Sappanone_A (BioDeep_00000395501)

   

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 3-((3,4-dihydroxyphenyl)methylene)-2,3-dihydro-7-hydroxy-, (3E)-

化学式: C16H12O5 (284.0685)
中文名称: 苏木酮A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=CC2=CC(=C(C=C2)O)O)C(=O)C3=C(O1)C=C(C=C3)O
InChI: InChI=1S/C16H12O5/c17-11-2-3-12-15(7-11)21-8-10(16(12)20)5-9-1-4-13(18)14(19)6-9/h1-7,17-19H,8H2/b10-5+

描述信息

Sappanone A is a natural product found in Biancaea decapetala, Biancaea sappan, and Caesalpinia pulcherrima with data available.
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma[1].

同义名列表

10 个代谢物同义名

4H-1-Benzopyran-4-one, 3-((3,4-dihydroxyphenyl)methylene)-2,3-dihydro-7-hydroxy-, (3E)-; 4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-, (3E)-; (3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one; (3E)-3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one; (3E)-3-((3,4-Dihydroxyphenyl)methylene)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3-((3,4-dihydroxyphenyl)methylene)-2,3-dihydro-7-hydroxy-; 3-((3,4-Dihydroxyphenyl)methylene)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one; (3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxychromen-4-one; 3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one; Sappanone A



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • You-Zhi Wang, Yu-Long Wang, Hao-Jie Che, Yi-He Jia, Hui-Fang Wang, Lin-Fei Zuo, Kan Yang, Ting-Ting Li, Jin-Xin Wang. Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L. Journal of ethnopharmacology. 2023 Mar; 304(?):116020. doi: 10.1016/j.jep.2022.116020. [PMID: 36529254]
  • Meihua Wang, Zhilin Chen, Lei Yang, Lei Ding. Sappanone A Protects Against Inflammation, Oxidative Stress and Apoptosis in Cerebral Ischemia-Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress. Inflammation. 2021 Jun; 44(3):934-945. doi: 10.1007/s10753-020-01388-6. [PMID: 33411101]
  • Jingwei Zhao, An Zhu, Yuqing Sun, Wenjing Zhang, Tao Zhang, Yadong Gao, Danping Shan, Shuo Wang, Guojun Li, Kewu Zeng, Qi Wang. Beneficial effects of sappanone A on lifespan and thermotolerance in Caenorhabditis elegans. European journal of pharmacology. 2020 Dec; 888(?):173558. doi: 10.1016/j.ejphar.2020.173558. [PMID: 32941928]
  • Le Duc Dat, Bing Tian Zhao, Nguyen Duc Hung, Jeong Hyung Lee, Byung Sun Min, Mi Hee Woo. Lignan derivatives from Selaginella tamariscina and their nitric oxide inhibitory effects in LPS-stimulated RAW 264.7 cells. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):524-529. doi: 10.1016/j.bmcl.2016.12.028. [PMID: 28038832]
  • Lin Kang, Huanfen Zhao, Chen Chen, Xiuzhi Zhang, Mingtang Xu, Huijun Duan. Sappanone A protects mice against cisplatin-induced kidney injury. International immunopharmacology. 2016 Sep; 38(?):246-51. doi: 10.1016/j.intimp.2016.05.019. [PMID: 27318179]
  • Te-Sheng Chang, Shih-Yu Chao, Hsiou-Yu Ding. Melanogenesis inhibition by homoisoflavavone sappanone A from Caesalpinia sappan. International journal of molecular sciences. 2012; 13(8):10359-10367. doi: 10.3390/ijms130810359. [PMID: 22949866]