guvacine (BioDeep_00000395450)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C6H10ClNO2 (163.040003)
中文名称: 去甲槟榔次碱, 去甲槟榔次碱盐酸盐, 盐酸去甲槟榔次碱, 四氢烟酸盐酸盐, 盐酸四氢烟酸
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 6.12%
分子结构信息
SMILES: C1C=C(CNC1)C(=O)O.Cl
InChI: 1H
描述信息
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).
同义名列表
15 个代谢物同义名
guvacine; 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, hydrochloride salt; 1,2,5,6-Tetrahydro-pyridine-3-carboxylic acid hydrochloride; 1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride; 1,2,3,6-Tetrahydropyridine-5-carboxylic acid hydrochloride; 1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride; 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride; 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HCL; Guvacine hydrochloride, >=97\\% (NMR), solid; GUVACINE HYDROCHLORIDE >96\\% \ GABA UPTAK; FGNUNVVTHHKDAM-UHFFFAOYSA-N; Guvacine hydrochloride; guvacine hydrobromide; Guvacine HCl; Tox21_500571
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pangzhen Zhang, Nathaniel Quan En Chua, Simon Dang, Ashleigh Davis, Kah Wee Chong, Stephen S Prime, Nicola Cirillo. Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents-Does Fibroblast Senescence Play a Role?.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031637. [PMID: 35163557] - Jiao Wu, He Zhang, Shijie Wang, Langxing Yuan, Paul Grünhofer, Lukas Schreiber, Yinglang Wan. Tissue-specific and maturity-dependent distribution of pyridine alkaloids in Areca triandra.
Journal of plant research.
2019 Jul; 132(4):531-540. doi:
10.1007/s10265-019-01115-9. [PMID: 31127431] - Kinga Sałat, Adrian Podkowa, Natalia Malikowska, Felix Kern, Jörg Pabel, Ewelina Wojcieszak, Katarzyna Kulig, Klaus T Wanner, Beata Strach, Elżbieta Wyska. Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties.
Neuropharmacology.
2017 02; 113(Pt A):331-342. doi:
10.1016/j.neuropharm.2016.10.019. [PMID: 27771379] - Adrian A Franke, Xingnan Li, Jennifer F Lai. Pilot study of the pharmacokinetics of betel nut and betel quid biomarkers in saliva, urine, and hair of betel consumers.
Drug testing and analysis.
2016 Oct; 8(10):1095-1099. doi:
10.1002/dta.1912. [PMID: 26619803] - Hongli Yu, Lijuan Tang, Hao Wu, Kuilong Wang, Baochang Cai, Xingde Zhang, Chengchao Zhang, Yunzhi Yin. Determination of contents of four alkaloids in Pericarpium arecae by quantitative analysis of multi-components by single-marker.
Pakistan journal of pharmaceutical sciences.
2016 Jul; 29(4):1269-74. doi:
". [PMID: 27393441] - Rune Nørgaard Rasmussen, Candela Lagunas, Jakob Plum, René Holm, Carsten Uhd Nielsen. Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Jan; 82(?):138-46. doi:
10.1016/j.ejps.2015.11.020. [PMID: 26631583] - Jingsong Yuan, Dajian Yang, Yonghong Liang, Wenping Gao, Zhipeng Ren, Wei Zeng, Baorong Wang, Jian Han, Dean Guo. Alkaloids from areca (betel) nuts and their effects on human sperm motility in vitro.
Journal of food science.
2012 Apr; 77(4):T70-8. doi:
10.1111/j.1750-3841.2012.02653.x. [PMID: 22515256] - L J Knutsen, K E Andersen, J Lau, B F Lundt, R F Henry, H E Morton, L Naerum, H Petersen, H Stephensen, P D Suzdak, M D Swedberg, C Thomsen, P O Sørensen. Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
Journal of medicinal chemistry.
1999 Sep; 42(18):3447-62. doi:
10.1021/jm981027k. [PMID: 10479278] - C K Wang, C H Peng. The mutagenicities of alkaloids and N-nitrosoguvacoline from betel quid.
Mutation research.
1996 Aug; 360(3):165-71. doi:
10.1016/s0165-1161(96)90013-8. [PMID: 8692215] - E Falch, B S Meldrum, P Krogsgaard-Larsen. GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid.
Drug design and delivery.
1987 Sep; 2(1):9-21. doi:
. [PMID: 3509345] - D Lodge, G A Johnston, D R Curtis, S J Brand. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system.
Brain research.
1977 Nov; 136(3):513-22. doi:
10.1016/0006-8993(77)90075-0. [PMID: 922499]