2,2,3-TRIMETHYLBUTANE (BioDeep_00000377538)
代谢物信息卡片
2,2,3-TRIMETHYLBUTANE
化学式: C7H16 (100.1252)
中文名称: 2,2,3-三甲基丁烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C)(C)C
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yu Aoh, Tsung-Wei Hou, Cheng-Chia Yang, Ching-Mao Chang, Shih-Pin Chen, I-Ju Tsai, Chin-Wen Cheng, Chun-Pai Yang. Update on gepants for the treatment of chronic migraine.
Journal of the Chinese Medical Association : JCMA.
2024 Apr; 87(4):350-356. doi:
10.1097/jcma.0000000000001070. [PMID: 38349136] - Sen Zhao, Jinyuan Chen, Chenhao Zhong, Liang Meng, Yanjiao Wang. Nontargeted metabolomic insights into the behavioral effects of 5-MeO-MiPT in zebrafish (Danio rerio).
Ecotoxicology and environmental safety.
2024 Mar; 272(?):116044. doi:
10.1016/j.ecoenv.2024.116044. [PMID: 38295732] - Rubi Barman, Pranjit Kumar Bora, Jadumoni Saikia, Parthapratim Konwar, Aditya Sarkar, Phirose Kemprai, Siddhartha Proteem Saikia, Saikat Haldar, Adrian Slater, Dipanwita Banik. Hypothetical biosynthetic pathways of pharmaceutically potential hallucinogenic metabolites in Myristicaceae, mechanistic convergence and co-evolutionary trends in plants and humans.
Phytochemistry.
2024 Feb; 218(?):113928. doi:
10.1016/j.phytochem.2023.113928. [PMID: 38035973] - Marco Pepe, Mohsen Hesami, Karla A de la Cerda, Melissa L Perreault, Tom Hsiang, Andrew Maxwell Phineas Jones. A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond.
Biotechnology advances.
2023 12; 69(?):108247. doi:
10.1016/j.biotechadv.2023.108247. [PMID: 37659744] - Lei-Qi Liu, Jing-Ze Chen, Wu-Sheng Fu, Cui-Ying Tang. [Determination of amanita peptide and tryptamine toxins in wild mushrooms by high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2023 Nov; 41(11):976-985. doi:
10.3724/sp.j.1123.2023.07013. [PMID: 37968816] - Daijing Wei, Yun Yang, Ruiying Xi, Yunqing He, Ighodaro Igbe, Fei Wang, Guolin Zhang, Yinggang Luo. Hunteriasines A - D, tryptamine-derived alkaloids from Hunteria umbellata.
Phytochemistry.
2023 Sep; 213(?):113752. doi:
10.1016/j.phytochem.2023.113752. [PMID: 37330032] - Lixiang Zhai, Haitao Xiao, Chengyuan Lin, Hoi Leong Xavier Wong, Yan Y Lam, Mengxue Gong, Guojun Wu, Ziwan Ning, Chunhua Huang, Yijing Zhang, Chao Yang, Jingyuan Luo, Lu Zhang, Ling Zhao, Chenhong Zhang, Johnson Yiu-Nam Lau, Aiping Lu, Lok-Ting Lau, Wei Jia, Liping Zhao, Zhao-Xiang Bian. Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome.
Nature communications.
2023 Aug; 14(1):4986. doi:
10.1038/s41467-023-40552-y. [PMID: 37591886] - Kyunghee Kim, Mohammadamin Shahsavarani, Jorge Jonathan Oswaldo Garza-García, Jack Edward Carlisle, Jun Guo, Vincenzo De Luca, Yang Qu. Biosynthesis of kratom opioids.
The New phytologist.
2023 Jul; ?(?):. doi:
10.1111/nph.19162. [PMID: 37518950] - Fateme Zohairi, Himanshu Khandelia, Ali Asghar Hakami Zanjani. Interaction of psychedelic tryptamine derivatives with a lipid bilayer.
Chemistry and physics of lipids.
2023 Mar; 251(?):105279. doi:
10.1016/j.chemphyslip.2023.105279. [PMID: 36627076] - Jie Chen, Yueqi Zhang, Huanran Yin, Wei Liu, Xin Hu, Dongqin Li, Caixia Lan, Lifeng Gao, Zhonghu He, Fa Cui, Alisdair R Fernie, Wei Chen. The pathway of melatonin biosynthesis in common wheat (Triticum aestivum).
Journal of pineal research.
2023 Mar; 74(2):e12841. doi:
10.1111/jpi.12841. [PMID: 36396897] - Marcus Daniel Brandbjerg Bohn Lorensen, Nanna Bjarnholt, Benoit St-Pierre, Vincent Courdavault, Sarah Heinicke, Sarah O'Connor, Christian Janfelt. Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging.
Phytochemistry.
2023 Feb; ?(?):113620. doi:
10.1016/j.phytochem.2023.113620. [PMID: 36863602] - Luiz Leonardo Saldanha, Pierre-Marie Allard, Guilherme Dilarri, Santiago Codesido, Víctor González-Ruiz, Emerson Ferreira Queiroz, Henrique Ferreira, Jean-Luc Wolfender. Metabolomic- and Molecular Networking-Based Exploration of the Chemical Responses Induced in Citrus sinensis Leaves Inoculated with Xanthomonas citri.
Journal of agricultural and food chemistry.
2022 Nov; 70(46):14693-14705. doi:
10.1021/acs.jafc.2c05156. [PMID: 36350271] - Eric Amenyogbe, Jun Luo, Wei-Jie Fu, Emmanuel Delwin Abarike, Zhong-Liang Wang, Jian-Sheng Huang, Christian Larbi Ayisi, Gang Chen. Effects of autochthonous strains mixture on gut microbiota and metabolic profile in cobia (Rachycentron canadum).
Scientific reports.
2022 10; 12(1):17410. doi:
10.1038/s41598-022-19663-x. [PMID: 36258024] - Albert Katchborian-Neto, Mário Ferreira Conceição Santos, Diego Fernandes Vilas-Boas, Elda Gonçalves Dos Santos, Márcia Paranho Veloso, Paula Carolina Pires Bueno, Ivo Santana Caldas, Marisi Gomes Soares, Danielle Ferreira Dias, Daniela Aparecida Chagas-Paula. Immunological Modulation and Control of Parasitaemia by Ayahuasca Compounds: Therapeutic Potential for Chagas's Disease.
Chemistry & biodiversity.
2022 Oct; 19(10):e202200409. doi:
10.1002/cbdv.202200409. [PMID: 36163588] - Wenting Fei, Jianjun Zhang, Linyuan Wang, Yi Yang, Yan Chen, Yawen Chen, Ran Tao, Yingli Zhu. A clinical study to observe the efficacy and safety of Besunyen Detox Tea for constipation.
Medicine.
2022 Sep; 101(38):e30729. doi:
10.1097/md.0000000000030729. [PMID: 36197168] - Justin C Miller, Mary A Schuler. Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases.
The Journal of biological chemistry.
2022 09; 298(9):102237. doi:
10.1016/j.jbc.2022.102237. [PMID: 35809640] - Dyandevi Mathure, Hemantkumar Ranpise, Rajendra Awasthi, Atmaram Pawar. Formulation and Characterization of Nanostructured Lipid Carriers of Rizatriptan Benzoate-Loaded In Situ Nasal Gel for Brain Targeting.
Assay and drug development technologies.
2022 07; 20(5):211-224. doi:
10.1089/adt.2022.044. [PMID: 35771865] - Lea Wagmann, Sascha K Manier, Markus R Meyer. Can the Intake of a Synthetic Tryptamine be Detected Only by Blood Plasma Analysis? A Clinical Toxicology Case Involving 4-HO-MET.
Journal of analytical toxicology.
2022 May; 46(5):567-572. doi:
10.1093/jat/bkab062. [PMID: 34100553] - Kateřina Bělonožníková, Veronika Hýsková, Josef Chmelík, Daniel Kavan, Noemi Čeřovská, Helena Ryšlavá. Pythium oligandrum in plant protection and growth promotion: Secretion of hydrolytic enzymes, elicitors and tryptamine as auxin precursor.
Microbiological research.
2022 May; 258(?):126976. doi:
10.1016/j.micres.2022.126976. [PMID: 35158298] - Magdalene Huen-Yin Tang, Hok-Fung Tong, Ka-Chung Wong, Yeow-Kuan Chong. Ropinirole metabolite mimics a new psychoactive substance (4-HO-MET) in LC-MS/MS.
Forensic science international.
2022 Feb; 331(?):111151. doi:
10.1016/j.forsciint.2021.111151. [PMID: 34973484] - Hyeon Hwa Nam, Ji Hye Lee, Seung Mok Ryu, Sueun Lee, Sungyu Yang, Pureum Noh, Byung Cheol Moon, Joong Sun Kim, Yun-Soo Seo. Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma.
Journal of ethnopharmacology.
2022 Jan; 282(?):114574. doi:
10.1016/j.jep.2021.114574. [PMID: 34461187] - Sunena Jha, Dinanath Mishra. Evaluation of Brain Targeting Potential of Zolmitriptan Mucoadhesive Nanoparticles for Intranasal Drug Delivery.
Pharmaceutical nanotechnology.
2022; 10(2):113-124. doi:
10.2174/2211738510666220303160414. [PMID: 35240970] - Lingling Han, Yudi Jia, Yanjia Zhao, Chen Sun, Min Zhao, Ying Peng, Jiang Zheng. Metabolic activation of zolmitriptan mediated by CYP2D6.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Nov; 51(11):1292-1302. doi:
10.1080/00498254.2021.1938290. [PMID: 34096834] - Rajasree G Krishnan, Beena Saraswathyamma. Murexide-derived in vitro electrochemical sensor for the simultaneous determination of neurochemicals.
Analytical and bioanalytical chemistry.
2021 Nov; 413(27):6803-6812. doi:
10.1007/s00216-021-03282-y. [PMID: 33774711] - Chun-Pai Yang, Chih-Sung Liang, Ching-Mao Chang, Cheng-Chia Yang, Po-Hsuan Shih, Yun-Chain Yau, Kuo-Tung Tang, Shuu-Jiun Wang. Comparison of New Pharmacologic Agents With Triptans for Treatment of Migraine: A Systematic Review and Meta-analysis.
JAMA network open.
2021 10; 4(10):e2128544. doi:
10.1001/jamanetworkopen.2021.28544. [PMID: 34633423] - Pakinaz Y Khashaba, Azza H Rageh, Noha N Atia, Sally A El Zohny. Vortex-assisted dispersive solid phase microextraction using Fe3O4/FeOOH magnetic nanocomposites for high-performance thin-layer chromatographic determination of zolmitriptan in rabbit plasma samples.
Journal of chromatography. A.
2021 Aug; 1651(?):462276. doi:
10.1016/j.chroma.2021.462276. [PMID: 34107401] - Stefano Negri, Mauro Commisso, Linda Avesani, Flavia Guzzo. The case of tryptamine and serotonin in plants: a mysterious precursor for an illustrious metabolite.
Journal of experimental botany.
2021 07; 72(15):5336-5355. doi:
10.1093/jxb/erab220. [PMID: 34009335] - Olafur B Davidsson, Isa A Olofsson, Lisette Ja Kogelman, Michael Asger Andersen, Klaus Rostgaard, Henrik Hjalgrim, Jes Olesen, Thomas Folkmann Hansen. Twenty-five years of triptans - a nationwide population study.
Cephalalgia : an international journal of headache.
2021 07; 41(8):894-904. doi:
10.1177/0333102421991809. [PMID: 33583217] - Jiahui Shao, Yucong Li, Zunfeng Li, Zhihui Xu, Weibing Xun, Nan Zhang, Haichao Feng, Youzhi Miao, Qirong Shen, Ruifu Zhang. Participating mechanism of a major contributing gene ysnE for auxin biosynthesis in Bacillus amyloliquefaciens SQR9.
Journal of basic microbiology.
2021 Jun; 61(6):569-575. doi:
10.1002/jobm.202100098. [PMID: 33914927] - Sascha K Manier, Christina Felske, Josef Zapp, Niels Eckstein, Markus R Meyer. Studies on the In Vitro and In Vivo Metabolic Fate of the New Psychoactive Substance N-Ethyl-N-Propyltryptamine for Analytical Purposes.
Journal of analytical toxicology.
2021 Feb; 45(2):195-202. doi:
10.1093/jat/bkaa060. [PMID: 32507893] - Peisen Su, Lanfei Zhao, Wen Li, Jinxiao Zhao, Jun Yan, Xin Ma, Anfei Li, Hongwei Wang, Lingrang Kong. Integrated metabolo-transcriptomics and functional characterization reveals that the wheat auxin receptor TIR1 negatively regulates defense against Fusarium graminearum.
Journal of integrative plant biology.
2021 Feb; 63(2):340-352. doi:
10.1111/jipb.12992. [PMID: 32678930] - Qing-Ru Liu, Juan Li, Xiao-Fang Zhao, Bo Xu, Xing-Hua Xiao, Jie Ren, Shun-Xiang Li. Alkaloids and phenylpropanoid from Rhizomes of Arundo donax L.
Natural product research.
2021 Feb; 35(3):465-470. doi:
10.1080/14786419.2019.1638378. [PMID: 31328554] - Yusuf Ali Altuncı, Melike Aydoğdu, Eda Açıkgöz, Ümmü Güven, Fahriye Düzağaç, Aslı Atasoy, Nebile Dağlıoğlu, Serap Annette Akgür. New Psychoactive Substance 5-MeO-MiPT In vivo Acute Toxicity and Hystotoxicological Study.
Balkan medical journal.
2021 01; 38(1):34-42. doi:
10.4274/balkanmedj.galenos.2020.2019.11.68. [PMID: 32936075] - Dagang Tian, Fang Yang, Yuqing Niu, Yan Lin, Zaijie Chen, Gang Li, Qiong Luo, Feng Wang, Mo Wang. Loss function of SL (sekiguchi lesion) in the rice cultivar Minghui 86 leads to enhanced resistance to (hemi)biotrophic pathogens.
BMC plant biology.
2020 Nov; 20(1):507. doi:
10.1186/s12870-020-02724-6. [PMID: 33148178] - Analía A Gomez, Zareath P Terán Baptista, Tsvetelina Mandova, Angeliki Barouti, Marina Kritsanida, Raphaël Grougnet, Marta A Vattuone, Diego A Sampietro. Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species.
Natural product research.
2020 Nov; 34(22):3299-3302. doi:
10.1080/14786419.2018.1560286. [PMID: 30663391] - Jyoti Singh Jadaun, Amit Kumar Kushwaha, Neelam S Sangwan, Lokesh Kumar Narnoliya, Smrati Mishra, Rajender Singh Sangwan. WRKY1-mediated regulation of tryptophan decarboxylase in tryptamine generation for withanamide production in Withania somnifera (Ashwagandha).
Plant cell reports.
2020 Nov; 39(11):1443-1465. doi:
10.1007/s00299-020-02574-4. [PMID: 32789542] - Valeria Tellone, Patrizia Dragone, Rossella Picollo, Maria Teresa Rosignoli, Fabio Garofolo, Alessandra Del Vecchio, Fabrizio Calisti, Alessandro Comandini, Frank Donath, Barbara Schug, Ralph-Steven Wedemeyer. A novel rizatriptan oral gel formulation: Bioavailability and bioequivalence.
International journal of clinical pharmacology and therapeutics.
2020 Oct; 58(10):583-594. doi:
10.5414/cp203652. [PMID: 32716291] - Janis Fricke, Robert Kargbo, Lars Regestein, Claudius Lenz, Gundela Peschel, Miriam A Rosenbaum, Alexander Sherwood, Dirk Hoffmeister. Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin.
Chemistry (Weinheim an der Bergstrasse, Germany).
2020 Jul; 26(37):8281-8285. doi:
10.1002/chem.202000134. [PMID: 32101345] - Abhijeet Jakate, Ramesh Boinpally, Matthew Butler, Kaifeng Lu, Danielle McGeeney, Antonia Periclou. Evaluation of the Pharmacokinetic Interaction of Ubrogepant Coadministered With Sumatriptan and of the Safety of Ubrogepant With Triptans.
Headache.
2020 07; 60(7):1340-1350. doi:
10.1111/head.13862. [PMID: 32573795] - Hana Leontovyčová, Lucie Trdá, Petre Ivanov Dobrev, Vladimír Šašek, Elise Gay, Marie-Hélène Balesdent, Lenka Burketová. Auxin biosynthesis in the phytopathogenic fungus Leptosphaeria maculans is associated with enhanced transcription of indole-3-pyruvate decarboxylase LmIPDC2 and tryptophan aminotransferase LmTAM1.
Research in microbiology.
2020 Jul; 171(5-6):174-184. doi:
10.1016/j.resmic.2020.05.001. [PMID: 32540203] - David B Clemow, Kirk W Johnson, Helen M Hochstetler, Michael H Ossipov, Ann M Hake, Andrew M Blumenfeld. Lasmiditan mechanism of action - review of a selective 5-HT1F agonist.
The journal of headache and pain.
2020 Jun; 21(1):71. doi:
10.1186/s10194-020-01132-3. [PMID: 32522164] - Shengyuan Yu, Yanlei Zhang, Yuan Yao, Haijun Cao. Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database.
The journal of headache and pain.
2020 May; 21(1):53. doi:
10.1186/s10194-020-01117-2. [PMID: 32404048] - Maedeh Nouri, Mostafa Rahimnejad, Ghasem Najafpour, Ali Akbar Moghadamnia. Simultaneous voltammetric determination of rizatriptan and acetaminophen using a carbon paste electrode modified with NiFe2O4 nanoparticles.
Mikrochimica acta.
2020 05; 187(6):315. doi:
10.1007/s00604-020-04290-y. [PMID: 32383071] - Yisheng Luo, Yongqiang Yang, Yi Shen, Longjiang Li, Jiayi Huang, Li Tang, Li Zhang. Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice.
Innate immunity.
2020 05; 26(4):319-327. doi:
10.1177/1753425919890912. [PMID: 31779498] - Xiaohong Fan, Junfang Li, Xuemei Deng, Yingmei Lu, Yiyue Feng, Shumeng Ma, Huaixiu Wen, Quanyi Zhao, Wen Tan, Tao Shi, Zhen Wang. Design, synthesis and bioactivity study of N-salicyloyl tryptamine derivatives as multifunctional agents for the treatment of neuroinflammation.
European journal of medicinal chemistry.
2020 May; 193(?):112217. doi:
10.1016/j.ejmech.2020.112217. [PMID: 32182488] - Xiwen Tong, Yundan Wang, Pengcheng Yang, Chengshu Wang, Le Kang. Tryptamine accumulation caused by deletion of MrMao-1 in Metarhizium genome significantly enhances insecticidal virulence.
PLoS genetics.
2020 04; 16(4):e1008675. doi:
10.1371/journal.pgen.1008675. [PMID: 32271756] - Brian G O'Flynn, Eric M Lewandowski, Karin Claire Prins, Gabriela Suarez, Angelica N McCaskey, Nasha M Rios-Guzman, Ryan L Anderson, Britney A Shepherd, Ioannis Gelis, James W Leahy, Yu Chen, David J Merkler. Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target.
ACS chemical biology.
2020 02; 15(2):513-523. doi:
10.1021/acschembio.9b00973. [PMID: 31967772] - Randa Hanie Awadeen, Mariza Fouad Boughdady, Mahasen Mohamed Meshali. Quality by Design Approach for Preparation of Zolmitriptan/Chitosan Nanostructured Lipid Carrier Particles - Formulation and Pharmacodynamic Assessment.
International journal of nanomedicine.
2020; 15(?):8553-8568. doi:
10.2147/ijn.s274352. [PMID: 33173292] - Jakub Staroń, Rafał Kurczab, Dawid Warszycki, Grzegorz Satała, Martyna Krawczyk, Ryszard Bugno, Tomasz Lenda, Piotr Popik, Adam S Hogendorf, Agata Hogendorf, Krzysztof Dubiel, Mikołaj Matłoka, Rafał Moszczyński-Pętkowski, Jerzy Pieczykolan, Maciej Wieczorek, Paweł Zajdel, Andrzej J Bojarski. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties.
European journal of medicinal chemistry.
2020 Jan; 185(?):111857. doi:
10.1016/j.ejmech.2019.111857. [PMID: 31734022] - Jason Barricklow, Joseph Tweed, Christopher L Holliman, Ragu Ramanathan. Evaluation of OptiFlow™-MS/MS for bioanalysis of pharmaceutical drugs and metabolites.
Bioanalysis.
2020 Jan; 12(1):23-34. doi:
10.4155/bio-2019-0250. [PMID: 31849261] - Farshid Ali Naghi Zadeh Khezri, C S R Lakshmi, Rama Bukka, Malviya Nidhi, Shachindra L Nargund. Pharmacokinetic study and brain tissue analysis of Zolmitriptan loaded chitosan nanoparticles in rats by LC-MS method.
International journal of biological macromolecules.
2020 Jan; 142(?):52-62. doi:
10.1016/j.ijbiomac.2019.08.236. [PMID: 31593739] - Boxian Huang, Chunfeng Qian, Chenyue Ding, Qingxia Meng, Qinyan Zou, Hong Li. Fetal liver mesenchymal stem cells restore ovarian function in premature ovarian insufficiency by targeting MT1.
Stem cell research & therapy.
2019 11; 10(1):362. doi:
10.1186/s13287-019-1490-8. [PMID: 31783916] - Mourad Tayebi, Charles M El-Hage, Pedro Pinczowski, Pam Whiteley, Monique David, Qiao-Xin Li, Shiji Varghese, Meena Mikhael, Umma Habiba, David Harman, Liliana Tatarczuch, Mirjana Bogeski, Ian Birchall, Kirsty Ferguson, Larry Walker, Colin Masters, Brian A Summers. Plant poisoning leads to alpha-synucleinopathy and neuromelanopathy in kangaroos.
Scientific reports.
2019 11; 9(1):16546. doi:
10.1038/s41598-019-53396-8. [PMID: 31723225] - Mengyuan Hou, Hongxia Liu, Yunfei Li, Ling Xu, Yingchun He, Yinghua Lv, Qingshan Zheng, Lujin Li. Efficacy of triptans for the treatment of acute migraines: a quantitative comparison based on the dose-effect and time-course characteristics.
European journal of clinical pharmacology.
2019 Oct; 75(10):1369-1378. doi:
10.1007/s00228-019-02748-4. [PMID: 31446449] - Yang Yu, Mei-Fen Bao, Jing Wu, Jing Chen, Yu-Rong Yang, Johann Schinnerl, Xiang-Hai Cai. Tabernabovines A-C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina.
Organic letters.
2019 08; 21(15):5938-5942. doi:
10.1021/acs.orglett.9b02060. [PMID: 31294995] - Vimal Maurya, Pranesh Kumar, Sreemoyee Chakraborti, Ashok K Singh, Archana S Bhadauria, Umesh Kumar, Dinesh Kumar, Arnab Pramanik, Biswajit Saha, Venkatesh Kumar R, Sunil Babu Gosipatala, Bolay Bhattachariya, Biswanath Maity, Sudipta Saha. Zolmitriptan attenuates hepatocellular carcinoma via activation of caspase mediated apoptosis.
Chemico-biological interactions.
2019 Aug; 308(?):120-129. doi:
10.1016/j.cbi.2019.05.033. [PMID: 31129132] - Lu Zhang, Fang Li, Xiaomin Su, Yue Li, Yining Wang, Ruonan Fang, Yingying Guo, Tongzhu Jin, Huitong Shan, Xiaoguang Zhao, Rui Yang, Hongli Shan, Haihai Liang. Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Experimental & molecular medicine.
2019 07; 51(7):1-12. doi:
10.1038/s12276-019-0273-8. [PMID: 31273199] - Ariane Dolly Kenmogne Kouam, Sidonie Beatrice Kenmogne, Jules Songue Lobe, Emmanuel Ngeufa Happi, Hans-Georg Stammler, Alain François Kamdem Waffo, Norbert Sewald, Jean Duplex Wansi. A rotameric tryptamide alkaloid from the roots of Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae).
Fitoterapia.
2019 Jun; 135(?):9-14. doi:
10.1016/j.fitote.2019.03.028. [PMID: 30946943] - Zhendong Zhu, Rongnan Li, Yinghua Lv, Wenxian Zeng. Melatonin protects rabbit spermatozoa from cryo-damage via decreasing oxidative stress.
Cryobiology.
2019 06; 88(?):1-8. doi:
10.1016/j.cryobiol.2019.04.009. [PMID: 31034812] - Alma Vázquez-Luna, Fabio García-García, Diana I Caudillo Contreras, Eduardo Rivadeneyra-Domínguez, Rafael Díaz-Sobac. Effect of orange juice and tryptamine on the behavior and c-fos expression of Wistar rats.
Metabolic brain disease.
2019 04; 34(2):519-525. doi:
10.1007/s11011-018-0365-5. [PMID: 30604026] - Kanwal, Majid Khan, Arshia, Khalid Mohammed Khan, Shahnaz Parveen, Muniza Shaikh, Narjis Fatima, M Iqbal Choudhary. Syntheses, in vitro urease inhibitory activities of urea and thiourea derivatives of tryptamine, their molecular docking and cytotoxic studies.
Bioorganic chemistry.
2019 03; 83(?):595-610. doi:
10.1016/j.bioorg.2018.10.070. [PMID: 30513472] - Mauro Commisso, Stefano Negri, Martino Bianconi, Sofia Gambini, Sara Avesani, Stefania Ceoldo, Linda Avesani, Flavia Guzzo. Untargeted and Targeted Metabolomics and Tryptophan Decarboxylase In Vivo Characterization Provide Novel Insight on the Development of Kiwifruits (Actinidia deliciosa).
International journal of molecular sciences.
2019 Feb; 20(4):. doi:
10.3390/ijms20040897. [PMID: 30791398] - Tiantian Ye, Xiaoming Yin, Lei Yu, Shu-Jian Zheng, Wen-Jing Cai, Yan Wu, Yu-Qi Feng. Metabolic analysis of the melatonin biosynthesis pathway using chemical labeling coupled with liquid chromatography-mass spectrometry.
Journal of pineal research.
2019 Jan; 66(1):e12531. doi:
10.1111/jpi.12531. [PMID: 30299556] - Brian Torres, James S Tyler, Kenneth A Satyshur, Arnold E Ruoho. Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants.
PloS one.
2019; 14(7):e0219664. doi:
10.1371/journal.pone.0219664. [PMID: 31310642] - Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki, Hiroyuki Kusuhara. Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier.
Drug metabolism and disposition: the biological fate of chemicals.
2018 11; 46(11):1767-1775. doi:
10.1124/dmd.118.081877. [PMID: 30154106] - Felix Blei, Janis Fricke, Jonas Wick, Jason C Slot, Dirk Hoffmeister. Iterative l-Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication.
Chembiochem : a European journal of chemical biology.
2018 10; 19(20):2160-2166. doi:
10.1002/cbic.201800336. [PMID: 30098085] - Geofrey Sing'ombe Ombiro, Taku Sawai, Yoshiteru Noutoshi, Yuta Nishina, Hidenori Matsui, Mikihiro Yamamoto, Kazuhiro Toyoda, Yuki Ichinose. Specific growth inhibitors of Ralstonia solanacearum, Xanthomonas oryzae pv. oryzae, X. campestris pv. campestris, and Clavibacter michiganensis subsp. michiganensis.
Microbiological research.
2018 Oct; 215(?):29-35. doi:
10.1016/j.micres.2018.06.005. [PMID: 30172306] - Nancy Abdel Hamid Abou Youssef, Abeer Ahmed Kassem, Ragwa Mohamed Farid, Fatma Ahmed Ismail, Magda Abd Elsamea El-Massik, Nabila Ahmed Boraie. A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: Preparation, characterization and in vivo evaluation.
International journal of pharmaceutics.
2018 Sep; 548(1):609-624. doi:
10.1016/j.ijpharm.2018.07.014. [PMID: 30033394] - Pia Simona Bruni, Katharina Elisabeth Grafinger, Susanne Nussbaumer, Stefan König, Stefan Schürch, Wolfgang Weinmann. Study of the in vitro and in vivo metabolism of 4-HO-MET.
Forensic science international.
2018 Sep; 290(?):103-110. doi:
10.1016/j.forsciint.2018.06.037. [PMID: 30015274] - Desiree Pressnitz, Eva-Maria Fischereder, Jakob Pletz, Christina Kofler, Lucas Hammerer, Katharina Hiebler, Horst Lechner, Nina Richter, Elisabeth Eger, Wolfgang Kroutil. Asymmetric Synthesis of (R)-1-Alkyl-Substituted Tetrahydro-ß-carbolines Catalyzed by Strictosidine Synthases.
Angewandte Chemie (International ed. in English).
2018 08; 57(33):10683-10687. doi:
10.1002/anie.201803372. [PMID: 29852524] - Yang Yu, Yan Lv, Yana Shi, Tao Li, Yanchun Chen, Dake Zhao, Zhiwei Zhao. The Role of Phyto-Melatonin and Related Metabolites in Response to Stress.
Molecules (Basel, Switzerland).
2018 Jul; 23(8):. doi:
10.3390/molecules23081887. [PMID: 30060559] - Yogesh Bhattarai, Brianna B Williams, Eric J Battaglioli, Weston R Whitaker, Lisa Till, Madhusudan Grover, David R Linden, Yasutada Akiba, Karunya K Kandimalla, Nicholas C Zachos, Jonathan D Kaunitz, Justin L Sonnenburg, Michael A Fischbach, Gianrico Farrugia, Purna C Kashyap. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.
Cell host & microbe.
2018 06; 23(6):775-785.e5. doi:
10.1016/j.chom.2018.05.004. [PMID: 29902441] - Chris Dockendorff, Disha M Gandhi, Ian H Kimball, Kenneth S Eum, Radda Rusinova, Helgi I Ingólfsson, Ruchi Kapoor, Thasin Peyear, Matthew W Dodge, Stephen F Martin, Richard W Aldrich, Olaf S Andersen, Jon T Sack. Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.
Biochemistry.
2018 05; 57(18):2733-2743. doi:
10.1021/acs.biochem.8b00292. [PMID: 29616558] - Smitha Krishnan, Yufang Ding, Nima Saedi, Maria Choi, Gautham V Sridharan, David H Sherr, Martin L Yarmush, Robert C Alaniz, Arul Jayaraman, Kyongbum Lee. Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages.
Cell reports.
2018 04; 23(4):1099-1111. doi:
10.1016/j.celrep.2018.03.109. [PMID: 29694888] - Katharina Elisabeth Grafinger, Marianne Hädener, Stefan König, Wolfgang Weinmann. Study of the in vitro and in vivo metabolism of the tryptamine 5-MeO-MiPT using human liver microsomes and real case samples.
Drug testing and analysis.
2018 Mar; 10(3):562-574. doi:
10.1002/dta.2245. [PMID: 28677880] - Jan Honegr, Rafael Dolezal, David Malinak, Marketa Benkova, Ondrej Soukup, Joyce S F D de Almeida, Tanos C C Franca, Kamil Kuca, Roman Prymula. Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery.
Molecules (Basel, Switzerland).
2018 Jan; 23(1):. doi:
10.3390/molecules23010102. [PMID: 29300367] - Yu Kyong Kim, Kwang-Hee Shin, Jeffrey Alderman, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee. Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects.
Drug design, development and therapy.
2018; 12(?):331-337. doi:
10.2147/dddt.s149119. [PMID: 29497279] - Abhishek Sharma, Priyanka Verma, Archana Mathur, Ajay Kumar Mathur. Genetic engineering approach using early Vinca alkaloid biosynthesis genes led to increased tryptamine and terpenoid indole alkaloids biosynthesis in differentiating cultures of Catharanthus roseus.
Protoplasma.
2018 Jan; 255(1):425-435. doi:
10.1007/s00709-017-1151-7. [PMID: 28808798] - Dennis McKenna, Jordi Riba. New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca.
Current topics in behavioral neurosciences.
2018 ; 36(?):283-311. doi:
10.1007/7854_2016_472. [PMID: 28401525] - Achim T Caspar, Jonas B Gaab, Julian A Michely, Simon D Brandt, Markus R Meyer, Hans H Maurer. Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5-MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MSn , and LC-HR-MS/MS.
Drug testing and analysis.
2018 Jan; 10(1):184-195. doi:
10.1002/dta.2197. [PMID: 28342193] - Shou-Long Deng, Tie-Cheng Sun, Kun Yu, Zhi-Peng Wang, Bao-Lu Zhang, Yan Zhang, Xiu-Xia Wang, Zheng-Xing Lian, Yi-Xun Liu. Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen.
Free radical biology & medicine.
2017 12; 113(?):347-354. doi:
10.1016/j.freeradbiomed.2017.10.342. [PMID: 29051117] - Luiz C Klein-Júnior, Sylvian Cretton, Pierre-Marie Allard, Grégory Genta-Jouve, Carolina S Passos, Juliana Salton, Pablo Bertelli, Marion Pupier, Damien Jeannerat, Yvan Vander Heyden, André L Gasper, Jean-Luc Wolfender, Philippe Christen, Amélia T Henriques. Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis.
Journal of natural products.
2017 11; 80(11):3032-3037. doi:
10.1021/acs.jnatprod.7b00681. [PMID: 29120642] - Andreas Berger, Elias Tanuhadi, Lothar Brecker, Johann Schinnerl, Karin Valant-Vetschera. Chemodiversity of tryptamine-derived alkaloids in six Costa Rican Palicourea species (Rubiaceae-Palicoureeae).
Phytochemistry.
2017 Nov; 143(?):124-131. doi:
10.1016/j.phytochem.2017.07.016. [PMID: 28806604] - Wangda Zhou, Jianguo Li, Bruce Birmingham, Hongmei Xu, Stefan Lillieborg, Diansong Zhou, Nidal Al-Huniti. Population Pharmacokinetic Analysis of Zolmitriptan and Its Metabolite in Adults and Adolescents to Support Dose Selection in Children With Migraine.
Journal of clinical pharmacology.
2017 10; 57(10):1258-1267. doi:
10.1002/jcph.935. [PMID: 28581633] - Sameh Ahmed, Noha N Atia. Fast and efficient zirconia-based reversed phase chromatography for selective determination of triptans in rat plasma.
Journal of pharmaceutical and biomedical analysis.
2017 Sep; 143(?):241-251. doi:
10.1016/j.jpba.2017.05.047. [PMID: 28618340] - Harilal Patel, Prakash Patel, Nirav Modi, Shaival Shah, Ashok Ghoghari, Bhavesh Variya, Ritu Laddha, Dipesh Baradia, Nitin Dobaria, Pavak Mehta, Nuggehally R Srinivas. One should avoid retro-orbital pharmacokinetic sample collections for intranasal dosing in rats: Illustration of spurious pharmacokinetics generated for anti-migraine drugs zolmitriptan and eletriptan.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Aug; 106(?):87-93. doi:
10.1016/j.ejps.2017.05.044. [PMID: 28549679] - M Suhaib Azim, Nidhi B Agarwal, Divya Vohora. Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine.
Epilepsy & behavior : E&B.
2017 07; 72(?):140-144. doi:
10.1016/j.yebeh.2017.03.019. [PMID: 28578215] - Atsushi Ishihara, Rie Kumeda, Noriko Hayashi, Yukari Yagi, Nanase Sakaguchi, Yu Kokubo, Naoki Ube, Shin-Ichi Tebayashi, Kotomi Ueno. Induced accumulation of tyramine, serotonin, and related amines in response to Bipolaris sorokiniana infection in barley.
Bioscience, biotechnology, and biochemistry.
2017 Jun; 81(6):1090-1098. doi:
10.1080/09168451.2017.1290520. [PMID: 28485206] - Peter S Backlund, Henryk F Urbanski, Mark A Doll, David W Hein, Marjan Bozinoski, Christopher E Mason, Steven L Coon, David C Klein. Daily Rhythm in Plasma N-acetyltryptamine.
Journal of biological rhythms.
2017 06; 32(3):195-211. doi:
10.1177/0748730417700458. [PMID: 28466676] - Jae B Park. N-Caffeoyltryptamine, a Potent Anti-Inflammatory Phenolic Amide, Suppressed MCP-1 Expression in LPS-stimulated THP-1 Cells and Rats Fed a High-Fat Diet.
International journal of molecular sciences.
2017 May; 18(6):. doi:
10.3390/ijms18061148. [PMID: 28555020] - G D'Andrea, G Bussone, P Di Fiore, F Perini, A Gucciardi, A Bolner, M Aguggia, G Saracco, E Galloni, G Giordano, A Leon. Pathogenesis of chronic cluster headache and bouts: role of tryptamine, arginine metabolism and α1-agonists.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2017 May; 38(Suppl 1):37-43. doi:
10.1007/s10072-017-2862-4. [PMID: 28527056] - Piotr Luliński, Magdalena Bamburowicz-Klimkowska, Mariusz Dana, Dorota Maciejewska. Development of a validated strategy for the determination of tryptamine in human cerebrospinal fluid in the presence of competitors using molecularly imprinted polymers.
Journal of separation science.
2017 Apr; 40(8):1824-1833. doi:
10.1002/jssc.201601349. [PMID: 28195396] - Luigi De Masi, Domenico Castaldo, Domenico Pignone, Luigi Servillo, Angelo Facchiano. Experimental Evidence and In Silico Identification of Tryptophan Decarboxylase in Citrus Genus.
Molecules (Basel, Switzerland).
2017 Feb; 22(2):. doi:
10.3390/molecules22020272. [PMID: 28208655] - Priti Girotra, Shailendra Kumar Singh. Multivariate Optimization of Rizatriptan Benzoate-Loaded Solid Lipid Nanoparticles for Brain Targeting and Migraine Management.
AAPS PharmSciTech.
2017 Feb; 18(2):517-528. doi:
10.1208/s12249-016-0532-0. [PMID: 27126007] - Lily A Arya. Rationale for Investigating Stool Metabolites and Microbiota in Women With Fecal Incontinence.
Diseases of the colon and rectum.
2017 Feb; 60(2):249-252. doi:
10.1097/dcr.0000000000000751. [PMID: 28059923] - Julian A Michely, Simon D Brandt, Markus R Meyer, Hans H Maurer. Biotransformation and detectability of the new psychoactive substances N,N-diallyltryptamine (DALT) derivatives 5-fluoro-DALT, 7-methyl-DALT, and 5,6-methylenedioxy-DALT in urine using GC-MS, LC-MSn, and LC-HR-MS/MS.
Analytical and bioanalytical chemistry.
2017 Feb; 409(6):1681-1695. doi:
10.1007/s00216-016-0117-5. [PMID: 27933361] - Kun Han, Si-jie Lu, Su Zeng, Lu-shan Yu. [Induction study of CYP3A2 in male rats by zolmitriptan].
Yao xue xue bao = Acta pharmaceutica Sinica.
2017 Jan; 52(1):44-50. doi:
NULL. [PMID: 29911377] - Sabine Fräbel, Markus Krischke, Agata Staniek, Heribert Warzecha. Recombinant flavin-dependent halogenases are functional in tobacco chloroplasts without co-expression of flavin reductase genes.
Biotechnology journal.
2016 Dec; 11(12):1586-1594. doi:
10.1002/biot.201600337. [PMID: 27687297] - Samad Nejad Ebrahimi, Zahra Bagheri-Zomorrodi, Abolfazl Shakeri, Milad Iranshahy, Milena Masullo, Sonia Piacente, Mehrdad Iranshahi. The Absolute Configuration and Cytotoxic Properties of Roehybridine β-N-oxide.
Natural product communications.
2016 Dec; 11(12):1813-1816. doi:
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