Rosoxacin (BioDeep_00000033265)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid

化学式: C17H14N2O3 (294.10043740000003)
中文名称: 罗索沙星
谱图信息: 最多检出来源 Danio rerio(blood) 26.21%

Reviewed

Last reviewed on 2024-07-19.

Cite this Page

Rosoxacin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/rosoxacin (retrieved 2024-11-10) (BioDeep RN: BioDeep_00000033265). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCN1C=C(C(=O)C2=C1C=C(C=C2)C3=CC=NC=C3)C(=O)O
InChI: InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)

描述信息

Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D000890 - Anti-Infective Agents

同义名列表

16 个代谢物同义名

1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid; 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylic acid; 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylate; Rosoxacinum; Acrosoxacin; Win-35,213; Win 35,213; Rosoxacina; Rosoxacine; rosoxacin; Win 35213; Eradacin; Eradacil; Roxadyl; Eracine; ROS



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Krishnaprasad Baby, Swastika Maity, Chetan H Mehta, Akhil Suresh, Usha Y Nayak, Yogendra Nayak. Targeting SARS-CoV-2 RNA-dependent RNA polymerase: An in silico drug repurposing for COVID-19. F1000Research. 2020; 9(?):1166. doi: 10.12688/f1000research.26359.1. [PMID: 33204411]
  • Ondřej Zvěřina, Pavel Coufalík, Miloš Barták, Michal Petrov, Josef Komárek. The contents and distributions of cadmium, mercury, and lead in Usnea antarctica lichens from Solorina Valley, James Ross Island (Antarctica). Environmental monitoring and assessment. 2017 Dec; 190(1):13. doi: 10.1007/s10661-017-6397-1. [PMID: 29230543]
  • Ashraf M Mahmoud, Nasr Y Khalil, Ibrahim A Darwish, Tarek Aboul-Fadl. Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate. International journal of analytical chemistry. 2009; 2009(?):810104. doi: 10.1155/2009/810104. [PMID: 20140080]
  • M P Wentland, R B Perni, P H Dorff, R P Brundage, M J Castaldi, T R Bailey, P M Carabateas, E R Bacon, D C Young, M G Woods. 3-Quinolinecarboxamides. A series of novel orally-active antiherpetic agents. Journal of medicinal chemistry. 1993 May; 36(11):1580-96. doi: 10.1021/jm00063a008. [PMID: 8388470]
  • A M Cárdenas, M P Cortés, E Fernández, W Peña. Lipid peroxidation and loss of potassium from red blood cells produced by phototoxic quinolones. Toxicology. 1992; 72(2):145-51. doi: 10.1016/0300-483x(92)90108-q. [PMID: 1314435]
  • J T Smith. Frequency and expression of mutational resistance to the 4-quinolone antibacterials. Scandinavian journal of infectious diseases. Supplementum. 1986; 49(?):115-23. doi: . [PMID: 3547618]
  • P C Frimodt-Møller, T Dørflinger, P O Madsen. Distribution of ciprofloxacin in the dog prostate and various tissues. Urological research. 1984; 12(6):283-6. doi: 10.1007/bf00258036. [PMID: 6240821]
  • K M Jensen, P O Madsen. Distribution of quinoline carboxylic acid derivatives in the dog prostate. The Prostate. 1983; 4(4):407-14. doi: 10.1002/pros.2990040411. [PMID: 6223287]
  • G B Park, J Saneski, T Weng, J Edelson. Pharmacokinetics of rosoxacin in human volunteers. Journal of pharmaceutical sciences. 1982 Apr; 71(4):461-2. doi: 10.1002/jps.2600710424. [PMID: 7086661]
  • C D Hulem, S E Old, L D Zeleznick, I H Leopold. Intraocular penetration of rosoxacin in rabbits. Archives of ophthalmology (Chicago, Ill. : 1960). 1982 Apr; 100(4):646-9. doi: 10.1001/archopht.1982.01030030648025. [PMID: 7073586]
  • K M Jensen, R B Patel, P G Welling, P O Madsen. Human prostatic tissue concentrations of rosoxacin. The Prostate. 1982; 3(5):523-9. doi: 10.1002/pros.2990030511. [PMID: 7145776]
  • S Maigaard, N Frimodt-Möller, P O Madsen. Rosoxacin distribution in kidney and prostate: experimental studies in dogs. Urological research. 1980; 8(2):113-6. doi: 10.1007/bf00271438. [PMID: 7394950]
  • S Maigaard, N Frimodt-Möller, U Hoyme, P O Madsen. Rosoxacin and cinoxacin distribution in prostate, vagina, and female urethra. An experimental study in dogs. Investigative urology. 1979 Sep; 17(2):149-52. doi: . [PMID: 468515]
  • M P Kullberg, R Koss, S O'Neil, J Edelson. High-performance liquid chromatographic analysis of rosoxacin and its N-oxide metabolite in plasma and urine. Journal of chromatography. 1979 May; 173(1):155-63. doi: 10.1016/s0021-9673(01)80455-6. [PMID: 546869]