dmnq (BioDeep_00000338311)
natural product
代谢物信息卡片
化学式: C12H10O4 (218.0579)
中文名称: 2,3-二甲氧基-1,4-萘醌
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C(=O)C2=CC=CC=C2C1=O)OC
InChI: InChI=1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:64215
- PubChem: 3136
- ChEMBL: CHEMBL402468
- CAS: 6956-96-3
- PMhub: MS000134232
- LOTUS: LTS0033176
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 24079 - Bignoniaceae: LTS0033176
- 2759 - Eukaryota: LTS0033176
- 3398 - Magnoliopsida: LTS0033176
- 211923 - Newbouldia: LTS0033176
- 211924 - Newbouldia laevis: 10.1248/CPB.53.616
- 211924 - Newbouldia laevis: LTS0033176
- 35493 - Streptophyta: LTS0033176
- 58023 - Tracheophyta: LTS0033176
- 33090 - Viridiplantae: LTS0033176
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Xiao-Yu Lu, Bing-Chen Liu, Li-Hua Wang, Li-Li Yang, Qing Bao, Yu-Jia Zhai, Abdel A Alli, Tiffany L Thai, Douglas C Eaton, Wei-Zhi Wang, He-Ping Ma. Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes.
Biochimica et biophysica acta.
2015 May; 1853(5):965-74. doi:
10.1016/j.bbamcr.2015.01.007
. [PMID: 25601712] - Katarína Kozics, Veronika Klusová, Annamária Srančíková, Pavol Mučaji, Darina Slameňová, Lubica Hunáková, Barbara Kusznierewicz, Eva Horváthová. Effects of Salvia officinalis and Thymus vulgaris on oxidant-induced DNA damage and antioxidant status in HepG2 cells.
Food chemistry.
2013 Dec; 141(3):2198-206. doi:
10.1016/j.foodchem.2013.04.089
. [PMID: 23870948] - Lonnie Schneider, Samantha Giordano, Blake R Zelickson, Michelle S Johnson, Gloria A Benavides, Xiaosen Ouyang, Naomi Fineberg, Victor M Darley-Usmar, Jianhua Zhang. Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.
Free radical biology & medicine.
2011 Dec; 51(11):2007-17. doi:
10.1016/j.freeradbiomed.2011.08.030
. [PMID: 21945098] - Yasuhiro Ishihara, Satomi Ishii, Yufu Sakai, Nobue Yamamura, Yukiko Onishi, Norio Shimamoto. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
Journal of applied toxicology : JAT.
2011 Mar; 31(2):173-8. doi:
10.1002/jat.1578
. [PMID: 20803752] - Yapo Guillaume Aboua, Stefan Stephanus du Plessis, Patricia Reichgelt, Nicole Brooks. The in vitro effects of superoxide, some commercially available antioxidants and red palm oil on sperm motility.
Asian journal of andrology.
2009 Nov; 11(6):695-702. doi:
10.1038/aja.2009.55
. [PMID: 19802000] - Joel D Parry, Amy V Pointon, Ursula Lutz, Friederike Teichert, Joanne K Charlwood, Pui Hei Chan, Toby J Athersuch, Emma L Taylor, Rajinder Singh, Jinli Luo, Kate M Phillips, Angelique Vetillard, Jonathan J Lyon, Hector C Keun, Werner K Lutz, Timothy W Gant. Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
Chemical research in toxicology.
2009 Apr; 22(4):717-25. doi:
10.1021/tx800472z
. [PMID: 19338340] - An S Tan, Michael V Berridge. Differential effects of redox-cycling and arylating quinones on trans-plasma membrane electron transport.
BioFactors (Oxford, England).
2008; 34(3):183-90. doi:
10.3233/bio-2009-1071
. [PMID: 19734119] - Blanka Burýsková, Klára Hilscherová, Ludek Bláha, Blahoslav Marsálek, Ivan Holoubek. Toxicity and modulations of biomarkers in Xenopus laevis embryos exposed to polycyclic aromatic hydrocarbons and their N-heterocyclic derivatives.
Environmental toxicology.
2006 Dec; 21(6):590-8. doi:
10.1002/tox.20222
. [PMID: 17091503] - Yasuhiro Ishihara, Dai Shiba, Norio Shimamoto. Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.
Toxicology and applied pharmacology.
2006 Jul; 214(2):109-17. doi:
10.1016/j.taap.2005.12.003
. [PMID: 16430935] - Roger F Duncan, Hazel Peterson, Curt H Hagedorn, Alex Sevanian. Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells.
The Biochemical journal.
2003 Jan; 369(Pt 2):213-25. doi:
10.1042/bj20020435
. [PMID: 12215171] - Carlos Martínez-Salgado, Nélida Eleno, Paula Tavares, Alicia Rodríguez-Barbero, Javier García-Criado, Juan P Bolaños, José M López-Novoa. Involvement of reactive oxygen species on gentamicin-induced mesangial cell activation.
Kidney international.
2002 Nov; 62(5):1682-92. doi:
10.1046/j.1523-1755.2002.00635.x
. [PMID: 12371968] - Andrea Pautz, Rochus Franzen, Simone Dorsch, Boris Böddinghaus, Verena A Briner, Josef Pfeilschifter, Andrea Huwiler. Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells.
Kidney international.
2002 Mar; 61(3):790-6. doi:
10.1046/j.1523-1755.2002.00222.x
. [PMID: 11849427] - Douglas R Moellering, Anna-Liisa Levonen, Young-Mi Go, Rakesh P Patel, Dale A Dickinson, Henry Jay Forman, Victor M Darley-Usmar. Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress.
The Biochemical journal.
2002 Feb; 362(Pt 1):51-9. doi:
10.1042/0264-6021:3620051
. [PMID: 11829739] - K B Sandau, J Zhou, T Kietzmann, B Brüne. Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide.
The Journal of biological chemistry.
2001 Oct; 276(43):39805-11. doi:
10.1074/jbc.m107689200
. [PMID: 11514583] - S R Kim, J Y Lee, M Y Lee, S M Chung, O N Bae, J H Chung. Association of quinone-induced platelet anti-aggregation with cytotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology.
2001 Jul; 62(1):176-82. doi:
10.1093/toxsci/62.1.176
. [PMID: 11399805] - A Huwiler, B Böddinghaus, A Pautz, S Dorsch, R Franzen, V A Briner, V Brade, J Pfeilschifter. Superoxide potently induces ceramide formation in glomerular endothelial cells.
Biochemical and biophysical research communications.
2001 Jun; 284(2):404-10. doi:
10.1006/bbrc.2001.4941
. [PMID: 11394893] - K Sandau, J Pfeilschifter, B Brüne. Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis.
Kidney international.
1997 Aug; 52(2):378-86. doi:
10.1038/ki.1997.344
. [PMID: 9263993] - M M Shi, A Kugelman, T Iwamoto, L Tian, H J Forman. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells.
The Journal of biological chemistry.
1994 Oct; 269(42):26512-7. doi:
10.1016/s0021-9258(18)47224-9
. [PMID: 7929374] - Y Chen, T M Chan. Orthovanadate and 2,3-dimethoxy-1,4-naphthoquinone augment growth factor-induced cell proliferation and c-fos gene expression in 3T3-L1 cells.
Archives of biochemistry and biophysics.
1993 Aug; 305(1):9-16. doi:
10.1006/abbi.1993.1387
. [PMID: 8393647] - M Floreani, F Carpenedo. The catecholamine-mediated positive inotropic effect of simple quinones is related to superoxide anion generation.
The Journal of pharmacology and experimental therapeutics.
1992 Feb; 260(2):468-73. doi:
"
. [PMID: 1310736]