Epimedin A (BioDeep_00000395803)

Main id: BioDeep_00000230973

 

PANOMIX_OTCML-2023


代谢物信息卡片


3-(((2S,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C39H50O20 (838.28953)
中文名称: 淫羊霍定 A, 朝藿定 A, 朝藿定A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)=C(C/C=C(\C)/C)C2OC(C3C=CC(OC)=CC=3)=C(O[C@H]3[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)C=2C(O)=C1
InChI: InChI=1S/C39H50O20/c1-14(2)5-10-18-20(54-37-31(50)28(47)25(44)21(12-40)55-37)11-19(42)23-27(46)35(33(57-34(18)23)16-6-8-17(52-4)9-7-16)58-39-36(30(49)24(43)15(3)53-39)59-38-32(51)29(48)26(45)22(13-41)56-38/h5-9,11,15,21-22,24-26,28-32,36-45,47-51H,10,12-13H2,1-4H3/t15-,21+,22+,24-,25+,26+,28-,29-,30+,31+,32+,36+,37+,38-,39-/m0/s1

描述信息

3-(((2S,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one is a natural product found in Epimedium sagittatum with data available.
Epimedin A is a natural compound extracted from Herba Epimedii.
Epimedin A is a natural compound extracted from Herba Epimedii.

同义名列表

3 个代谢物同义名

Epimedin A; 3-(((2S,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; anhydroicaritin 3-glucosyl-1-3-rhamnoside-7-glucoside



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ying Liu, Yanan Bi, Lijuan Chai, Lei Song, Juyang Huang, Qin Wang, Yunzhang Li, Kun Zhou. Development of epimedin A complex drugs for treating the osteoporosis. Journal of materials science. Materials in medicine. 2021 Jan; 32(1):17. doi: 10.1007/s10856-020-06472-9. [PMID: 33506368]
  • Yuping Shen, Yi Lu, Jing Gao, Yeting Zhu, Man Wang, Shunli Jing, Lili Xu, Huan Yang, Xiaobin Jia. Efficient preparation of rare Sagittatoside A from epimedin A, by recyclable aqueous organic two-phase enzymatic hydrolysis. Natural product research. 2019 Nov; 33(21):3095-3102. doi: 10.1080/14786419.2018.1519820. [PMID: 30470129]
  • Wei Xiang, Tong-Chuan Suo, Hua Yu, An-Ping Li, Shou-Qing Zhang, Chun-Hua Wang, Yan Zhu, Zheng Li. A new strategy for choosing 'Q-markers' via network pharmacology, application to the quality control of a Chinese medical preparation. Journal of food and drug analysis. 2018 04; 26(2):858-868. doi: 10.1016/j.jfda.2017.10.003. [PMID: 29567258]
  • Yani Guo, Xiufeng Wang, Jing Gao. Simultaneous Preparation and Comparison of the Osteogenic Effects of Epimedins A - C and Icariin from Epimedium brevicornu. Chemistry & biodiversity. 2018 Apr; 15(4):e1700578. doi: 10.1002/cbdv.201700578. [PMID: 29451707]
  • Da Hye Kim, Hyun Ah Jung, Hee Sook Sohn, Jin Woong Kim, Jae Sue Choi. Potential of Icariin Metabolites from Epimedium koreanum Nakai as Antidiabetic Therapeutic Agents. Molecules (Basel, Switzerland). 2017 Jun; 22(6):. doi: 10.3390/molecules22060986. [PMID: 28608833]
  • Junqian Pan, Baolin Guo. Effects of Light Intensity on the Growth, Photosynthetic Characteristics, and Flavonoid Content of Epimedium pseudowushanense B.L.Guo. Molecules (Basel, Switzerland). 2016 Nov; 21(11):. doi: 10.3390/molecules21111475. [PMID: 27827937]
  • Shun-Jun Xu, Ya-Ling Zhu, Jie-Jing Yu, Shuai Sun, Yi-Juan Xu, Liu Yang. [Pharmacokinetics of epimedin A, B, C and icariin of Chuankezhi injection in rat]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Jan; 41(1):129-133. doi: 10.4268/cjcmm20160125. [PMID: 28845654]
  • Jianjun Chen, Yanqin Xu, Guoyan Wei, Sihong Liao, Yanjun Zhang, Wenjun Huang, Ling Yuan, Ying Wang. Chemotypic and genetic diversity in Epimedium sagittatum from different geographical regions of China. Phytochemistry. 2015 Aug; 116(?):180-187. doi: 10.1016/j.phytochem.2015.04.005. [PMID: 25936868]
  • Yang Zhan, Ying-Jie Wei, E Sun, Feng-Juan Xu, Xiao-Bin Jia. [Two-dimensional zebrafish model combined with hyphenated chromatographic techniques for evaluation anti-osteoporosis activity of epimendin A and its metabolite baohuoside I]. Yao xue xue bao = Acta pharmaceutica Sinica. 2014 Jun; 49(6):932-7. doi: ". [PMID: 25212043]
  • Yan Chen, Ying Wang, Jing Zhou, Xia Gao, Ding Qu, Congyan Liu. Study on the mechanism of intestinal absorption of epimedins a, B and C in the Caco-2 cell model. Molecules (Basel, Switzerland). 2014 Jan; 19(1):686-98. doi: 10.3390/molecules19010686. [PMID: 24402200]
  • Yanqin Xu, Zuozhou Li, Ling Yuan, Xuejun Zhang, Dayan Lu, Hongwen Huang, Ying Wang. Variation of epimedins A - C and icariin in ten representative populations of Epimedium brevicornu Maxim., and implications for utilization. Chemistry & biodiversity. 2013 Apr; 10(4):711-21. doi: 10.1002/cbdv.201100424. [PMID: 23576357]
  • Qiong Liang, Guoyan Wei, Jianjun Chen, Ying Wang, Hongwen Huang. Variation of medicinal components in a unique geographical accession of horny goat weed Epimedium sagittatum Maxim. (Berberidaceae). Molecules (Basel, Switzerland). 2012 Nov; 17(11):13345-56. doi: 10.3390/molecules171113345. [PMID: 23138537]
  • M Nurul Islam, Unyong Kim, Dong-Hyun Kim, Mi-Sook Dong, Hye Hyun Yoo. High-performance liquid chromatography-based multivariate analysis to predict the estrogenic activity of an Epimedium koreanum extract. Bioscience, biotechnology, and biochemistry. 2012; 76(5):923-7. doi: 10.1271/bbb.110922. [PMID: 22738960]
  • Chuanyi Wang, Jinyi Cao, Yun Liang, Wenhua Huang, Baolin Guo. [Sampling in quality control of medicinal materials-A case of Epimedium]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Apr; 34(8):1011-4. doi: ". [PMID: 19639790]
  • Hua-Feng Zhang, Tian-Shun Yang, Zuo-Zhou Li, Ying Wang. Simultaneous extraction of epimedin A, B, C and icariin from Herba Epimedii by ultrasonic technique. Ultrasonics sonochemistry. 2008 Apr; 15(4):376-385. doi: 10.1016/j.ultsonch.2007.09.002. [PMID: 17951093]
  • Li-Kuan Pei, Wen-Hua Huang, Tian-Gu He, Bao-Lin Guo. [Systematic studies on quality of main species of Herba epimedii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Nov; 32(21):2217-22. doi: ". [PMID: 18309658]