Dutasteride (BioDeep_00000033297)
human metabolite blood metabolite
代谢物信息卡片
(1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-3-ene-14-carboxamide
化学式: C27H30F6N2O2 (528.2211)
中文名称: 度他雄胺
谱图信息:
最多检出来源 Homo sapiens(blood) 99.13%
分子结构信息
SMILES: CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C
InChI: InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
描述信息
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group, but while dutasteride inhibits both isoforms of 5-alpha reductase, finasteride inhibits only one. Even so, a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH. [Wikipedia]
G - Genito urinary system and sex hormones > G04 - Urologicals > G04C - Drugs used in benign prostatic hypertrophy > G04CB - Testosterone-5-alpha reductase inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058891 - 5-alpha Reductase Inhibitors
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C242 - Anti-Androgen
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C2319 - 5 Alpha-Reductase Inhibitor
C1892 - Chemopreventive Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
11 个代谢物同义名
(1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-3-ene-14-carboxamide; alpha,alpha,alpha,Alpha,alpha,alpha-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2,5-xylidide; (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; Α,α,α,alpha,alpha,alpha-hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2,5-xylidide; a,a,a,Alpha,alpha,alpha-hexafluoro-3-oxo-4-aza-5a-androst-1-ene-17b-carboxy-2,5-xylidide; 17beta-N-(2,5-Bis(trifluoromethyl))phenyl-carbamoyl-4-aza-5alpha-androst-1-en-3-one; (5a,17b)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; (5Α,17β)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; Dutasteride; Avodart; 745, GG
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:521033
- PubChem: 6918296
- HMDB: HMDB0015258
- DrugBank: DB01126
- ChEMBL: CHEMBL1200969
- Wikipedia: Dutasteride
- MeSH: Dutasteride
- chemspider: 5293502
- CAS: 164656-23-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Aleksandar Kuzmanov, Souzan Salemi, Florian A Schmid, Irene A Burger, Daniel Eberli, Benedikt Kranzbühler. Improved Prostate-Specific Membrane Antigen (PSMA) Stimulation Using a Super Additive Effect of Dutasteride and Lovastatin In Vitro.
International journal of molecular sciences.
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10.3390/ijms241512338. [PMID: 37569712] - Naoki Wada, Noriyuki Abe, Kotona Miyauchi, Mayumi Ishikawa, Shogo Makino, Hidehiro Kakizaki. Dutasteride add-on treatment to tadalafil for patients with benign prostatic enlargement is similarly effective as dutasteride add-on treatment to alpha blocker: a propensity-score matching analysis.
International urology and nephrology.
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2022 03; 11(3):318-323. doi:
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2022 Jan; 54(1):31-36. doi:
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Journal of pharmaceutical and biomedical analysis.
2021 Nov; 206(?):114362. doi:
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Endocrine.
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2020 Dec; 18(2):327-337. doi:
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2020 03; 12(5):4337-4347. doi:
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Drug testing and analysis.
2019 Nov; 11(11-12):1737-1746. doi:
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2019 10; 202(4):635. doi:
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Endocrinology.
2019 09; 160(9):2061-2073. doi:
10.1210/en.2019-00236. [PMID: 31199473] - Mohammad Khalid Zia, Tooba Siddiqui, Syed Saqib Ali, Haseeb Ahsan, Fahim Halim Khan. Deciphering the binding of dutasteride with human alpha-2-macroglobulin: Molecular docking and calorimetric approach.
International journal of biological macromolecules.
2019 Jul; 133(?):1081-1089. doi:
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2019 05; 16(2):205-211. doi:
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BMC urology.
2019 Mar; 19(1):17. doi:
10.1186/s12894-019-0446-8. [PMID: 30871552] - Steven A Kaplan. Re: Long-Term Dutasteride Therapy in Men with Benign Prostatic Hyperplasia Alters Glucose and Lipid Profiles and Increases Severity of Erectile Dysfunction.
The Journal of urology.
2019 03; 201(3):416-417. doi:
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Journal of the European Academy of Dermatology and Venereology : JEADV.
2018 Dec; 32(12):2112-2125. doi:
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2018 09; 27(5):449-452. doi:
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Clinical biochemistry.
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Hinyokika kiyo. Acta urologica Japonica.
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2018 01; 25(1):70-74. doi:
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The Journal of steroid biochemistry and molecular biology.
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American journal of therapeutics.
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The Journal of urology.
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The Prostate.
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Lower urinary tract symptoms.
2017 May; 9(2):67-74. doi:
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Investigative and clinical urology.
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Andrology.
2017 03; 5(2):347-353. doi:
10.1111/andr.12297. [PMID: 27813338] - Rana R McKay, Lillian Werner, Elahe A Mostaghel, Rosina Lis, Olga Voznesensky, Zhenwei Zhang, Brett T Marck, Alvin M Matsumoto, Liran Domachevsky, Katherine A Zukotynski, Manoj Bhasin, Glenn J Bubley, Bruce Montgomery, Philip W Kantoff, Steven P Balk, Mary-Ellen Taplin. A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2017 Feb; 23(4):935-945. doi:
10.1158/1078-0432.ccr-16-0987. [PMID: 27683182] - Tom Feng, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland. Serum cholesterol and risk of lower urinary tract symptoms progression: Results from the Reduction by Dutasteride of Prostate Cancer Events study.
International journal of urology : official journal of the Japanese Urological Association.
2017 02; 24(2):151-156. doi:
10.1111/iju.13265. [PMID: 28004415] - N Enatsu, H Miyake, T Haraguchi, K Chiba, M Fujisawa. Effects of dutasteride on serum free-testosterone and clinical significance of testosterone changes.
Andrologia.
2016 Dec; 48(10):1195-1201. doi:
10.1111/and.12560. [PMID: 26952737] - Zhenfei Li, Mohammad Alyamani, Jianneng Li, Kevin Rogacki, Mohamed Abazeed, Sunil K Upadhyay, Steven P Balk, Mary-Ellen Taplin, Richard J Auchus, Nima Sharifi. Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy.
Nature.
2016 05; 533(7604):547-51. doi:
10.1038/nature17954. [PMID: 27225130] - Shu-Wu Xie, Guo-Ting Li, Li-Juan Qu, Yang Cao, Qian Wang, Jie-Yun Zhou, Rui-Hua Zhong, Xiang-Jie Guo, Yan Zhu. Identification of New Epididymal Luminal Fluid Proteins Involved in Sperm Maturation in Infertile Rats Treated by Dutasteride Using iTRAQ.
Molecules (Basel, Switzerland).
2016 May; 21(5):. doi:
10.3390/molecules21050602. [PMID: 27187330] - Antonio Alcaraz, Joaquín Carballido-Rodríguez, Miguel Unda-Urzaiz, Rafael Medina-López, José L Ruiz-Cerdá, Federico Rodríguez-Rubio, Darío García-Rojo, Francisco J Brenes-Bermúdez, José M Cózar-Olmo, Víctor Baena-González, José Manasanch. Quality of life in patients with lower urinary tract symptoms associated with BPH: change over time in real-life practice according to treatment--the QUALIPROST study.
International urology and nephrology.
2016 May; 48(5):645-56. doi:
10.1007/s11255-015-1206-7. [PMID: 26810324] - Pedro E Martinez, David R Rubinow, Lynnette K Nieman, Deloris E Koziol, A Leslie Morrow, Crystal E Schiller, Dahima Cintron, Karla D Thompson, Khursheed K Khine, Peter J Schmidt. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2016 Mar; 41(4):1093-102. doi:
10.1038/npp.2015.246. [PMID: 26272051] - Saurabh Aggarwal, Manoj Kumar Mahapatra, Rajnish Kumar, Tilak R Bhardwaj, Rolf W Hartmann, Jörg Haupenthal, Manoj Kumar. Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors.
Bioorganic & medicinal chemistry.
2016 Feb; 24(4):779-88. doi:
10.1016/j.bmc.2015.12.048. [PMID: 26780831] - Jonathan M Hazlehurst, Andrei I Oprescu, Nikolaos Nikolaou, Riccardo Di Guida, Annabel E K Grinbergs, Nigel P Davies, Robert B Flintham, Matthew J Armstrong, Angela E Taylor, Beverly A Hughes, Jinglei Yu, Leanne Hodson, Warwick B Dunn, Jeremy W Tomlinson. Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
The Journal of clinical endocrinology and metabolism.
2016 Jan; 101(1):103-13. doi:
10.1210/jc.2015-2928. [PMID: 26574953] - Naoki Wada, Kazumi Hashizume, Seiji Matsumoto, Hidehiro Kakizaki. Dutasteride improves bone mineral density in male patients with lower urinary tract symptoms and prostatic enlargement: a preliminary study.
The aging male : the official journal of the International Society for the Study of the Aging Male.
2016; 19(1):12-4. doi:
10.3109/13685538.2015.1072155. [PMID: 26225793] - Kazuhisa Hagiwara, Takuya Koie, Hiromichi Iwamura, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama. Efficacy and Safety of Silodosin and Dutasteride Combination Therapy in Acute Urinary Retention due to Benign Prostatic Hyperplasia: A Single-Arm Prospective Study.
BioMed research international.
2016; 2016(?):4975851. doi:
10.1155/2016/4975851. [PMID: 27195288] - Nadhir Litim, Mélanie Bourque, Sara Al Sweidi, Marc Morissette, Thérèse Di Paolo. The 5α-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson's disease.
Neuropharmacology.
2015 Oct; 97(?):86-94. doi:
10.1016/j.neuropharm.2015.05.015. [PMID: 26006269] - Victor C Lin, Chun-Hou Liao, Chung-Cheng Wang, Hann-Chorng Kuo. 5α-Reductase inhibitor is less effective in men with small prostate volume and low serum prostatic specific antigen level.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2015 Sep; 114(9):865-71. doi:
10.1016/j.jfma.2013.08.006. [PMID: 24064231] - Claus G Roehrborn, Igor Oyarzabal Perez, Erik P M Roos, Nicolae Calomfirescu, Betsy Brotherton, Fang Wang, Juan Manuel Palacios, Averyan Vasylyev, Michael J Manyak. Efficacy and safety of a fixed-dose combination of dutasteride and tamsulosin treatment (Duodart(®) ) compared with watchful waiting with initiation of tamsulosin therapy if symptoms do not improve, both provided with lifestyle advice, in the management of treatment-naïve men with moderately symptomatic benign prostatic hyperplasia: 2-year CONDUCT study results.
BJU international.
2015 Sep; 116(3):450-9. doi:
10.1111/bju.13033. [PMID: 25565364] - Takashi Yoshida, Hidefumi Kinoshita, Takahiro Nakamoto, Masaaki Yanishi, Motohiko Sugi, Takashi Murota, Tadashi Matsuda. Conservative Treatment for Benign Prostatic Hyperplasia in Patients With Bladder Stones.
Urology.
2015 Sep; 86(3):450-3. doi:
10.1016/j.urology.2015.04.022. [PMID: 26235850] - Min-Soo Kim, Eun-Sol Ha, Gwang-Ho Choo, In-Hwan Baek. Preparation and in vivo evaluation of a dutasteride-loaded solid-supersaturatable self-microemulsifying drug delivery system.
International journal of molecular sciences.
2015 May; 16(5):10821-33. doi:
10.3390/ijms160510821. [PMID: 25984604] - Takahiro Maeda, Eiji Kikuchi, Masanori Hasegawa, Katsura Ishioka, Masayuki Hagiwara, Yasumasa Miyazaki, Toshiaki Shinojima, Akira Miyajima, Mototsugu Oya. Solifenacin or mirabegron could improve persistent overactive bladder symptoms after dutasteride treatment in patients with benign prostatic hyperplasia.
Urology.
2015 May; 85(5):1151-1155. doi:
10.1016/j.urology.2015.01.028. [PMID: 25770728] - Peter Weibl, Tobias Klatte, Peter Laurinc, Roman Tomaškin, Shahrokh F Shariat, Miroslav Helbich, Danica Fackovcova, Peter Bujdák. Patient's behavior and attitudes toward the management of benign prostatic hyperplasia among patients with the risk of disease progression: prospective study by 'Prostate and Expectations of Treatment Epidemiology Research (PETER) study group'.
Wiener klinische Wochenschrift.
2015 May; 127(9-10):363-8. doi:
10.1007/s00508-014-0668-4. [PMID: 25447967] - Marta M Wells, Tommy S Tillman, David D Mowrey, Tianmo Sun, Yan Xu, Pei Tang. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain.
Journal of medicinal chemistry.
2015 Apr; 58(7):2958-2966. doi:
10.1021/jm501873p. [PMID: 25790278] - Tetsuya Shindo, Kohei Hashimoto, Takashi Shimizu, Naoki Itoh, Naoya Masumori. Significance of intraprostatic architecture and regrowth velocity for considering discontinuation of dutasteride after combination therapy with an alpha blocker: a prospective, pilot study.
Korean journal of urology.
2015 Apr; 56(4):305-9. doi:
10.4111/kju.2015.56.4.305. [PMID: 25874044] - Dong Wang, Xinmin Zha, Keiko Nagase, Hironobu Akino, Ikunobu Muramatsu, Hideaki Ito, Osamu Yokoyama. Effects of the 5α-reductase inhibitor dutasteride on rat prostate α1A-adrenergic receptor and its mediated contractility.
Urology.
2015 Mar; 85(3):704.e9-14. doi:
10.1016/j.urology.2014.12.002. [PMID: 25733305] - Dong Hoon Lee, Dong Woo Yeom, Ye Seul Song, Ha Ra Cho, Yong Seok Choi, Myung Joo Kang, Young Wook Choi. Improved oral absorption of dutasteride via Soluplus®-based supersaturable self-emulsifying drug delivery system (S-SEDDS).
International journal of pharmaceutics.
2015 Jan; 478(1):341-347. doi:
10.1016/j.ijpharm.2014.11.060. [PMID: 25437113] - Shu-wu Xie, Li-juan Qu, Xian-ying Zhou, Jie-yun Zhou, Guo-ting Li, Ji-hong Bi, Xiang-jie Guo, Zhao Li, Lin Cao, Yan Zhu. [Inhibitory effect of dutasteride on the expressions of epididymal Claudin1 and β-catenin in male rats].
Zhonghua nan ke xue = National journal of andrology.
2015 Jan; 21(1):17-22. doi:
NULL. [PMID: 25707134] - Naoki Wada, Seiji Matsumoto, Masafumi Kita, Kazumi Hashizume, Hidehiro Kakizaki. Decreased urinary nerve growth factor reflects prostatic volume reduction and relief of outlet obstruction in patients with benign prostatic enlargement treated with dutasteride.
International journal of urology : official journal of the Japanese Urological Association.
2014 Dec; 21(12):1258-62. doi:
10.1111/iju.12570. [PMID: 25039474] - Abdulmaged M Traish, Andre T Guay, Michael Zitzmann. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis.
Hormone molecular biology and clinical investigation.
2014 Dec; 20(3):73-80. doi:
10.1515/hmbci-2014-0025. [PMID: 25460297] - Masahiko Inahara, Masahiro Sugiura, Kanya Kaga, Kyokusin Hou, Kazuhiro Araki, Hiroshi Masuda, Satoko Kojima, Yukio Naya. [Clinical outcomes after combined therapy with dutasteride in patients with unsuccessful trial without catheter after treatment with an alpha1-adrenergic receptor blocker monotherapy for acute urinary retention caused by prostatic hyperplasia].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2014 Oct; 105(4):190-5. doi:
10.5980/jpnjurol.105.190. [PMID: 25757349] - Giuseppe Morgia, Daniele Urzì, Giorgio Ivan Russo. [5ARI and PSA: evidences].
Urologia.
2014 Sep; 81 Suppl 24(?):4-11. doi:
10.5301/urologia.5000068. [PMID: 24803356] - Indira Radin Mačukat, Josip Spanjol, Zeljka Crncevič Orlič, Marta Zuvič Butorac, Marin Marinovič, Dora Fučkar Ćupič. The effect of 5alpha-reductase inhibition with finasteride and dutasteride on bone mineral density in older men with benign prostatic hyperplasia.
Collegium antropologicum.
2014 Sep; 38(3):835-9. doi:
. [PMID: 25420363] - Rita Upreti, Katherine A Hughes, Dawn E W Livingstone, Calum D Gray, Fiona C Minns, David P Macfarlane, Ian Marshall, Laurence H Stewart, Brian R Walker, Ruth Andrew. 5α-reductase type 1 modulates insulin sensitivity in men.
The Journal of clinical endocrinology and metabolism.
2014 Aug; 99(8):E1397-406. doi:
10.1210/jc.2014-1395. [PMID: 24823464] - Yoshihisa Matsukawa, Momokazu Gotoh, Masashi Kato, Yasuhito Funahashi, Michiro Narita, Kotoko Mitsui. Effects of dutasteride on storage and voiding symptoms in male patients with lower urinary tract symptoms as a result of benign prostatic obstruction: the 1-year outcomes from a prospective urodynamic study.
International journal of urology : official journal of the Japanese Urological Association.
2014 Aug; 21(8):826-30. doi:
10.1111/iju.12438. [PMID: 24661225] - Kazuhiro Araki, Yukio Naya, Masahiko Inahara, Fumio Suzuki, Syo Ota, Hirokatsu Tsuji, Kazuo Mikami, Mitsuru Yanagisawa, Yusuke Awa, Hiroyoshi Suzuki. Early effect of dutasteride added to alpha-1 blocker therapy for patients with lower urinary tract symptoms associated with benign prostatic hyperplasia.
International journal of urology : official journal of the Japanese Urological Association.
2014 Aug; 21(8):815-9. doi:
10.1111/iju.12459. [PMID: 24735081] - N Osman, C R Chapple. Contemporary issues with pharmacotherapy for lower urinary tract symptoms.
International journal of clinical practice.
2014 May; 68(5):541-2. doi:
10.1111/ijcp.12302. [PMID: 24750526] - Mitsunobu Masuda, Tetsuo Murai, Yutaka Osada, Masaki Kawai, Jun Kasuga, Yumiko Yokomizo, Shinnosuke Kuroda, Mami Nakamura, Go Noguchi. [Additional administration of dutasteride in patients with benign prostatic hyperplasia who did not respond sufficiently to α1-adrenoceptor antagonist : investigation of clinical factors affecting the therapeutic effect of dutasteride].
Hinyokika kiyo. Acta urologica Japonica.
2014 Feb; 60(2):61-7. doi:
NULL. [PMID: 24755815] - Xiangyang Xie, Yanfang Yang, Qiang Chi, ZhiPing Li, Hui Zhang, Ying Li, Yang Yang. Controlled release of dutasteride from biodegradable microspheres: in vitro and in vivo studies.
PloS one.
2014; 9(12):e114835. doi:
10.1371/journal.pone.0114835. [PMID: 25541985] - Goutham Vemana, Robert J Hamilton, Gerald L Andriole, Stephen J Freedland. Chemoprevention of prostate cancer.
Annual review of medicine.
2014; 65(?):111-23. doi:
10.1146/annurev-med-121211-091759. [PMID: 24188663] - Pritesh Contractor, Hemal Kurani, Swati Guttikar, Pranav S Shrivastav. Reliable and sensitive determination of dutasteride in human plasma by liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2013 Sep; 27(9):1168-76. doi:
10.1002/bmc.2923. [PMID: 23636821] - S J Freedland, R J Hamilton, L Gerber, L L Banez, D M Moreira, G L Andriole, R S Rittmaster. Statin use and risk of prostate cancer and high-grade prostate cancer: results from the REDUCE study.
Prostate cancer and prostatic diseases.
2013 Sep; 16(3):254-9. doi:
10.1038/pcan.2013.10. [PMID: 23567655] - F Arena. [Specific antigen prostatic changes during treatment with finasteride or dutasteride for benign prostatic hyperplasia].
Minerva urologica e nefrologica = The Italian journal of urology and nephrology.
2013 Sep; 65(3):211-6. doi:
NULL. [PMID: 23872632] - Teemu J Murtola, Paula M Kujala, Teuvo L J Tammela. High-grade prostate cancer and biochemical recurrence after radical prostatectomy among men using 5α-reductase inhibitors and alpha-blockers.
The Prostate.
2013 Jun; 73(9):923-31. doi:
10.1002/pros.22638. [PMID: 23334943] - Antonio Luigi Pastore, Simone Mariani, Francesco Barrese, Giovanni Palleschi, Armando Manuel Valentini, Luca Pacini, Vincenzo Petrozza, Antonio Carbone, Manlio Cappa. Transurethral resection of prostate and the role of pharmacological treatment with dutasteride in decreasing surgical blood loss.
Journal of endourology.
2013 Jan; 27(1):68-70. doi:
10.1089/end.2012.0231. [PMID: 23030716] - Roberto L Muller, Leah Gerber, Daniel M Moreira, Gerald Andriole, Ramiro Castro-Santamaria, Stephen J Freedland. Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial.
European urology.
2012 Nov; 62(5):757-64. doi:
10.1016/j.eururo.2012.05.025. [PMID: 22658758] - S A Kaplan, D E Chung, R K Lee, S Scofield, A E Te. A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride.
International journal of clinical practice.
2012 Nov; 66(11):1052-5. doi:
10.1111/j.1742-1241.2012.03010.x. [PMID: 23067029] - Naoki Wada, Kazumi Hashidume, Gaku Tamaki, Masafumi Kita, Tatsuya Iwata, Seiji Matsumoto, Hidehiro Kakizaki. [Add-on effect of dutasteride in patients with benign prostatic hyperplasia treated with alpha blocker : its effect on overactive bladder].
Hinyokika kiyo. Acta urologica Japonica.
2012 Sep; 58(9):475-80. doi:
NULL. [PMID: 23070385] - Steven A Kaplan, Richard K Lee, Doreen E Chung, Alexis E Te, Douglas S Scherr, Ash Tewari, E Darracott Vaughan. Prostate biopsy in response to a change in nadir prostate specific antigen of 0.4 ng/ml after treatment with 5α-reductase inhibitors markedly enhances the detection rate of prostate cancer.
The Journal of urology.
2012 Sep; 188(3):757-61. doi:
10.1016/j.juro.2012.04.111. [PMID: 22818135] - Elahe A Mostaghel, Daniel W Lin, John K Amory, Jonathan L Wright, Brett T Marck, Peter S Nelson, Alvin M Matsumoto, William J Bremner, Stephanie T Page. Impact of male hormonal contraception on prostate androgens and androgen action in healthy men: a randomized, controlled trial.
The Journal of clinical endocrinology and metabolism.
2012 Aug; 97(8):2809-17. doi:
10.1210/jc.2012-1536. [PMID: 22659250] - Katya B Rubinow, Tomas Vaisar, Chongren Tang, Alvin M Matsumoto, Jay W Heinecke, Stephanie T Page. Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity.
Journal of lipid research.
2012 Jul; 53(7):1376-83. doi:
10.1194/jlr.p026005. [PMID: 22504910] - S Y Shin, Y H Shin, S W Lee, J Y Shin, C H Kim. Blood donors on teratogenic drugs and donor deferral periods in a clinical situation.
Vox sanguinis.
2012 May; 102(4):362-4. doi:
10.1111/j.1423-0410.2011.01566.x. [PMID: 22211799] - Joseph C Klink, Ranko Miocinovic, Cristina Magi Galluzzi, Eric A Klein. High-grade prostatic intraepithelial neoplasia.
Korean journal of urology.
2012 May; 53(5):297-303. doi:
10.4111/kju.2012.53.5.297. [PMID: 22670187]
