Scleroglucan (BioDeep_00000033701)

   

human metabolite Endogenous


代谢物信息卡片


2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite

化学式: C24H44O20P2 (714.1901084)
中文名称: 硬葡聚糖
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3C(C(OC(C3O)P)CO)O)O)OC4C(C(C(C(O4)CO)O)OP)O)O)O)O)O)O
InChI: InChI=1S/C24H44O20P2/c25-1-5-9(28)13(32)14(33)21(38-5)37-4-8-12(31)18(42-23-16(35)20(44-46)11(30)6(2-26)39-23)15(34)22(40-8)43-19-10(29)7(3-27)41-24(45)17(19)36/h5-36H,1-4,45-46H2

描述信息

Lentinan is found in mushrooms. Elaborated by the fungus Lentinus edodes (shiitake) Lentinan is a beta-glucan with a glycosidic -1,3: -1,6 linkage. It is an anti-tumor polysaccharide from the shiitake (Lentinula edodes) mushroom. Lentinan is a polysaccharide which is free of nitrogen, and has a molecular weight of approximently 500,000 Da. Lentinan is one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems

同义名列表

4 个代谢物同义名

2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite; SCLEROGLUCAN; Sclerogum; Sclerosan



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Islam A Elsehemy, Azza M Noor El Deen, Hassan M Awad, Mohamed H Kalaba, Saad A Moghannem, Ibrahim H Tolba, Mohamed A M Farid. Structural, physical characteristics and biological activities assessment of scleroglucan from a local strain Athelia rolfsii TEMG. International journal of biological macromolecules. 2020 Nov; 163(?):1196-1207. doi: 10.1016/j.ijbiomac.2020.06.272. [PMID: 32622769]
  • Gianfranco Bocchinfuso, Claudia Mazzuca, Chiara Sandolo, Silvia Margheritelli, Franco Alhaique, Tommasina Coviello, Antonio Palleschi. Guar gum and scleroglucan interactions with borax: experimental and theoretical studies of an unexpected similarity. The journal of physical chemistry. B. 2010 Oct; 114(41):13059-68. doi: 10.1021/jp105838t. [PMID: 20863102]
  • Jochen Schmid, Dirk Müller-Hagen, Thomas Bekel, Laura Funk, Ulf Stahl, Volker Sieber, Vera Meyer. Transcriptome sequencing and comparative transcriptome analysis of the scleroglucan producer Sclerotium rolfsii. BMC genomics. 2010 May; 11(?):329. doi: 10.1186/1471-2164-11-329. [PMID: 20504312]
  • Tommasina Coviello, Franco Alhaique, Antonello Dorigo, Pietro Matricardi, Mario Grassi. Two galactomannans and scleroglucan as matrices for drug delivery: preparation and release studies. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2007 May; 66(2):200-9. doi: 10.1016/j.ejpb.2006.10.024. [PMID: 17156985]
  • Way-Shyan Wang, Shao-Wen Hung, Yu-Hsing Lin, Ching-Yu Tu, Min-Liang Wong, Shiow-Her Chiou, Meng-Tong Shieh. The effects of five different glycans on innate immune responses by phagocytes of hybrid tilapia and Japanese eels Anguilla japonica. Journal of aquatic animal health. 2007 Mar; 19(1):49-59. doi: 10.1577/h06-020.1. [PMID: 18236632]
  • M Carafa, C Marianecci, V Annibaldi, A Di Stefano, P Sozio, E Santucci. Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: development, characterization and interaction with leuprolide. International journal of pharmaceutics. 2006 Nov; 325(1-2):155-62. doi: 10.1016/j.ijpharm.2006.06.040. [PMID: 16884870]
  • Peter J Rice, Brent E Lockhart, Luke A Barker, Elizabeth L Adams, Harry E Ensley, David L Williams. Pharmacokinetics of fungal (1-3)-beta-D-glucans following intravenous administration in rats. International immunopharmacology. 2004 Sep; 4(9):1209-15. doi: 10.1016/j.intimp.2004.05.013. [PMID: 15251116]
  • B H Falch, T Espevik, L Ryan, B T Stokke. The cytokine stimulating activity of (1-->3)-beta-D-glucans is dependent on the triple helix conformation. Carbohydrate research. 2000 Nov; 329(3):587-96. doi: 10.1016/s0008-6215(00)00222-6. [PMID: 11128587]
  • P Mastromarino, R Petruzziello, S Macchia, S Rieti, R Nicoletti, N Orsi. Antiviral activity of natural and semisynthetic polysaccharides on the early steps of rubella virus infection. The Journal of antimicrobial chemotherapy. 1997 Mar; 39(3):339-45. doi: 10.1093/jac/39.3.339. [PMID: 9096183]
  • M Marchetti, S Pisani, V Pietropaolo, L Seganti, R Nicoletti, A Degener, N Orsi. Antiviral effect of a polysaccharide from Sclerotium glucanicum towards herpes simplex virus type 1 infection. Planta medica. 1996 Aug; 62(4):303-7. doi: 10.1055/s-2006-957889. [PMID: 8792659]