Hesperidinmethylchalcone (BioDeep_00000395624)

Main id: BioDeep_00000231176

 

PANOMIX_OTCML-2023


代谢物信息卡片


(E)-3-(3-Hydroxy-4-methoxyphenyl)-1-(2-hydroxy-6-methoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one

化学式: C29H36O15 (624.2054106)
中文名称: 橙皮苷甲基查尔酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C(C(=C3)OC)C(=O)C=CC4=CC(=C(C=C4)OC)O)O)O)O)O)O)O)O
InChI: InChI=1S/C29H36O15/c1-12-22(33)24(35)26(37)28(42-12)41-11-20-23(34)25(36)27(38)29(44-20)43-14-9-17(32)21(19(10-14)40-3)15(30)6-4-13-5-7-18(39-2)16(31)8-13/h4-10,12,20,22-29,31-38H,11H2,1-3H3/b6-4+/t12-,20+,22-,23+,24+,25-,26+,27+,28+,29+/m0/s1

描述信息

Hesperidin methylchalcone is a natural product found in Myrtus communis with data available.
Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone inhibits inflammation and pain. Hesperidin methylchalcone exhibits vasoprotective activity[1].

同义名列表

21 个代谢物同义名

(E)-3-(3-Hydroxy-4-methoxyphenyl)-1-(2-hydroxy-6-methoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one; (E)-3-(3-hydroxy-4-methoxy-phenyl)-1-[2-hydroxy-6-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-phenyl]prop-2-en-1-one; 2-Propen-1-one, 1-[4-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-, (2E)-; 2-Propen-1-one, 1-(4-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxy-6-methoxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-, (2E)-; 2-PROPEN-1-ONE,1-(4-((6-O-(6-DEOXY-ALFA-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2-HYDROXY-6-METHOXYPHENYL)-3-(3-HYDROXY-4-METHOXYPHENYL)-, (E)-; (E)-1-(4-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2-HYDROXY-6-METHOXYPHENYL)-3-(3-HYDROXY-4-METHOXYPHENYL)-2-PROPEN-1-ONE; (E)-1-(4-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxy-6-methoxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one; (E)-1-[4-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one; 1-(4-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxy-6-methoxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one; Chalcone, 2,3,4-trihydroxy-4,6-dimethoxy-, 4-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside); HESPERIDIN METHYL CHALCONE [WHO-DD]; HESPERIDIN METHYL CHALCONE [VANDF]; HESPERIDIN METHYL CHALCONE [INCI]; Hesperidin methyl chalcone; hesperidine methylchalcone; hesperidin methyl chalone; Hesperidin methylchalcone; Hesperidinmethylchalcone; UNII-4T2GVA922X; 4T2GVA922X; EYELISS



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Prithiviraj Swasthikka Roshni, Rajaiah Alexpandi, Gurusamy Abirami, Ravindran Durgadevi, Yurong Cai, Ponnuchamy Kumar, Arumugam Veera Ravi. Hesperidin methyl chalcone, a citrus flavonoid, inhibits Aeromonas hydrophila infection mediated by quorum sensing. Microbial pathogenesis. 2023 Apr; 177(?):106029. doi: 10.1016/j.micpath.2023.106029. [PMID: 36775212]
  • Songsong Liu, Kang Liu, Yuwei Wang, Chou Wu, Yang Xiao, Siqi Liu, Jingsu Yu, Zeqiang Ma, Huanjie Liang, Xiangling Li, Yixing Li, Lei Zhou. Hesperidin methyl chalcone ameliorates lipid metabolic disorders by activating lipase activity and increasing energy metabolism. Biochimica et biophysica acta. Molecular basis of disease. 2023 02; 1869(2):166620. doi: 10.1016/j.bbadis.2022.166620. [PMID: 36494040]
  • Nayara A Artero, Marília F Manchope, Thacyana T Carvalho, Telma Saraiva-Santos, Mariana M Bertozzi, Jessica A Carneiro, Anelise Franciosi, Amanda M Dionisio, Tiago H Zaninelli, Victor Fattori, Camila R Ferraz, Maiara Piva, Sandra S Mizokami, Doumit Camilios-Neto, Rubia Casagrande, Waldiceu A Verri. Hesperidin Methyl Chalcone Reduces the Arthritis Caused by TiO2 in Mice: Targeting Inflammation, Oxidative Stress, Cytokine Production, and Nociceptor Sensory Neuron Activation. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020872. [PMID: 36677929]
  • Nicolas Monjotin, Guillaume Tenca. Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells. Microvascular research. 2022 01; 139(?):104274. doi: 10.1016/j.mvr.2021.104274. [PMID: 34717967]
  • Stavros K Kakkos, Eliete Bouskela, Arkadiusz Jawien, Andrew N Nicolaides. New data on chronic venous disease: a new place for Cyclo 3® Fort. International angiology : a journal of the International Union of Angiology. 2018 Feb; 37(1):85-92. doi: 10.23736/s0392-9590.17.03935-9. [PMID: 29063748]
  • Arkadiusz Jawien, Eliete Bouskela, François A Allaert, Andrew N Nicolaïdes. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. International angiology : a journal of the International Union of Angiology. 2017 Feb; 36(1):31-41. doi: 10.23736/s0392-9590.16.03788-3. [PMID: 28124877]
  • Renata M Martinez, Felipe A Pinho-Ribeiro, Vinicius S Steffen, Carla V Caviglione, Danilo Pala, Marcela M Baracat, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrande. Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2016 Apr; 15(4):554-63. doi: 10.1039/c5pp00467e. [PMID: 27021784]
  • François-A Allaert. Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease. International angiology : a journal of the International Union of Angiology. 2016 Apr; 35(2):111-6. doi: ". [PMID: 26928296]
  • Jerzy Chudek, Jacek Mikosiński, Andrzej Kobielski, Artur Hering, Tomasz Aleksiejew-Kleszczyński, Jacek Umiński, Tomasz Zubilewicz, Wojciech Kobusiewicz, Marek Iłżecki, Andrzej Wojtak, Janusz Stec, Tomasz Urbanek. Patients' satisfaction with therapy methods of advanced chronic venous disease. International angiology : a journal of the International Union of Angiology. 2016 Feb; 35(1):98-107. doi: ". [PMID: 26406967]
  • Renata M Martinez, Felipe A Pinho-Ribeiro, Vinicius S Steffen, Carla V Caviglione, Josiane A Vignoli, Marcela M Baracat, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrande. Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage. Journal of photochemistry and photobiology. B, Biology. 2015 Jul; 148(?):145-153. doi: 10.1016/j.jphotobiol.2015.03.030. [PMID: 25916506]
  • F A Allaert, C Hugue, M Cazaubon, J M Renaudin, T Clavel, P Escourrou. Correlation between improvement in functional signs and plethysmographic parameters during venoactive treatment (Cyclo 3 Fort). International angiology : a journal of the International Union of Angiology. 2011 Jun; 30(3):272-7. doi: ". [PMID: 21617611]
  • J J Guex, L Avril, E Enrici, E Enriquez, C Lis, C Taïeb. Quality of life improvement in Latin American patients suffering from chronic venous disorder using a combination of Ruscus aculeatus and hesperidin methyl-chalcone and ascorbic acid (quality study). International angiology : a journal of the International Union of Angiology. 2010 Dec; 29(6):525-32. doi: ". [PMID: 21173734]
  • G R Aguilar Peralta, J Arévalo Gardoqui, F J Llamas Macías, V H Navarro Ceja, S A Mendoza Cisneros, C G Martínez Macías. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. International angiology : a journal of the International Union of Angiology. 2007 Dec; 26(4):378-84. doi: ". [PMID: 18091707]
  • N Bouaziz, C Michiels, D Janssens, N Berna, F Eliaers, E Panconi, J Remacle. Effect of Ruscus extract and hesperidin methylchalcone on hypoxia-induced activation of endothelial cells. International angiology : a journal of the International Union of Angiology. 1999 Dec; 18(4):306-12. doi: ". [PMID: 10811519]
  • E Bouskela, F Z Cyrino, G Marcelon. Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch. Journal of cardiovascular pharmacology. 1993 Aug; 22(2):225-30. doi: 10.1097/00005344-199308000-00009. [PMID: 7692162]
  • J L Chanal, H Cousse, M T Sicart, B Bonnaud, R Marignan. Absorption and elimination of (14C) hesperidin methylchalcone in the rat. European journal of drug metabolism and pharmacokinetics. 1981; 6(3):171-7. doi: 10.1007/bf03189486. [PMID: 7308237]