PD173074 (BioDeep_00000391049)
代谢物信息卡片
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
化学式: C28H41N7O3 (523.3270716000001)
中文名称: PD173074
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCCCN=c1ncc2cc(-c3cc(OC)cc(OC)c3)c(N=C(O)NC(C)(C)C)nc2[nH]1
InChI: InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:63448
- PubChem: 1401
- ChEMBL: CHEMBL189584
- CAS: 219580-11-7
- PMhub: MS000241229
- RefMet: PD173074
分类词条
相关代谢途径
Reactome(2)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Sarah Justesen, Kirsten V Haugegaard, Jacob B Hansen, Harald S Hansen, Birgitte Andersen. The autocrine role of FGF21 in cultured adipocytes.
The Biochemical journal.
2020 07; 477(13):2477-2487. doi:
10.1042/bcj20200220. [PMID: 32648929] - Satoshi Takasugi, Miho Shioyama, Masami Kitade, Masashi Nagata, Taketo Yamaji. Involvement of estrogen in phosphorus-induced nephrocalcinosis through fibroblast growth factor 23.
Scientific reports.
2020 03; 10(1):4864. doi:
10.1038/s41598-020-61858-7. [PMID: 32184468] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Brian Czaya, Wacharee Seeherunvong, Saurav Singh, Christopher Yanucil, Phillip Ruiz, Yasmir Quiroz, Alexander Grabner, Chryso Katsoufis, Sethuraman Swaminathan, Carolyn Abitbol, Bernardo Rodriguez-Iturbe, Christian Faul, Michael Freundlich. Cardioprotective Effects of Paricalcitol Alone and in Combination With FGF23 Receptor Inhibition in Chronic Renal Failure: Experimental and Clinical Studies.
American journal of hypertension.
2019 01; 32(1):34-44. doi:
10.1093/ajh/hpy154. [PMID: 30329020] - Maja Životić, Björn Tampe, Gerhard Müller, Claudia Müller, Aleksandar Lipkovski, Xingbo Xu, Gunsmaa Nyamsuren, Michael Zeisberg, Jasmina Marković-Lipkovski. Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells.
PloS one.
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10.1371/journal.pone.0206786. [PMID: 30383875] - Alia Hassan, Karina Durlacher, Justin Silver, Tally Naveh-Many, Ronen Levi. The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia.
American journal of physiology. Renal physiology.
2016 Feb; 310(3):F217-21. doi:
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Cardiovascular research.
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Sep; 28(36):8897-907. doi:
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Blood.
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10.1182/blood-2003-10-3650. [PMID: 14715624] - S D Skaper, W J Kee, L Facci, G Macdonald, P Doherty, F S Walsh. The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects.
Journal of neurochemistry.
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