Etonogestrel (BioDeep_00000033216)
Secondary id: BioDeep_00000015016
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
(1S,2R,10S,11S,14R,15S)-15-ethyl-14-ethynyl-14-hydroxy-17-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
化学式: C22H28O2 (324.2089188)
中文名称: 依托孕烯
谱图信息:
最多检出来源 Homo sapiens(COVID-19)(blood) 17.19%
分子结构信息
SMILES: CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
InChI: InChI=1S/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
描述信息
Etonogestrel is only found in individuals that have used or taken this drug. It is a molecule used in hormonal contraceptives, most notably the subdermal implant Implanon. [Wikipedia]Etonogestrel binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like etonogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
同义名列表
12 个代谢物同义名
(1S,2R,10S,11S,14R,15S)-15-ethyl-14-ethynyl-14-hydroxy-17-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 13-Ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one; Nourypharma brand OF 3-keto-desogestrel; Organon brand OF 3-keto-desogestrel; 3-Keto-desogestrel; 3-Ketodesogestrel; 3-oxo Desogestrel; 3-Oxodesogestrel; Etonogestrelum; Etonogestrel; Nexplanon; Implanon
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:50777
- KEGG: C75537
- PubChem: 6917715
- HMDB: HMDB0014439
- DrugBank: DB00294
- ChEMBL: CHEMBL1531
- Wikipedia: Etonogestrel
- chemspider: 5292944
- CAS: 54048-10-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Farhad Kafi Mallak, Helena Kopp Kallner. Migration of a subdermal contraceptive implant into a subsegmental pulmonary artery and etonogestrel serum concentration over time - a case report.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2022 Jun; 27(3):261-264. doi:
10.1080/13625187.2022.2036977. [PMID: 35174737] - Aaron Lazorwitz, Morgan Pena, Jeanelle Sheeder, Stephanie Teal. Effect of Topiramate on Serum Etonogestrel Concentrations Among Contraceptive Implant Users.
Obstetrics and gynecology.
2022 04; 139(4):579-587. doi:
10.1097/aog.0000000000004697. [PMID: 35594123] - Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal. Variability in repeat serum etonogestrel concentrations among contraceptive implant users during the steady-release pharmacokinetic period.
Contraception.
2022 04; 108(?):65-68. doi:
10.1016/j.contraception.2021.12.008. [PMID: 34973207] - Regis Kreitchmann, Alice Stek, Brookie M Best, Edmund Capparelli, JiaJia Wang, David Shapiro, Nahida Chakhtoura, Mark Mirochnick, Ahizechukwu C Eke. Interactions between etonogestrel-releasing contraceptive implant and 3 antiretroviral regimens.
Contraception.
2022 01; 105(?):67-74. doi:
10.1016/j.contraception.2021.08.006. [PMID: 34407424] - Le-Kai Nie, Hong-Li Zou, Lei Cheng, Pei-Hai Zhang. Subcutaneous etonogestrel implant combined with endometrial ablation for the treatment of adenomyosis: two case reports.
The journal of obstetrics and gynaecology research.
2022 Jan; 48(1):262-265. doi:
10.1111/jog.15084. [PMID: 34713941] - Aaron Lazorwitz, Christina L Aquilante, Jonathan A Shortt, Jeanelle Sheeder, Stephanie Teal, Christopher R Gignoux. Applicability of ancestral genotyping in pharmacogenomic research with hormonal contraception.
Clinical and translational science.
2021 09; 14(5):1713-1718. doi:
10.1111/cts.13014. [PMID: 33650294] - Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal. An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2021 Aug; 26(4):323-325. doi:
10.1080/13625187.2021.1887475. [PMID: 33596152] - Lekai Nie, Hongli Zou, Xiaotian Ma, Lei Cheng, Jun Jiao, Fenghua Wang, Weifeng Liang, Peihai Zhang. A clinical observational study on the efficacy of subcutaneous etonogestrel implants for adenomyosis in 20 patients.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2021 Aug; 37(8):735-739. doi:
10.1080/09513590.2021.1922886. [PMID: 34160336] - Mariane Massaini Barbieri, Thuany Bento Herculano, Amanda Dantas Silva, Luis Bahamondes, Cassia Raquel Teatin Juliato, Fernanda Garanhani Surita. Acceptability of ENG-releasing subdermal implants among postpartum Brazilian young women during the COVID-19 pandemic.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
2021 Jul; 154(1):106-112. doi:
10.1002/ijgo.13663. [PMID: 33656758] - Alida M Gertz, Ian J Bishop, Boikhutso Simon, Kwana Lechiile, Opelo Badubi, Aamirah Mussa, Carolyn L Westhoff, Chelsea Morroni. Comparison of plasma etonogestrel concentrations sampled from the contralateral-to-implant and ipsilateral-to-implant arms of contraceptive implant users.
Contraception.
2020 12; 102(6):403-405. doi:
10.1016/j.contraception.2020.08.011. [PMID: 32858051] - Cesare Battaglia, Bruno Battaglia, Paolo Casadio, Roberta Rizzo, Paolo G Artini. Metformin metabolic and vascular effects in normal weight hyperinsulinemic polycystic ovary syndrome patients treated with contraceptive vaginal ring. A pilot study.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2020 Dec; 36(12):1062-1069. doi:
10.1080/09513590.2020.1770213. [PMID: 32544018] - Ian J Bishop, Alida M Gertz, Boikhutso Simon, Leabaneng Tawe, Kwana Lechiile, Serena Liu, Nicholas Teodoro, Aamirah Mussa, Ava Avalos, Sifelani Malima, Tshego Maotwe, Lesego Mokganya, Carolyn L Westhoff, Chelsea Morroni. Etonogestrel concentrations among contraceptive implant users in Botswana using and not using dolutegravir-based antiretroviral therapy.
Contraception.
2020 09; 102(3):174-179. doi:
10.1016/j.contraception.2020.04.019. [PMID: 32387328] - Aaron Lazorwitz, Rebecca Seale, Anne Davis, Maryam Guiahi. A pilot study on the effect of isotretinoin on serum etonogestrel concentrations in contraceptive implant users.
Contraception.
2020 07; 102(1):58-60. doi:
10.1016/j.contraception.2020.04.011. [PMID: 32325076] - Meilin He, Guozhong Yang, Xiaoyu Zhao, Suohui Zhang, Yunhua Gao. Intradermal Implantable PLGA Microneedles for Etonogestrel Sustained Release.
Journal of pharmaceutical sciences.
2020 06; 109(6):1958-1966. doi:
10.1016/j.xphs.2020.02.009. [PMID: 32084376] - David W Haas, Yoninah S Cramer, Catherine Godfrey, Susan L Rosenkranz, Francesca Aweeka, Baiba Berzins, Robert Coombs, Kristine Coughlin, Laura E Moran, David Gingrich, Carmen D Zorrilla, Paxton Baker, Susan E Cohn, Kimberly K Scarsi. Pharmacogenetic interactions between antiretroviral drugs and vaginally administered hormonal contraceptives.
Pharmacogenetics and genomics.
2020 04; 30(3):45-53. doi:
10.1097/fpc.0000000000000396. [PMID: 32106141] - Deborah Margatho, Nelsilene Mota Carvalho, Luis Bahamondes. Endometriosis-associated pain scores and biomarkers in users of the etonogestrel-releasing subdermal implant or the 52-mg levonorgestrel-releasing intrauterine system for up to 24 months.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2020 Apr; 25(2):133-140. doi:
10.1080/13625187.2020.1725461. [PMID: 32069126] - Lisa B Haddad, Alison Swaims-Kohlmeier, C Christina Mehta, Richard E Haaland, Nakita L Brown, Anandi N Sheth, Hsin Chien, Kehmia Titanji, Sharon L Achilles, Davis Lupo, Clyde E Hart, Igho Ofotokun. Impact of etonogestrel implant use on T-cell and cytokine profiles in the female genital tract and blood.
PloS one.
2020; 15(3):e0230473. doi:
10.1371/journal.pone.0230473. [PMID: 32214321] - Rena C Patel, Randy M Stalter, Katherine K Thomas, Bani Tamraz, Steven W Blue, David W Erikson, Christina J Kim, Edward J Kelly, Kavita Nanda, Athena P Kourtis, Jairam R Lingappa, Nelly Mugo, Jared M Baeten, Kimberly K Scarsi. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.
AIDS (London, England).
2019 11; 33(13):1995-2004. doi:
10.1097/qad.0000000000002308. [PMID: 31306173] - Aaron Lazorwitz, Christina L Aquilante, Eva Dindinger, Margaret Harrison, Jeanelle Sheeder, Stephanie Teal. Relationship Between Etonogestrel Concentrations and Bleeding Patterns in Contraceptive Implant Users.
Obstetrics and gynecology.
2019 10; 134(4):807-813. doi:
10.1097/aog.0000000000003452. [PMID: 31503152] - Kimberly K Scarsi, Yoninah S Cramer, Susan L Rosenkranz, Francesca Aweeka, Baiba Berzins, Robert W Coombs, Kristine Coughlin, Laura E Moran, Carmen D Zorrilla, Victor Akelo, Mariam Aziz, Ruth K Friedman, David Gingrich, Shobha Swaminathan, Catherine Godfrey, Susan E Cohn. Antiretroviral therapy and vaginally administered contraceptive hormones: a three-arm, pharmacokinetic study.
The lancet. HIV.
2019 09; 6(9):e601-e612. doi:
10.1016/s2352-3018(19)30155-9. [PMID: 31498109] - Aaron Lazorwitz, Christina L Aquilante, Jeanelle Sheeder, Maryam Guiahi, Stephanie Teal. Relationship between patient characteristics and serum etonogestrel concentrations in contraceptive implant users.
Contraception.
2019 07; 100(1):37-41. doi:
10.1016/j.contraception.2019.03.045. [PMID: 30980827] - Amihai Rottenstreich, Ram Elazary, Uriel Elchalal, Gabriel Levin. Re: Plasma concentrations of etonogestrel in obese women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study.
BJOG : an international journal of obstetrics and gynaecology.
2019 04; 126(5):676-677. doi:
10.1111/1471-0528.15556. [PMID: 30461162] - Charlotte Ginstman, Jan Brynhildsen. Authors' reply re: Plasma concentrations of etonogestrel in obese women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study.
BJOG : an international journal of obstetrics and gynaecology.
2019 04; 126(5):677. doi:
10.1111/1471-0528.15557. [PMID: 30461174] - Aaron Lazorwitz, Christina L Aquilante, Kris Oreschak, Jeanelle Sheeder, Maryam Guiahi, Stephanie Teal. Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.
Obstetrics and gynecology.
2019 04; 133(4):783-794. doi:
10.1097/aog.0000000000003189. [PMID: 30870275] - C Ginstman, J Frisk, B Carlsson, A Ärlemalm, S Hägg, J Brynhildsen. Plasma concentrations of etonogestrel in women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study.
BJOG : an international journal of obstetrics and gynaecology.
2019 Mar; 126(4):486-492. doi:
10.1111/1471-0528.15511. [PMID: 30347490] - Lyndsey R Buckner, Erma Z Drobnis, Molly S Augustine, Lynette K Rogers, Jill Akers, Patricia D Mott, Thomas J Hope, Alison J Quayle, Danny J Schust. Cervical and systemic concentrations of long acting hormonal contraceptive (LARC) progestins depend on delivery method: Implications for the study of HIV transmission.
PloS one.
2019; 14(5):e0214152. doi:
10.1371/journal.pone.0214152. [PMID: 31095572] - Deborah Margatho, Nelsilene Mota Carvalho, Larissa Eloy, Luis Bahamondes. Assessment of biomarkers in women with endometriosis-associated pain using the ENG contraceptive implant or the 52 mg LNG-IUS: a non-inferiority randomised clinical trial.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2018 Oct; 23(5):344-350. doi:
10.1080/13625187.2018.1531117. [PMID: 30372645] - Rachel E Zigler, Tessa Madden, Caitlin Ashby, Leping Wan, Colleen McNicholas. Ulipristal Acetate for Unscheduled Bleeding in Etonogestrel Implant Users: A Randomized Controlled Trial.
Obstetrics and gynecology.
2018 10; 132(4):888-894. doi:
10.1097/aog.0000000000002810. [PMID: 30130351] - Jianbo Wu, Yuxiu Huang, Lihong Chen, Jifen Hu, Yilu Zou. Treatment of Adenomyosis with Subcutaneous Etonogestrel Implants: A Clinical Observational Study in 17 Patients.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Sep; 24(?):6085-6092. doi:
10.12659/msm.908979. [PMID: 30171680] - Sneha G Nair, Daxesh P Patel, Frank J Gonzalez, Bhargav M Patel, Puran Singhal, Darshan V Chaudhary. Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study.
Biomedical chromatography : BMC.
2018 May; 32(5):e4165. doi:
10.1002/bmc.4165. [PMID: 29228469] - Meilin He, Guozhong Yang, Suohui Zhang, Xiaoyu Zhao, Yunhua Gao. Dissolving Microneedles Loaded With Etonogestrel Microcrystal Particles for Intradermal Sustained Delivery.
Journal of pharmaceutical sciences.
2018 04; 107(4):1037-1045. doi:
10.1016/j.xphs.2017.11.013. [PMID: 29175412] - Jaime Algorta, Maria Diaz, Raquel de Benito, Marc Lefebvre, Eric Sicard, Milton Furtado, Pedro Antonio Regidor, Celestino Ronchi. Pharmacokinetic bioequivalence, safety and acceptability of Ornibel®, a new polymer composition contraceptive vaginal ring (etonogestrel/ethinylestradiol 11.00/3.474 mg) compared with Nuvaring® (etonogestrel/ethinylestradiol 11.7/2.7 mg).
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2017 Dec; 22(6):429-438. doi:
10.1080/13625187.2017.1413179. [PMID: 29336615] - Colleen McNicholas, Erin Swor, Leping Wan, Jeffrey F Peipert. Prolonged use of the etonogestrel implant and levonorgestrel intrauterine device: 2 years beyond Food and Drug Administration-approved duration.
American journal of obstetrics and gynecology.
2017 06; 216(6):586.e1-586.e6. doi:
10.1016/j.ajog.2017.01.036. [PMID: 28147241] - Aaron Lazorwitz, Anne Davis, Maryke Swartz, Maryam Guiahi. The effect of carbamazepine on etonogestrel concentrations in contraceptive implant users.
Contraception.
2017 Jun; 95(6):571-577. doi:
10.1016/j.contraception.2017.03.004. [PMID: 28288788] - Katharine B Simmons, Alison B Edelman, Rongwei Fu, Jeffrey T Jensen. Tamoxifen for the treatment of breakthrough bleeding with the etonogestrel implant: a randomized controlled trial.
Contraception.
2017 Feb; 95(2):198-204. doi:
10.1016/j.contraception.2016.10.001. [PMID: 27725164] - Jaqueline Villas-Boas, Luiz C Vilodre, Helena Malerba, Mila Pontremoli Salcedo, Mirela Foresti Jiménez, Patrícia El Beitune. Metabolic safety of the etonogestrel contraceptive implant in healthy women over a 3-year period.
European journal of obstetrics, gynecology, and reproductive biology.
2016 Jul; 202(?):51-4. doi:
10.1016/j.ejogrb.2016.04.025. [PMID: 27164485] - Colleen McNicholas, Ragini Maddipati, Qiuhong Zhao, Erin Swor, Jeffrey F Peipert. Use of the etonogestrel implant and levonorgestrel intrauterine device beyond the U.S. Food and Drug Administration-approved duration.
Obstetrics and gynecology.
2015 Mar; 125(3):599-604. doi:
10.1097/aog.0000000000000690. [PMID: 25730221] - Jesus Hernandez-Juarez, Ethel A Garcia-Latorre, Manuel Moreno-Hernandez, Jose Fernando Moran-Perez, Miguel Angel Rodriguez-Escobedo, Gerardo Cogque-Hernandez, Rubén Julián-Nacer, Xochitl Hernandez-Giron, Rosalia Palafox-Gomez, Irma Isordia-Salas, Abraham Majluf-Cruz. Metabolic effects of the contraceptive skin patch and subdermal contraceptive implant in Mexican women: a prospective study.
Reproductive health.
2014 Apr; 11(?):33. doi:
10.1186/1742-4755-11-33. [PMID: 24767248] - Tiffany Thomas, Kelsey Petrie, Joonho Shim, Kirsten M Abildskov, Carolyn L Westhoff, Serge Cremers. A UPLC-MS/MS method for therapeutic drug monitoring of etonogestrel.
Therapeutic drug monitoring.
2013 Dec; 35(6):844-8. doi:
10.1097/ftd.0b013e31829a10fa. [PMID: 24081205] - Luis Bahamondes, M Valeria Bahamondes, Waleska Modesto, Ian B Tilley, Alviclér Magalhães, João Luiz Pinto e Silva, Eliana Amaral, Daniel R Mishell. Effect of hormonal contraceptives during breastfeeding on infant's milk ingestion and growth.
Fertility and sterility.
2013 Aug; 100(2):445-50. doi:
10.1016/j.fertnstert.2013.03.039. [PMID: 23623474] - Sanna Kallio, Johanna Puurunen, Aimo Ruokonen, Tommi Vaskivuo, Terhi Piltonen, Juha S Tapanainen. Antimüllerian hormone levels decrease in women using combined contraception independently of administration route.
Fertility and sterility.
2013 Apr; 99(5):1305-10. doi:
10.1016/j.fertnstert.2012.11.034. [PMID: 23260855] - Monica Dragoman, Kelsey Petrie, Anupama Torgal, Tiffany Thomas, Serge Cremers, Carolyn L Westhoff. Contraceptive vaginal ring effectiveness is maintained during 6 weeks of use: a prospective study of normal BMI and obese women.
Contraception.
2013 Apr; 87(4):432-6. doi:
10.1016/j.contraception.2012.12.001. [PMID: 23312933] - Sara Mornar, Lingtak-Neander Chan, Stephanie Mistretta, Amy Neustadt, Summer Martins, Melissa Gilliam. Pharmacokinetics of the etonogestrel contraceptive implant in obese women.
American journal of obstetrics and gynecology.
2012 Aug; 207(2):110.e1-6. doi:
10.1016/j.ajog.2012.05.002. [PMID: 22717269] - Carolyn L Westhoff, Anupama H Torgal, Elizabeth Rose Mayeda, Kelsey Petrie, Tiffany Thomas, Monica Dragoman, Serge Cremers. Pharmacokinetics and ovarian suppression during use of a contraceptive vaginal ring in normal-weight and obese women.
American journal of obstetrics and gynecology.
2012 Jul; 207(1):39.e1-6. doi:
10.1016/j.ajog.2012.04.022. [PMID: 22727346] - Hanna Xu, Jennifer A Wade, Jeffrey F Peipert, Qiuhong Zhao, Tessa Madden, Gina M Secura. Contraceptive failure rates of etonogestrel subdermal implants in overweight and obese women.
Obstetrics and gynecology.
2012 Jul; 120(1):21-6. doi:
10.1097/aog.0b013e318259565a. [PMID: 22678035] - Christina Moser, Daniela Zoderer, Gerhard Luef, Markus Rauchenzauner, Ludwig Wildt, Andrea Griesmacher, Christoph Seger. Simultaneous online SPE-LC-MS/MS quantification of six widely used synthetic progestins in human plasma.
Analytical and bioanalytical chemistry.
2012 May; 403(4):961-72. doi:
10.1007/s00216-011-5612-0. [PMID: 22160205] - María Ángeles Pena, Emilio Sanz, Silvia Francisco, Ainhara Alonso, Zurine Abajo, Izaskun Felipe, Jaume Pascual, Digna Tost, Sandra Bailac. Randomized, Crossover and Single-Dose Bioquivalence Study of Two Oral Desogestrel Formulations (Film-Coated Tablets of 75 μg) in Healthy Female Volunteers.
Scientia pharmaceutica.
2012 Apr; 80(2):419-31. doi:
10.3797/scipharm.1111-18. [PMID: 22896827] - Cristina Aparecida Falbo Guazzelli, Fernando Augusto Barreiros, Ricardo Barbosa, Maria Regina Torloni, Marcia Barbieri. Extended regimens of the contraceptive vaginal ring versus hormonal oral contraceptives: effects on lipid metabolism.
Contraception.
2012 Apr; 85(4):389-93. doi:
10.1016/j.contraception.2011.08.014. [PMID: 22067754] - M Stowasser, A H Ahmed, E Pimenta, P J Taylor, R D Gordon. Factors affecting the aldosterone/renin ratio.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2012 Mar; 44(3):170-6. doi:
10.1055/s-0031-1295460. [PMID: 22147655] - Cristina A F Guazzelli, Fernando A Barreiros, Maria R Torloni, Marcia Barbieri. Effects of extended regimens of the contraceptive vaginal ring on carbohydrate metabolism.
Contraception.
2012 Mar; 85(3):253-6. doi:
10.1016/j.contraception.2011.07.009. [PMID: 22067767] - Julie Bouquier, Virginie Fulda, Anne-Sophie Bats, Fabrice Lécuru, Cyrille Huchon. A life-threatening ectopic pregnancy with etonogestrel implant.
Contraception.
2012 Feb; 85(2):215-7. doi:
10.1016/j.contraception.2011.07.008. [PMID: 22067768] - Cécile Ciangura, Nicola Corigliano, Arnaud Basdevant, Stéphane Mouly, Xavier Declèves, Philippe Touraine, Celia Lloret-Linares. Etonorgestrel concentrations in morbidly obese women following Roux-en-Y gastric bypass surgery: three case reports.
Contraception.
2011 Dec; 84(6):649-51. doi:
10.1016/j.contraception.2011.03.015. [PMID: 22078197] - Gabriele S Merki-Feld, Marinella Rosselli, Bruno Imthurn, Katharina Spanaus. No effect of Implanon® on inflammatory cardiovascular parameters.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2011 Nov; 27(11):951-5. doi:
10.3109/09513590.2011.564684. [PMID: 21438668] - Cristina A F Guazzelli, Flaviano Teixeira de Queiroz, Marcia Barbieri, Fernando A Barreiros, Maria Regina Torloni, Fabio F Araujo. Metabolic effects of contraceptive implants in adolescents.
Contraception.
2011 Oct; 84(4):409-12. doi:
10.1016/j.contraception.2011.02.006. [PMID: 21920197] - Fernando Augusto Barreiros, Cristina Aparecida Falbo Guazzelli, Ricardo Barbosa, Maria Regina Torloni, Marcia Barbieri, Fabio F Araujo. Extended regimens of the combined contraceptive vaginal ring containing etonogestrel and ethinyl estradiol: effects on lipid metabolism.
Contraception.
2011 Aug; 84(2):155-9. doi:
10.1016/j.contraception.2010.11.002. [PMID: 21757057] - Ashraf H Ahmed, Richard D Gordon, Paul J Taylor, Gregory Ward, Eduardo Pimenta, Michael Stowasser. Effect of contraceptives on aldosterone/renin ratio may vary according to the components of contraceptive, renin assay method, and possibly route of administration.
The Journal of clinical endocrinology and metabolism.
2011 Jun; 96(6):1797-804. doi:
10.1210/jc.2010-2918. [PMID: 21411552] - Ney Carter do Carmo Borges, Rafael Barrientos Astigarraga, Carlos Eduardo Sverdloff, Bruno Carter Borges, Thaís Rodrigues Paiva, Paulo Rebelo Galvinas, Ronilson Agnaldo Moreno. Budesonide quantification by HPLC coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry. Application to a comparative systemic bioavailability of two budesonide formulations in healthy volunteers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Feb; 879(3-4):236-42. doi:
10.1016/j.jchromb.2010.12.003. [PMID: 21233029] - Jennifer Kerns, Philip Darney. Vaginal ring contraception.
Contraception.
2011 Feb; 83(2):107-15. doi:
10.1016/j.contraception.2010.07.008. [PMID: 21237335] - Gabriele S Merki-Feld, Bruno Imthurn, Marinella Rosselli, Katharina Spanaus. Implanon use lowers plasma concentrations of high-molecular-weight adiponectin.
Fertility and sterility.
2011 Jan; 95(1):23-7. doi:
10.1016/j.fertnstert.2010.05.018. [PMID: 20576266] - Smriti R C Bhatta, Radwan Faraj. Restoration of fertility after removal of extrauterine mirena coil: a case report and review of the literature.
Case reports in obstetrics and gynecology.
2011; 2011(?):189565. doi:
10.1155/2011/189565. [PMID: 22567494] - J T Mutihir, D D Nyango. Indications for removal of etonogestrel implant within two years of use in Jos, Nigeria.
East African medical journal.
2010 Nov; 87(11):461-4. doi:
NULL. [PMID: 23457809] - Johan Verhaeghe. Hormonal contraception in women with the metabolic syndrome: a narrative review.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2010 Oct; 15(5):305-13. doi:
10.3109/13625187.2010.502583. [PMID: 20695771] - Konrad Bork. Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.
2010 Jul; 6(1):15. doi:
10.1186/1710-1492-6-15. [PMID: 20667118] - Berna Dilbaz, Ozlem Ozdegirmenci, Eray Caliskan, Serdar Dilbaz, Ali Haberal. Effect of etonogestrel implant on serum lipids, liver function tests and hemoglobin levels.
Contraception.
2010 Jun; 81(6):510-4. doi:
10.1016/j.contraception.2010.01.014. [PMID: 20472118] - D M Paternoster, F Riboni, M Bertolino, G Garofalo, E Lazzarich, N Surico, P Stratta. The contraceptive vaginal ring in women with renal and liver transplantation: analysis of preliminary results.
Transplantation proceedings.
2010 May; 42(4):1162-5. doi:
10.1016/j.transproceed.2010.03.132. [PMID: 20534250] - Mariangela Massaro, Costantino Di Carlo, Virginia Gargano, Carmen Formisano, Giuseppe Bifulco, Carmine Nappi. Effects of the contraceptive patch and the vaginal ring on bone metabolism and bone mineral density: a prospective, controlled, randomized study.
Contraception.
2010 Mar; 81(3):209-14. doi:
10.1016/j.contraception.2009.09.011. [PMID: 20159176] - Xiao-Fen Liu, Cun-Gang Ding, Qing-Hua Ge, Zhen Zhou, Xiao-Jin Zhi. [Simultaneous determination of gestodene, etonogestrel and ethinylestradiol in plasma by LC-MS/MS following derivatization].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 Jan; 45(1):87-92. doi:
NULL. [PMID: 21351455] - E F Hynes, K A Handasyde, Geoff Shaw, Marilyn B Renfree. Levonorgestrel, not etonogestrel, provides contraception in free-ranging koalas.
Reproduction, fertility, and development.
2010; 22(6):913-9. doi:
10.1071/rd09253. [PMID: 20591325] - Prabhudas R Palan, Felix Strube, Juraj Letko, Azra Sadikovic, Magdy S Mikhail. Effects of oral, vaginal, and transdermal hormonal contraception on serum levels of coenzyme q(10), vitamin e, and total antioxidant activity.
Obstetrics and gynecology international.
2010; 2010(?):. doi:
10.1155/2010/925635. [PMID: 20814444] - Milena Bastos Brito, Rui Alberto Ferriani, Silvana Maria Quintana, Marta Edna Holanda Diogenes Yazlle, Marcos Felipe Silva de Sá, Carolina Sales Vieira. Safety of the etonogestrel-releasing implant during the immediate postpartum period: a pilot study.
Contraception.
2009 Dec; 80(6):519-26. doi:
10.1016/j.contraception.2009.05.124. [PMID: 19913145] - Ahmed Nasr, Hanan M Nafeh. Effect of etonogestrel contraceptive implant (Implanon) on portal blood flow and liver functions.
Contraception.
2009 Mar; 79(3):236-9. doi:
10.1016/j.contraception.2008.09.010. [PMID: 19185679] - Liane Will-Shahab, Steffen Bauer, Ullrich Kunter, Ivar Roots, Axel Brattström. St John's wort extract (Ze 117) does not alter the pharmacokinetics of a low-dose oral contraceptive.
European journal of clinical pharmacology.
2009 Mar; 65(3):287-94. doi:
10.1007/s00228-008-0587-2. [PMID: 19015839] - Lisa Vicente, Denisa Mendonça, Marina Dingle, Rui Duarte, J Manuel Boavida. Etonogestrel implant in women with diabetes mellitus.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2008 Dec; 13(4):387-95. doi:
10.1080/13625180802382604. [PMID: 19117254] - G S Merki-Feld, B Imthurn, B Seifert. Effects of the progestagen-only contraceptive implant Implanon on transforming growth factor beta1 and endothelin-1.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2008 Oct; 40(10):692-6. doi:
10.1055/s-2008-1073149. [PMID: 18500679] - M Murat Inal, Yusuf Yildirim, Kenan Ertopcu, M Eftal Avci, Isa Ozelmas, Sivekar Tinar. Effect of the subdermal contraceptive etonogestrel implant (Implanon) on biochemical and hormonal parameters (three years follow-up).
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2008 Sep; 13(3):238-42. doi:
10.1080/13625180802075315. [PMID: 18609340] - Gabriele S Merki-Feld, Bruno Imthurn, Burkhardt Seifert. Effects of the progestagen-only contraceptive implant Implanon on cardiovascular risk factors.
Clinical endocrinology.
2008 Mar; 68(3):355-60. doi:
10.1111/j.1365-2265.2007.03046.x. [PMID: 17854390] - Heather Hohmann, Mitchell D Creinin. The contraceptive implant.
Clinical obstetrics and gynecology.
2007 Dec; 50(4):907-17. doi:
10.1097/grf.0b013e318159c2f6. [PMID: 17982333] - Frans J M E Roumen. The contraceptive vaginal ring compared with the combined oral contraceptive pill: a comprehensive review of randomized controlled trials.
Contraception.
2007 Jun; 75(6):420-9. doi:
10.1016/j.contraception.2007.01.013. [PMID: 17519147] - Melanie J Walton, Richard A Anderson, Andrew T Kicman, Rob A Elton, Karolina Ossowska, David T Baird. A diurnal variation in testicular hormone production is maintained following gonadotrophin suppression in normal men.
Clinical endocrinology.
2007 Jan; 66(1):123-9. doi:
10.1111/j.1365-2265.2006.02696.x. [PMID: 17201811] - Stefano Luisi, Lavinia Estrela Borges, Lucia Lazzeri, Ariana Dell'Anna, Filiberto Maria Severi, Felice Petraglia. Vaginally administered estroprogestinic decreases serum inhibin A and inhibin B levels and reduces endometrial thickness.
Fertility and sterility.
2006 Nov; 86(5):1483-7. doi:
10.1016/j.fertnstert.2006.04.032. [PMID: 16989826] - Tuomas Korhonen, Ari Tolonen, Jouko Uusitalo, Stefan Lundgren, Jorma Jalonen, Kari Laine. The role of CYP2C and CYP3A in the disposition of 3-keto-desogestrel after administration of desogestrel.
British journal of clinical pharmacology.
2005 Jul; 60(1):69-75. doi:
10.1111/j.1365-2125.2005.02382.x. [PMID: 15963096] - Peter Dogterom, Michiel W van den Heuvel, Torben Thomsen. Absence of pharmacokinetic interactions of the combined contraceptive vaginal ring NuvaRing with oral amoxicillin or doxycycline in two randomised trials.
Clinical pharmacokinetics.
2005; 44(4):429-38. doi:
10.2165/00003088-200544040-00007. [PMID: 15828855] - B M Brady, M Walton, N Hollow, A T Kicman, D T Baird, R A Anderson. Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception.
Human reproduction (Oxford, England).
2004 Nov; 19(11):2658-67. doi:
10.1093/humrep/deh491. [PMID: 15333595] - Arijit Biswas, Sinjini Biswas, Osborne A C Viegas. Effect of etonogestrel subdermal contraceptive implant (Implanon) on liver function tests -- a randomized comparative study with Norplant implants.
Contraception.
2004 Nov; 70(5):379-82. doi:
10.1016/j.contraception.2004.05.011. [PMID: 15504376] - M Tuppurainen, R Klimscheffskij, M Venhola, Th O M Dieben. The combined contraceptive vaginal ring (NuvaRing) and lipid metabolism: a comparative study.
Contraception.
2004 May; 69(5):389-94. doi:
10.1016/j.contraception.2004.01.004. [PMID: 15105061] - Carole H J Verhoeven, Th O M Dieben. The combined contraceptive vaginal ring, NuvaRing, and tampon co-usage.
Contraception.
2004 Mar; 69(3):197-9. doi:
10.1016/j.contraception.2003.10.014. [PMID: 14969666] - C H J Verhoeven, M W van den Heuvel, T M T Mulders, Th O M Dieben. The contraceptive vaginal ring, NuvaRing, and antimycotic co-medication.
Contraception.
2004 Feb; 69(2):129-32. doi:
10.1016/j.contraception.2003.10.001. [PMID: 14759617] - Susan A Ballagh. Vaginal rings for menopausal symptom relief.
Drugs & aging.
2004; 21(12):757-66. doi:
10.2165/00002512-200421120-00001. [PMID: 15382956] - Arabelle Pfrunder, Monika Schiesser, Simone Gerber, Manuel Haschke, Johannes Bitzer, Juergen Drewe. Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial.
British journal of clinical pharmacology.
2003 Dec; 56(6):683-90. doi:
10.1046/j.1365-2125.2003.02005.x. [PMID: 14616430] - Arijit Biswas, Osborne A C Viegas, Asim C Roy. Effect of Implanon and Norplant subdermal contraceptive implants on serum lipids--a randomized comparative study.
Contraception.
2003 Sep; 68(3):189-93. doi:
10.1016/s0010-7824(03)00145-8. [PMID: 14561539] - T Haring, T M T Mulders. The combined contraceptive ring NuvaRing and spermicide co-medication.
Contraception.
2003 Apr; 67(4):271-2. doi:
10.1016/s0010-7824(03)00002-7. [PMID: 12684146] - H Seeger, D Wallwiener, A O Mueck. The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2003 Feb; 35(2):76-80. doi:
10.1055/s-2003-39061. [PMID: 12734785] - Irving Sivin. Risks and benefits, advantages and disadvantages of levonorgestrel-releasing contraceptive implants.
Drug safety.
2003; 26(5):303-35. doi:
10.2165/00002018-200326050-00002. [PMID: 12650633] - Horacio B Croxatt. Progestin implants for female contraception.
Contraception.
2002 Jan; 65(1):15-9. doi:
10.1016/s0010-7824(01)00293-1. [PMID: 11861051] - Laneta J Dorflinger. Metabolic effects of implantable steroid contraceptives for women.
Contraception.
2002 Jan; 65(1):47-62. doi:
10.1016/s0010-7824(01)00290-6. [PMID: 11861055] - Soledad Díaz. Contraceptive implants and lactation.
Contraception.
2002 Jan; 65(1):39-46. doi:
10.1016/s0010-7824(01)00295-5. [PMID: 11861054] - B Harwood, D R Mishell. Contraceptive vaginal rings.
Seminars in reproductive medicine.
2001 Dec; 19(4):381-90. doi:
10.1055/s-2001-18646. [PMID: 11727180] - T M Mulders, T O Dieben. Use of the novel combined contraceptive vaginal ring NuvaRing for ovulation inhibition.
Fertility and sterility.
2001 May; 75(5):865-70. doi:
10.1016/s0015-0282(01)01689-2. [PMID: 11334895] - G Klinger, T Piater, R Jäger, B Küntzel, R Schön, G Hobe. Non-protein bound dienogest in serum and salivary dienogest in women taking the oral contraceptives Certostat and Valette.
Die Pharmazie.
2001 Apr; 56(4):325-8. doi:
NULL. [PMID: 11338674]