L-Gulonolactone (BioDeep_00000003575)
Secondary id: BioDeep_00000415738
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019
代谢物信息卡片
化学式: C6H10O6 (178.04773600000001)
中文名称: L-古洛糖酸-gamma-内酯, 古洛糖酸内酯, L-古洛糖酸-γ-内酯, L-古洛糖酸-γ-内酯, L-古洛糖酸-γ-内酯
谱图信息:
最多检出来源 Homo sapiens(feces) 0.16%
分子结构信息
SMILES: C(C(C1C(C(C(=O)O1)O)O)O)O
InChI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
描述信息
L-Gulonolactone (also known as reduced ascorbic acid, RAA) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8), which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals. The enzyme L-Gulono-1,4-lactone oxidase is missing in scurvy-prone, vitamin C-deficient animals, such as humans. L-Gulonolactone is present in human blood and has been used as one of the markers to compare changes in exercise-induced oxidative stress. (PMID: 16956367, 16494601) [HMDB]
L-Gulonolactone (also known as reduced ascorbic acid, RAA) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8), which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals. The enzyme L-Gulono-1,4-lactone oxidase is missing in scurvy-prone, vitamin C-deficient animals, such as humans. L-Gulonolactone is present in human blood and has been used as one of the markers to compare changes in exercise-induced oxidative stress. (PMID:16956367, 16494601).
COVID info from COVID-19 Disease Map
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L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
同义名列表
29 个代谢物同义名
(3S,4R,5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-one; L-(+)-Gulonic acid gamma-lactone; L-Gulonic acid γ-lactone; L-(+)-Gulonic acid γ-lactone; L-Gulonic acid gamma-lactone; L-Gulonic γ-lactone; Gulonolactone, (D)-isomer; Gulonolactone, (L)-isomer; L-(+)-gulono-1,4-Lactone; L-Gulonate gamma-lactone; L-Gulonic acid γ-lactone; L-Gulonic acid g-lactone; L-Gulono-gamma-lactone; Reduced ascorbic acid; L-Gulonate γ-lactone; L-Gulonate g-lactone; d-talono-1,4-lactone; Dihydroascorbic acid; L-Gulono-1,4-lactone; gamma-Gulonolactone; L-Gulonic g-lactone; L-Gulono-γ-lactone; L-Gulono-g-lactone; Reduced ascorbate; L-Gulonolactone; g-Gulonolactone; Γ-gulonolactone; Gulonolactone; Gulonolactone
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:17587
- KEGG: C01040
- PubChem: 439373
- PubChem: 608
- HMDB: HMDB0003466
- Metlin: METLIN64612
- Metlin: METLIN3314
- Wikipedia: L-gulonolactone oxidase
- MetaCyc: L-GULONO-1-4-LACTONE
- MetaCyc: CPD-330
- KNApSAcK: C00053429
- foodb: FDB023179
- chemspider: 388493
- CAS: 3327-64-8
- CAS: 1128-23-0
- PMhub: MS000010052
- PubChem: 4282
- PDB-CCD: X8L
- 3DMET: B01369
- NIKKAJI: J208.558E
- RefMet: L-Gulonolactone
- medchemexpress: HY-W016628
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-912
分类词条
相关代谢途径
Reactome(0)
PlantCyc(2)
代谢反应
34 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(11)
- L-ascorbate biosynthesis II (L-gulose pathway):
β-L-gulose 1-phosphate + H2O ⟶ L-gulopyranose + phosphate - L-ascorbate biosynthesis IV:
H2O + L-gulono-1,4-lactone ⟶ H+ + L-gulonate - L-ascorbate biosynthesis II (L-gulose pathway):
β-L-gulose 1-phosphate + H2O ⟶ L-gulopyranose + phosphate - L-ascorbate biosynthesis IV:
L-gulono-1,4-lactone + O2 ⟶ L-xylo-hex-3-ulono-1,4-lactone + hydrogen peroxide - ascorbate biosynthesis:
L-gulonate ⟶ H2O + L-gulono-1,4-lactone - L-ascorbate biosynthesis IV:
H2O + L-gulono-1,4-lactone ⟶ H+ + L-gulonate - L-ascorbate biosynthesis IV:
H2O + L-gulono-1,4-lactone ⟶ H+ + L-gulonate - L-ascorbate biosynthesis IV:
L-gulonate + NADP+ ⟶ aldehydo-D-glucuronate + H+ + NADPH - L-ascorbate biosynthesis VI:
L-gulonate + NADP+ ⟶ D-glucuronate + H+ + NADPH - L-ascorbate biosynthesis IV:
L-gulonate + NADP+ ⟶ aldehydo-D-glucuronate + H+ + NADPH - L-ascorbate biosynthesis IV:
L-gulonate + NADP+ ⟶ aldehydo-D-glucuronate + H+ + NADPH
Plant Reactome(0)
INOH(0)
PlantCyc(20)
- L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis VI (plants, myo-inositol pathway):
L-gulonate + NADP+ ⟶ aldehydo-D-glucuronate + H+ + NADPH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (L-gulose pathway):
GDP-α-D-mannose ⟶ GDP-β-L-gulose - L-ascorbate biosynthesis II (L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (L-gulose pathway):
GDP-α-D-mannose ⟶ GDP-β-L-gulose - L-ascorbate biosynthesis II (plants, L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (L-gulose pathway):
L-gulopyranose + NAD+ ⟶ H+ + L-gulono-1,4-lactone + NADH - L-ascorbate biosynthesis II (L-gulose pathway):
GDP-α-D-mannose ⟶ GDP-β-L-gulose
COVID-19 Disease Map(1)
- @COVID-19 Disease
Map["name"]:
2-Methyl-3-acetoacetyl-CoA + Coenzyme A ⟶ Acetyl-CoA + Propanoyl-CoA
PathBank(1)
- Ascorbate Biosynthesis:
Hydrogen Ion + NADPH + aldehydo-D-glucuronate ⟶ Gulonic acid + NADP
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hongbin Tu, Yu Wang, Hongyan Li, Lauren R Brinster, Mark Levine. Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo.
EBioMedicine.
2017 Sep; 23(?):125-135. doi:
10.1016/j.ebiom.2017.08.017. [PMID: 28851583] - Yi Li, Chang-Xin Shi, Karen L Mossman, Jack Rosenfeld, Yong Chool Boo, Herb E Schellhorn. Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase.
Human gene therapy.
2008 Dec; 19(12):1349-58. doi:
10.1089/hum.2008.0106. [PMID: 18764764] - F H Kratzer, H J Almquist, P Vohra. Effect of diet on growth and plasma ascorbic acid in chicks.
Poultry science.
1996 Jan; 75(1):82-9. doi:
10.3382/ps.0750082. [PMID: 8650116] - A Papas, J R Ingalls, L D Campbell. Studies on the effects of rapeseed meal on thyroid status of cattle, glucosinolate and iodine content of milk and other parameters.
The Journal of nutrition.
1979 Jul; 109(7):1129-39. doi:
10.1093/jn/109.7.1129. [PMID: 448457] - . .
.
. doi:
. [PMID: 7138847]