4b-Hydroxycholesterol (BioDeep_00000033093)
human metabolite Endogenous blood metabolite
代谢物信息卡片
(1S,2R,5S,6R,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-ene-5,6-diol
化学式: C27H46O2 (402.34976159999997)
中文名称: 胆甾-5-烯-3,4-二醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4O)O)C)C
InChI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1
描述信息
4[beta]-Hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians [HMDB]
4[beta]-Hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.
同义名列表
22 个代谢物同义名
(1S,2R,5S,6R,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-ene-5,6-diol; (3beta,4alpha)-Isomer OF cholest-5-ene-3,4-diol; (3beta,4beta)-Cholest-5-ene-3,4-diol; 3beta,4beta-Dihydroxycholest-5-ene; (4b)-Cholest-5-ene-3beta,4-diol; (3Β,4β)-cholest-5-ene-3,4-diol; Cholest-5-ene-3beta,4beta-diol; (3b,4b)-Cholest-5-ene-3,4-diol; cholest-5-en-3beta,4beta-diol; (4b)-Cholest-5-ene-3b,4-diol; 4b-Cholest-5-ene-3b,4-diol; Cholest-5-en-3beta,4b-diol; (4b)-4-Hydroxycholesterol; 4beta-Hydroxycholesterol; Cholest-5-ene-3b,4b-diol; Cholest-5-en-3b,4b-diol; Cholest-5-en-3β,4β-diol; 4b-Hydroxy-cholesterol; Cholest-5-ene-3,4-diol; 4Β-hydroxy-cholesterol; 4b-Hydroxycholesterol; 4-Hydroxycholesterol
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:85778
- PubChem: 3247060
- HMDB: HMDB0013643
- ChEMBL: CHEMBL497411
- foodb: FDB029614
- chemspider: 2497521
- CAS: 17320-10-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(1)
- Cholesterol metabolism with Bloch and Kandutsch-Russell pathways:
7-dehydodesmosterol ⟶ 7-dehdrocholesterol
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kine Eide Kvitne, Kristine Hole, Veronica Krogstad, Birgit Malene Wollmann, Christine Wegler, Line K Johnson, Jens K Hertel, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B Andersson, Rune Sandbu, Jøran Hjelmesæth, Eva Skovlund, Hege Christensen, Rasmus Jansson-Löfmark, Anders Åsberg, Espen Molden, Ida Robertsen. Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.
European journal of clinical pharmacology.
2022 Aug; 78(8):1289-1299. doi:
10.1007/s00228-022-03336-9. [PMID: 35648149] - Roosa Rahunen, Outi Kummu, Vesa Koivukangas, Heidi Hautajärvi, Jukka Hakkola, Jaana Rysä, Janne Hukkanen. Pregnane X Receptor‒4β-Hydroxycholesterol Axis in the Regulation of Overweight- and Obesity-Induced Hypertension.
Journal of the American Heart Association.
2022 03; 11(6):e023492. doi:
10.1161/jaha.121.023492. [PMID: 35229613] - A David Rodrigues, Linda S Wood, Manoli Vourvahis, Andrew Rowland. Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil.
Clinical pharmacology and therapeutics.
2022 02; 111(2):425-434. doi:
10.1002/cpt.2440. [PMID: 34623637] - Dieter Lütjohann, Frans Stellaard, Anja Kerksiek, Jörn Lötsch, Bruno G Oertel. Serum 4β-hydroxycholesterol increases during fluconazole treatment.
European journal of clinical pharmacology.
2021 May; 77(5):659-669. doi:
10.1007/s00228-020-03041-5. [PMID: 33201347] - Janne Hukkanen, Jukka Hakkola. PXR and 4β-Hydroxycholesterol Axis and the Components of Metabolic Syndrome.
Cells.
2020 11; 9(11):. doi:
10.3390/cells9112445. [PMID: 33182477] - Yueping Zhang, Cliff Chen, Shen-Jue Chen, Xue-Qing Chen, David J Shuster, Pawel D Puszczalo, R Marcus Fancher, Zheng Yang, Michael Sinz, Hong Shen. Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
The Journal of pharmacology and experimental therapeutics.
2020 10; 375(1):139-151. doi:
10.1124/jpet.120.000139. [PMID: 32719071] - Fatemeh Hassani-Nezhad-Gashti, Tuire Salonurmi, Heidi Hautajärvi, Jaana Rysä, Jukka Hakkola, Janne Hukkanen. Pregnane X Receptor Activator Rifampin Increases Blood Pressure and Stimulates Plasma Renin Activity.
Clinical pharmacology and therapeutics.
2020 10; 108(4):856-865. doi:
10.1002/cpt.1871. [PMID: 32344455] - Daisuke Yamamuro, Hisataka Yamazaki, Jun-Ichi Osuga, Kenta Okada, Tetsuji Wakabayashi, Akihito Takei, Shoko Takei, Manabu Takahashi, Shuichi Nagashima, Adriaan G Holleboom, Masayuki Kuroda, Hideaki Bujo, Shun Ishibashi. Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT.
Journal of lipid research.
2020 09; 61(9):1287-1299. doi:
10.1194/jlr.ra119000512. [PMID: 32561542] - Ken Ogasawara, Patricia M LoRusso, Anthony J Olszanski, Olivier Rixe, Christine Xu, Jian Yin, Maria Palmisano, Gopal Krishna. Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach.
Cancer chemotherapy and pharmacology.
2020 07; 86(1):87-95. doi:
10.1007/s00280-020-04102-3. [PMID: 32537715] - Kohei Hoshikawa, Takafumi Naito, Shunta Akutsu, Masao Saotome, Yuichiro Maekawa, Junichi Kawakami. Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients.
Basic & clinical pharmacology & toxicology.
2020 Apr; 126(4):353-363. doi:
10.1111/bcpt.13355. [PMID: 31652395] - Sophie Gravel, Jean-Louis Chiasson, Fleur Gaudette, Jacques Turgeon, Veronique Michaud. Use of 4β-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes.
Clinical pharmacology and therapeutics.
2019 10; 106(4):831-840. doi:
10.1002/cpt.1472. [PMID: 31002385] - Takafumi Naito, Junya Ohshiro, Hikaru Sato, Eiji Torikai, Motohiro Suzuki, Noriyoshi Ogawa, Junichi Kawakami. Relationships between concomitant biologic DMARDs and prednisolone administration and blood tacrolimus exposure or serum CYP3A4/5-related markers in rheumatoid arthritis patients.
Clinical biochemistry.
2019 Jul; 69(?):8-14. doi:
10.1016/j.clinbiochem.2019.05.003. [PMID: 31077643] - Agnieszka Prytuła, Karlien Cransberg, Ann Raes. Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?.
Pediatric nephrology (Berlin, Germany).
2019 07; 34(7):1201-1210. doi:
10.1007/s00467-018-4030-3. [PMID: 30058048] - Scott R Penzak, Carlos Rojas-Fernandez. 4β-Hydroxycholesterol as an Endogenous Biomarker for CYP3A Activity: Literature Review and Critical Evaluation.
Journal of clinical pharmacology.
2019 05; 59(5):611-624. doi:
10.1002/jcph.1391. [PMID: 30748026] - Caroline Gjestad, Kristine Hole, Tore Haslemo, Ulf Diczfalusy, Espen Molden. Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol-an Interaction Study in Healthy Volunteers.
The AAPS journal.
2019 04; 21(4):58. doi:
10.1208/s12248-019-0330-1. [PMID: 31020430] - Yosuke Suzuki, Nanako Muraya, Takashi Fujioka, Fuminori Sato, Ryota Tanaka, Kunihiro Matsumoto, Yuhki Sato, Keiko Ohno, Hiromitsu Mimata, Satoshi Kishino, Hiroki Itoh. Factors involved in phenoconversion of CYP3A using 4β-hydroxycholesterol in stable kidney transplant recipients.
Pharmacological reports : PR.
2019 Apr; 71(2):276-281. doi:
10.1016/j.pharep.2018.12.007. [PMID: 30826567] - Harunobu Tahara, Miwa Watanabe, Maki Hasegawa. A comparative study for detecting CYP3A induction by CYP3A probe drugs and endogenous markers in cynomolgus monkeys.
Biopharmaceutics & drug disposition.
2019 Feb; 40(2):81-93. doi:
10.1002/bdd.2173. [PMID: 30724384] - Heidi Hautajärvi, Janne Hukkanen, Miia Turpeinen, Sampo Mattila, Ari Tolonen. Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Nov; 1100-1101(?):179-186. doi:
10.1016/j.jchromb.2018.09.028. [PMID: 30340067] - Kristine Hole, Petra L Heiberg, Caroline Gjestad, Lise L Mehus, Øyvind Rø, Espen Molden. Elevated 4β-hydroxycholesterol/cholesterol ratio in anorexia nervosa patients.
Pharmacology research & perspectives.
2018 10; 6(5):e00430. doi:
10.1002/prp2.430. [PMID: 30214813] - Kristine Hole, Birgit M Wollmann, Camilla Nguyen, Tore Haslemo, Espen Molden. Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker.
Therapeutic drug monitoring.
2018 08; 40(4):463-468. doi:
10.1097/ftd.0000000000000518. [PMID: 29649093] - Andrew HyoungJin Kim, Bora Kim, Su-Jin Rhee, Yujin Lee, Joong Shin Park, Seung Mi Lee, Sun Min Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho. Assessment of induced CYP3A activity in pregnant women using 4β-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker.
Drug metabolism and pharmacokinetics.
2018 Jun; 33(3):173-178. doi:
10.1016/j.dmpk.2018.04.004. [PMID: 29759884] - Takeshi Hirayama, Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Sho-Ichiro Yara, Motoyuki Kohjima, Makoto Nakamuta, Yasushi Matsuzaki. Differences in the Serum 4β-hydroxycholesterol Levels of Patients with Chronic Hepatitis C Virus (HCV) Infection: A Possible Impact on the Efficacy and Safety of Interferon (IFN)-free Treatment.
Internal medicine (Tokyo, Japan).
2018 May; 57(9):1219-1227. doi:
10.2169/internalmedicine.9479-17. [PMID: 29279486] - Shin-Ichiro Nitta, Mari Hashimoto, Yasuhiro Kazuki, Shoko Takehara, Hiraku Suzuki, Mitsuo Oshimura, Hidetaka Akita, Kan Chiba, Kaoru Kobayashi. Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.
The AAPS journal.
2018 04; 20(3):61. doi:
10.1208/s12248-018-0186-9. [PMID: 29858698] - Caroline Gjestad, Tore Haslemo, Ole A Andreassen, Espen Molden. 4β-Hydroxycholesterol level significantly correlates with steady-state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients.
British journal of clinical pharmacology.
2017 Nov; 83(11):2398-2405. doi:
10.1111/bcp.13341. [PMID: 28585378] - Thomas Vanhove, Mahmoud Hasan, Pieter Annaert, Stefan Oswald, Dirk R J Kuypers. Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.
British journal of clinical pharmacology.
2017 Nov; 83(11):2406-2415. doi:
10.1111/bcp.13343. [PMID: 28603840] - Elisabet Størset, Kristine Hole, Karsten Midtvedt, Stein Bergan, Espen Molden, Anders Åsberg. The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation.
British journal of clinical pharmacology.
2017 07; 83(7):1457-1465. doi:
10.1111/bcp.13248. [PMID: 28146606] - Jaeseong Oh, Andrew HyoungJin Kim, SeungHwan Lee, Hyunjeong Cho, Yon Su Kim, Mi Young Bahng, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu. Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel dipeptidyl peptidase-4 inhibitor, evogliptin (DA-1229).
Diabetes, obesity & metabolism.
2017 02; 19(2):294-298. doi:
10.1111/dom.12813. [PMID: 27761990] - Jialin Mao, Iain Martin, James McLeod, Gail Nolan, Robert van Horn, Manoli Vourvahis, Yvonne S Lin. Perspective: 4β-hydroxycholesterol as an emerging endogenous biomarker of hepatic CYP3A.
Drug metabolism reviews.
2017 02; 49(1):18-34. doi:
10.1080/03602532.2016.1239630. [PMID: 27718639] - Xuemin Jiang, Catherine Dutreix, Venkateswar Jarugula, Sam Rebello, Christina S Won, Haiying Sun. An Exposure-Response Modeling Approach to Examine the Relationship Between Potency of CYP3A Inducer and Plasma 4β-Hydroxycholesterol in Healthy Subjects.
Clinical pharmacology in drug development.
2017 Jan; 6(1):19-26. doi:
10.1002/cpdd.267. [PMID: 27138546] - Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Pieter Annaert, Ulf Diczfalusy, Dirk R J Kuypers. Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.
British journal of clinical pharmacology.
2016 12; 82(6):1539-1549. doi:
10.1111/bcp.13083. [PMID: 27501475] - Mahmoud Hasan, Werner Siegmund, Stefan Oswald. Rapid LC-MS/MS method for the determination of 4-hydroxycholesterol/cholesterol ratio in serum as endogenous biomarker for CYP3A activity in human and foals.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Oct; 1033-1034(?):193-199. doi:
10.1016/j.jchromb.2016.08.006. [PMID: 27565568] - Anne-Françoise Aubry, Brian Dean, Ulf Diczfalusy, Angela Goodenough, André Iffland, James McLeod, Naidong Weng, Ziping Yang. Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity.
The AAPS journal.
2016 09; 18(5):1056-1066. doi:
10.1208/s12248-016-9949-3. [PMID: 27350147] - Linda Björkhem-Bergman, Hanna Nylén, Mats Eriksson, Paolo Parini, Ulf Diczfalusy. Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations.
Basic & clinical pharmacology & toxicology.
2016 Jun; 118(6):499-502. doi:
10.1111/bcpt.12537. [PMID: 26617265] - Takuya Ishida, Takafumi Naito, Hikaru Sato, Junichi Kawakami. Relationship between the plasma fentanyl and serum 4β-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain.
Drug metabolism and pharmacokinetics.
2016 Jun; 31(3):242-8. doi:
10.1016/j.dmpk.2016.04.001. [PMID: 27236640] - Sarah J Woolsey, Melanie D Beaton, Yun-Hee Choi, George K Dresser, Steven E Gryn, Richard B Kim, Rommel G Tirona. Relationships between Endogenous Plasma Biomarkers of Constitutive Cytochrome P450 3A Activity and Single-Time-Point Oral Midazolam Microdose Phenotype in Healthy Subjects.
Basic & clinical pharmacology & toxicology.
2016 Apr; 118(4):284-91. doi:
10.1111/bcpt.12492. [PMID: 26399557] - Zoltán Pataj, Gerhard Liebisch, Gerd Schmitz, Silke Matysik. Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry.
Journal of chromatography. A.
2016 Mar; 1439(?):82-88. doi:
10.1016/j.chroma.2015.11.015. [PMID: 26607314] - Caroline Gjestad, Duy Khanh Huynh, Tore Haslemo, Espen Molden. 4β-hydroxycholesterol correlates with dose but not steady-state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation?.
British journal of clinical pharmacology.
2016 Feb; 81(2):269-76. doi:
10.1111/bcp.12833. [PMID: 26574235] - Y-J Xue, Matthew Hoffmann, Zeen Tong, Xinqun Irene Wu, Martha Vallejo, Brian Melo, Ying Ye, Michael Thomas, Yong Liu, Daniel Weiss, Sekhar Surapaneni. Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction.
Bioanalysis.
2016 Feb; 8(3):215-28. doi:
10.4155/bio.15.241. [PMID: 26805594] - Takafumi Naito, Naoko Kubono, Takuya Ishida, Shuhei Deguchi, Masahisa Sugihara, Hiroaki Itoh, Naohiro Kanayama, Junichi Kawakami. CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine.
Drug metabolism and pharmacokinetics.
2015 Dec; 30(6):419-24. doi:
10.1016/j.dmpk.2015.08.008. [PMID: 26654672] - Buster Mannheimer, Henrik Wagner, Claes-Göran Östenson, Ulf Diczfalusy. No impact of vitamin D on the CYP3A biomarker 4β-hydroxycholesterol in patients with abnormal glucose regulation.
PloS one.
2015; 10(4):e0121984. doi:
10.1371/journal.pone.0121984. [PMID: 25835492] - Sreeneeranj Kasichayanula, David W Boulton, Wen-Lin Luo, A David Rodrigues, Zheng Yang, Angela Goodenough, Michelle Lee, Mohammed Jemal, Frank LaCreta. Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.
British journal of clinical pharmacology.
2014 Nov; 78(5):1122-34. doi:
10.1111/bcp.12425. [PMID: 24837659] - Hanna Nylén, Linda Björkhem-Bergman, Lena Ekström, Hyung-Keun Roh, Leif Bertilsson, Erik Eliasson, Jonatan D Lindh, Ulf Diczfalusy. Plasma levels of 25-hydroxyvitamin D3 and in vivo markers of cytochrome P450 3A activity in Swedes and Koreans: effects of a genetic polymorphism and oral contraceptives.
Basic & clinical pharmacology & toxicology.
2014 Oct; 115(4):366-71. doi:
10.1111/bcpt.12230. [PMID: 24655660] - Catherine Dutreix, Sebastien Lorenzo, Yanfeng Wang. Comparison of two endogenous biomarkers of CYP3A4 activity in a drug-drug interaction study between midostaurin and rifampicin.
European journal of clinical pharmacology.
2014 Aug; 70(8):915-20. doi:
10.1007/s00228-014-1675-0. [PMID: 24839948] - Mike-Qingtao Huang, Weisheng Lin, Weimin Wang, Wei Zhang, Zhongping John Lin, Naidong Weng. Quantitation of P450 3A4 endogenous biomarker - 4β-hydroxycholesterol - in human plasma using LC/ESI-MS/MS.
Biomedical chromatography : BMC.
2014 Jun; 28(6):794-801. doi:
10.1002/bmc.3131. [PMID: 24861746] - Ke Li, Sylvia Zhao, Lingling Zhang, Xiaoyun Wu, Pan Shu, Yang Wang, Hao Feng, Zheming Gu, Helen Han Hsu. 4β-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys.
Drug metabolism and disposition: the biological fate of chemicals.
2014 May; 42(5):839-43. doi:
10.1124/dmd.114.057224. [PMID: 24595680] - Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Motoyuki Kohjima, Makoto Nakamuta, Yasushi Matsuzaki. Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection.
Biochemical and biophysical research communications.
2014 Apr; 446(3):736-40. doi:
10.1016/j.bbrc.2014.01.176. [PMID: 24525121] - Yosuke Suzuki, Hiroki Itoh, Takashi Fujioka, Fuminori Sato, Kanako Kawasaki, Yukie Sato, Yuhki Sato, Keiko Ohno, Hiromitsu Mimata, Satoshi Kishino. Association of plasma concentration of 4β-hydroxycholesterol with CYP3A5 polymorphism and plasma concentration of indoxyl sulfate in stable kidney transplant recipients.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Jan; 42(1):105-10. doi:
10.1124/dmd.113.054171. [PMID: 24135442] - Yaodong Xu, Yang Yuan, Lisa Smith, Rick Edom, Naidong Weng, Rao Mamidi, Jose Silva, David C Evans, Heng-Keang Lim. LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume.
Journal of pharmaceutical and biomedical analysis.
2013 Nov; 85(?):145-54. doi:
10.1016/j.jpba.2013.07.016. [PMID: 23948760] - K-H Shin, M H Choi, K S Lim, K-S Yu, I-J Jang, J-Y Cho. Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance.
Clinical pharmacology and therapeutics.
2013 Nov; 94(5):601-9. doi:
10.1038/clpt.2013.128. [PMID: 23784264] - Yosuke Suzuki, Hiroki Itoh, Fuminori Sato, Kanako Kawasaki, Yukie Sato, Takashi Fujioka, Yuhki Sato, Keiko Ohno, Hiromitsu Mimata, Satoshi Kishino. Significant increase in plasma 4β-hydroxycholesterol concentration in patients after kidney transplantation.
Journal of lipid research.
2013 Sep; 54(9):2568-72. doi:
10.1194/jlr.p040022. [PMID: 23833241] - Linda Björkhem-Bergman, Tobias Bäckström, Hanna Nylén, Yuko Rönquist-Nii, Eva Bredberg, Tommy B Andersson, Leif Bertilsson, Ulf Diczfalusy. Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Aug; 41(8):1488-93. doi:
10.1124/dmd.113.052316. [PMID: 23674608] - Yvonne Mårde Arrhén, Hanna Nylén, Anita Lövgren-Sandblom, Kajsa P Kanebratt, Katarina Wide, Ulf Diczfalusy. A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction.
British journal of clinical pharmacology.
2013 Jun; 75(6):1536-40. doi:
10.1111/bcp.12016. [PMID: 23116409] - Linda Björkhem-Bergman, Hanna Nylén, Anna-Carin Norlin, Jonatan D Lindh, Lena Ekström, Erik Eliasson, Peter Bergman, Ulf Diczfalusy. Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Apr; 41(4):704-8. doi:
10.1124/dmd.113.051136. [PMID: 23386704] - Tatsuya Higashi, Katsumi Kawasaki, Nagisa Matsumoto, Shoujiro Ogawa, Kuniko Mitamura, Shigeo Ikegawa. LC/MS/MS of steroids having vicinal diol as electrospray-active boronates.
Chemical & pharmaceutical bulletin.
2013; 61(3):326-32. doi:
10.1248/cpb.c12-00979. [PMID: 23449202] - Angela K Goodenough, Joelle M Onorato, Zheng Ouyang, Shu Chang, A David Rodrigues, Sreeneeranj Kasichayanula, Shu-Pang Huang, Wesley Turley, Richard Burrell, Marc Bifano, Mohammed Jemal, Frank LaCreta, Adrienne Tymiak, David Wang-Iverson. Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis.
Chemical research in toxicology.
2011 Sep; 24(9):1575-85. doi:
10.1021/tx2001898. [PMID: 21728364] - Jette Peters, Wiebke Block, Stefan Oswald, Johanna Freyer, Markus Grube, Heyo K Kroemer, Marc Lämmer, Dieter Lütjohann, Monica Venner, Werner Siegmund. Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Sep; 39(9):1643-9. doi:
10.1124/dmd.111.039206. [PMID: 21690264] - Nico C van de Merbel, Kees J Bronsema, Mischa W J van Hout, Ralf Nilsson, Henrik Sillén. A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma.
Journal of pharmaceutical and biomedical analysis.
2011 Jul; 55(5):1089-95. doi:
10.1016/j.jpba.2011.03.017. [PMID: 21507593] - Hanna Nylén, Sofia Sergel, Lisa Forsberg, Synnöve Lindemalm, Leif Bertilsson, Katarina Wide, Ulf Diczfalusy. Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol.
European journal of clinical pharmacology.
2011 Jul; 67(7):715-22. doi:
10.1007/s00228-010-0984-1. [PMID: 21246351] - E Gebeyehu, E Engidawork, A Bijnsdorp, A Aminy, U Diczfalusy, E Aklillu. Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians.
The pharmacogenomics journal.
2011 Apr; 11(2):130-7. doi:
10.1038/tpj.2010.16. [PMID: 20231858] - Ulf Diczfalusy, Hanna Nylén, Pontus Elander, Leif Bertilsson. 4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.
British journal of clinical pharmacology.
2011 Feb; 71(2):183-9. doi:
10.1111/j.1365-2125.2010.03773.x. [PMID: 21219398] - Zheng Yang, A David Rodrigues. Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric?.
Journal of clinical pharmacology.
2010 Nov; 50(11):1330-8. doi:
10.1177/0091270009360041. [PMID: 20197489] - D Lütjohann, M Marinova, B Schneider, J Oldenburg, K von Bergmann, T Bieber, I Björkhem, U Diczfalusy. 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.
International journal of clinical pharmacology and therapeutics.
2009 Dec; 47(12):709-15. doi:
10.5414/cpp47709. [PMID: 19954708] - Mats Allmyr, Georgios Panagiotidis, Erik Sparve, Ulf Diczfalusy, Gunilla Sandborgh-Englund. Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.
Basic & clinical pharmacology & toxicology.
2009 Nov; 105(5):339-44. doi:
10.1111/j.1742-7843.2009.00455.x. [PMID: 19686543] - D Tomalik-Scharte, D Lütjohann, O Doroshyenko, D Frank, A Jetter, U Fuhr. Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?.
Clinical pharmacology and therapeutics.
2009 Aug; 86(2):147-53. doi:
10.1038/clpt.2009.72. [PMID: 19458613] - Akira Honda, Kouwa Yamashita, Takashi Hara, Tadashi Ikegami, Teruo Miyazaki, Mutsumi Shirai, Guorong Xu, Mitsuteru Numazawa, Yasushi Matsuzaki. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.
Journal of lipid research.
2009 Feb; 50(2):350-7. doi:
10.1194/jlr.d800040-jlr200. [PMID: 18815436] - Ulf Diczfalusy, Kajsa P Kanebratt, Eva Bredberg, Tommy B Andersson, Ylva Böttiger, Leif Bertilsson. 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.
British journal of clinical pharmacology.
2009 Jan; 67(1):38-43. doi:
10.1111/j.1365-2125.2008.03309.x. [PMID: 19006545] - K P Kanebratt, U Diczfalusy, T Bäckström, E Sparve, E Bredberg, Y Böttiger, T B Andersson, L Bertilsson. Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol.
Clinical pharmacology and therapeutics.
2008 Nov; 84(5):589-94. doi:
10.1038/clpt.2008.132. [PMID: 18650803] - F Josephson, L Bertilsson, Y Böttiger, L Flamholc, M Gisslén, V Ormaasen, A Sönnerborg, U Diczfalusy. CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels.
European journal of clinical pharmacology.
2008 Aug; 64(8):775-81. doi:
10.1007/s00228-008-0492-8. [PMID: 18458892] - Katarina Wide, Hanna Larsson, Leif Bertilsson, Ulf Diczfalusy. Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.
British journal of clinical pharmacology.
2008 May; 65(5):708-15. doi:
10.1111/j.1365-2125.2007.03078.x. [PMID: 18279471] - Ulf Diczfalusy, Jun Miura, Hyung-Keun Roh, Rajaa A Mirghani, Jane Sayi, Hanna Larsson, Karl G Bodin, Annika Allqvist, Mary Jande, Jong-Wook Kim, Eleni Aklillu, Lars L Gustafsson, Leif Bertilsson. 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.
Pharmacogenetics and genomics.
2008 Mar; 18(3):201-8. doi:
10.1097/fpc.0b013e3282f50ee9. [PMID: 18300941] - Mikko Niemi, Kari T Kivistö, Ulf Diczfalusy, Karl Bodin, Leif Bertilsson, Martin F Fromm, Michel Eichelbaum. Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.
Pharmacogenetics and genomics.
2006 Aug; 16(8):565-8. doi:
10.1097/01.fpc.0000215070.52212.0e. [PMID: 16847425] - Ulf Diczfalusy. Analysis of cholesterol oxidation products in biological samples.
Journal of AOAC International.
2004 Mar; 87(2):467-73. doi:
10.1093/jaoac/87.2.467. [PMID: 15164842] - Karl Bodin, Ulla Andersson, Eva Rystedt, Ewa Ellis, Maria Norlin, Irina Pikuleva, Gösta Eggertsen, Ingemar Björkhem, Ulf Diczfalusy. Metabolism of 4 beta -hydroxycholesterol in humans.
The Journal of biological chemistry.
2002 Aug; 277(35):31534-40. doi:
10.1074/jbc.m201712200. [PMID: 12077124] - K Bodin, L Bretillon, Y Aden, L Bertilsson, U Broomé, C Einarsson, U Diczfalusy. Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.
The Journal of biological chemistry.
2001 Oct; 276(42):38685-9. doi:
10.1074/jbc.m105127200. [PMID: 11514559] - O Breuer, S Dzeletovic, E Lund, U Diczfalusy. The oxysterols cholest-5-ene-3 beta,4 alpha-diol, cholest-5-ene-3 beta,4 beta-diol and cholestane-3 beta,5 alpha,6 alpha-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques.
Biochimica et biophysica acta.
1996 Jul; 1302(2):145-52. doi:
10.1016/0005-2760(96)00052-5. [PMID: 8695664] - O Breuer. Identification and quantitation of cholest-5-ene-3 beta,4 beta-diol in rat liver and human plasma.
Journal of lipid research.
1995 Nov; 36(11):2275-81. doi:
10.1016/s0022-2275(20)39708-x. [PMID: 8656065] - O Sova, B Pástorová. Study of cystinaminopeptidase heterogeneity in animal sera by the isoelectric focusing method.
Physiologia Bohemoslovaca.
1976; 25(2):139-45. doi:
NULL. [PMID: 4848]