4-Trimethylammoniobutanoate (BioDeep_00000002995)
BioNovoGene_Lab2019
代谢物信息卡片
4-Trimethylammoniobutanoate
化学式: C7H16NO2+ (146.1181)
中文名称: 海葵碱, (3-羧丙基)三甲基氯化铵
谱图信息:
最多检出来源 Homo sapiens(lipidsearch) 7.8%
分子结构信息
SMILES: C[N+](C)(C)CCCC(=O)O
InChI: InChI=1S/C7H15NO2/c1-8(2,3)6-4-5-7(9)10/h4-6H2,1-3H3/p+1
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:1941
- KEGG: C01181
- PubChem: 134
- CAS: 10329-41-6
- PubChem: 4408
- PDB-CCD: NM2
- 3DMET: B00256
- NIKKAJI: J38.536K
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-194
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
7 个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH(3)
- Lysine degradation ( Lysine degradation ):
2-Oxo-glutaric acid + L-Lysine + NADH ⟶ H2O + L-Saccharopine + NAD+ - NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid ( Lysine degradation ):
4-Trimethyl-ammonio-butanal + H2O + NAD+ ⟶ 4-Trimethyl-ammonio-butanoic acid + NADH - NAD+ + 4-Trimethyl-ammonio-butanal + H2O = NADH + 4-Trimethyl-ammonio-butanoic acid ( Lysine degradation ):
4-Trimethyl-ammonio-butanal + H2O + NAD+ ⟶ 4-Trimethyl-ammonio-butanoic acid + NADH
PlantCyc()
COVID-19 Disease Map()
PathBank(4)
- Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid - Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid - Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid - Carnitine Synthesis:
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen ⟶ Carbon dioxide + L-Carnitine + Succinic acid
PharmGKB()
1 个相关的物种来源信息
- 4896 - Schizosaccharomyces pombe: 10.1039/C4MB00346B
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 | |
|---|---|---|
| plasma membrane | 1 | BCHE |
| extracellular space | 1 | BCHE |
| Secreted | 1 | BCHE |
| extracellular region | 1 | BCHE |
| blood microparticle | 1 | BCHE |
| endoplasmic reticulum lumen | 1 | BCHE |
| nuclear envelope lumen | 1 | BCHE |
文献列表
- Haoran Wei, Mingming Zhao, Junfang Wu, Chenze Li, Man Huang, Jianing Gao, Qi Zhang, Liang Ji, Yan Wang, Chunxia Zhao, Erdan Dong, Lemin Zheng, Dao Wen Wang. Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events.
The Journal of clinical endocrinology and metabolism.
2022 11; 107(12):e4360-e4370. doi:
10.1210/clinem/dgac519. [PMID: 36062477] - Florian Jacques, Yingjuan Zhao, Martina Kopečná, Radka Končitíková, David Kopečný, Sonia Rippa, Yolande Perrin. Roles for ALDH10 enzymes in γ-butyrobetaine synthesis, seed development, germination, and salt tolerance in Arabidopsis.
Journal of experimental botany.
2020 12; 71(22):7088-7102. doi:
10.1093/jxb/eraa394. [PMID: 32845293] - Pascal Bazire, Nadia Perchat, Ekaterina Darii, Christophe Lechaplais, Marcel Salanoubat, Alain Perret. Characterization of l-Carnitine Metabolism in Sinorhizobium meliloti.
Journal of bacteriology.
2019 04; 201(7):. doi:
10.1128/jb.00772-18. [PMID: 30670548] - Aarti Gautam, Seid Muhie, Nabarun Chakraborty, Allison Hoke, Duncan Donohue, Stacy Ann Miller, Rasha Hammamieh, Marti Jett. Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis.
Metabolomics : Official journal of the Metabolomic Society.
2018 12; 15(1):2. doi:
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The Journal of nutrition.
2018 02; 148(2):194-201. doi:
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Molecular genetics and metabolism.
2015 Dec; 116(4):231-41. doi:
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Vascular pharmacology.
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2010 Sep; 467(7312):233-6. doi:
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BMC pregnancy and childbirth.
2010 Apr; 10(?):17. doi:
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Journal of molecular biology.
2010 Mar; 396(4):870-82. doi:
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Basic & clinical pharmacology & toxicology.
2009 Dec; 105(6):387-94. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2009 Oct; 297(4):G681-6. doi:
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European journal of clinical nutrition.
2009 Sep; 63(9):1098-105. doi:
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Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2009 Jul; 153(3):324-31. doi:
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Arhiv za higijenu rada i toksikologiju.
2009 Jun; 60(2):147-56. doi:
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Mechanisms of ageing and development.
2009 Apr; 130(4):227-33. doi:
10.1016/j.mad.2008.12.002. [PMID: 19150623] - Reinis Vilskersts, Edgars Liepinsh, Lukasz Mateuszuk, Solveiga Grinberga, Ivars Kalvinsh, Stefan Chlopicki, Maija Dambrova. Mildronate, a regulator of energy metabolism, reduces atherosclerosis in apoE/LDLR-/- mice.
Pharmacology.
2009; 83(5):287-93. doi:
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The British journal of nutrition.
2009 Jan; 101(2):190-6. doi:
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Life sciences.
2008 Oct; 83(17-18):613-9. doi:
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Physiology & behavior.
2008 Oct; 95(3):341-7. doi:
10.1016/j.physbeh.2008.06.012. [PMID: 18640137] - Sonja Primassin, Frank Ter Veld, Ertan Mayatepek, Ute Spiekerkoetter. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine.
Pediatric research.
2008 Jun; 63(6):632-7. doi:
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European journal of pharmacology.
2008 Mar; 583(1):11-7. doi:
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Experimental biology and medicine (Maywood, N.J.).
2008 Mar; 233(3):356-65. doi:
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Clinical chemistry.
2007 Dec; 53(12):2169-76. doi:
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Biomeditsinskaia khimiia.
2007 Nov; 53(6):672-82. doi:
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Pharmacological research.
2007 Aug; 56(2):175-83. doi:
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Archives of pharmacal research.
2007 Aug; 30(8):1041-6. doi:
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Journal of cardiovascular pharmacology.
2006 Dec; 48(6):314-9. doi:
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Biochimica et biophysica acta.
2006 Dec; 1761(12):1469-81. doi:
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Journal of inherited metabolic disease.
2006 Oct; 29(5):631-6. doi:
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Journal of Zhejiang University. Science. B.
2006 Sep; 7(9):708-12. doi:
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2006 Feb; 21(2):450-8. doi:
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Life sciences.
2005 Oct; 77(24):3078-91. doi:
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Rapid communications in mass spectrometry : RCM.
2004; 18(11):1233-8. doi:
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2004 Jan; 94(1):46-50. doi:
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2003 May; 13(10):1695-8. doi:
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