, C J A Punt, A van Oosterom. Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours.
European journal of cancer (Oxford, England : 1990).
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