Hypothiocyanite (BioDeep_00000032779)

   

human metabolite Endogenous


代谢物信息卡片


N,6-didehydro-3,6-dihydro-3-Methyl-adenosine

化学式: CHNOS (74.9778856)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(#N)SO
InChI: InChI=1S/CHNOS/c2-1-4-3/h3H

描述信息

As it is an organic compound, hypothiocyanite occurs naturally in the antimicrobial immune system of the human respiratory tract in a redox reaction catalyzed by the enzyme lactoperoxidase. It has been researched extensively for its capabilities as an alternative antibiotic as it is harmless to human body cells while being cytotoxic to bacteria. Of late, the exact processes for making hypothiocyanite have been patented as such an effective antimicrobial has many commercial applications. Whether or not this antimicrobial compound comprises the entirety of the immune system of the respiratory tract remains to be seen.; Hypothiocyanite is the anion [OSCN]- and the conjugate base of hypothiocyanous acid. It is an organic compound part of the thiocyanates as it contains the functional group SCN. It is formed when an oxygen is singly bonded to the thiocyanate group. Hypothiocyanous acid (HOSCN) is a fairly weak acid as its acid dissociation constant is 5.3 [HMDB]
As it is an organic compound, hypothiocyanite occurs naturally in the antimicrobial immune system of the human respiratory tract in a redox reaction catalyzed by the enzyme lactoperoxidase. It has been researched extensively for its capabilities as an alternative antibiotic as it is harmless to human body cells while being cytotoxic to bacteria. Of late, the exact processes for making hypothiocyanite have been patented as such an effective antimicrobial has many commercial applications. Whether or not this antimicrobial compound comprises the entirety of the immune system of the respiratory tract remains to be seen. Hypothiocyanite is the anion [OSCN]- and the conjugate base of hypothiocyanous acid. It is an organic compound part of the thiocyanates as it contains the functional group SCN. It is formed when an oxygen is singly bonded to the thiocyanate group. Hypothiocyanous acid (HOSCN) is a fairly weak acid as its acid dissociation constant is 5.3.
D000890 - Anti-Infective Agents

同义名列表

11 个代谢物同义名

N,6-didehydro-3,6-dihydro-3-Methyl-adenosine; (Hydroxysulphanyl)formonitrile; (Hydroxysulfanyl)formonitrile; OSCN-hypothiocyanite ion; Cyanosulphoxylic acid; Cyanosulfoxylic acid; Hypothiocyanite ion; Cyanosulphoxylate; Cyanosulfoxylate; Hypocyanous acid; Hypothiocyanite



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

42 个相关的代谢反应过程信息。

Reactome(42)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • L Cegolon. Investigating hypothiocyanite against SARS-CoV-2. International journal of hygiene and environmental health. 2020 06; 227(?):113520. doi: 10.1016/j.ijheh.2020.113520. [PMID: 32305009]
  • Urmi Patel, Aaron Gingerich, Lauren Widman, Demba Sarr, Ralph A Tripp, Balázs Rada. Susceptibility of influenza viruses to hypothiocyanite and hypoiodite produced by lactoperoxidase in a cell-free system. PloS one. 2018; 13(7):e0199167. doi: 10.1371/journal.pone.0199167. [PMID: 30044776]
  • Jana Gau, Martine Prévost, Pierre Van Antwerpen, Menyhárt-Botond Sarosi, Steffen Rodewald, Jürgen Arnhold, Jörg Flemmig. Tannins and Tannin-Related Derivatives Enhance the (Pseudo-)Halogenating Activity of Lactoperoxidase. Journal of natural products. 2017 05; 80(5):1328-1338. doi: 10.1021/acs.jnatprod.6b00915. [PMID: 28368593]
  • Aaron Gingerich, Lan Pang, Jarod Hanson, Daniel Dlugolenski, Rebecca Streich, Eric R Lafontaine, Tamás Nagy, Ralph A Tripp, Balázs Rada. Hypothiocyanite produced by human and rat respiratory epithelial cells inactivates extracellular H1N2 influenza A virus. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2016 Jan; 65(1):71-80. doi: 10.1007/s00011-015-0892-z. [PMID: 26608498]
  • Fahd O Ismael, Tessa J Barrett, Diba Sheipouri, Bronwyn E Brown, Michael J Davies, Clare L Hawkins. Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?. PloS one. 2016; 11(12):e0168844. doi: 10.1371/journal.pone.0168844. [PMID: 27997605]
  • Jörg Flemmig, Dorothea Rusch, Monika Ewa Czerwińska, Hans-Wilhelm Rauwald, Jürgen Arnhold. Components of a standardised olive leaf dry extract (Ph. Eur.) promote hypothiocyanite production by lactoperoxidase. Archives of biochemistry and biophysics. 2014 May; 549(?):17-25. doi: 10.1016/j.abb.2014.03.006. [PMID: 24657078]
  • F Bafort, J P Barthelemy, O Parisi, J P Perraudin, H M Jijakli. Development of a colorimetric method for the dosage of OI- anions and I2 in aqueous media. Communications in agricultural and applied biological sciences. 2014; 79(1):155-60. doi: ". [PMID: 25864331]
  • Anthony J Fischer, Nicholas J Lennemann, Sateesh Krishnamurthy, Péter Pócza, Lakshmi Durairaj, Janice L Launspach, Bethany A Rhein, Christine Wohlford-Lenane, Daniel Lorentzen, Botond Bánfi, Paul B McCray. Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. American journal of respiratory cell and molecular biology. 2011 Oct; 45(4):874-81. doi: 10.1165/rcmb.2010-0329oc. [PMID: 21441383]
  • Daniel Lorentzen, Lakshmi Durairaj, Alejandro A Pezzulo, Yoko Nakano, Janice Launspach, David A Stoltz, Gideon Zamba, Paul B McCray, Joseph Zabner, Michael J Welsh, William M Nauseef, Botond Bánfi. Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions. Free radical biology & medicine. 2011 May; 50(9):1144-50. doi: 10.1016/j.freeradbiomed.2011.02.013. [PMID: 21334431]
  • Bheki A Xulu, Michael T Ashby. Small molecular, macromolecular, and cellular chloramines react with thiocyanate to give the human defense factor hypothiocyanite. Biochemistry. 2010 Mar; 49(9):2068-74. doi: 10.1021/bi902089w. [PMID: 20085320]
  • K Shin, K Yamauchi, S Teraguchi, H Hayasawa, I Imoto. Susceptibility of Helicobacter pylori and its urease activity to the peroxidase-hydrogen peroxide-thiocyanate antimicrobial system. Journal of medical microbiology. 2002 Mar; 51(3):231-237. doi: 10.1099/0022-1317-51-3-231. [PMID: 11871618]
  • J Tenovuo. Antimicrobial function of human saliva--how important is it for oral health?. Acta odontologica Scandinavica. 1998 Oct; 56(5):250-6. doi: 10.1080/000163598428400. [PMID: 9860091]
  • L S Cornejo, S López de Blanc, F Femopase, A Azcurra, S Calamari, L J Battellino, S T Dorronsoro de Cattoni. Evolution of saliva and serum components in patients with oral candidosis topically treated with Ketoconazole and Nystatin. Acta odontologica latinoamericana : AOL. 1998; 11(1):15-25. doi: NULL. [PMID: 11885450]