bafilomycin A1 (BioDeep_00000300271)

   

natural product Chemicals and Drugs Antibiotics


代谢物信息卡片


NCGC00163426-02_C35H58O9_alpha-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-4-methyl-5-C-(1-methylethyl)-, (5R)-

化学式: C35H58O9 (622.4080618)
中文名称: 巴佛洛霉素A1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
InChI: InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

描述信息

The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D004791 - Enzyme Inhibitors

同义名列表

3 个代谢物同义名

bafilomycin A1; Bafilomycin A1 from Streptomyces griseus, >=90\\% (HPLC); NCGC00163426-02_C35H58O9_alpha-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-4-methyl-5-C-(1-methylethyl)-, (5R)-



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Solomiia Bychkova, Mykola Bychkov, Dani Dordevic, Monika Vítězová, Simon K-M R Rittmann, Ivan Kushkevych. Bafilomycin A1 Molecular Effect on ATPase Activity of Subcellular Fraction of Human Colorectal Cancer and Rat Liver. International journal of molecular sciences. 2024 Jan; 25(3):. doi: 10.3390/ijms25031657. [PMID: 38338935]
  • Hanjun Zhao, Lu Lu, Zheng Peng, Lin-Lei Chen, Xinjin Meng, Chuyuan Zhang, Jonathan Daniel Ip, Wan-Mui Chan, Allen Wing-Ho Chu, Kwok-Hung Chan, Dong-Yan Jin, Honglin Chen, Kwok-Yung Yuen, Kelvin Kai-Wang To. SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells. Emerging microbes & infections. 2022 Dec; 11(1):277-283. doi: 10.1080/22221751.2021.2023329. [PMID: 34951565]
  • Peter T A Linders, Melina Ioannidis, Martin Ter Beest, Geert van den Bogaart. Fluorescence Lifetime Imaging of pH along the Secretory Pathway. ACS chemical biology. 2022 01; 17(1):240-251. doi: 10.1021/acschembio.1c00907. [PMID: 35000377]
  • Martina P Liebl, Sarah C Meister, Lisa Frey, Kristina Hendrich, Anja Klemmer, Bettina Wohlfart, Christopher Untucht, Judith Nuber, Christian Pohl, Viktor Lakics. Robust LC3B lipidation analysis by precisely adjusting autophagic flux. Scientific reports. 2022 01; 12(1):79. doi: 10.1038/s41598-021-03875-8. [PMID: 34996966]
  • Nemanja Vujić, Ivan Bradić, Madeleine Goeritzer, Katharina B Kuentzel, Silvia Rainer, Dagmar Kratky, Branislav Radović. ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages. Autophagy. 2021 11; 17(11):3402-3407. doi: 10.1080/15548627.2021.1874132. [PMID: 33459130]
  • Anqi Kong, Yao Zhang, Bo Ning, Kongdong Li, Zhen Ren, Shuya Dai, Dongfeng Chen, Yang Zhou, Jie Gu, Haifeng Shi. Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis. Chemico-biological interactions. 2021 Oct; 348(?):109649. doi: 10.1016/j.cbi.2021.109649. [PMID: 34516972]
  • Mohammed Samer Shaban, Christin Müller, Christin Mayr-Buro, Hendrik Weiser, Johanna Meier-Soelch, Benadict Vincent Albert, Axel Weber, Uwe Linne, Torsten Hain, Ilya Babayev, Nadja Karl, Nina Hofmann, Stephan Becker, Susanne Herold, M Lienhard Schmitz, John Ziebuhr, Michael Kracht. Multi-level inhibition of coronavirus replication by chemical ER stress. Nature communications. 2021 09; 12(1):5536. doi: 10.1038/s41467-021-25551-1. [PMID: 34545074]
  • Jiarui Zhao, Bo Hu, Han Xiao, Qiong Yang, Qi Cao, Xia Li, Qian Zhang, Aiguo Ji, Shuliang Song. Fucoidan reduces lipid accumulation by promoting foam cell autophagy via TFEB. Carbohydrate polymers. 2021 Sep; 268(?):118247. doi: 10.1016/j.carbpol.2021.118247. [PMID: 34127226]
  • Satoshi Miyagaki, Ken Kikuchi, Jun Mori, Gary D Lopaschuk, Tomoko Iehara, Hajime Hosoi. Inhibition of lipid metabolism exerts antitumor effects on rhabdomyosarcoma. Cancer medicine. 2021 09; 10(18):6442-6455. doi: 10.1002/cam4.4185. [PMID: 34472721]
  • Chaitra Prabhakara, Rashmi Godbole, Parijat Sil, Sowmya Jahnavi, Shah-E-Jahan Gulzar, Thomas S van Zanten, Dhruv Sheth, Neeraja Subhash, Anchal Chandra, Akshatha Shivaraj, Patricia Panikulam, Ibrahim U, Vijay Kumar Nuthakki, Theja Parassini Puthiyapurayil, Riyaz Ahmed, Ashaq Hussain Najar, Sai Manoz Lingamallu, Snigdhadev Das, Bhagyashri Mahajan, Praveen Vemula, Sandip B Bharate, Parvinder Pal Singh, Ram Vishwakarma, Arjun Guha, Varadharajan Sundaramurthy, Satyajit Mayor. Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors. PLoS pathogens. 2021 07; 17(7):e1009706. doi: 10.1371/journal.ppat.1009706. [PMID: 34252168]
  • Chao Shang, Xinyu Zhuang, He Zhang, Yiquan Li, Yilong Zhu, Jing Lu, Chenchen Ge, Jianan Cong, Tingyu Li, Mingyao Tian, Ningyi Jin, Xiao Li. Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice. Virology journal. 2021 02; 18(1):46. doi: 10.1186/s12985-021-01515-1. [PMID: 33639976]
  • Katharina Bublitz, Sabine Böckmann, Kirsten Peters, Burkhard Hinz. Cannabinoid-Induced Autophagy and Heme Oxygenase-1 Determine the Fate of Adipose Tissue-Derived Mesenchymal Stem Cells under Stressful Conditions. Cells. 2020 10; 9(10):. doi: 10.3390/cells9102298. [PMID: 33076330]
  • Shan Chen, Xiuyan Feng, Xinxin Chen, Zhizhi Zhuang, Jia Xiao, Haian Fu, Janet D Klein, Xiaonan H Wang, Robert S Hoover, Douglas C Eaton, Hui Cai. 14-3-3γ, a novel regulator of the large-conductance Ca2+-activated K+ channel. American journal of physiology. Renal physiology. 2020 07; 319(1):F52-F62. doi: 10.1152/ajprenal.00584.2019. [PMID: 32463725]
  • Chen Yang, Hong-Luan Wu, Zhi-Hang Li, Xiao-Cui Chen, Hong-Yong Su, Xiao-Yan Guo, Ning An, Kai-Peng Jing, Qing-Jun Pan, Hua-Feng Liu. Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β). Medical science monitor : international medical journal of experimental and clinical research. 2020 Jun; 26(?):e922673. doi: 10.12659/msm.922673. [PMID: 32555132]
  • Yu Zhang, Xiao Ding, Yu-Xi Yuan, Ling-Li Guo, Xiao-Jiang Hao. Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification. Journal of natural products. 2020 05; 83(5):1432-1439. doi: 10.1021/acs.jnatprod.9b00856. [PMID: 32356659]
  • David S Enyart, Chelsea L Crocker, Jennifer R Stansell, Madeleine Cutrone, Meghann M Dintino, Stephen T Kinsey, Stephan L Brown, Bradley L Baumgarner. Low-dose caffeine administration increases fatty acid utilization and mitochondrial turnover in C2C12 skeletal myotubes. Physiological reports. 2020 01; 8(1):e14340. doi: 10.14814/phy2.14340. [PMID: 31960608]
  • Stina Leskelä, Nadine Huber, Hannah Rostalski, Teemu Natunen, Anne M Remes, Mari Takalo, Mikko Hiltunen, Annakaisa Haapasalo. C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner. Cells. 2019 10; 8(10):. doi: 10.3390/cells8101233. [PMID: 31658762]
  • Tian Tang, Wenhui Xu, Ji Ma, Huajing Wang, Zhao Cui, Tingliang Jiang, Canghai Li. Inhibitory Mechanisms of DHA/CQ on pH and Iron Homeostasis of Erythrocytic Stage Growth of Plasmodium Falciparum. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101941. [PMID: 31137574]
  • Katarzyna Owczarek, Yuliya Chykunova, Christian Jassoy, Beata Maksym, Zenon Rajfur, Krzysztof Pyrc. Zika virus: mapping and reprogramming the entry. Cell communication and signaling : CCS. 2019 05; 17(1):41. doi: 10.1186/s12964-019-0349-z. [PMID: 31053158]
  • Tatsuru Hayashi, Hiroshi Tsuchikawa, Yuichi Umegawa, Michio Murata. Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycin A1 and its desmethyl derivative bearing 19F-labeling. Bioorganic & medicinal chemistry. 2019 04; 27(8):1677-1682. doi: 10.1016/j.bmc.2019.03.017. [PMID: 30878192]
  • Naomi Matsumoto, Mayumi Nakanishi-Matsui. Proton pumping V-ATPase inhibitor bafilomycin A1 affects Rab7 lysosomal localization and abolishes anterograde trafficking of osteoclast secretory lysosomes. Biochemical and biophysical research communications. 2019 03; 510(3):421-426. doi: 10.1016/j.bbrc.2019.01.118. [PMID: 30717974]
  • Qirong Wen, Jiao Liu, Rui Kang, Borong Zhou, Daolin Tang. The release and activity of HMGB1 in ferroptosis. Biochemical and biophysical research communications. 2019 03; 510(2):278-283. doi: 10.1016/j.bbrc.2019.01.090. [PMID: 30686534]
  • Shilpi Sharma, Mary K Lewinski, John Guatelli. An N-Glycosylated Form of SERINC5 Is Specifically Incorporated into HIV-1 Virions. Journal of virology. 2018 11; 92(22):. doi: 10.1128/jvi.00753-18. [PMID: 30158294]
  • Shuhui Wang Lorkowski, Gregory Brubaker, Kailash Gulshan, Jonathan D Smith. V-ATPase (Vacuolar ATPase) Activity Required for ABCA1 (ATP-Binding Cassette Protein A1)-Mediated Cholesterol Efflux. Arteriosclerosis, thrombosis, and vascular biology. 2018 11; 38(11):2615-2625. doi: 10.1161/atvbaha.118.311814. [PMID: 30354238]
  • Ognian C Ikonomov, George Altankov, Diego Sbrissa, Assia Shisheva. PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation. Toxicology and applied pharmacology. 2018 10; 356(?):151-158. doi: 10.1016/j.taap.2018.08.001. [PMID: 30098992]
  • Gavin C Higgins, Tuong-Vi Nguyen, Georg Ramm, Melinda T Coughlan. Methods in renal research: Measurement of autophagic flux in the renal cortex ex vivo. Nephrology (Carlton, Vic.). 2018 Sep; 23(9):815-820. doi: 10.1111/nep.13251. [PMID: 29504645]
  • Minghua Liu, Ge Zhao, Dan Zhang, Weixiao An, Honglin Lai, Xiaofang Li, Shousong Cao, Xiukun Lin. Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells. International journal of oncology. 2018 Sep; 53(3):1363-1373. doi: 10.3892/ijo.2018.4465. [PMID: 30015913]
  • Tomohisa Ito, Takashi Ando, Miki Suzuki-Karasaki, Tomohiko Tokunaga, Yukihiro Yoshida, Toyoko Ochiai, Yasuaki Tokuhashi, Yoshihiro Suzuki-Karasaki. Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL. International journal of oncology. 2018 Aug; 53(2):503-514. doi: 10.3892/ijo.2018.4413. [PMID: 29845256]
  • Xianglong Zhao, Wangjie Xu, Jiajie Wu, Dong Zhang, Abdelrahman Abou-Shakra, Ling Di, Zhaoxia Wang, Lianyun Wang, Fan Yang, Zhongdong Qiao. Nicotine induced autophagy of Leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone. The international journal of biochemistry & cell biology. 2018 07; 100(?):30-41. doi: 10.1016/j.biocel.2018.05.001. [PMID: 29753783]
  • Jing Shi, Ran Xiong, Tao Zhou, Peiyi Su, Xihe Zhang, Xusheng Qiu, Hongmei Li, Sunan Li, Changqing Yu, Bin Wang, Chan Ding, Thomas E Smithgall, Yong-Hui Zheng. HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System. Journal of virology. 2018 06; 92(11):. doi: 10.1128/jvi.00196-18. [PMID: 29514909]
  • Stéphane Demine, Silvia Tejerina, Benoît Bihin, Marc Thiry, Nagabushana Reddy, Patricia Renard, Martine Raes, Michel Jadot, Thierry Arnould. Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytes. Journal of cellular physiology. 2018 Feb; 233(2):1247-1265. doi: 10.1002/jcp.25994. [PMID: 28488768]
  • Mario Mauthe, Idil Orhon, Cecilia Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, Robert P Coppes, Nikolai Engedal, Muriel Mari, Fulvio Reggiori. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018; 14(8):1435-1455. doi: 10.1080/15548627.2018.1474314. [PMID: 29940786]
  • David Y W Ng, Roman Vill, Yuzhou Wu, Kaloian Koynov, Yu Tokura, Weina Liu, Susanne Sihler, Andreas Kreyes, Sandra Ritz, Holger Barth, Ulrich Ziener, Tanja Weil. Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues. Nature communications. 2017 11; 8(1):1850. doi: 10.1038/s41467-017-02020-2. [PMID: 29185444]
  • Jibiao Li, Cheng Chen, Yuan Li, David J Matye, Yifeng Wang, Wen-Xing Ding, Tiangang Li. Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes. Biochimica et biophysica acta. Molecular basis of disease. 2017 11; 1863(11):2924-2933. doi: 10.1016/j.bbadis.2017.08.012. [PMID: 28844948]
  • Brock P Herdman, James C Paton, Hui Wang, Travis Beddoe, Adrienne W Paton. Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi. Infection and immunity. 2017 08; 85(8):. doi: 10.1128/iai.00214-17. [PMID: 28533468]
  • Zerihun T Dame, Pornthip Ruanpanun. Production of macrolide antibiotics from a cytotoxic soil Streptomyces sp. strain ZDB. World journal of microbiology & biotechnology. 2017 Jul; 33(7):139. doi: 10.1007/s11274-017-2306-6. [PMID: 28585168]
  • Mengyao Yu, Xiaoyan Xu, Nan Jiang, Wei Wei, Fang Li, Liming He, Xia Luo. Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells. Journal of ethnopharmacology. 2017 Feb; 198(?):167-173. doi: 10.1016/j.jep.2017.01.007. [PMID: 28077330]
  • V Hreniukh, S Bychkova, O Kulachkovsky, A Babsky. Effect of bafilomycin and NAADP on membrane-associated ATPases and respiration of isolated mitochondria of the murine Nemeth-Kellner lymphoma. Cell biochemistry and function. 2016 Dec; 34(8):579-587. doi: 10.1002/cbf.3231. [PMID: 27862060]
  • Cátia S Pereira, Joana P Guedes, Marília Gonçalves, Luís Loureiro, Lisandra Castro, Hernâni Gerós, Lígia R Rodrigues, Manuela Côrte-Real. Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase. Oncotarget. 2016 09; 7(38):62144-62158. doi: 10.18632/oncotarget.11394. [PMID: 27556694]
  • Lauren M Compton, Ognian C Ikonomov, Diego Sbrissa, Puneet Garg, Assia Shisheva. Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency. American journal of physiology. Cell physiology. 2016 09; 311(3):C366-77. doi: 10.1152/ajpcell.00104.2016. [PMID: 27335171]
  • Longhua Liu, Louise D Zheng, Peng Zou, Joseph Brooke, Cayleen Smith, Yun Chau Long, Fabio A Almeida, Dongmin Liu, Zhiyong Cheng. FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes. Cell cycle (Georgetown, Tex.). 2016 Aug; 15(15):2033-41. doi: 10.1080/15384101.2016.1192732. [PMID: 27260854]
  • Qiulun Lu, Yufeng Yao, Zhenkun Hu, Changqing Hu, Qixue Song, Jian Ye, Chengqi Xu, Annabel Z Wang, Qiuyun Chen, Qing Kenneth Wang. Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease. PLoS biology. 2016 08; 14(8):e1002529. doi: 10.1371/journal.pbio.1002529. [PMID: 27513923]
  • Hyo Jin Park, Tae Hee Kim, So Won Kim, Shin Hye Noh, Kyeong Jee Cho, Choe Choi, Eun Young Kwon, Yang Ji Choi, Heon Yung Gee, Ji Ha Choi. Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3. Scientific reports. 2016 06; 6(?):26872. doi: 10.1038/srep26872. [PMID: 27256251]
  • Shanhu Qian, Lan Sun, Jiaqi Li, Junqing Wu, Gang Hu, Yixiang Han, Kang Yu, Shenghui Zhang. MAP30 inhibits autophagy through enhancing acetyltransferase p300 and induces apoptosis in acute myeloid leukemia cells. Oncology reports. 2016 Jun; 35(6):3705-13. doi: 10.3892/or.2016.4705. [PMID: 27035419]
  • Suvadip Mallick, Aritri Dutta, Ankur Chaudhuri, Debasri Mukherjee, Somaditya Dey, Subhadra Halder, Joydip Ghosh, Debarati Mukherjee, Sirin Salma Sultana, Gunjan Biswas, Tapan Kumar Lai, Pradyumna Patra, Indranil Sarkar, Sibani Chakraborty, Bhaskar Saha, Krishnendu Acharya, Chiranjib Pal. Successful Therapy of Murine Visceral Leishmaniasis with Astrakurkurone, a Triterpene Isolated from the Mushroom Astraeus hygrometricus, Involves the Induction of Protective Cell-Mediated Immunity and TLR9. Antimicrobial agents and chemotherapy. 2016 05; 60(5):2696-708. doi: 10.1128/aac.01943-15. [PMID: 26883702]
  • Nan Ding, Yi Jiang, Li Han, Xiu Chen, Jian Ma, Xiaodan Qu, Yu Mu, Jiang Liu, Liya Li, Chenglin Jiang, Xueshi Huang. Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces. Journal of natural products. 2016 Apr; 79(4):799-805. doi: 10.1021/acs.jnatprod.5b00827. [PMID: 26933756]
  • Khondoker Alam, Sonia Pahwa, Xueying Wang, Pengyue Zhang, Kai Ding, Alaa H Abuznait, Lang Li, Wei Yue. Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Molecular pharmaceutics. 2016 Mar; 13(3):839-51. doi: 10.1021/acs.molpharmaceut.5b00763. [PMID: 26750564]
  • Yong-Liang Han, Hai-Xing Song, Qiong Liao, Yin Yu, Shao-Fen Jian, Joe Eugene Lepo, Qiang Liu, Xiang-Min Rong, Chang Tian, Jing Zeng, Chun-Yun Guan, Abdelbagi M Ismail, Zhen-Hua Zhang. Nitrogen Use Efficiency Is Mediated by Vacuolar Nitrate Sequestration Capacity in Roots of Brassica napus. Plant physiology. 2016 Mar; 170(3):1684-98. doi: 10.1104/pp.15.01377. [PMID: 26757990]
  • Herman Burger, Alexander T den Dekker, Sandra Segeletz, Antonius W M Boersma, Peter de Bruijn, Maria Debiec-Rychter, Takahiro Taguchi, Stefan Sleijfer, Alex Sparreboom, Ron H J Mathijssen, Erik A C Wiemer. Lysosomal Sequestration Determines Intracellular Imatinib Levels. Molecular pharmacology. 2015 Sep; 88(3):477-87. doi: 10.1124/mol.114.097451. [PMID: 26108972]
  • Yong Zhang, Ming-liang Chen, Yong Zhou, Long Yi, Yan-xiang Gao, Li Ran, Shi-hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun-dong Zhu, Qian-yong Zhang, Man-tian Mi. Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway. Molecular nutrition & food research. 2015 Aug; 59(8):1443-57. doi: 10.1002/mnfr.201500016. [PMID: 25943029]
  • Eugene Chang, Lisa Kim, Se Eun Park, Eun-Jung Rhee, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Cheol-Young Park. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World journal of gastroenterology. 2015 Jul; 21(25):7754-63. doi: 10.3748/wjg.v21.i25.7754. [PMID: 26167075]
  • Qilong Gao, Huaimin Liu, Yamin Yao, Liang Geng, Xinfeng Zhang, Lifeng Jiang, Bian Shi, Feng Yang. Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. Journal of applied toxicology : JAT. 2015 May; 35(5):485-92. doi: 10.1002/jat.3049. [PMID: 25178877]
  • Mingfeng Ma, Xiaofan Guo, Ye Chang, Chao Li, Xin Meng, Si Li, Zhen-Xian Du, Hua-Qin Wang, Yingxian Sun. Advanced glycation end products promote proliferation and suppress autophagy via reduction of Cathepsin D in rat vascular smooth muscle cells. Molecular and cellular biochemistry. 2015 May; 403(1-2):73-83. doi: 10.1007/s11010-015-2338-x. [PMID: 25673507]
  • Hajime Shibata, Hiroshi Tsuchikawa, Tatsuru Hayashi, Nobuaki Matsumori, Michio Murata, Takeo Usui. Modification of bafilomycin structure to efficiently synthesize solid-state NMR probes that selectively bind to vacuolar-type ATPase. Chemistry, an Asian journal. 2015 Apr; 10(4):915-24. doi: 10.1002/asia.201403299. [PMID: 25605557]
  • Jin Sook Yoon, Hyun Jung Lee, Min Kyung Chae, Eun Jig Lee. Autophagy is involved in the initiation and progression of Graves' orbitopathy. Thyroid : official journal of the American Thyroid Association. 2015 Apr; 25(4):445-54. doi: 10.1089/thy.2014.0300. [PMID: 25687157]
  • Swati Jain, Daniel Keys, Trevor Nydam, Robert J Plenter, Charles L Edelstein, Alkesh Jani. Inhibition of autophagy increases apoptosis during re-warming after cold storage in renal tubular epithelial cells. Transplant international : official journal of the European Society for Organ Transplantation. 2015 Feb; 28(2):214-23. doi: 10.1111/tri.12465. [PMID: 25270002]
  • Behzad Yeganeh, Saeid Ghavami, Andrea L Kroeker, Thomas H Mahood, Gerald L Stelmack, Thomas Klonisch, Kevin M Coombs, Andrew J Halayko. Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1. American journal of physiology. Lung cellular and molecular physiology. 2015 Feb; 308(3):L270-86. doi: 10.1152/ajplung.00011.2014. [PMID: 25361566]
  • Suleman Hussain, Svend Davanger. Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits. PloS one. 2015; 10(10):e0140868. doi: 10.1371/journal.pone.0140868. [PMID: 26488171]
  • Ioana Alesutan, Katharina Musculus, Tatsiana Castor, Kousi Alzoubi, Jakob Voelkl, Florian Lang. Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine. Kidney & blood pressure research. 2015; 40(5):490-9. doi: 10.1159/000368524. [PMID: 26418500]
  • Zhongyu Liu, Jun Liu, Li Li, Dan Nie, Qilei Tao, Jian Wu, Jiajun Fan, Chen Lin, Shuwei Zhao, Dianwen Ju. Inhibition of Autophagy Potentiated the Antitumor Effect of Nedaplatin in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells. PloS one. 2015; 10(8):e0135236. doi: 10.1371/journal.pone.0135236. [PMID: 26288183]
  • Yue Cai, Yuhong Wang, Jia Xu, Xu Zuo, Yanfang Xu. Down-regulation of ether-a-go-go-related gene potassium channel protein through sustained stimulation of AT1 receptor by angiotensin II. Biochemical and biophysical research communications. 2014 Sep; 452(3):852-7. doi: 10.1016/j.bbrc.2014.09.014. [PMID: 25218469]
  • Mei-Ya Fu, Ya-Jun He, Xia Lv, Zhi-He Liu, Yan Shen, Guo-Rong Ye, Yan-Mei Deng, Jian-Chang Shu. Transforming growth factor‑β1 reduces apoptosis via autophagy activation in hepatic stellate cells. Molecular medicine reports. 2014 Sep; 10(3):1282-8. doi: 10.3892/mmr.2014.2383. [PMID: 25059289]
  • Bo Wang, Qing Yang, Yuan-yuan Sun, Yi-fan Xing, Ying-bin Wang, Xiao-ting Lu, Wen-wu Bai, Xiao-qiong Liu, Yu-xia Zhao. Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice. Journal of cellular and molecular medicine. 2014 Aug; 18(8):1599-611. doi: 10.1111/jcmm.12312. [PMID: 24889822]
  • Masahiro Nagahama, Chihiro Takahashi, Kouhei Aoyanagi, Ryo Tashiro, Keiko Kobayashi, Yoshihiko Sakaguchi, Kazumi Ishidoh, Jun Sakurai. Intracellular trafficking of Clostridium botulinum C2 toxin. Toxicon : official journal of the International Society on Toxinology. 2014 May; 82(?):76-82. doi: 10.1016/j.toxicon.2014.02.009. [PMID: 24582943]
  • Ying-Jey Guh, Yung-Che Tseng, Chao-Yew Yang, Pung-Pung Hwang. Endothelin-1 regulates H⁺-ATPase-dependent transepithelial H⁺ secretion in zebrafish. Endocrinology. 2014 May; 155(5):1728-37. doi: 10.1210/en.2013-1775. [PMID: 24424055]
  • Julia E Rasmussen, John T Sheridan, William Polk, Catrin M Davies, Robert Tarran. Cigarette smoke-induced Ca2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. The Journal of biological chemistry. 2014 Mar; 289(11):7671-81. doi: 10.1074/jbc.m113.545137. [PMID: 24448802]
  • Beatrix Pfanzagl, Daniel Andergassen, Johanna Edlmayr, Katarzyna Niespodziana, Rudolf Valenta, Dieter Blaas. Entry of human rhinovirus 89 via ICAM-1 into HeLa epithelial cells is inhibited by actin skeleton disruption and by bafilomycin. Archives of virology. 2014 Jan; 159(1):125-40. doi: 10.1007/s00705-013-1797-1. [PMID: 23913188]
  • Takahide Matsui, Mitsunori Fukuda. Methods of analysis of the membrane trafficking pathway from recycling endosomes to lysosomes. Methods in enzymology. 2014; 534(?):195-206. doi: 10.1016/b978-0-12-397926-1.00011-1. [PMID: 24359955]
  • Cheng-Yun Jin, Hai Yang Yu, Cheol Park, Min Ho Han, Su Hyun Hong, Kyoung-Sook Kim, Young-Choon Lee, Young-Chae Chang, Jaehun Cheong, Sung-Kwon Moon, Gi-Young Kim, Hyung-In Moon, Wun-Jae Kim, Jai-Heon Lee, Yung Hyun Choi. Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells. International journal of oncology. 2013 Dec; 43(6):1943-50. doi: 10.3892/ijo.2013.2143. [PMID: 24141596]
  • Zhongchao Gai, Xiaojuan Zhang, Mayira Islam, Xia Wang, Aiying Li, Yongbo Yang, Yi Li, Jianxin Peng, Huazhu Hong, Kaiyu Liu. Characterization of Atg8 in lepidopteran insect cells. Archives of insect biochemistry and physiology. 2013 Oct; 84(2):57-77. doi: 10.1002/arch.21114. [PMID: 23959953]
  • Patience Musiwaro, Matthew Smith, Maria Manifava, Simon A Walker, Nicholas T Ktistakis. Characteristics and requirements of basal autophagy in HEK 293 cells. Autophagy. 2013 Sep; 9(9):1407-17. doi: 10.4161/auto.25455. [PMID: 23800949]
  • Sofia Avnet, Gemma Di Pompo, Silvia Lemma, Manuela Salerno, Francesca Perut, Gloria Bonuccelli, Donatella Granchi, Nicoletta Zini, Nicola Baldini. V-ATPase is a candidate therapeutic target for Ewing sarcoma. Biochimica et biophysica acta. 2013 Aug; 1832(8):1105-16. doi: 10.1016/j.bbadis.2013.04.003. [PMID: 23579072]
  • Xifeng Lu, Ingrid M Garrelds, Carsten A Wagner, A H Jan Danser, Marcel E Meima. (Pro)renin receptor is required for prorenin-dependent and -independent regulation of vacuolar H⁺-ATPase activity in MDCK.C11 collecting duct cells. American journal of physiology. Renal physiology. 2013 Aug; 305(3):F417-25. doi: 10.1152/ajprenal.00037.2013. [PMID: 23698123]
  • Caroline Roy, Valérie Gagné, Maria J G Fernandes, François Marceau. High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs. Toxicology and applied pharmacology. 2013 Jul; 270(2):77-86. doi: 10.1016/j.taap.2013.04.004. [PMID: 23603060]
  • T Russo-Abrahão, M Alves-Bezerra, D Majerowicz, A L Freitas-Mesquita, C F Dick, K C Gondim, J R Meyer-Fernandes. Transport of inorganic phosphate in Leishmania infantum and compensatory regulation at low inorganic phosphate concentration. Biochimica et biophysica acta. 2013 Mar; 1830(3):2683-9. doi: . [PMID: 23671929]
  • Rosanne Varkevisser, Marien J C Houtman, Maaike Waasdorp, Joyce C K Man, Raimond Heukers, Hiroki Takanari, Ralph G Tieland, Paul M P van Bergen En Henegouwen, Marc A Vos, Marcel A G van der Heyden. Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine. Pflugers Archiv : European journal of physiology. 2013 Feb; 465(2):247-59. doi: 10.1007/s00424-012-1189-5. [PMID: 23192368]
  • Hannah V McCue, Joanna D Wardyn, Robert D Burgoyne, Lee P Haynes. Generation and characterization of a lysosomally targeted, genetically encoded Ca(2+)-sensor. The Biochemical journal. 2013 Jan; 449(2):449-57. doi: 10.1042/bj20120898. [PMID: 23098255]
  • Deepali N Tukaye, Sang-Ho Kwon, Wiliam B Guggino. The GAP portion of Pseudomonas aeruginosa type III secreted toxin ExoS upregulates total and surface levels of wild type CFTR. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2013; 31(1):153-65. doi: 10.1159/000343357. [PMID: 23428533]
  • Patrycja Kozik, Nicola A Hodson, Daniela A Sahlender, Nikol Simecek, Christina Soromani, Jiahua Wu, Lucy M Collinson, Margaret S Robinson. A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase. Nature cell biology. 2013 Jan; 15(1):50-60. doi: 10.1038/ncb2652. [PMID: 23263279]
  • Zain Bengali, P S Satheshkumar, Bernard Moss. Orthopoxvirus species and strain differences in cell entry. Virology. 2012 Nov; 433(2):506-12. doi: 10.1016/j.virol.2012.08.044. [PMID: 22999097]
  • Shu-Er Chow, Yu-Wen Chen, Chi-Ang Liang, Yao-Kuan Huang, Jong-Shyan Wang. Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. Journal of cellular biochemistry. 2012 Nov; 113(11):3476-85. doi: 10.1002/jcb.24224. [PMID: 22689083]
  • Masahiro Nagahama, Mariko Umezaki, Ryo Tashiro, Masataka Oda, Keiko Kobayashi, Masahiro Shibutani, Teruhisa Takagishi, Kazumi Ishidoh, Mitsunori Fukuda, Jun Sakurai. Intracellular trafficking of Clostridium perfringens iota-toxin b. Infection and immunity. 2012 Oct; 80(10):3410-6. doi: 10.1128/iai.00483-12. [PMID: 22825447]
  • Aster Legesse-Miller, Irene Raitman, Erin M Haley, Albert Liao, Lova L Sun, David J Wang, Nithya Krishnan, Johanna M S Lemons, Eric J Suh, Elizabeth L Johnson, Benjamin A Lund, Hilary A Coller. Quiescent fibroblasts are protected from proteasome inhibition-mediated toxicity. Molecular biology of the cell. 2012 Sep; 23(18):3566-81. doi: 10.1091/mbc.e12-03-0192. [PMID: 22875985]
  • Bernard Gay, Eric Bernard, Maxime Solignat, Nathalie Chazal, Christian Devaux, Laurence Briant. pH-dependent entry of chikungunya virus into Aedes albopictus cells. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2012 Aug; 12(6):1275-81. doi: 10.1016/j.meegid.2012.02.003. [PMID: 22386853]
  • C F Dick, A L A Dos-Santos, D Majerowicz, K C Gondim, C Caruso-Neves, I V Silva, A Vieyra, J R Meyer-Fernandes. Na+-dependent and Na+-independent mechanisms for inorganic phosphate uptake in Trypanosoma rangeli. Biochimica et biophysica acta. 2012 Jul; 1820(7):1001-8. doi: 10.1016/j.bbagen.2012.02.019. [PMID: 22456227]
  • Wen Liu, Núria M Pastor-Soler, Carlos Schreck, Beth Zavilowitz, Thomas R Kleyman, Lisa M Satlin. Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). American journal of physiology. Renal physiology. 2012 Jan; 302(1):F205-15. doi: 10.1152/ajprenal.00179.2011. [PMID: 21957178]
  • Lien F R Thoen, Eduardo L M Guimarães, Laurent Dollé, Inge Mannaerts, Mustapha Najimi, Etienne Sokal, Leo A van Grunsven. A role for autophagy during hepatic stellate cell activation. Journal of hepatology. 2011 Dec; 55(6):1353-60. doi: 10.1016/j.jhep.2011.07.010. [PMID: 21803012]
  • Henriette Kauntz, Souad Bousserouel, Francine Gossé, Francis Raul. Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. Apoptosis : an international journal on programmed cell death. 2011 Oct; 16(10):1042-53. doi: 10.1007/s10495-011-0631-z. [PMID: 21779837]
  • José R Pérez-Castiñeira, Agustín Hernández, Rocío Drake, Aurelio Serrano. A plant proton-pumping inorganic pyrophosphatase functionally complements the vacuolar ATPase transport activity and confers bafilomycin resistance in yeast. The Biochemical journal. 2011 Jul; 437(2):269-78. doi: 10.1042/bj20110447. [PMID: 21612578]
  • Yi Chang, Yu-Wan Lin, Su-Jane Wang. Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A. Naunyn-Schmiedeberg's archives of pharmacology. 2011 Jul; 384(1):59-70. doi: 10.1007/s00210-011-0630-1. [PMID: 21541760]
  • Hanene Zbidi, Isaac Jardin, Geoffrey E Woodard, Jose J Lopez, Alejandro Berna-Erro, Ginés M Salido, Juan A Rosado. STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets. The Journal of biological chemistry. 2011 Apr; 286(14):12257-70. doi: 10.1074/jbc.m110.190694. [PMID: 21321120]
  • Shahnaz Shahidi-Noghabi, Els J M Van Damme, Winnok H De Vos, Guy Smagghe. Internalization of Sambucus nigra agglutinins I and II in insect midgut CF-203 cells. Archives of insect biochemistry and physiology. 2011 Apr; 76(4):211-22. doi: 10.1002/arch.20405. [PMID: 21254203]
  • Yoko Hirata, Norihiro Shimokawa, Kentaro Oh-hashi, Zu-Xi Yu, Kazutoshi Kiuchi. Acidification of the Golgi apparatus is indispensable for maturation but not for cell surface delivery of Ret. Journal of neurochemistry. 2010 Nov; 115(3):606-13. doi: 10.1111/j.1471-4159.2010.06966.x. [PMID: 20796177]
  • Xiaobing Wang, Quanhong Liu, Zhezhi Wang, Pan Wang, Ping Zhao, Xianghong Zhao, Liang Yang, Yixiang Li. Role of autophagy in sonodynamic therapy-induced cytotoxicity in S180 cells. Ultrasound in medicine & biology. 2010 Nov; 36(11):1933-46. doi: 10.1016/j.ultrasmedbio.2010.06.022. [PMID: 20888686]
  • Ann L Wozniak, Stephen Griffin, David Rowlands, Mark Harris, MinKyung Yi, Stanley M Lemon, Steven A Weinman. Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production. PLoS pathogens. 2010 Sep; 6(9):e1001087. doi: 10.1371/journal.ppat.1001087. [PMID: 20824094]
  • M Siebelmann, J Wensing, E J Verspohl. The impact of ANG II and IV on INS-1 cells and on blood glucose and plasma insulin. Journal of receptor and signal transduction research. 2010 Aug; 30(4):234-45. doi: 10.3109/10799893.2010.487491. [PMID: 20524779]
  • Petr Obrdlik, Kerstin Diekert, Natalie Watzke, Christine Keipert, Ulrich Pehl, Catrin Brosch, Nicole Boehm, Inga Bick, Maarten Ruitenberg, Walter Volknandt, Bela Kelety. Electrophysiological characterization of ATPases in native synaptic vesicles and synaptic plasma membranes. The Biochemical journal. 2010 Mar; 427(1):151-9. doi: 10.1042/bj20091380. [PMID: 20100168]
  • Narendranath Reddy Chintagari, Amarjit Mishra, Lijing Su, Yang Wang, Sahlu Ayalew, Steven D Hartson, Lin Liu. Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. PloS one. 2010 Feb; 5(2):e9228. doi: 10.1371/journal.pone.0009228. [PMID: 20169059]
  • Yaodong Zhao, Qiang Huang, Jicheng Yang, Meiqing Lou, Aidong Wang, Jun Dong, Zhenghong Qin, Tianyi Zhang. Autophagy impairment inhibits differentiation of glioma stem/progenitor cells. Brain research. 2010 Feb; 1313(?):250-8. doi: 10.1016/j.brainres.2009.12.004. [PMID: 20004652]