Zopiclone (BioDeep_00000033306)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylic acid

化学式: C17H17ClN6O3 (388.1050602)
中文名称: 佐匹克隆
谱图信息: 最多检出来源 Homo sapiens(urine) 50%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Zopiclone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/zopiclone (retrieved 2024-11-05) (BioDeep RN: BioDeep_00000033306). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=NC=C(Cl)C=C1
InChI: InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3

描述信息

Zopiclone is only found in individuals that have used or taken this drug. It is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclones benzodiazepine pharmacological properties it also has some barbiturate like properties. Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Both zopiclone and benzodiazepines act indiscriminately at the benzodiazepine binding site on α1, α2, α3 and α5 GABAA containing receptors as full agonists causing an enhancement of the inhibitory actions of GABA to produce the therapeutic (hypnotic and anxiolytic) and adverse effects of zopiclone.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CF - Benzodiazepine related drugs
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic

同义名列表

38 个代谢物同义名

6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylic acid; 6-(5-Chloro-2-pyridyl)-6,7-dihydro- 7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methyl-1- piperazinecarboxylate; 6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate; 6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; Zopiclon-neuraxpharm; Zopiclon-ratiopharm; Zopiclon von CT; Ratio-zopiclone; Zopiclon stada; (+-)-Zopiclone; Zopiclon-teva; Zopiclon beta; Zopiclon abz; Nu-zopiclone; Zopiclon tad; Zopiclon azu; Zopiclodura; Zopiclon al; Zopiclonum; Zopi-puren; Zopiclona; Zimoclone; Zopicalma; zopiclone; Zorclone; Somnosan; Zimovane; Optidorm; Zopicalm; Imovane; Rhovane; Zopitan; Limovan; Ximovan; Zileze; Siaten; Amoban; Zop



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yongshuai Jing, Wenjing Cheng, Mingsong Li, Yameng Zhang, Xinyue Pang, Xiaoyue Qiu, Yuguang Zheng, Danshen Zhang, Lanfang Wu. Structural Characterization, Rheological Properties, Antioxidant and Anti-Inflammatory Activities of Polysaccharides from Zingiber officinale. Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Mar; 78(1):160-165. doi: 10.1007/s11130-022-01033-7. [PMID: 36437417]
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  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Linlin Fang, Yanyan Zhao, Chao Wang, Changyuan Wang, Xu Han, Pengjun Chen, Lizhu Zhao, Jingping Wang, Shuang Li, Zhen Jiang. Preparation of a thiols β-cyclodextrin/gold nanoparticles-coated open tubular column for capillary electrochromatography enantioseparations. Journal of separation science. 2020 Jun; 43(11):2209-2216. doi: 10.1002/jssc.201901323. [PMID: 32160391]
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  • Lina Dorthea Bruun, Kari Kjeldstadli, Vidar Temte, Morris Birdal, Liliana Bachs, Marit Langødegård, Dag Helge Strand, Kristin Irene Gaare, Elisabeth Øiestad, Gudrun Høiseth. Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental Oral Dosing. Journal of analytical toxicology. 2019 Jun; 43(5):369-377. doi: 10.1093/jat/bky083. [PMID: 30615130]
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  • R N El-Shaheny, A Alattas, J J Nasr, N El-Enany, F Belal. Simultaneous determination of zopiclone and its degradation product and main impurity (2-amino-5-chloropyridine) by micellar liquid chromatography with time-programmed fluorescence detection: preliminary investigation for biological monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Oct; 907(?):49-55. doi: 10.1016/j.jchromb.2012.08.034. [PMID: 22999478]
  • Stephanie J Marin, Mark Roberts, Michelle Wood, Gwendolyn A McMillin. Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma. Journal of analytical toxicology. 2012 Sep; 36(7):472-6. doi: 10.1093/jat/bks059. [PMID: 22833647]
  • Zi-ru Cheng, Li-ming Chen, Ming-hua Zhang. [Determination of zopiclone in serum by gas chromatographic method]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2012 Apr; 30(4):314-5. doi: NULL. [PMID: 22804949]
  • Alberto Salomone, Enrico Gerace, Paola Brizio, M Carla Gennaro, Marco Vincenti. A fast liquid chromatography-tandem mass spectrometry method for determining benzodiazepines and analogues in urine. Validation and application to real cases of forensic interest. Journal of pharmaceutical and biomedical analysis. 2011 Nov; 56(3):582-91. doi: 10.1016/j.jpba.2011.06.007. [PMID: 21737221]
  • Daniela Remane, Markus R Meyer, Dirk K Wissenbach, Hans H Maurer. Ultra high performance liquid chromatographic-tandem mass spectrometric multi-analyte procedure for target screening and quantification in human blood plasma: validation and application for 31 neuroleptics, 28 benzodiazepines, and Z-drugs. Analytical and bioanalytical chemistry. 2011 Sep; 401(4):1341-52. doi: 10.1007/s00216-011-5187-9. [PMID: 21773738]
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