Dexbrompheniramine (BioDeep_00000033229)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


[(3S)-3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine

化学式: C16H19BrN2 (318.0732)
中文名称: 溴苯那敏
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2
InChI: InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1

描述信息

Dexbrompheniramine is only found in individuals that have used or taken this drug. It is an antihistamine used to treat allergic conditions such as hay fever or urticaria. Dexbrompheniramine competitively binds to the histamine H1-receptor. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AB - Substituted alkylamines
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist

同义名列表

12 个代谢物同义名

[(3S)-3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine; Dexbrompheniramine Maleate; (S)-(+)-Brompheniramine; (+)-Brompheniraminum; Dexbrompheniraminum; (S)-Brompheniramine; dexbrompheniramine; D-Brompheniramine; Parabromodylamine; Dexbromfeniramina; Parabromdylamine; Disophrol



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Peter Mikus, Katarína Maráková, Jozef Marák, Dusan Kaniansky, Iva Valásková, Emil Havránek. Possibilities of column coupling electrophoresis provided with a fiber-based diode array detection in enantioselective analysis of drugs in pharmaceutical and clinical samples. Journal of chromatography. A. 2008 Jan; 1179(1):9-16. doi: 10.1016/j.chroma.2007.09.012. [PMID: 17905259]
  • C C Lin, H K Kim, J Lim, C Digiore, S Symchowicz, R Gural. Steady-state bioavailability of dexbrompheniramine and pseudoephedrine from a repeat-action combination tablet. Journal of pharmaceutical sciences. 1985 Jan; 74(1):25-8. doi: 10.1002/jps.2600740107. [PMID: 3981411]