dl-Isoserine (BioDeep_00000288671)

   


Metabolite Card


dl-Isoserine

  Formula: C3H7NO3 (105.0426)
Chinese Names: 异丝氨酸
  Spectrum Hits: Top Source Homo sapiens(not specific) 33.33%

Molecular Structure

SMILES: NCC(O)C(=O)O
InChI:

Description

Synonyms

1 synonym names

dl-Isoserine



Cross Reference

3 cross reference id

Classification Terms

Related Pathways

Reactome()

BioCyc()

PlantCyc()

Biological Process

related biological process reactions.

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

Sub-cellular location Genes


Literature Reference

  • Paula Zaręba, Beata Gryzło, Katarzyna Malawska, Kinga Sałat, Georg C Höfner, Alicja Nowaczyk, Łukasz Fijałkowski, Anna Rapacz, Adrian Podkowa, Anna Furgała, Paweł Żmudzki, Klaus T Wanner, Barbara Malawska, Katarzyna Kulig. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. European journal of medicinal chemistry. 2020 Feb; 188(?):111920. doi: 10.1016/j.ejmech.2019.111920. [PMID: 31901745]
  • Maria Ek Lie, Emma K Gowing, Nina B Johansen, Nils Ole Dalby, Louise Thiesen, Petrine Wellendorph, Andrew N Clarkson. GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2019 01; 39(1):74-88. doi: 10.1177/0271678x17744123. [PMID: 29160736]
  • Fredd Vergara, Ales Svatos, Bernd Schneider, Michael Reichelt, Jonathan Gershenzon, Ute Wittstock. Glycine conjugates in a lepidopteran insect herbivore--the metabolism of benzylglucosinolate in the cabbage white butterfly, Pieris rapae. Chembiochem : a European journal of chemical biology. 2006 Dec; 7(12):1982-9. doi: 10.1002/cbic.200600280. [PMID: 17086559]
  • Andrea Kragler, Georg Höfner, Klaus T Wanner. Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4. European journal of pharmacology. 2005 Sep; 519(1-2):43-7. doi: 10.1016/j.ejphar.2005.06.053. [PMID: 16111674]
  • B S Coller, K T Springer, L E Scudder, J L Kutok, M Ceruso, G D Prestwich. Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation. The Journal of biological chemistry. 1993 Oct; 268(28):20741-3. doi: . [PMID: 8104935]
  • C Pelassy, D Mary, C Aussel. Effects of the serine analogues isoserine and serinol on interleukin-2 synthesis and phospholipid metabolism in a human T cell line Jurkat. Journal of lipid mediators. 1991 Jan; 3(1):79-89. doi: ". [PMID: 1768842]


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