Cyanosulfurous acid anion (BioDeep_00000032768)

描述信息

The OSCN- ion inhibits bacterial glyceraldehyde 3-P dehydrogenases (11, 24) and. thereby stops the bacterial production of acids from sugars. The inhibition of bacterial acid production by OSCN- has been implicated as playing an important role in the prevention of dental caries. Lactoperoxidase in the presence of thiocyanate detoxifies hydrogen peroxide by converting it into OSCN-, and OSCN- prevents bacteria from excreting hydrogen peroxide by inhibiting glyceraldehyde 3-P dehydrogenase. Because of this inhibition, no NADH is generated in the bacteria, and the hydrogen peroxide-producing NADH oxidases become short of their substrate, NADH. This inhibition of glycolysis usually has a bacteriostatic effect. In recent studies, significant levels of OSCN- have been found in saliva collected directly from the ducts of the salivary glands. This indicates that hydrogen peroxide is actually produced within the salivary glands; thus, lactoperoxidase and thiocyanate may also play an important role in protecting the salivary glands and ducts against hydrogen peroxide toxicity. The products of the lactoperoxidase-thiocyanate-hydrogen peroxide reaction have also been reported to be bactericidal. This effect has been ascribed to OSCN-, but it has also been suggested that higher oxyacids of the thiocyanate ion, cyanosulfurous and cyanosulfuric acids, may be formed in the lactoperoxidase reaction, and these acids may be the effective molecular species in the. killing.
The OSCN- ion inhibits bacterial glyceraldehyde 3-P dehydrogenases (11, 24) and

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