2-(Aminomethyl)phenol (BioDeep_00000372787)
代谢物信息卡片
2-(Aminomethyl)phenol
化学式: C7H9NO (123.0684104)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: NCC1CCCCC1O
InChI:
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tuerdi Subati, Zhenjiang Yang, Matthew B Murphy, Joshua M Stark, David Z Trykall, Sean S Davies, Joey V Barnett, Katherine T Murray. Isolevuglandins Promote Mitochondrial Dysfunction and Electrophysiologic Abnormalities in Atrial Cardiomyocytes.
Cells.
2024 Mar; 13(6):. doi:
10.3390/cells13060483. [PMID: 38534327] - Alain P Gobert, Mohammad Asim, Thaddeus M Smith, Kamery J Williams, Daniel P Barry, Margaret M Allaman, Kara M McNamara, Caroline V Hawkins, Alberto G Delgado, Shilin Zhao, M Blanca Piazuelo, M Kay Washington, Lori A Coburn, John A Rathmacher, Keith T Wilson. Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment.
Oncogene.
2023 05; 42(20):1685-1691. doi:
10.1038/s41388-023-02691-w. [PMID: 37037901] - John A Rathmacher, John C Fuller, Naji N Abumrad, Charles R Flynn. Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans.
Inflammation.
2023 Mar; ?(?):. doi:
10.1007/s10753-023-01801-w. [PMID: 36935449] - Alain P Gobert, Mohammad Asim, Thaddeus M Smith, Kamery J Williams, Daniel P Barry, Margaret M Allaman, Kara M McNamara, Caroline V Hawkins, Alberto G Delgado, M Blanca Piazuelo, John A Rathmacher, Keith T Wilson. The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 158(?):114092. doi:
10.1016/j.biopha.2022.114092. [PMID: 36493697] - Matthew J O'Neill, Zachary T Yoneda, Diane M Crawford, Fei Ye, Mingfang Ao, Lisa M Pitchford, John A Rathmacher, Katherine T Murray, Wendell S Akers, Dan M Roden, Gregory F Michaud, M Benjamin Shoemaker. 2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device.
Trials.
2021 Aug; 22(1):576. doi:
10.1186/s13063-021-05553-6. [PMID: 34454591] - Alain P Gobert, Olivier Boutaud, Mohammad Asim, Irene A Zagol-Ikapitte, Alberto G Delgado, Yvonne L Latour, Jordan L Finley, Kshipra Singh, Thomas G Verriere, Margaret M Allaman, Daniel P Barry, Kara M McNamara, Johanna C Sierra, Venkataraman Amarnath, Mohammed N Tantawy, Diane Bimczok, M Blanca Piazuelo, M Kay Washington, Shilin Zhao, Lori A Coburn, Keith T Wilson. Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis.
Gastroenterology.
2021 03; 160(4):1256-1268.e9. doi:
10.1053/j.gastro.2020.11.006. [PMID: 33189701] - Huan Tao, Jiansheng Huang, Patricia G Yancey, Valery Yermalitsky, John L Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A Oates, L Jackson Roberts, Sean S Davies, MacRae F Linton. Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice.
Nature communications.
2020 08; 11(1):4084. doi:
10.1038/s41467-020-17915-w. [PMID: 32796843] - Sean S Davies, Linda S May-Zhang, Olivier Boutaud, Venkataraman Amarnath, Annet Kirabo, David G Harrison. Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions.
Pharmacology & therapeutics.
2020 01; 205(?):107418. doi:
10.1016/j.pharmthera.2019.107418. [PMID: 31629006] - John C Fuller, Lisa M Pitchford, Naji N Abumrad, John A Rathmacher. Subchronic (90-day) repeated dose oral toxicity study of 2-hydroxybenzylamine acetate in rabbit.
Regulatory toxicology and pharmacology : RTP.
2018 Dec; 100(?):52-58. doi:
10.1016/j.yrtph.2018.10.017. [PMID: 30359704] - John C Fuller, Lisa M Pitchford, Ryan D Morrison, J Scott Daniels, Charles R Flynn, Naji N Abumrad, John A Oates, Olivier Boutaud, John A Rathmacher. In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Nov; 121(?):541-548. doi:
10.1016/j.fct.2018.09.047. [PMID: 30253245] - John C Fuller, Lisa M Pitchford, Naji N Abumrad, John A Rathmacher. Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate in rats.
Regulatory toxicology and pharmacology : RTP.
2018 Nov; 99(?):225-232. doi:
10.1016/j.yrtph.2018.09.025. [PMID: 30266239] - William G McMaster, Annet Kirabo, Meena S Madhur, David G Harrison. Inflammation, immunity, and hypertensive end-organ damage.
Circulation research.
2015 Mar; 116(6):1022-33. doi:
10.1161/circresaha.116.303697. [PMID: 25767287] - Sean S Davies, Chris Bodine, Elena Matafonova, Brooke G Pantazides, Nathalie Bernoud-Hubac, Fiona E Harrison, Sandra J Olson, Thomas J Montine, Venkataraman Amarnath, L Jackson Roberts. Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice.
Journal of Alzheimer's disease : JAD.
2011; 27(1):49-59. doi:
10.3233/jad-2011-102118. [PMID: 21709376] - Sean S Davies, Eric J Brantley, Paul A Voziyan, Venkataraman Amarnath, Irene Zagol-Ikapitte, Olivier Boutaud, Billy G Hudson, John A Oates, L Jackson Roberts. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.
Biochemistry.
2006 Dec; 45(51):15756-67. doi:
10.1021/bi061860g. [PMID: 17176098] - G E Stokker, E M Schultz, R L Smith, E J Cragoe, H F Russo, L S Watson, C T Ludden, C S Sweet. 2-(Aminomethyl)phenols, a new class of saluretic agents. 6. Effects of N,O-spiroannulation and subsequent quaternization.
Journal of medicinal chemistry.
1983 Apr; 26(4):585-90. doi:
10.1021/jm00358a024. [PMID: 6834393] - A A Deana, G E Stokker, E M Schultz, R L Smith, E J Cragoe, H F Russo, L S Watson. 2-(Aminomethyl)phenols, a new class of saluretic agents. 5. Fused-ring analogues.
Journal of medicinal chemistry.
1983 Apr; 26(4):580-5. doi:
10.1021/jm00358a023. [PMID: 6834392]