Sofalcone (BioDeep_00000036569)

   

human metabolite


代谢物信息卡片


2-[5-[(3-Methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]-acetic acid

化学式: C27H30O6 (450.204228)
中文名称: 索法酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCOC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2)OCC=C(C)C)OCC(=O)O)C
InChI: InChI=1S/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30)/b12-7+

描述信息

Sofalcone belongs to the family of Chalcones and Dihydrochalcones. These are organic compounds containing 1,3-Diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar,or its derivatives formed by substitution.
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents

同义名列表

12 个代谢物同义名

2-[5-[(3-Methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]-acetic acid; 2-[5-[(3-Methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]-acetate; 2-{5-[(3-methylbut-2-en-1-yl)oxy]-2-[(2E)-3-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}prop-2-enoyl]phenoxy}acetic acid; 2-Carboxymethoxy-4,4-bis(3-methyl-2-butenyloxy)chalcone; Sofalconum; Tofalcone; Sofalcona; Sofalcone; SU-88; Solon; Lavin; SU 88



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tong Yang, Dandan Liu, Yulei Li, Ying Zhang, Yinhua Zhu, Junzhe Zhang, Chen Wang, Shujie Zhang, Yin Kwan Wong, Piao Luo, Qiuyan Guo, Fei Xia, Tianyu Zhong, Huan Tang, Jigang Wang. Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1. Chemical communications (Cambridge, England). 2023 Jul; 59(58):8981-8984. doi: 10.1039/d3cc00577a. [PMID: 37394927]
  • Ling Wang, Lin Song, Xuehua Jiang. Quantification of sofalcone in human plasma and urine by high performance liquid chromatography-mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2011 Jul; 55(5):1179-85. doi: 10.1016/j.jpba.2011.03.040. [PMID: 21530127]
  • Aidong Wen, Zhipeng Wang, Taijun Hang, Yanyan Jia, Tingting Zhang, Yin Wu, Xuan Gao, Zhifu Yang. Analysis of sofalcone in human plasma by high performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 856(1-2):348-52. doi: 10.1016/j.jchromb.2007.05.014. [PMID: 17586104]
  • O S Zayachkivska, S J Konturek, D Drozdowicz, P C Konturek, T Brzozowski, M R Ghegotsky. Gastroprotective effects of flavonoids in plant extracts. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2005 Mar; 56 Suppl 1(?):219-31. doi: ". [PMID: 15800396]
  • H Yoshiyama, H Nakamura, T Okamoto, K Okita, T Nakazawa. A novel in vitro effect of the mucosal protective agent sofalcone--inhibition of chemotactic motility in Helicobacter pylori. Alimentary pharmacology & therapeutics. 2000 Apr; 14 Suppl 1(?):230-6. doi: 10.1046/j.1365-2036.2000.014s1230.x. [PMID: 10807429]
  • M Suzuki, T Kitahora, S Nagahashi, H Suzuki, M Mori, T Hibi, H Ishii. Gastric urease activity is inversely associated with the success of treatment for Helicobacter pylori: effect of sofalcone. Journal of clinical gastroenterology. 1998; 27 Suppl 1(?):S183-6. doi: 10.1097/00004836-199800001-00030. [PMID: 9872519]
  • T Yoshikawa, S Nakamura, S Takahashi, Y Naito, M Kondo. Effect of sofalcone on gastric mucosal injury induced by ischemia-reperfusion and its antioxidant properties. Journal of clinical gastroenterology. 1993; 17 Suppl 1(?):S111-5. doi: 10.1097/00004836-199312001-00020. [PMID: 8283005]
  • S Murakami, M Muramatsu, H Aihara, S Otomo. Inhibition of gastric H+,K(+)-ATPase by the anti-ulcer agent, sofalcone. Biochemical pharmacology. 1991 Sep; 42(7):1447-51. doi: 10.1016/0006-2952(91)90458-h. [PMID: 1656986]
  • B L Slomiany, H Nishikawa, J Piotrowski, K Okazaki, A Slomiany. Lipolytic activity of Campylobacter pylori: effect of sofalcone. Digestion. 1989; 43(1-2):33-40. doi: 10.1159/000199858. [PMID: 2806755]
  • J Yamahara, M Mochizuki, H Q Rong, H Matsuda, H Fujimura. The anti-ulcer effect in rats of ginger constituents. Journal of ethnopharmacology. 1988 Jul; 23(2-3):299-304. doi: 10.1016/0378-8741(88)90009-8. [PMID: 3193792]
  • S J Konturek, T Mrzozowski, D Drozdowicz, W Pawlik, R Sendur. Gastroprotective and ulcer healing effects of solon, a synthetic flavonoid derivative of sophoradin. Hepato-gastroenterology. 1987 Aug; 34(4):164-70. doi: ". [PMID: 3478294]
  • J Sarosiek, J Bilski, H Tsukada, A Slomiany, B L Slomiany. Effect of solon on gastric mucus viscosity, permeability to hydrogen ion, and susceptibility to pepsin. Digestion. 1987; 37(4):238-46. doi: 10.1159/000199507. [PMID: 2824264]
  • S J Konturek, T Radecki, T Brzozowski, D Drozdowicz, I Piastucki, M Muramatsu, M Tanaka, H Aihara. Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins. European journal of pharmacology. 1986 Jun; 125(2):185-92. doi: 10.1016/0014-2999(86)90026-9. [PMID: 3743635]