Demecolcine (BioDeep_00000395806)
Main id: BioDeep_00000003607
PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
化学式: C21H25NO5 (371.173264)
中文名称: 秋水仙胺, 脱羰秋水仙碱, 秋水仙碱
谱图信息:
最多检出来源 Viridiplantae(plant) 14.81%
分子结构信息
SMILES: CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
InChI: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
描述信息
(-)-demecolcine is a secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is an alkaloid and a secondary amino compound.
Demecolcine is a natural product found in Colchicum arenarium, Colchicum crocifolium, and other organisms with data available.
Demecolcine is a colchicine analog with potential antimitotic and antineoplastic activities. Demecolcine acid binds to the colchicine-binding site of tubulin, inhibiting its polymerization into microtubules, causing cell cycle arrest at metaphase and preventing cell division.
An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CC - Colchicine derivatives
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
ATC code: L01CC01
Origin: Plant; SubCategory_DNP: Isoquinoline alkaloids, Phenethylisoquinoline alkaloids, Colchicine alkaloids
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.681
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.679
Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research[1][2].
Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research[1][2].
同义名列表
72 个代谢物同义名
(7S)-7-(methylamino)-1,2,3,10-tetrakis(methyloxy)-6,7-dihydrobenzo[a]heptalen-9(5H)-one; 1,2,3,10-Tetramethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one (Demecolcine); Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; Benzo[a]heptalen-9(5H)-one,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one; 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo(alpha)heptalen-9(5H)-one; (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one; (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one; 1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one #; (S)-1,2,3,10-tetramethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one; 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo(a)heptalen-9(5H)-one; Demecolcine, Hybri-Max(TM), powder, gamma-irradiated, hybridoma tested; 6,2,3,10-tetramethoxy-7-(methylamino)-benzo[.alpha.]heptalen-9(5H)-one; Demecolcine, >=98.0\\% (sum of enantiomers, HPLC); 4-Amino-furazan-3-carboxylicacidmethylamide; Colchicine, 7-deacetamido-7-(methylamino)-; Colcemid;Colchamin;Desmecolcine;Kolchamin; Colcemid, N-methyl-N-deacetyl-colchicine; Alkaloid H 3, from colchicum antumnale; Colchicine, N-deacetyl-N-methyl-; N-Methyl-N-desacetylcolchicine; N-Desacetyl-N-methylcolchicine; Colchicine, deacetyl-N-methyl-; Colchine, N-deacetyl-N-methyl; N-Methyl-N-deacetylcolchicine; N-Deacetyl-N-methylcolchicine; NNJPGOLRFBJNIW-HNNXBMFYSA-N; Deacetyl-N-methylcolchicine; N-Desacetylmethylcolchicine; Demecolcine, >=98\\% (HPLC); Demecolcine [INN:BAN:DCF]; Demecolcina [INN-Spanish]; Desacetylmethylcolchicine; Demecolcine, (+-)-Isomer; Demecolcinum [INN-Latin]; Deacetylmethylcolchicine; DEMECOLCINE [WHO-DD]; Santavys substance F; DEMECOLCINE [INN]; Kolchicin [Czech]; DEMECOLCINE [MI]; BCBcMAP01_000022; Methylcolchicine; UNII-Z01IVE25KI; (-)-Demecolcine; (-)-Colchamine; Reichsteins F; Desmecolchine; Tox21_112296; Alkaloid H 3; Demecolcinum; Desmecolcine; Demecolcina; Demicolcine; Substance F; SMP1_000076; Demecolcine; Demecolcin; Z01IVE25KI; Colchamine; Kolchamin; Colcemide; Colchamin; Kolchicin; Kolkamin; Colcemid; Omaine; Omain; LON; Demecolcine; Demecolcine
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:4393
- KEGG: C11250
- PubChem: 220401
- DrugBank: DB13318
- ChEMBL: CHEMBL312862
- Wikipedia: Demecolcine
- MeSH: Demecolcine
- ChemIDplus: 0000477305
- KNApSAcK: C00027138
- CAS: 477-30-5
- MoNA: NGA00564
- MoNA: NGA00563
- MoNA: NGA00562
- MoNA: NGA00561
- MoNA: CB000122
- MoNA: BML81072
- MoNA: BML81070
- MoNA: BML01026
- MoNA: BML01018
- MoNA: BML01010
- medchemexpress: HY-N0282
- PubChem: 13427
- NIKKAJI: J9.231B
- KNApSAcK: 4393
- LOTUS: LTS0223323
- wikidata: Q903666
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- P Zeebul Trinita Shannan, Susan G Suganya, E Angel Jemima, M Ramesh. In vitro anticancer activity of Hirudinaria manillensis methanolic extract and its validation using in silico molecular docking approach.
Medical oncology (Northwood, London, England).
2024 Mar; 41(4):88. doi:
10.1007/s12032-024-02321-9
. [PMID: 38491315] - Rajapandiyan Krishnamoorthy, Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Abdulraheem R Adisa, Mohammed A Al-Shuniaber, Mustafa A Gassem, Ali A Alshatwi. Antimicrobial activity of nanoemulsion on drug-resistant bacterial pathogens.
Microbial pathogenesis.
2018 Jul; 120(?):85-96. doi:
10.1016/j.micpath.2018.04.035
. [PMID: 29684541] - Shalane K Yacovone, Amanda M Smelser, Jed C Macosko, George Holzwarth, David A Ornelles, Douglas S Lyles. Migration of Nucleocapsids in Vesicular Stomatitis Virus-Infected Cells Is Dependent on both Microtubules and Actin Filaments.
Journal of virology.
2016 07; 90(13):6159-70. doi:
10.1128/jvi.00488-16
. [PMID: 27122580] - Ran Lin, Donald C Chang, Yi-Kuen Lee. Single-cell electroendocytosis on a micro chip using in situ fluorescence microscopy.
Biomedical microdevices.
2011 Dec; 13(6):1063-73. doi:
10.1007/s10544-011-9576-9
. [PMID: 21800146] - Massimo Moretti, Roberta Bonfiglioli, Donatella Feretti, Sofia Pavanello, Francesca Mussi, Maria G Grollino, Milena Villarini, Anna Barbieri, Elisabetta Ceretti, Mariella Carrieri, Annamaria Buschini, Massimo Appolloni, Luca Dominici, Laura Sabatini, Umberto Gelatti, Giovanni B Bartolucci, Paola Poli, Laura Stronati, Giuseppe Mastrangelo, Silvano Monarca. A study protocol for the evaluation of occupational mutagenic/carcinogenic risks in subjects exposed to antineoplastic drugs: a multicentric project.
BMC public health.
2011 Mar; 11(?):195. doi:
10.1186/1471-2458-11-195
. [PMID: 21450074] - Junqiang Ye, Shuibing Chen, Tom Maniatis. Cardiac glycosides are potent inhibitors of interferon-β gene expression.
Nature chemical biology.
2011 Jan; 7(1):25-33. doi:
10.1038/nchembio.476
. [PMID: 21076398] - Esmaeil Biazar, Majid Heidari, Azadeh Asefnejad, Azadeh Asefnezhad, Naser Montazeri. The relationship between cellular adhesion and surface roughness in polystyrene modified by microwave plasma radiation.
International journal of nanomedicine.
2011; 6(?):631-9. doi:
10.2147/ijn.s17218
. [PMID: 21698084] - Saeed Heidari Keshel, S Neda Kh Azhdadi, Azadeh Asefnejad, Azadeh Asefnezhad, Mohammad Sadraeian, Mohamad Montazeri, Esmaeil Biazar. The relationship between cellular adhesion and surface roughness for polyurethane modified by microwave plasma radiation.
International journal of nanomedicine.
2011; 6(?):641-7. doi:
10.2147/ijn.s17180
. [PMID: 21556340] - Elena Díaz-Rodríguez, Stela Álvarez-Fernández, Xi Chen, Bruno Paiva, Ricardo López-Pérez, Juan Luis García-Hernández, Jesús F San Miguel, Atanasio Pandiella. Deficient spindle assembly checkpoint in multiple myeloma.
PloS one.
2011; 6(11):e27583. doi:
10.1371/journal.pone.0027583
. [PMID: 22132115] - Nicole M Wakida, Elliot L Botvinick, Justin Lin, Michael W Berns. An intact centrosome is required for the maintenance of polarization during directional cell migration.
PloS one.
2010 Dec; 5(12):e15462. doi:
10.1371/journal.pone.0015462
. [PMID: 21203421] - Resham Lal Gurung, Shi Ni Lim, Aik Kia Khaw, Jasmine Fen Fen Soon, Kirthan Shenoy, Safiyya Mohamed Ali, Manikandan Jayapal, Swaminathan Sethu, Rajamanickam Baskar, M Prakash Hande. Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells.
PloS one.
2010 Aug; 5(8):e12124. doi:
10.1371/journal.pone.0012124
. [PMID: 20711342] - Ryuuichi D Itoh, Hideo Yamasaki, Andi Septiana, Shigeo Yoshida, Makoto T Fujiwara. Chemical induction of rapid and reversible plastid filamentation in Arabidopsis thaliana roots.
Physiologia plantarum.
2010 Jun; 139(2):144-58. doi:
10.1111/j.1399-3054.2010.01352.x
. [PMID: 20088905] - Raffaella Melzi, Barbara Antonioli, Alessia Mercalli, Manuela Battaglia, Andrea Valle, Stefano Pluchino, Rossella Galli, Valeria Sordi, Emanuele Bosi, Gianvito Martino, Ezio Bonifacio, Claudio Doglioni, Lorenzo Piemonti. Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice.
PloS one.
2010 Apr; 5(4):e10357. doi:
10.1371/journal.pone.0010357
. [PMID: 20436918] - Angel Gu, Zhifang Zhang, Nan Zhang, Walter Tsark, John E Shively. Generation of human CEACAM1 transgenic mice and binding of Neisseria Opa protein to their neutrophils.
PloS one.
2010 Apr; 5(4):e10067. doi:
10.1371/journal.pone.0010067
. [PMID: 20404914] - Kevin M Tyler, Gerd K Wagner, Qiong Wu, Katharina T Huber. Functional significance may underlie the taxonomic utility of single amino acid substitutions in conserved proteins.
Journal of molecular evolution.
2010 Apr; 70(4):395-402. doi:
10.1007/s00239-010-9338-y
. [PMID: 20386893] - Annamaria Buschini, Lisa Ferrarini, Susanna Franzoni, Serena Galati, Mirca Lazzaretti, Francesca Mussi, Cristina Northfleet de Albuquerque, Tânia Maria Araújo Domingues Zucchi, Paola Poli. Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.
Journal of parasitology research.
2009; 2009(?):463575. doi:
10.1155/2009/463575
. [PMID: 20981287] - María Sol Brassesco, Ana Paula Montaldi, Elza Tiemi Sakamoto-Hojo. Preferential induction of MLL(Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide.
Genetics and molecular biology.
2009 Jan; 32(1):144-50. doi:
10.1590/s1415-47572009000100022
. [PMID: 21637660] - Yuk-Kien Chong, Tan-Boon Toh, Norazean Zaiden, Anuradha Poonepalli, Siew Hong Leong, Catherine Ee Ling Ong, Yiting Yu, Patrick B Tan, Siew-Ju See, Wai-Hoe Ng, Ivan Ng, Manoor P Hande, Oi Lian Kon, Beng-Ti Ang, Carol Tang. Cryopreservation of neurospheres derived from human glioblastoma multiforme.
Stem cells (Dayton, Ohio).
2009 Jan; 27(1):29-39. doi:
10.1634/stemcells.2008-0009
. [PMID: 18845764] - Michelle Boone, Peter M T Deen. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Pflugers Archiv : European journal of physiology.
2008 Sep; 456(6):1005-24. doi:
10.1007/s00424-008-0498-1
. [PMID: 18431594] - Kohsuke Chida, Meiko Taguchi. Change in localization of alkaline phosphatase and mannosidase II by colchicine treatment of primary cultures of fetal rat hepatocytes.
Acta histochemica et cytochemica.
2008 Feb; 41(1):1-5. doi:
10.1267/ahc.07010
. [PMID: 18320021] - F Q Alali, K Tawaha, T El-Elimat. Determination of (-)-demecolcine and (-)-colchicine content in selected Jordanian Colchicum species.
Die Pharmazie.
2007 Oct; 62(10):739-42. doi:
. [PMID: 18236776]
- P Phatak, J C Cookson, F Dai, V Smith, R B Gartenhaus, M F G Stevens, A M Burger. Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.
British journal of cancer.
2007 Apr; 96(8):1223-33. doi:
10.1038/sj.bjc.6603691
. [PMID: 17406367] - Beatriz Rodríguez-Bayona, Sandrine Ruchaud, Carmen Rodríguez, Mario Linares, Antonio Astola, Manuela Ortiz, William C Earnshaw, Manuel M Valdivia. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome.
Journal of autoimmune diseases.
2007 Jan; 4(?):1. doi:
10.1186/1740-2557-4-1
. [PMID: 17222351] - Takeshi Suzuki, Toshiyuki Matsuzaki, Haruo Hagiwara, Takeo Aoki, Yukiko Tajika-Takahashi, Kuniaki Takata. Apical localization of sodium-dependent glucose transporter SGLT1 is maintained by cholesterol and microtubules.
Acta histochemica et cytochemica.
2006 Dec; 39(6):155-61. doi:
10.1267/ahc.06024
. [PMID: 17327902] - Martha C Gómez, Charles Earle Pope, Mónica López, C Dumas, Angelica Giraldo, Betsy L Dresser. Chromosomal aneuploidy in African Wildcat somatic cells and cloned embryos.
Cloning and stem cells.
2006; 8(2):69-78. doi:
10.1089/clo.2006.8.69
. [PMID: 16776599] - Yuki Tajika, Toshiyuki Matsuzaki, Takeshi Suzuki, Abdushukur Ablimit, Takeo Aoki, Haruo Hagiwara, Michio Kuwahara, Sei Sasaki, Kuniaki Takata. Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments.
Histochemistry and cell biology.
2005 Jul; 124(1):1-12. doi:
10.1007/s00418-005-0010-3
. [PMID: 16049696] - T Lund, T Stokke, Ø E Olsen, Ø Fodstad. Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.
British journal of cancer.
2005 May; 92(9):1773-81. doi:
10.1038/sj.bjc.6602537
. [PMID: 15827557] - Taruho S Kuroda, Hiroshi Maita, Takanori Tabata, Takahiro Taira, Hirotake Kitaura, Hiroyoshi Ariga, Sanae M M Iguchi-Ariga. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase.
Gene.
2004 Sep; 340(1):83-98. doi:
10.1016/j.gene.2004.05.025
. [PMID: 15556297] - Alis C Hughes, Rachel Errington, Rosemary Fricker-Gates, Lesley Jones. Endophilin A3 forms filamentous structures that colocalise with microtubules but not with actin filaments.
Brain research. Molecular brain research.
2004 Sep; 128(2):182-92. doi:
10.1016/j.molbrainres.2004.06.016
. [PMID: 15363893] - Therese Nilsson, Stig Lenhoff, Lars Rylander, Mattias Höglund, Ingemar Turesson, Felix Mitelman, Jan Westin, Bertil Johansson. High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation.
British journal of haematology.
2004 Aug; 126(4):487-94. doi:
10.1111/j.1365-2141.2004.05060.x
. [PMID: 15287940] - Jens Nürnberger, Andreas Kribben, Anabelle Opazo Saez, Gerd Heusch, Thomas Philipp, Carrie L Phillips. The Invs gene encodes a microtubule-associated protein.
Journal of the American Society of Nephrology : JASN.
2004 Jul; 15(7):1700-10. doi:
10.1097/01.asn.0000128291.30249.d0
. [PMID: 15213257] - Guang-Peng Li, Thomas D Bunch, Kenneth L White, Kenneth I Aston, Lora N Meerdo, Barry J Pate, Benjamin R Sessions. Development, chromosomal composition, and cell allocation of bovine cloned blastocyst derived from chemically assisted enucleation and cultured in conditioned media.
Molecular reproduction and development.
2004 Jun; 68(2):189-97. doi:
10.1002/mrd.20071
. [PMID: 15095340] - V B Bystrevskaia, T M Vinogradova, V N Smirnov. [Endothelial microtubules as integral part of the mechanism controlling the level of stimulated secretion of van Willebrand factor].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.
2004 May; 90(5):522-36. doi:
. [PMID: 15341079]
- Elena Rebollo, Salud Llamazares, José Reina, Cayetano Gonzalez. Contribution of noncentrosomal microtubules to spindle assembly in Drosophila spermatocytes.
PLoS biology.
2004 Jan; 2(1):E8. doi:
10.1371/journal.pbio.0020008
. [PMID: 14758368] - Irina B Alieva, Ivan A Vorobjev. Vertebrate primary cilia: a sensory part of centrosomal complex in tissue cells, but a 'sleeping beauty' in cultured cells?.
Cell biology international.
2004; 28(2):139-50. doi:
10.1016/j.cellbi.2003.11.013
. [PMID: 14984760] - Tip W Loo, M Claire Bartlett, David M Clarke. Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
The Journal of biological chemistry.
2003 Jun; 278(23):20449-52. doi:
10.1074/jbc.c300154200
. [PMID: 12711602] - Hongwei Yu, Bhaswati Pandit, Eric Klett, Mi-Hye Lee, Kangmo Lu, Khalil Helou, Ikuo Ikeda, Nami Egashira, Masao Sato, Richard Klein, Ashok Batta, Gerald Salen, Shailendra B Patel. The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats.
BMC cardiovascular disorders.
2003 Jun; 3(?):4. doi:
10.1186/1471-2261-3-4
. [PMID: 12783625] - Joanna M Gilbert, Ilya G Goldberg, Thomas L Benjamin. Cell penetration and trafficking of polyomavirus.
Journal of virology.
2003 Feb; 77(4):2615-22. doi:
10.1128/jvi.77.4.2615-2622.2003
. [PMID: 12552000] - Yoshihito Shiono, Nobuyo Shiono, Shujiro Seo, Syuichi Oka, Yoshimitsu Yamazaki. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2002 Sep; 57(9-10):923-9. doi:
10.1515/znc-2002-9-1028
. [PMID: 12440735] - Haruo Hagiwara, Kuniaki Takata. Depolymerization of microtubules by colcemid induces the formation of elongated and centriole-nonassociated striated rootlets in PtK(2) cells.
Cell and tissue research.
2002 Aug; 309(2):287-92. doi:
10.1007/s00441-002-0560-9
. [PMID: 12172788] - T M Vinogradova, V E Roudnik, V B Bystrevskaya, V N Smirnov. Centrosome-directed translocation of Weibel-Palade bodies is rapidly induced by thrombin, calyculin A, or cytochalasin B in human aortic endothelial cells.
Cell motility and the cytoskeleton.
2000 Oct; 47(2):141-53. doi:
10.1002/1097-0169(200010)47:2<141::aid-cm5>3.0.co;2-u
. [PMID: 11013394] - C L Rieder, R Cole. Microtubule disassembly delays the G2-M transition in vertebrates.
Current biology : CB.
2000 Sep; 10(17):1067-70. doi:
10.1016/s0960-9822(00)00678-3
. [PMID: 10996076] - L Girnita, A Girnita, M Wang, J M Meis-Kindblom, L G Kindblom, O Larsson. A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells.
Oncogene.
2000 Aug; 19(37):4298-301. doi:
10.1038/sj.onc.1203755
. [PMID: 10980604] - B W Gallaher, A Berthold, J Klammt, M Knüpfer, J Kratzsch, M Bartsch, W Kiess. Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage.
Cellular and molecular biology (Noisy-le-Grand, France).
2000 Feb; 46(1):79-88. doi:
NULL
. [PMID: 10726974] - Y A Rovensky, L V Domnina, O Y Ivanova, J M Vasiliev. Locomotory behaviour of epitheliocytes and fibroblasts on metallic grids.
Journal of cell science.
1999 Apr; 112 ( Pt 8)(?):1273-82. doi:
10.1242/jcs.112.8.1273
. [PMID: 10085261] - P Traub, C Bauer, R Hartig, S Grüb, J Stahl. Colocalization of single ribosomes with intermediate filaments in puromycin-treated and serum-starved mouse embryo fibroblasts.
Biology of the cell.
1998 Jul; 90(4):319-37. doi:
. [PMID: 9800350]
- M H Lam, S L Olsen, W A Rankin, P W Ho, T J Martin, M T Gillespie, J M Moseley. PTHrP and cell division: expression and localization of PTHrP in a keratinocyte cell line (HaCaT) during the cell cycle.
Journal of cellular physiology.
1997 Dec; 173(3):433-46. doi:
10.1002/(sici)1097-4652(199712)173:3<433::aid-jcp16>3.0.co;2-c
. [PMID: 9369957] - F N Sackey, C S Watson, B Gametchu. Cell cycle regulation of membrane glucocorticoid receptor in CCRF-CEM human ALL cells: correlation to apoptosis.
The American journal of physiology.
1997 Sep; 273(3 Pt 1):E571-83. doi:
10.1152/ajpendo.1997.273.3.e571
. [PMID: 9316448] - T A Oelschlaeger, B D Tall. Invasion of cultured human epithelial cells by Klebsiella pneumoniae isolated from the urinary tract.
Infection and immunity.
1997 Jul; 65(7):2950-8. doi:
10.1128/iai.65.7.2950-2958.1997
. [PMID: 9199471] - E A Wiemer, T Wenzel, T J Deerinck, M H Ellisman, S Subramani. Visualization of the peroxisomal compartment in living mammalian cells: dynamic behavior and association with microtubules.
The Journal of cell biology.
1997 Jan; 136(1):71-80. doi:
10.1083/jcb.136.1.71
. [PMID: 9008704] - G H Degen, M M Gerber, S Obrecht-Pflumio, G Dirheimer. Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures.
Archives of toxicology.
1997; 71(6):365-71. doi:
10.1007/s002040050400
. [PMID: 9195018] - T Enomoto. Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade.
Cell structure and function.
1996 Oct; 21(5):317-26. doi:
10.1247/csf.21.317
. [PMID: 9118237] - F G Blankenberg, R W Storrs, L Naumovski, T Goralski, D Spielman. Detection of apoptotic cell death by proton nuclear magnetic resonance spectroscopy.
Blood.
1996 Mar; 87(5):1951-6. doi:
NULL
. [PMID: 8634443] - R Pagan, I Martín, A Alonso, M Llobera, S Vilaró. Vimentin filaments follow the preexisting cytokeratin network during epithelial-mesenchymal transition of cultured neonatal rat hepatocytes.
Experimental cell research.
1996 Feb; 222(2):333-44. doi:
10.1006/excr.1996.0043
. [PMID: 8598222] - A Ferrer-Martinez, A Felipe, B Nicholson, J Casado, M Pastor-Anglada, J McGivan. Induction of the high-affinity Na(+)-dependent glutamate transport system XAG- by hypertonic stress in the renal epithelial cell line NBL-1.
The Biochemical journal.
1995 Sep; 310 ( Pt 2)(?):689-92. doi:
10.1042/bj3100689
. [PMID: 7654212] - V B Dugina, A Y Alexandrova, K Lane, E Bulanova, J M Vasiliev. The role of the microtubular system in the cell response to HGF/SF.
Journal of cell science.
1995 Apr; 108 ( Pt 4)(?):1659-67. doi:
10.1242/jcs.108.4.1659
. [PMID: 7542257] - B Wójciak-Stothard, A S Curtis, W Monaghan, M McGrath, I Sommer, C D Wilkinson. Role of the cytoskeleton in the reaction of fibroblasts to multiple grooved substrata.
Cell motility and the cytoskeleton.
1995; 31(2):147-58. doi:
10.1002/cm.970310207
. [PMID: 7553908] - C J McGinn, E M Miller, M J Lindstrom, K A Kunugi, P G Johnston, T J Kinsella. The role of cell cycle redistribution in radiosensitization: implications regarding the mechanism of fluorodeoxyuridine radiosensitization.
International journal of radiation oncology, biology, physics.
1994 Nov; 30(4):851-9. doi:
10.1016/0360-3016(94)90360-3
. [PMID: 7960987] - M R Soma, R Baetta, S Bergamaschi, M R De Renzis, C Davegna, F Battaini, R Fumagalli, S Govoni. PKC activity in rat C6 glioma cells: changes associated with cell cycle and simvastatin treatment.
Biochemical and biophysical research communications.
1994 Apr; 200(2):1143-9. doi:
10.1006/bbrc.1994.1570
. [PMID: 8179595] - H J Yoo, B K Vig. Chromosomes lacking kinetochore proteins: their meta-anaphase location suggests potential malsegregation.
Mutagenesis.
1993 Nov; 8(6):553-60. doi:
10.1093/mutage/8.6.553
. [PMID: 8133785] - G J Leitch, Q He, S Wallace, G S Visvesvara. Inhibition of the spore polar filament extrusion of the microsporidium, Encephalitozoon hellem, isolated from an AIDS patient.
The Journal of eukaryotic microbiology.
1993 Nov; 40(6):711-7. doi:
10.1111/j.1550-7408.1993.tb04463.x
. [PMID: 8292991] - C R Simerly, N B Hecht, E Goldberg, G Schatten. Tracing the incorporation of the sperm tail in the mouse zygote and early embryo using an anti-testicular alpha-tubulin antibody.
Developmental biology.
1993 Aug; 158(2):536-48. doi:
10.1006/dbio.1993.1211
. [PMID: 8344468] - I H Fentie, F J Roisen. The effects of cytoskeletal altering agents on the surface topography of GM1 in neuro-2A neuroblastoma cell membranes.
Journal of neurocytology.
1993 Jun; 22(6):498-506. doi:
10.1007/bf01181569
. [PMID: 8102177] - F Mitsuyama, T Kanno. Localization of Ca(2+)-calmodulin to the kinetochore of C6 glioma cells: an investigation of the anti-tumour effects of calmodulin antagonists in the treatment of brain tumours.
Neurological research.
1993 Apr; 15(2):131-5. doi:
10.1080/01616412.1993.11740123
. [PMID: 8099208] - C Soler, A Felipe, F J Casado, J D McGivan, M Pastor-Anglada. Hyperosmolarity leads to an increase in derepressed system A activity in the renal epithelial cell line NBL-1.
The Biochemical journal.
1993 Feb; 289 ( Pt 3)(?):653-8. doi:
10.1042/bj2890653
. [PMID: 8435065] - J Vicar, L Klusáková, V Simánek. Changes in colchicine and demecolcine content during vegetation period of colchicum autumnale L.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae.
1993; 136(?):5-7. doi:
"
. [PMID: 7887202] - M E Phillips, A Taylor. Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules.
The Journal of physiology.
1992 Oct; 456(?):591-608. doi:
10.1113/jphysiol.1992.sp019355
. [PMID: 1338105] - E Balint, M Cheng, B Rupp, P M Grimley, A Aszalos. Cytoskeletal modulation of plasma membrane events induced by interferon-alpha.
Journal of interferon research.
1992 Aug; 12(4):249-55. doi:
10.1089/jir.1992.12.249
. [PMID: 1331257] - J Hagmann, D Dagan, M M Burger. Release of endosomal content induced by plasma membrane tension: video image intensification time lapse analysis.
Experimental cell research.
1992 Feb; 198(2):298-304. doi:
10.1016/0014-4827(92)90383-j
. [PMID: 1345903] - I Nishiyama, T Fujii. Laminin-induced process outgrowth from isolated fetal rat C-cells.
Experimental cell research.
1992 Feb; 198(2):214-20. doi:
10.1016/0014-4827(92)90373-g
. [PMID: 1729130] - J G Steele, B A Dalton, P A Underwood, G J Smith. Differences in adhesion to tissue culture plastic of clonally related transformed and control sublines from an epithelial cell strain.
Journal of cell science.
1991 Sep; 100 ( Pt 1)(?):195-203. doi:
10.1242/jcs.100.1.195
. [PMID: 1724449] - K Tsuji, A Ueno, T Ide. Dual effect of protein kinase C on the induction of DNA synthesis by colcemid in G0-arrested human diploid fibroblasts.
Cell structure and function.
1991 Feb; 16(1):73-80. doi:
10.1247/csf.16.73
. [PMID: 2032310] - J Kiuru, L Viinikka, G Myllylä, K Pesonen, J Perheentupa. Cytoskeleton-dependent release of human platelet epidermal growth factor.
Life sciences.
1991; 49(26):1997-2003. doi:
10.1016/0024-3205(91)90642-o
. [PMID: 1749310] - R J Ko, W Y Li, R T Koda. Determination of the antimitotic agents N-desacetylcolchicine, demecolcine and colchicine in serum and urine.
Journal of chromatography.
1990 Feb; 525(2):411-8. doi:
10.1016/s0378-4347(00)83417-9
. [PMID: 2329167] - M Scanlon, S M Laster, J G Wood, L R Gooding. Cytolysis by tumor necrosis factor is preceded by a rapid and specific dissolution of microfilaments.
Proceedings of the National Academy of Sciences of the United States of America.
1989 Jan; 86(1):182-6. doi:
10.1073/pnas.86.1.182
. [PMID: 2643096] - L Lewis-Alberti. Altering the vector of polarity of BHK syncytia changes their motile behavior.
Cell motility and the cytoskeleton.
1989; 14(2):187-93. doi:
10.1002/cm.970140205
. [PMID: 2611890] - T Nishiyama, N Tominaga, K Nakajima, T Hayashi. Quantitative evaluation of the factors affecting the process of fibroblast-mediated collagen gel contraction by separating the process into three phases.
Collagen and related research.
1988 May; 8(3):259-73. doi:
10.1016/s0174-173x(88)80045-1
. [PMID: 3396309] - C Sellitto, R Kuriyama. Distribution of pericentriolar material in multipolar spindles induced by colcemid treatment in Chinese hamster ovary cells.
Journal of cell science.
1988 Jan; 89 ( Pt 1)(?):57-65. doi:
10.1242/jcs.89.1.57
. [PMID: 3047157] - M Valentino, M Governa, R Fiorini, G Curatola. Changes of membrane fluidity in chemotactic peptide-stimulated polymorphonuclear leukocytes.
Biochemical and biophysical research communications.
1986 Dec; 141(3):1151-6. doi:
10.1016/s0006-291x(86)80164-4
. [PMID: 3814118] - A Iu Sungurov, T M Sharlaeva. [Modification of the interphase death of thymocytes by using colcemid].
Radiobiologiia.
1986 Nov; 26(6):805-9. doi:
NULL
. [PMID: 3809417] - R S Prather, N L First. Effect of cytochalasin B and demecolcine on freeze-thaw survival of murine embryos in vitro.
The Journal of experimental zoology.
1986 Jul; 239(1):37-40. doi:
10.1002/jez.1402390106
. [PMID: 3746227] - G Schatten, C Simerly, H Schatten. Microtubule configurations during fertilization, mitosis, and early development in the mouse and the requirement for egg microtubule-mediated motility during mammalian fertilization.
Proceedings of the National Academy of Sciences of the United States of America.
1985 Jun; 82(12):4152-6. doi:
10.1073/pnas.82.12.4152
. [PMID: 3889922] - A Aszalos, G C Yang, M M Gottesman. Depolymerization of microtubules increases the motional freedom of molecular probes in cellular plasma membranes.
The Journal of cell biology.
1985 May; 100(5):1357-62. doi:
10.1083/jcb.100.5.1357
. [PMID: 3988793] - D L Gard, M W Kirschner. A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line.
The Journal of cell biology.
1985 Mar; 100(3):764-74. doi:
10.1083/jcb.100.3.764
. [PMID: 2857724] - L V Domnina, J A Rovensky, J M Vasiliev, I M Gelfand. Effect of microtubule-destroying drugs on the spreading and shape of cultured epithelial cells.
Journal of cell science.
1985 Mar; 74(?):267-82. doi:
10.1242/jcs.74.1.267
. [PMID: 3897252] - I V Sandoval, J S Bonifacino, R D Klausner, M Henkart, J Wehland. Role of microtubules in the organization and localization of the Golgi apparatus.
The Journal of cell biology.
1984 Jul; 99(1 Pt 2):113s-118s. doi:
10.1083/jcb.99.1.113s
. [PMID: 6146626] - J A Connolly. Role of the cytoskeleton in the formation, stabilization, and removal of acetylcholine receptor clusters in cultured muscle cells.
The Journal of cell biology.
1984 Jul; 99(1 Pt 1):148-54. doi:
10.1083/jcb.99.1.148
. [PMID: 6539781] - I B Roninson, H T Abelson, D E Housman, N Howell, A Varshavsky. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells.
Nature.
1984 Jun; 309(5969):626-8. doi:
10.1038/309626a0
. [PMID: 6728022] - R van Wijk, A M Otto, L Jimenez de Asua. Effect of serum and growth factors on heat sensitivity in Swiss mouse 3T3 cells.
Journal of cellular physiology.
1984 May; 119(2):155-62. doi:
10.1002/jcp.1041190203
. [PMID: 6371027] - D A Spero, F J Roisen. Ganglioside-mediated enhancement of the cytoskeletal organization and activity in neuro-2a neuroblastoma cells.
Brain research.
1984 Mar; 315(1):37-48. doi:
10.1016/0165-3806(84)90075-0
. [PMID: 6722580] - V Ia Karmysheva, N V Ovsiannikova, T A Ivannikova. [Inhibiting effect of colcemid on the development of cytopathic changes due to the Sindbis virus].
Voprosy virusologii.
1984 Mar; 29(2):201-6. doi:
NULL
. [PMID: 6328766] - J E Celis, J V Small, P M Larsen, S J Fey, J De Mey, A Celis. Intermediate filaments in monkey kidney TC7 cells: focal centers and interrelationship with other cytoskeletal systems.
Proceedings of the National Academy of Sciences of the United States of America.
1984 Feb; 81(4):1117-21. doi:
10.1073/pnas.81.4.1117
. [PMID: 6199791] - C Hartmann, A Golde, J Villaudy, I Park, G Vernet, V Krsmanovic. Study of pp60v-src protein kinase activity in synchronized chicken embryo fibroblasts infected with Rous sarcoma virus.
Experimental cell research.
1984 Jan; 150(1):242-9. doi:
10.1016/0014-4827(84)90719-5
. [PMID: 6319162] - F J Roisen, D A Spero, S J Held, G Yorke, H Bartfeld. Ganglioside induced surface activity and neurite formation of Neuro-2a neuroblastoma cells.
Advances in experimental medicine and biology.
1984; 174(?):499-511. doi:
10.1007/978-1-4684-1200-0_42
. [PMID: 6741743] - L S Chai, A A Sandberg. Effect of divalent cations and chelators on metaphase to telophase progression and nuclear envelope formation in Chinese hamster cells.
Cell calcium.
1983 Oct; 4(4):237-52. doi:
10.1016/0143-4160(83)90002-7
. [PMID: 6416677] - A V Khomenko, G P Pinaev. [Effect of cytoskeleton-disrupting on the redistribution of the surface receptors of cultured cells].
Tsitologiia.
1983 Oct; 25(10):1137-44. doi:
NULL
. [PMID: 6686355] - A Onfelt. Spindle disturbances in mammalian cells. I. Changes in the quantity of free sulfhydryl groups in relation to survival and C-mitosis in V79 Chinese hamster cells after treatment with colcemid, diamide, carbaryl and methyl mercury.
Chemico-biological interactions.
1983 Sep; 46(2):201-17. doi:
10.1016/0009-2797(83)90029-7
. [PMID: 6414728] - K V Rote, M Rechsteiner. Degradation of microinjected proteins: effects of lysosomotropic agents and inhibitors of autophagy.
Journal of cellular physiology.
1983 Jul; 116(1):103-10. doi:
10.1002/jcp.1041160116
. [PMID: 6853609] - R F Brooks, F N Richmond. Microtubule-organizing centres during the cell cycle of 3T3 cells.
Journal of cell science.
1983 May; 61(?):231-45. doi:
10.1242/jcs.61.1.231
. [PMID: 6350330]