2,2,9-Trimethyldecane (BioDeep_00000033748)
human metabolite Endogenous
代谢物信息卡片
1-Octadecanol, mixed with 1-hexadecanol
化学式: C13H28 (184.2190888)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCCCCC(C)(C)C
InChI: InChI=1S/C13H28/c1-12(2)10-8-6-7-9-11-13(3,4)5/h12H,6-11H2,1-5H3
描述信息
2,2,9-Trimethyldecane is found in fruits. 2,2,9-Trimethyldecane is a constituent of the fruit of Prunus domestica (plum)
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 545800
- HMDB: HMDB0030314
- KNApSAcK: C00058151
- foodb: FDB002153
- chemspider: 475069
- CAS: 62238-00-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaohong Deng, Dandan Chen, Xianjun Sun, Jingcheng Dong, Jianhua Huang. Effects of ginger extract and its major component 6-gingerol on anti-tumor property through mitochondrial biogenesis in CD8+ T cells.
Journal of food science.
2022 Jul; 87(7):3307-3317. doi:
10.1111/1750-3841.16228. [PMID: 35708209] - Lingming Zhang, Jingdi Yan, Jianming Liu, Chao Meng, Fanglan Liu, Chunhua Xia. Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 101(?):154097. doi:
10.1016/j.phymed.2022.154097. [PMID: 35417848] - Nabila Zein, Fathy Yassin, Shaza Makled, Saqer S Alotaibi, Sarah M Albogami, Gomaa Mostafa-Hedeab, Gaber El-Saber Batiha, Yaser Hosny Ali Elewa. Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):113020. doi:
10.1016/j.biopha.2022.113020. [PMID: 35658249] - Xue Han, Panpan Liu, Bin Zheng, Muqing Zhang, Yuanyuan Zhang, Yucong Xue, Chenxu Liu, Xi Chu, Xiangting Wang, Shijiang Sun, Li Chu. 6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
The Journal of nutritional biochemistry.
2022 06; 104(?):108975. doi:
10.1016/j.jnutbio.2022.108975. [PMID: 35245652] - Li Zhong, Rui Wang, Qin-Hui Wen, Jian Li, Jia-Wei Lin, Xin-An Zeng. The interaction between bovine serum albumin and [6]-,[8]- and [10]-gingerol: An effective strategy to improve the solubility and stability of gingerol.
Food chemistry.
2022 Mar; 372(?):131280. doi:
10.1016/j.foodchem.2021.131280. [PMID: 34818732] - Quan-Cao Zhan, Yu-Zhe Liu, Yu-Meng Xi, Yan Zeng, Jia-Yu Tian, Li Liu, Dong Li, Yamahara Johji, Jian-Wei Wang. [6-Gingerol ameliorates adipose tissue insulin resistance in aging rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Mar; 47(6):1642-1649. doi:
10.19540/j.cnki.cjcmm.20211008.702. [PMID: 35347963] - James R Templeman, Kylie Hogan, Alexandra Blanchard, Christopher Pf Marinangeli, Alexandra Camara, Adronie Verbrugghe, Anna K Shoveller. Effect of raw and encapsulated policosanol on lipid profiles, blood biochemistry, activity, energy expenditure and macronutrient metabolism of adult cats.
Journal of feline medicine and surgery.
2022 02; 24(2):177-184. doi:
10.1177/1098612x211013738. [PMID: 33988050] - Chwan-Li Shen, Rui Wang, Guangchen Ji, Moamen M Elmassry, Masoud Zabet-Moghaddam, Heather Vellers, Abdul N Hamood, Xiaoxia Gong, Parvin Mirzaei, Shengmin Sang, Volker Neugebauer. Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation.
The Journal of nutritional biochemistry.
2022 02; 100(?):108904. doi:
10.1016/j.jnutbio.2021.108904. [PMID: 34748918] - Babatunde Joseph Oso, Akinwunmi Oluwaseun Adeoye, Ige Francis Olaoye. Pharmacoinformatics and hypothetical studies on allicin, curcumin, and gingerol as potential candidates against COVID-19-associated proteases.
Journal of biomolecular structure & dynamics.
2022 Jan; 40(1):389-400. doi:
10.1080/07391102.2020.1813630. [PMID: 32876538] - Palayakotai R Raghavan. Metadichol®: A Novel Nanolipid Formulation That Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses In Vitro.
BioMed research international.
2022; 2022(?):1558860. doi:
10.1155/2022/1558860. [PMID: 35039793] - Fabio Arena, Anna Rita Daniela Coda, Valentina Meschini, Roberto Verzicco, Arcangelo Liso. Droplets generated from toilets during urination as a possible vehicle of carbapenem-resistant Klebsiella pneumoniae.
Antimicrobial resistance and infection control.
2021 10; 10(1):149. doi:
10.1186/s13756-021-01023-5. [PMID: 34670621] - A Radice, F Fassio, E Meucci, M C L Iorno, D Macchia. Potential culprits for immediate hypersensitivity reactions to BNT162b2 mRNA COVID-19 vaccine: not just PEG.
European annals of allergy and clinical immunology.
2021 09; 53(5):240-242. doi:
10.23822/eurannaci.1764-1489.214. [PMID: 33913314] - Akalesh Kumar Verma, Vikas Kumar, Sweta Singh, Bhabesh Ch Goswami, Ihosvany Camps, Aishwarya Sekar, Sanghwa Yoon, Keun Woo Lee. Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111356. doi:
10.1016/j.biopha.2021.111356. [PMID: 33561649] - Milica Zrnic Ciric, Miodrag Ostojic, Ivana Baralic, Jelena Kotur-Stevuljevic, Brizita I Djordjevic, Stana Markovic, Stefan Zivkovic, Ivan Stankovic. Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy.
Nutrients.
2021 Mar; 13(3):. doi:
10.3390/nu13030903. [PMID: 33802219] - Yinxue Guo, Maorong Hu, Juan Ma, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H M Shair, Pingyu Ge. Protective effect of panaxydol against repeated administration of aristolochic acid on renal function and lipid peroxidation products via activating Keap1-Nrf2/ARE pathway in rat kidney.
Journal of biochemical and molecular toxicology.
2021 Jan; 35(1):e22619. doi:
10.1002/jbt.22619. [PMID: 32894623] - Seong-A Ju, Quang-Tam Nguyen, Thu-Ha T Nguyen, Jae-Hee Suh, Won G An, Zak Callaway, Yeonsoo Joe, Hun Taeg Chung, Byung-Sam Kim. Pretreatment with 6-Gingerol Ameliorates Sepsis-Induced Immune Dysfunction by Regulating the Cytokine Balance and Reducing Lymphocyte Apoptosis.
Oxidative medicine and cellular longevity.
2021; 2021(?):5427153. doi:
10.1155/2021/5427153. [PMID: 35003518] - Zhenya Zhai, Jianping Liu, Kai-Min Niu, Chong Lin, Yue Tu, Yichun Liu, Lichuang Cai, Huiping Liu, Kexian Ouyang. Integrated Metagenomics and Metabolomics to Reveal the Effects of Policosanol on Modulating the Gut Microbiota and Lipid Metabolism in Hyperlipidemic C57BL/6 Mice.
Frontiers in endocrinology.
2021; 12(?):722055. doi:
10.3389/fendo.2021.722055. [PMID: 34707567] - Shan Xu, Haibao Zhang, Tianjie Liu, Zixi Wang, Wenjie Yang, Tao Hou, Xinyang Wang, Dalin He, Pengsheng Zheng. 6-Gingerol suppresses tumor cell metastasis by increasing YAPser127 phosphorylation in renal cell carcinoma.
Journal of biochemical and molecular toxicology.
2021 Jan; 35(1):e22609. doi:
10.1002/jbt.22609. [PMID: 32926756] - Pippa Staps, William B Rizzo, Frédéric M Vaz, Marianna Bugiani, Martin Giera, Bram Heijs, Antoine H C van Kampen, Mia L Pras-Raves, Marjolein Breur, Annemieke Groen, Sacha Ferdinandusse, Marinette van der Graaf, Gert Van Goethem, Martin Lammens, Ron A Wevers, Michèl A A P Willemsen. Disturbed brain ether lipid metabolism and histology in Sjögren-Larsson syndrome.
Journal of inherited metabolic disease.
2020 11; 43(6):1265-1278. doi:
10.1002/jimd.12275. [PMID: 32557630] - Jing Wang, Yong Chen, Xiaosong Hu, Fengqin Feng, Luyun Cai, Fang Chen. Assessing the Effects of Ginger Extract on Polyphenol Profiles and the Subsequent Impact on the Fecal Microbiota by Simulating Digestion and Fermentation In Vitro.
Nutrients.
2020 Oct; 12(10):. doi:
10.3390/nu12103194. [PMID: 33086593] - Shogo Sesoko, Jinhong Huang, Takashige Okayama, Erika Nishida, Kazuhisa Miyoshi. Safety, Tolerability, Pharmacokinetics, and Food Effects on TAC-302 in Healthy Participants: Randomized, Double-Blind, Placebo-Controlled, Single-Dose and Multiple-Dose Studies.
Clinical pharmacology in drug development.
2020 10; 9(7):821-832. doi:
10.1002/cpdd.776. [PMID: 31970939] - Dana S'aulis, Emily A Khoury, Morgan Zabel, William B Rizzo. 1-O-Alkylglycerol accumulation reveals abnormal ether glycerolipid metabolism in Sjögren-Larsson syndrome.
Molecular genetics and metabolism.
2020 Sep; 131(1-2):253-258. doi:
10.1016/j.ymgme.2020.08.002. [PMID: 32800643] - Amanda Stefanson, Marica Bakovic. Dietary polyacetylene falcarinol upregulated intestinal heme oxygenase-1 and modified plasma cytokine profile in late phase lipopolysaccharide-induced acute inflammation in CB57BL/6 mice.
Nutrition research (New York, N.Y.).
2020 08; 80(?):89-105. doi:
10.1016/j.nutres.2020.06.014. [PMID: 32738564] - Xue Han, Panpan Liu, Miaomiao Liu, Ziheng Wei, Sen Fan, Xiangting Wang, Shijiang Sun, Li Chu. [6]-Gingerol Ameliorates ISO-Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF-κB Pathway.
Molecular nutrition & food research.
2020 07; 64(13):e2000003. doi:
10.1002/mnfr.202000003. [PMID: 32438504] - Chunlin Li, Yu Ding, Quanjin Si, Kailiang Li, Kun Xu. Multiple functions of policosanol in elderly patients with dyslipidemia.
The Journal of international medical research.
2020 Jul; 48(7):300060520936082. doi:
10.1177/0300060520936082. [PMID: 32703038] - Mohamed Ibrahim, Hatem A Sarhan, Youssef W Naguib, Hamdy Abdelkader. Design, characterization and in vivo evaluation of modified release baclofen floating coated beads.
International journal of pharmaceutics.
2020 May; 582(?):119344. doi:
10.1016/j.ijpharm.2020.119344. [PMID: 32315750] - Weimo Han, Mengchun Hou, Faming He, Wenhua Zhang, Bi Shi. Ecotoxicity and interacting mechanism of anionic surfactant sodium dodecyl sulfate (SDS) and its mixtures with nonionic surfactant fatty alcohol-polyoxyethlene ether (AEO).
Aquatic toxicology (Amsterdam, Netherlands).
2020 May; 222(?):105467. doi:
10.1016/j.aquatox.2020.105467. [PMID: 32208300] - Chao Wen, Ying Liu, Yuanwei Ye, Zhengguo Tao, Zongjia Cheng, Tian Wang, Yanmin Zhou. Effects of gingerols-rich extract of ginger on growth performance, serum metabolites, meat quality and antioxidant activity of heat-stressed broilers.
Journal of thermal biology.
2020 Apr; 89(?):102544. doi:
10.1016/j.jtherbio.2020.102544. [PMID: 32364987] - Jianxia Wen, Lu Zhang, Jian Wang, Jiabo Wang, Lifu Wang, Ruilin Wang, Ruisheng Li, Honghong Liu, Shizhang Wei, Haotian Li, Wenjun Zou, Yanling Zhao. Therapeutic effects of higenamine combined with [6]-gingerol on chronic heart failure induced by doxorubicin via ameliorating mitochondrial function.
Journal of cellular and molecular medicine.
2020 04; 24(7):4036-4050. doi:
10.1111/jcmm.15041. [PMID: 32073745] - Shan Xu, Haibao Zhang, Tianjie Liu, Wenjie Yang, Wei Lv, Dalin He, Peng Guo, Lei Li. 6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3β-cyclin D1 pathway in renal-cell carcinoma.
Cancer chemotherapy and pharmacology.
2020 02; 85(2):379-390. doi:
10.1007/s00280-019-03999-9. [PMID: 31832810] - Zhen Jie Low, Juan Xiong, Ying Xie, Guang-Lei Ma, Howard Saw, Hoa Thi Tran, Soo Lin Wong, Li Mei Pang, July Fong, Peng Lu, Jin-Feng Hu, Liang Yang, Yansong Miao, Zhao-Xun Liang. Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin.
Chemical communications (Cambridge, England).
2020 01; 56(5):822-825. doi:
10.1039/c9cc08908j. [PMID: 31848534] - Aminu Ishaka, Mustapha Umar Imam, Maznah Ismail. Nanoemulsification of Rice Bran Wax Policosanol Enhances Its Cardio-protective Effects via Modulation of Hepatic Peroxisome Proliferator-activated Receptor gamma in Hyperlipidemic Rats.
Journal of oleo science.
2020; 69(10):1287-1295. doi:
10.5650/jos.ess20098. [PMID: 33028753] - Fang-Ling Zhang, Bo-Wei Zhou, Zheng-Zheng Yan, Jin Zhao, Bing-Cheng Zhao, Wei-Feng Liu, Cai Li, Ke-Xuan Liu. 6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis.
Cytokine.
2020 01; 125(?):154854. doi:
10.1016/j.cyto.2019.154854. [PMID: 31539844] - Dahae Lee, Jaemin Lee, Kim Long Vu-Huynh, Thi Hong Van Le, Thi Hong Tuoi Do, Gwi Seo Hwang, Jeong Hill Park, Ki Sung Kang, Minh Duc Nguyen, Noriko Yamabe. Protective Effect of Panaxynol Isolated from Panax vietnamensis against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies.
Biomolecules.
2019 12; 9(12):. doi:
10.3390/biom9120890. [PMID: 31861234] - Sucai Song, Minyan Dang, Mukresh Kumar. Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism.
Inflammopharmacology.
2019 Dec; 27(6):1243-1254. doi:
10.1007/s10787-019-00569-6. [PMID: 30826930] - Stefano Dall'Acqua, Iztok Grabnar, Roberto Verardo, Enio Klaric, Luigi Marchionni, Eddie Luidy-Imada, Stefania Sut, Chiara Agostinis, Roberta Bulla, Beatrice Perissutti, Dario Voinovich. Combined extracts of Echinacea angustifolia DC. and Zingiber officinale Roscoe in softgel capsules: Pharmacokinetics and immunomodulatory effects assessed by gene expression profiling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Dec; 65(?):153090. doi:
10.1016/j.phymed.2019.153090. [PMID: 31557666] - Da-Eun Nam, Jeong-Moon Yun, Dakyung Kim, Ok-Kyung Kim. Policosanol Attenuates Cholesterol Synthesis via AMPK Activation in Hypercholesterolemic Rats.
Journal of medicinal food.
2019 Nov; 22(11):1110-1117. doi:
10.1089/jmf.2019.4491. [PMID: 31613687] - Joshua Buse, Jason L Robinson, Rosemary Shyne, Qingli Chi, Darlene Affleck, Donna Duce, Isolde Seiden-Long. Rising above helium: A hydrogen carrier gas chromatography flame ionization detection (GC-FID) method for the simultaneous quantification of toxic alcohols and ethylene glycol in human plasma specimens.
Clinical biochemistry.
2019 Nov; 73(?):98-104. doi:
10.1016/j.clinbiochem.2019.08.007. [PMID: 31425671] - Ting Du, Rongjin Sun, Shiming Du, Song Gao, Ming Hu, Yong Zhang, Jing Chen, Guangde Yang. Metabolic profiles of Xiao Chai Hu Tang in mouse plasma, bile and urine by the UHPLC-ESI-Q-TOF/MS technique.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1128(?):121767. doi:
10.1016/j.jchromb.2019.121767. [PMID: 31627161] - Xiao Liang, Yulin Chen, Li Wu, Abi Maharjan, Balmukunda Regmi, Jiwen Zhang, Shuangying Gui. In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Sep; 117(?):108993. doi:
10.1016/j.biopha.2019.108993. [PMID: 31228805] - Hye-Jeong Park, Dhananjay Yadav, Da-Jeong Jeong, Suk-Jeong Kim, Myung-Ae Bae, Jae-Ryong Kim, Kyung-Hyun Cho. Short-Term Consumption of Cuban Policosanol Lowers Aortic and Peripheral Blood Pressure and Ameliorates Serum Lipid Parameters in Healthy Korean Participants: Randomized, Double-Blinded, and Placebo-Controlled Study.
International journal of environmental research and public health.
2019 03; 16(5):. doi:
10.3390/ijerph16050809. [PMID: 30841655] - Li Liu, Ling Yao, Shang Wang, Zhiwei Chen, Tingli Han, Peng Ma, Lirong Jiang, Chunlin Yuan, Jinxiu Li, Dazhi Ke, Chunli Li, Johji Yamahara, Yuhao Li, Jianwei Wang. 6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1.
Molecular nutrition & food research.
2019 03; 63(6):e1800649. doi:
10.1002/mnfr.201800649. [PMID: 30575271] - Najia Shahid, Ayesha Iqbal, Amna Jabbar Siddiqui, Muhammad Shoaib, Syed Ghulam Musharraf. Plasma metabolite profiling and chemometric analyses of tobacco snuff dippers and patients with oral cancer: Relationship between metabolic signatures.
Head & neck.
2019 02; 41(2):291-300. doi:
10.1002/hed.25511. [PMID: 30548891] - Nabil N Al-Hashimi, Rand O Shahin, Aqeel N Al-Hashimi, Ajeal M Al Ajeal, Lubna H Tahtamouni, Chanbasha Basheer. Cetyl-alcohol-reinforced hollow fiber solid/liquid-phase microextraction and HPLC-DAD analysis of ezetimibe and simvastatin in human plasma and urine.
Biomedical chromatography : BMC.
2019 Feb; 33(2):e4410. doi:
10.1002/bmc.4410. [PMID: 30315647] - Ling-Ling Li, Ying Cui, Xing-Han Guo, Kai Ma, Ping Tian, Jing Feng, Jun-Ming Wang. Pharmacokinetics and Tissue Distribution of Gingerols and Shogaols from Ginger (Zingiber officinale Rosc.) in Rats by UPLC⁻Q-Exactive⁻HRMS.
Molecules (Basel, Switzerland).
2019 Jan; 24(3):. doi:
10.3390/molecules24030512. [PMID: 30708987] - Jinxiu Li, Shang Wang, Ling Yao, Peng Ma, Zhiwei Chen, Ting-Li Han, Chunlin Yuan, Jun Zhang, Lirong Jiang, Li Liu, Dazhi Ke, Chunli Li, Johji Yamahara, Yuhao Li, Jianwei Wang. 6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction.
Toxicology and applied pharmacology.
2019 01; 362(?):125-135. doi:
10.1016/j.taap.2018.11.001. [PMID: 30408433] - Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Reham Raafat El-Zeiky, Naif A Al-Gabri. New Insight on a Combination of Policosanol and 10-Dehydrogingerdione Phytochemicals as Inhibitors for Platelet Activation Biomarkers and Atherogenicity Risk in Dyslipidemic Rabbits: Role of CETP and PCSK9 Inhibition.
Applied biochemistry and biotechnology.
2018 Dec; 186(4):805-815. doi:
10.1007/s12010-018-2776-5. [PMID: 29740798] - Guangguo Tan, Xin Wang, Kui Liu, Xin Dong, Wenting Liao, Hong Wu. Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats.
Food & function.
2018 Nov; 9(11):5528-5535. doi:
10.1039/c8fo01217b. [PMID: 30209468] - Mohamed M Elseweidy, Hoda E Mohamed, Rania A Elrashidy, Hebatallah H Atteia, Gehad M Elnagar. Inhibition of Aortic Calcification by Policosanol in Dyslipidemic Rabbits Is Enhanced by Pentoxifylline: Potential Role of PCSK9.
Journal of cardiovascular pharmacology and therapeutics.
2018 11; 23(6):551-560. doi:
10.1177/1074248418775377. [PMID: 29742924] - Yimeng Zhou, Ning Li, Zhixia Qiu, Xiaoyu Lu, Min Fang, Xijing Chen, Lili Ren, Guangji Wang, Pingkai Ouyang. Superior anti-neoplastic activities of triacontanol-PEG conjugate: synthesis, characterization and biological evaluations.
Drug delivery.
2018 Nov; 25(1):1546-1559. doi:
10.1080/10717544.2018.1477864. [PMID: 30022695] - Shuai Wang, Miao Tian, Ronglai Yang, Yating Jing, Wei Chen, Jinliang Wang, Xian Zheng, Fengrong Wang. 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress.
Cardiovascular toxicology.
2018 10; 18(5):420-430. doi:
10.1007/s12012-018-9452-4. [PMID: 29605868] - Shohei Yoshida, Takahisa Noma, Kazuhisa Miyoshi, Hiroshi Tsukihara, Naoki Orimoto, Atsushi Hakozaki, Eiji Sasaki. Therapeutic effect of TAC-302, a cyclohexenoic fatty alcohol derivative, on bladder denervation-related storage and voiding dysfunctions in rats.
Neurourology and urodynamics.
2018 09; 37(7):2106-2113. doi:
10.1002/nau.23571. [PMID: 29635706] - Francisco Adelvane de Paulo Rodrigues, Alan Diego da Conceição Santos, Pedro Henrique Quintela Soares de Medeiros, Mara de Moura Gondim Prata, Tailane Caína de Souza Santos, James Almada da Silva, Gerly Anne de Castro Brito, Armênio Aguiar Dos Santos, Edilberto Rocha Silveira, Aldo Ângelo Moreira Lima, Alexandre Havt. Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulfonylmethane and dimethylamine production.
Scientific reports.
2018 08; 8(1):12154. doi:
10.1038/s41598-018-30522-6. [PMID: 30108263] - Xiaoyu Lu, Min Fang, Yu Dai, Yue Yang, Ali Fan, Jiaqiu Xu, Zhiying Qin, Yang Lu, Di Zhao, Xijing Chen, Ning Li. Quantification of triacontanol and its PEGylated prodrug in rat plasma by GC-MS/MS: Application to a pre-clinical pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jul; 1089(?):8-15. doi:
10.1016/j.jchromb.2018.04.037. [PMID: 29738967] - Raul-Augustin Mitran, Cristian Matei, Daniela Berger, Laura Băjenaru, Mihaela G Moisescu. Controlling drug release from mesoporous silica through an amorphous, nanoconfined 1-tetradecanol layer.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2018 Jun; 127(?):318-325. doi:
10.1016/j.ejpb.2018.02.020. [PMID: 29524598] - Kyung-Hyun Cho, Dhananjay Yadav, Suk-Jeong Kim, Jae-Ryong Kim. Blood Pressure Lowering Effect of Cuban Policosanol is Accompanied by Improvement of Hepatic Inflammation, Lipoprotein Profile, and HDL Quality in Spontaneously Hypertensive Rats.
Molecules (Basel, Switzerland).
2018 May; 23(5):. doi:
10.3390/molecules23051080. [PMID: 29751583] - Sanyog Jain, Pooja Yadav, Rajan Swami, Nitin Kumar Swarnakar, Varun Kushwah, Sameer S Katiyar. Lyotropic Liquid Crystalline Nanoparticles of Amphotericin B: Implication of Phytantriol and Glyceryl Monooleate on Bioavailability Enhancement.
AAPS PharmSciTech.
2018 May; 19(4):1699-1711. doi:
10.1208/s12249-018-0986-3. [PMID: 29532426] - Saoussem Harrabi, Azza Ferchichi, Asma Bacheli, Hayet Fellah. Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages.
Lipids in health and disease.
2018 Apr; 17(1):82. doi:
10.1186/s12944-018-0682-z. [PMID: 29661192] - Nicole C Smith, Sherri L Christian, Richard G Taylor, Javier Santander, Matthew L Rise. Immune modulatory properties of 6-gingerol and resveratrol in Atlantic salmon macrophages.
Molecular immunology.
2018 03; 95(?):10-19. doi:
10.1016/j.molimm.2018.01.004. [PMID: 29367081] - Tae Hwan Kim, Soyoung Shin, Sun Dong Yoo, Beom Soo Shin. Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice.
Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
10.3390/molecules23020349. [PMID: 29414892] - Michiyo Takagi, Kazunori Kimura, Ken-Ichi Nakashima, Makoto Inoue. Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids.
European journal of pharmacology.
2018 Feb; 820(?):138-145. doi:
10.1016/j.ejphar.2017.12.028. [PMID: 29248425] - Shohei Yoshida, Naoki Orimoto, Hiroshi Tsukihara, Takahisa Noma, Atsushi Hakozaki, Eiji Sasaki. TAC-302 promotes neurite outgrowth of isolated peripheral neurons and prevents bladder denervation related bladder dysfunctions following bladder outlet obstruction in rats.
Neurourology and urodynamics.
2018 02; 37(2):681-689. doi:
10.1002/nau.23375. [PMID: 28745805] - Kyung-Hyun Cho, Suk-Jeong Kim, Dhananjay Yadav, Jae-Yong Kim, Jae-Ryong Kim. Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double-Blinded, and Placebo-Controlled Study.
Oxidative medicine and cellular longevity.
2018; 2018(?):4809525. doi:
10.1155/2018/4809525. [PMID: 29854085] - Amanda L Stefanson, Marica Bakovic. Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses.
Oxidative medicine and cellular longevity.
2018; 2018(?):3153527. doi:
10.1155/2018/3153527. [PMID: 30420908] - Mahesh K Kaushik, Kosuke Aritake, Atsuko Takeuchi, Masashi Yanagisawa, Yoshihiro Urade. Octacosanol restores stress-affected sleep in mice by alleviating stress.
Scientific reports.
2017 08; 7(1):8892. doi:
10.1038/s41598-017-08874-2. [PMID: 28827687] - Mehdi Bin Samad, Md Nurul Absar Bin Mohsin, Bodiul Alam Razu, Mohammad Tashnim Hossain, Sinayat Mahzabeen, Naziat Unnoor, Ishrat Aklima Muna, Farjana Akhter, Ashraf Ul Kabir, J M A Hannan. [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice.
BMC complementary and alternative medicine.
2017 Aug; 17(1):395. doi:
10.1186/s12906-017-1903-0. [PMID: 28793909] - Mohammad Hassan Baig, Arif Tasleem Jan, Gulam Rabbani, Khurshid Ahmad, Jalaluddin M Ashraf, Taeyeon Kim, Han Sol Min, Yong Ho Lee, Won-Kyung Cho, Jin Yeul Ma, Eun Ju Lee, Inho Choi. Methylglyoxal and Advanced Glycation End products: Insight of the regulatory machinery affecting the myogenic program and of its modulation by natural compounds.
Scientific reports.
2017 07; 7(1):5916. doi:
10.1038/s41598-017-06067-5. [PMID: 28725008] - Ji Hae Lee, Yaoyao Jia, Trung Thanh Thach, Yuri Han, Bobae Kim, Chunyan Wu, Yeonji Kim, Woo Duck Seo, Sung-Joon Lee. Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice.
Nutrition research (New York, N.Y.).
2017 Jul; 43(?):89-99. doi:
10.1016/j.nutres.2017.05.013. [PMID: 28676202] - Deepmala Joshi, Sunil Kumar Srivastav, Sateesh Belemkar, Vaibhav A Dixit. Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jul; 91(?):645-655. doi:
10.1016/j.biopha.2017.04.108. [PMID: 28494418] - Ferial Aslani, Tim Sebastian, Miguel Keidel, Suada Fröhlich, Hans-Peter Elsässer, Hans-Christian Schuppe, Jörg Klug, Poornima Mahavadi, Monika Fijak, Martin Bergmann, Andreas Meinhardt, Sudhanshu Bhushan. Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells.
Molecular human reproduction.
2017 06; 23(6):370-380. doi:
10.1093/molehr/gax022. [PMID: 28379541] - M Salihu, B O Ajayi, I A Adedara, D de Souza, J B T Rocha, E O Farombi. 6-Gingerol-rich fraction from Zingiber officinale ameliorates carbendazim-induced endocrine disruption and toxicity in testes and epididymis of rats.
Andrologia.
2017 Jun; 49(5):. doi:
10.1111/and.12658. [PMID: 27546232] - Lin-Lin Fang, Ping Wang, Xiao-Li Wen, Xin Guo, Lin-da Luo, Jia Yu, Xing-Jie Guo. Layer-by-layer self-assembly of gold nanoparticles/thiols β-cyclodextrin coating as the stationary phase for enhanced chiral differentiation in open tubular capillary electrochromatography.
Talanta.
2017 May; 167(?):158-165. doi:
10.1016/j.talanta.2017.01.082. [PMID: 28340706] - L Long, S G Wu, F Yuan, H J Zhang, J Wang, G H Qi. Effects of dietary octacosanol supplementation on laying performance, egg quality, serum hormone levels, and expression of genes related to the reproductive axis in laying hens.
Poultry science.
2017 Apr; 96(4):894-903. doi:
10.3382/ps/pew316. [PMID: 27665009] - Jae-Yong Kim, Seong-Min Kim, Suk-Jeong Kim, Eun-Young Lee, Jae-Ryong Kim, Kyung-Hyun Cho. Consumption of policosanol enhances HDL functionality via CETP inhibition and reduces blood pressure and visceral fat in young and middle-aged subjects.
International journal of molecular medicine.
2017 Apr; 39(4):889-899. doi:
10.3892/ijmm.2017.2907. [PMID: 28259941] - Parisa Sadat Pournaderi, Parichehreh Yaghmaei, Hamidreza Khodaei, Zahra Noormohammadi, Seyed Hossein Hejazi. The effects of 6-Gingerol on reproductive improvement, liver functioning and Cyclooxygenase-2 gene expression in estradiol valerate - Induced polycystic ovary syndrome in Wistar rats.
Biochemical and biophysical research communications.
2017 03; 484(2):461-466. doi:
10.1016/j.bbrc.2017.01.057. [PMID: 28093231] - Kan Chen, Chang-Qian Wang, Yu-Qi Fan, Zhi-Hua Han, Yue Wang, Lin Gao, Hua-Su Zeng. [Lipid-lowering effect of seven traditional Chinese medicine monomers in zebrafish system].
Sheng li xue bao : [Acta physiologica Sinica].
2017 Feb; 69(1):55-60. doi:
. [PMID: 28217808] - Natalia de Las Heras, María Valero-Muñoz, Beatriz Martín-Fernández, Sandra Ballesteros, Antonio López-Farré, Baltasar Ruiz-Roso, Vicente Lahera. Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2017 Feb; 42(2):209-215. doi:
10.1139/apnm-2016-0374. [PMID: 28125276] - Chethan Sampath, Shengmin Sang, Mohamed Ahmedna. In vitro and in vivo inhibition of aldose reductase and advanced glycation end products by phloretin, epigallocatechin 3-gallate and [6]-gingerol.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):502-513. doi:
10.1016/j.biopha.2016.09.073. [PMID: 27685794] - Carola Schoenknecht, Gaby Andersen, Peter Schieberle. A novel method for the quantitation of gingerol glucuronides in human plasma or urine based on stable isotope dilution assays.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Nov; 1036-1037(?):1-9. doi:
10.1016/j.jchromb.2016.09.033. [PMID: 27700987] - Hany M El-Bassossy, Ahmed A Elberry, Salah A Ghareib, Ahmad Azhar, Zainy Mohammed Banjar, Malcolm L Watson. Cardioprotection by 6-gingerol in diabetic rats.
Biochemical and biophysical research communications.
2016 09; 477(4):908-914. doi:
10.1016/j.bbrc.2016.06.157. [PMID: 27378426] - Wei Sun, Yi-Sheng He, Ling-Hui Xu, Bi-Ying Zhang, Lian-Wen Qi, Jie Yang, Ping Li, Xiao-Dong Wen. Pharmacokinetic profiles of falcarindiol and oplopandiol in rats after oral administration of polyynes extract of Oplopanax elatus.
Chinese journal of natural medicines.
2016 Sep; 14(9):714-720. doi:
10.1016/s1875-5364(16)30085-1. [PMID: 27667518] - Jesus Millán, Arrigo F G Cicero, Francisco Torres, Anna Anguera. Effects of a nutraceutical combination containing berberine (BRB), policosanol, and red yeast rice (RYR), on lipid profile in hypercholesterolemic patients: A meta-analysis of randomised controlled trials.
Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis.
2016 Jul; 28(4):178-87. doi:
10.1016/j.arteri.2016.03.002. [PMID: 27131395] - T N Liu, C T Wu, F He, W Yuan, S X Li, H W Li, H Y Yu, M Wu. Relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effects of pravastatin in patients with hyperlipidemia.
Genetics and molecular research : GMR.
2016 Jun; 15(2):. doi:
10.4238/gmr.15028216. [PMID: 27323196] - Qi Fang, Yao-Hua Zhang, Yao-Long Shi, Jin-Hua Zhang, Jian-Xu Zhang. Individuality and Transgenerational Inheritance of Social Dominance and Sex Pheromones in Isogenic Male Mice.
Journal of experimental zoology. Part B, Molecular and developmental evolution.
2016 06; 326(4):225-36. doi:
10.1002/jez.b.22681. [PMID: 27283352] - Ahmed M S Hegazy, Mohammed M Mosaed, Saad H Elshafey, Naglaa A Bayomy. 6-gingerol ameliorates gentamicin induced renal cortex oxidative stress and apoptosis in adult male albino rats.
Tissue & cell.
2016 Jun; 48(3):208-16. doi:
10.1016/j.tice.2016.03.006. [PMID: 27036327] - Eun-Young Lee, Jeong-Ah Yoo, So-Mang Lim, Kyung-Hyun Cho. Anti-Aging and Tissue Regeneration Ability of Policosanol Along with Lipid-Lowering Effect in Hyperlipidemic Zebrafish via Enhancement of High-Density Lipoprotein Functionality.
Rejuvenation research.
2016 Apr; 19(2):149-58. doi:
10.1089/rej.2015.1745. [PMID: 26413884] - Carola Schoenknecht, Gaby Andersen, Ines Schmidts, Peter Schieberle. Quantitation of Gingerols in Human Plasma by Newly Developed Stable Isotope Dilution Assays and Assessment of Their Immunomodulatory Potential.
Journal of agricultural and food chemistry.
2016 Mar; 64(11):2269-79. doi:
10.1021/acs.jafc.6b00030. [PMID: 26939769] - Shuichi Setoguchi, Daisuke Watase, Nami Nagata-Akaho, Akinori Haratake, Kazuhisa Matsunaga, Jiro Takata. Pharmacokinetics of Paradol Analogues Orally Administered to Rats.
Journal of agricultural and food chemistry.
2016 Mar; 64(9):1932-7. doi:
10.1021/acs.jafc.5b05615. [PMID: 26868188] - Manish Jain, Ankita Singh, Vishal Singh, Preeti Maurya, Manoj Kumar Barthwal. Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation.
Journal of cardiovascular pharmacology and therapeutics.
2016 Mar; 21(2):187-200. doi:
10.1177/1074248415598003. [PMID: 26240073] - So-Mang Lim, Jeong-Ah Yoo, Eun-Young Lee, Kyung-Hyun Cho. Enhancement of High-Density Lipoprotein Cholesterol Functions by Encapsulation of Policosanol Exerts Anti-Senescence and Tissue Regeneration Effects Via Improvement of Anti-Glycation, Anti-Apoptosis, and Cholesteryl Ester Transfer Inhibition.
Rejuvenation research.
2016 Feb; 19(1):59-70. doi:
10.1089/rej.2015.1712. [PMID: 26161621] - Lijun Luo, Xue Mei, Yuecheng Xi, Chunyang Zhou, Ying Hui, Katsuhisa Kurogi, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu. Sulfation of 6-Gingerol by the Human Cytosolic Sulfotransferases: A Systematic Analysis.
Planta medica.
2016 Feb; 82(3):238-43. doi:
10.1055/s-0035-1558158. [PMID: 26544119] - Mariama Salihu, Babajide O Ajayi, Isaac A Adedara, Ebenezer O Farombi. 6-Gingerol-Rich Fraction from Zingiber officinale Prevents Hematotoxicity and Oxidative Damage in Kidney and Liver of Rats Exposed to Carbendazim.
Journal of dietary supplements.
2016; 13(4):433-48. doi:
10.3109/19390211.2015.1107802. [PMID: 26673969] - Isabel De Castro-Orós, Rosa Solà, Rosa María Valls, Angel Brea, Pilar Mozas, Jose Puzo, Miguel Pocoví. Genetic Variants of LDLR and PCSK9 Associated with Variations in Response to Antihypercholesterolemic Effects of Armolipid Plus with Berberine.
PloS one.
2016; 11(3):e0150785. doi:
10.1371/journal.pone.0150785. [PMID: 27015087] - Anna C Pham, Tri-Hung Nguyen, Cameron J Nowell, Bim Graham, Ben J Boyd. Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging.
Drug delivery and translational research.
2015 Dec; 5(6):566-74. doi:
10.1007/s13346-015-0253-z. [PMID: 26328930] - T M Solomenchuk, V Vosukh, A Bedzay, V G Koval, I M Chepka, V V Trotsko. [EFFICIENCY OF CONCOMITANT USE OF POLICOSANOL AND ROSUVASTATIN IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE AND MODERATE HEPATIC DYSFUNCTION].
Likars'ka sprava.
2015 Oct; ?(7-8):29-37. doi:
. [PMID: 27491147] - Alberto Mazza, Salvatore Lenti, Laura Schiavon, Marco Zuin, Maria D'Avino, Emilio Ramazzina, Edoardo Casiglia. Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk.
Advances in therapy.
2015 Jul; 32(7):680-90. doi:
10.1007/s12325-015-0229-x. [PMID: 26202829] - Intan Diana Mat Azmi, Linping Wu, Peter Popp Wibroe, Christa Nilsson, Jesper Østergaard, Stefan Stürup, Bente Gammelgaard, Arto Urtti, Seyed Moein Moghimi, Anan Yaghmur. Modulatory effect of human plasma on the internal nanostructure and size characteristics of liquid-crystalline nanocarriers.
Langmuir : the ACS journal of surfaces and colloids.
2015 May; 31(18):5042-9. doi:
10.1021/acs.langmuir.5b00830. [PMID: 25884233] - Chunfeng Wang, Ali Fan, Xiaojie Zhu, Yang Lu, Shuhua Deng, Wenchao Gao, Wei Zhang, Qi Liu, Xijing Chen. Trace quantification of 1-triacontanol in beagle plasma by GC-MS/MS and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2015 May; 29(5):749-55. doi:
10.1002/bmc.3351. [PMID: 25331188] - Thing-Fong Tzeng, Shorong-Shii Liou, Chia Ju Chang, I-Min Liu. [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Apr; 22(4):452-61. doi:
10.1016/j.phymed.2015.01.015. [PMID: 25925967]