Anidulafungin (BioDeep_00000033226)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0⁹,¹³]heptacosan-18-yl]-4-{4-[4-(pentyloxy)phenyl]phenyl}benzamide
化学式: C58H73N7O17 (1139.5062688)
中文名称: 阿尼芬净
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O
InChI: InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1
描述信息
Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile to caspofungin. [Wikipedia]
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents > D054714 - Echinocandins
C254 - Anti-Infective Agent > C514 - Antifungal Agent
同义名列表
7 个代谢物同义名
N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0⁹,¹³]heptacosan-18-yl]-4-{4-[4-(pentyloxy)phenyl]phenyl}benzamide; 1-((4R,5R)-4,5-Dihydroxy-N2-((4-(pentyloxy)(1,1:4,1-terphenyl)-4-yl)carbonyl)-L-ornithine)-echinocandin b; Anidulafunginum; Anidulafungina; Anidulafungine; Anidulafungin; Eraxis
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:55346
- PubChem: 166548
- HMDB: HMDB0014506
- DrugBank: DB00362
- ChEMBL: CHEMBL264241
- Wikipedia: Anidulafungin
- MeSH: Anidulafungin
- chemspider: 145752
- CAS: 166663-25-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 1883 Streptomyces: 10.1007/S13205-019-1946-7
- 1883 Streptomyces: 10.1007/S13205-019-1946-7
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Letícia Kraft, Victoria Stadler Tasca Ribeiro, Geiziane Aparecida Gonçalves, Paula Hansen Suss, Felipe Francisco Tuon. Comparison of amphotericin B lipid complex, deoxycholate amphotericin B, fluconazole, and anidulafungin activity against Candida albicans biofilm isolated from breakthrough candidemia.
Enfermedades infecciosas y microbiologia clinica (English ed.).
2023 Jan; ?(?):. doi:
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Revista do Instituto de Medicina Tropical de Sao Paulo.
2023; 65(?):e9. doi:
10.1590/s1678-9946202365009. [PMID: 36722671] - Panagiota-Christina Georgiou, Maiken Cavling Arendrup, Joseph Meletiadis. Early phenotypic detection of fluconazole- and anidulafungin-resistant Candida glabrata isolates.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1655-1661. doi:
10.1093/jac/dkac075. [PMID: 35323941] - Javad Naderi, Hans J Griesser, Bryan R Coad. Assessment of nonreleasing antifungal surface coatings bearing covalently attached pharmaceuticals.
Biointerphases.
2021 11; 16(6):061001. doi:
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Mycoses.
2021 Sep; 64(9):1062-1072. doi:
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Antimicrobial agents and chemotherapy.
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10.1128/aac.00549-21. [PMID: 34228541] - Melanie T Cushion, Parag Kumar, Ruying Lu, Alan Ashbaugh, Lilian W Adeojo, Raul Alfaro, Raphael Mannino, Edmund Tramont, Joseph A Kovacs. A Novel Encochleated Formulation Improves Atovaquone Activity in a Murine Model of Pneumocystis Pneumonia.
The Journal of infectious diseases.
2021 07; 224(2):326-331. doi:
10.1093/infdis/jiaa731. [PMID: 33245345] - Francesca Gioia, Alicia Gomez-Lopez, Maria Elena Alvarez, Elia Gomez-García de la Pedrosa, Pilar Martín-Davila, Manuel Cuenca-Estrella, Santiago Moreno, Jesús Fortun. Pharmacokinetics of echinocandins in suspected candida peritonitis: A potential risk for resistance.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Dec; 101(?):24-28. doi:
10.1016/j.ijid.2020.09.019. [PMID: 32937195] - Efstratios Mainas, Olympia Apostolopoulou, Maria Siopi, Styliani Apostolidi, Efthymios Neroutsos, Helene Mirfendereski, Sandrine Marchand, William Couet, Aris Dokoumetzidis, Georgia Valsami, Helen Sambatakou, George Dimopoulos, Joseph Meletiadis. Comparative pharmacokinetics of the three echinocandins in ICU patients.
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Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
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Mycopathologia.
2020 06; 185(3):597-598. doi:
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10.1016/j.jchromb.2019.121937. [PMID: 31958565] - Dong-Gun Lee, Hye-Jung Lee, Jean Li Yan, Stephen Sheng-Fong Lin, Jalal A Aram. Efficacy and safety of combination antifungal therapy in Korean haematological patients with invasive aspergillosis.
Mycoses.
2019 Oct; 62(10):969-978. doi:
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Antimicrobial agents and chemotherapy.
2019 09; 63(9):. doi:
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World journal of microbiology & biotechnology.
2019 Jul; 35(7):109. doi:
10.1007/s11274-019-2687-9. [PMID: 31280382] - Maiken Cavling Arendrup, Anuradha Chowdhary, Karen M T Astvad, Karin Meinike Jørgensen. APX001A In Vitro Activity against Contemporary Blood Isolates and Candida auris Determined by the EUCAST Reference Method.
Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.01225-18. [PMID: 30104264] - Ona Rogiers, Michelle Holtappels, Wafi Siala, Mohamed Lamkanfi, Françoise Van Bambeke, Katrien Lagrou, Patrick Van Dijck, Sona Kucharíková. Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies.
The Journal of antimicrobial chemotherapy.
2018 10; 73(10):2806-2814. doi:
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Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
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Antimicrobial agents and chemotherapy.
2018 03; 62(3):. doi:
10.1128/aac.02319-17. [PMID: 29311065] - Peter Kolbinger, Michael Gruber, Gabriel Roth, Bernhard M Graf, Karl-Peter Ittner. Filter Adsorption of Anidulafungin to a Polysulfone-Based Hemofilter During CVVHD In Vitro.
Artificial organs.
2018 Feb; 42(2):200-207. doi:
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Journal de mycologie medicale.
2017 Sep; 27(3):387-390. doi:
10.1016/j.mycmed.2017.04.001. [PMID: 28478968] - Adela Martin-Vicente, Javier Capilla, Josep Guarro. Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis.
Medical mycology.
2017 Jun; 55(4):457-460. doi:
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Archives of toxicology.
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Antimicrobial agents and chemotherapy.
2017 02; 61(2):. doi:
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2016 Dec; 65(12):1445-1451. doi:
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The Journal of antimicrobial chemotherapy.
2016 11; 71(11):3135-3147. doi:
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Antimicrobial agents and chemotherapy.
2016 11; 60(11):6872-6879. doi:
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Antimicrobial agents and chemotherapy.
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BMC infectious diseases.
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Antimicrobial agents and chemotherapy.
2015 Dec; 60(3):1226-33. doi:
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Medical mycology.
2015 Aug; 53(6):630-5. doi:
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Revista iberoamericana de micologia.
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Expert review of anti-infective therapy.
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Antimicrobial agents and chemotherapy.
2015; 59(6):3615-8. doi:
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Revista iberoamericana de micologia.
2015 Jan; 32(1):34-9. doi:
10.1016/j.riam.2013.10.008. [PMID: 24594291] - Tan N Doan, David C M Kong, Kashyap Patel, Patricia Walker, Andrew Spencer, Carl M J Kirkpatrick. Comparison of the probability of target attainment of anidulafungin against Candida spp. in patients with acute leukaemia.
International journal of antimicrobial agents.
2014 Nov; 44(5):450-7. doi:
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The Journal of antimicrobial chemotherapy.
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Antimicrobial agents and chemotherapy.
2014 06; 58(6):3550-2. doi:
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Mycoses.
2014 Jun; 57(6):377-9. doi:
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Journal of chemotherapy (Florence, Italy).
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2013 Dec; 57(12):6265-9. doi:
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2013 Apr; 57(4):1672-6. doi:
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The Journal of antimicrobial chemotherapy.
2013 Apr; 68(4):864-8. doi:
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2013 Jan; 57(1):281-8. doi:
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2012 Nov; 56(11):5875-82. doi:
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