19-Noraldosterone (BioDeep_00000036523)

   

human metabolite Endogenous


代谢物信息卡片


(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde

化学式: C20H26O5 (346.17801460000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(C2(C1C3CCC4=CC(=O)CCC4C3C(C2)O)C=O)C(=O)CO
InChI: InChI=1S/C20H26O5/c21-9-18(25)16-6-5-15-14-3-1-11-7-12(23)2-4-13(11)19(14)17(24)8-20(15,16)10-22/h7,10,13-17,19,21,24H,1-6,8-9H2/t13-,14-,15-,16+,17-,19+,20+/m0/s1

描述信息

19-noraldosterone belongs to the family of Gluco/mineralocorticoids, Progestogins and Derivatives. These are steroids whose structure is based on an hydroxylated prostane moiety.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

2 个代谢物同义名

(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde; 19-Noraldosterone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yoshiyu Takeda, Takashi Yoneda, Masashi Demura, Kenji Furukawa, Mikiya Usukura, Hiroshi Mabuchi. 19-Noraldosterone in pregnancy-induced hypertension. Steroids. 2002 Jun; 67(7):605-10. doi: 10.1016/s0039-128x(02)00009-0. [PMID: 11996933]
  • Y Takeda. 19-Noraldosterone. Critical reviews in biochemistry and molecular biology. 1999; 34(2):71-9. doi: 10.1080/10409239991209200. [PMID: 10333385]
  • Y Takeda, I Miyamori, T Yoneda, K Furukawa, H Hatakeyama, S Inaba, Y Ito, R Takeda, H Mabuchi. Effect of adrenocorticotropin stimulation on the synthesis of 19-noraldosterone in man. The Journal of clinical endocrinology and metabolism. 1996 May; 81(5):1852-5. doi: 10.1210/jcem.81.5.8626846. [PMID: 8626846]
  • Y Takeda, I Miyamori, T Yoneda, K Hurukawa, S Inaba, Y Ito, R Takeda. Urinary excretion of 19-noraldosterone in the spontaneously hypertensive rat and stroke-prone spontaneously hypertensive rat. Clinical and experimental pharmacology & physiology. Supplement. 1995 Dec; 22(1):S20-2. doi: 10.1111/j.1440-1681.1995.tb02882.x. [PMID: 9072356]
  • Y Takeda, I Miyamori, T Yoneda, K Iki, R Takeda. Effect of aging on urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone. The Journal of steroid biochemistry and molecular biology. 1995 Apr; 52(4):383-6. doi: 10.1016/0960-0760(94)00186-p. [PMID: 7734407]
  • Y Takeda, I Miyamori, R Takeda. Significance of 19-noraldosterone, a new mineralocorticoid, in clinical and experimental hypertension. Steroids. 1995 Jan; 60(1):137-42. doi: 10.1016/0039-128x(94)00032-8. [PMID: 7792799]
  • Y Takeda, I Miyamori, K Iki, R Takeda, P Vecsei. Urinary excretion of 19-noraldosterone, 18, 19-dihydroxycorticosterone and 18-hydroxy-19-norcorticosterone in patients with aldosterone-producing adenoma or idiopathic hyperaldosteronism. Acta endocrinologica. 1992 Jun; 126(6):484-8. doi: 10.1530/acta.0.1260484. [PMID: 1642080]
  • Y Takeda, I Miyamori, R Takeda, S Lewicka, P Vecsei. Effect of sodium restriction on urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone, newly identified mineralocorticoids in man. The Journal of clinical endocrinology and metabolism. 1992 May; 74(5):1195-7. doi: 10.1210/jcem.74.5.1569167. [PMID: 1569167]
  • M Harnik, Y Kashman, S Carmely, M Cojocaru. Preparation of 3 beta, 5 alpha-, 3 alpha, 5 alpha- and 3 alpha, 5 beta-tetrahydro derivatives of 19-noraldosterone by chemical synthesis and microbial bioconversion. Journal of steroid biochemistry. 1988 Jul; 31(1):97-105. doi: 10.1016/0022-4731(88)90211-7. [PMID: 3398535]
  • D J Morris, A S Brem, N A Saccoccio, M Pacholski, M Harnik. Mineralocorticoid activity of 19-hydroxyaldosterone, 19-nor-aldosterone, and 3 beta-hydroxy-delta 5-aldosterone: relative potencies measured in two bioassay systems. Endocrinology. 1986 Jun; 118(6):2505-9. doi: 10.1210/endo-118-6-2505. [PMID: 3084221]
  • D J Morris, J Gorsline, P A Tresco, M Harnik. The effects of 19-nor-aldosterone on blood pressure of adrenalectomized spontaneously hypertensive rats. Steroids. 1985 Dec; 46(6):1003-10. doi: 10.1016/s0039-128x(85)80007-6. [PMID: 3842021]