1,2-Dehydrosalsolinol (BioDeep_00000032681)

   

human metabolite Endogenous


代谢物信息卡片


1-Methyl-6,7-dihydroxy-3,4-dihydroisoquinolines

化学式: C10H11NO2 (177.0789746)
中文名称:
谱图信息: 最多检出来源 Bos taurus(endogenous) 75%

分子结构信息

SMILES: CC1=NCCC2=C1C=C(O)C(O)=C2
InChI: InChI=1S/C10H11NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-5,12-13H,2-3H2,1H3

描述信息

1,2-dehydrosalsolinol(1-methyl-6,7-dihydroxy-3,4-dihydroisoquinolines) is formed through the decarboxylation of salsolinol-1-carboxylic acid (1-methyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline-1-carboxylic acid), a novel endogenous catecholic adduct of dopamine and pyruvic acid, examined in nuclei-free homogenates of rat liver, whole brain, and kidney, as well as in buffer only. Liquid chromatographic analysis of incubations for varying times (30 min to 5 h) showed that the tetrahydroisoquinoline substrate decarboxylated oxidatively, forming the DSAL (PMID: 3369867). It is involved in Tyrosine Metabolism.
1,2-dehydrosalsolinol(1-methyl-6,7-dihydroxy-3,4-dihydroisoquinolines) is formed through the decarboxylation of salsolinol-1-carboxylic acid (1-methyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline-1-carboxylic acid), a novel endogenous catecholic adduct of dopamine and pyruvic acid, examined in nuclei-free homogenates of rat liver, whole brain, and kidney, as well as in buffer only. Liquid chromatographic analysis of incubations for varying times (30 min to 5 h) showed that the tetrahydroisoquinoline substrate decarboxylated oxidatively, forming the DSAL (PMID: 3369867)

同义名列表

5 个代谢物同义名

1-Methyl-6,7-dihydroxy-3,4-dihydroisoquinolines; 1-methyl-3,4-dihydroisoquinoline-6,7-diol; 3,4-dihydro-1-Methyl-6,7-isoquinolinediol; 1,2-Dehydrosalsolinol; DSAL



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Er-Lan Yang, Bin Sun, Zi-Yi Huang, Jian-Guang Lin, Bo Jiao, Lan Xiang. Synthesis, Purification, and Selective β2-AR Agonist and Bronchodilatory Effects of Catecholic Tetrahydroisoquinolines from Portulaca oleracea. Journal of natural products. 2019 11; 82(11):2986-2993. doi: 10.1021/acs.jnatprod.9b00418. [PMID: 31625751]
  • Tian-Yun Jin, Shao-Qiang Li, Cui-Rong Jin, Hao Shan, Rui-Min Wang, Ming-Xing Zhou, Ai-Ling Li, Ling-Yu Li, Shui-Yao Hu, Tao Shen, Lan Xiang. Catecholic Isoquinolines from Portulaca oleracea and Their Anti-inflammatory and β2-Adrenergic Receptor Agonist Activity. Journal of natural products. 2018 04; 81(4):768-777. doi: 10.1021/acs.jnatprod.7b00762. [PMID: 29517238]
  • Jamshed Warsi, Abeer Abousaab, Florian Lang. Up-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by ß-Klotho. Neuro-Signals. 2015; 23(1):59-70. doi: 10.1159/000442604. [PMID: 26684854]
  • P R Bieck, K H Antonin, G Farger, E B Nilsson, E K Schmidt, P Dostert, M Strolin Benedetti, P C Waldmeier. Clinical pharmacology of the new COMT inhibitor CGP 28,014. Neurochemical research. 1993 Nov; 18(11):1163-7. doi: 10.1007/bf00978368. [PMID: 8255368]
  • P Dostert, M Strolin Benedetti, F Della Vedova, C Allievi, R La Croix, G Dordain, D Vernay, F Durif. Dopamine-derived tetrahydroisoquinolines and Parkinson's disease. Advances in neurology. 1993; 60(?):218-23. doi: NULL. [PMID: 8420138]
  • P Dostert, M S Benedetti, V Bellotti, C Allievi, G Dordain. Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects. Journal of neural transmission. General section. 1990; 81(3):215-23. doi: 10.1007/bf01245043. [PMID: 2397085]
  • M A Collins, B Y Cheng. Oxidative decarboxylation of salsolinol-1-carboxylic acid to 1,2-dehydrosalsolinol: evidence for exclusive catalysis by particulate factors in rat kidney. Archives of biochemistry and biophysics. 1988 May; 263(1):86-95. doi: 10.1016/0003-9861(88)90616-9. [PMID: 3369867]