6'-Sialyllactose (BioDeep_00000028236)

   

human metabolite Endogenous Toxin


代谢物信息卡片


(2R,4S,5R,6R)-4-Hydroxy-5-[(1-hydroxyethylidene)amino]-2-{[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-2-yl]methoxy}-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

化学式: C23H39NO19 (633.2116184)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)OCC2C(C(C(C(O2)OC(C(CO)O)C(C(C=O)O)O)O)O)O)O
InChI: InChI=1S/C23H39NO19/c1-7(28)24-13-8(29)2-23(22(38)39,43-20(13)15(34)10(31)4-26)40-6-12-16(35)17(36)18(37)21(41-12)42-19(11(32)5-27)14(33)9(30)3-25/h3,8-21,26-27,29-37H,2,4-6H2,1H3,(H,24,28)(H,38,39)/t8-,9-,10+,11+,12+,13+,14+,15+,16-,17-,18+,19+,20+,21-,23+/m0/s1

描述信息

Sialyllactose is an oligossaccharide found in both human breast milk and cows milk. It is the predominant sialylated component in milk. Sialyllactose has recently been shown to inhibit the infection of HIV-1 virus. Sialyllactose is also responsible for the inhibitory activity of milk on cholera toxin. [HMDB]
Sialyllactose is an oligossaccharide found in both human breast milk and cows milk. It is the predominant sialylated component in milk. Sialyllactose has recently been shown to inhibit the infection of HIV-1 virus. Sialyllactose is also responsible for the inhibitory activity of milk on cholera toxin.

同义名列表

11 个代谢物同义名

(2R,4S,5R,6R)-4-Hydroxy-5-[(1-hydroxyethylidene)amino]-2-{[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-2-yl]methoxy}-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate; (2R,4S,5R,6R)-5-acetamido-4-hydroxy-2-{[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-2-yl]methoxy}-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid; O-(N-Acetyl-alpha-neuraminosyl)-(2-3)-O-beta-delta-galactopyranosyl-(1-4)-delta-glucose; O-(N-Acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-D-glucose; (2>6)-alpha-sialyllactose; 6-alpha-Sialyllactose; (2>6)-a-sialyllactose; (2>6)-sialyllactose; 6-Monosialyllactose; 6-a-Sialyllactose; 6-Sialyllactose



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Seok-In Jang, Han Young Eom, Jeong Ho Hwang, Lila Kim, Jong-Hwa Lee. Simultaneous Quantification of 3'- and 6'-Sialyllactose in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26041177. [PMID: 33671827]
  • Han Young Eom, Seok-In Jang, Jeong Ho Hwang, Lila Kim, Jong Seong Kang, Jong-Hwa Lee. Development and validation of a bioanalytical method of analyzing 3'- and 6'-sialyllactose using liquid chromatography-tandem mass spectrometry in minipig plasma and its application in a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2021 Feb; 195(?):113827. doi: 10.1016/j.jpba.2020.113827. [PMID: 33358084]
  • Han Young Eom, Seok-In Jang, Jong-Hwa Lee. Development and Validation of a Bioanalytical Method for 3'- and 6'-Sialyllactose in Minipig Liver and Kidney Using Liquid Chromatography-Tandem Mass Spectrometry and Its Application to Analysis of Tissue Distribution. Molecules (Basel, Switzerland). 2020 Dec; 25(23):. doi: 10.3390/molecules25235721. [PMID: 33287423]
  • Marcia H Monaco, Dae Hee Kim, Rit B Gurung, Sharon M Donovan. Evaluation of 6'-Sialyllactose Sodium Salt Supplementation to Formula on Growth and Clinical Parameters in Neonatal Piglets. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041030. [PMID: 32283716]
  • Sira Carolin Günther, Julian David Maier, Janine Vetter, Nikita Podvalnyy, Nikolay Khanzhin, Thierry Hennet, Silke Stertz. Antiviral potential of 3'-sialyllactose- and 6'-sialyllactose-conjugated dendritic polymers against human and avian influenza viruses. Scientific reports. 2020 01; 10(1):768. doi: 10.1038/s41598-020-57608-4. [PMID: 31964943]
  • Ramesh Prasad Pandey, Dae Hee Kim, Jinsuk Woo, Jaeyoung Song, Sang Ho Jang, Joon Bae Kim, Kwang Myun Cheong, Jin Sik Oh, Jae Kyung Sohng. Broad-spectrum neutralization of avian influenza viruses by sialylated human milk oligosaccharides: in vivo assessment of 3'-sialyllactose against H9N2 in chickens. Scientific reports. 2018 02; 8(1):2563. doi: 10.1038/s41598-018-20955-4. [PMID: 29416087]
  • Masanori Nagao, Yurina Fujiwara, Teruhiko Matsubara, Yu Hoshino, Toshinori Sato, Yoshiko Miura. Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus. Biomacromolecules. 2017 Dec; 18(12):4385-4392. doi: 10.1021/acs.biomac.7b01426. [PMID: 29111681]
  • E Vazquez, A Santos-Fandila, R Buck, R Rueda, M Ramirez. Major human milk oligosaccharides are absorbed into the systemic circulation after oral administration in rats. The British journal of nutrition. 2017 01; 117(2):237-247. doi: 10.1017/s0007114516004554. [PMID: 28179042]
  • JoMay Chow, Matthew R Panasevich, Danny Alexander, Brittany M Vester Boler, Mariana C Rossoni Serao, Trevor A Faber, Laura L Bauer, George C Fahey. Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation. Journal of proteome research. 2014 May; 13(5):2534-42. doi: 10.1021/pr500011w. [PMID: 24628373]
  • Stella Zevgiti, Juliana Gonzalez Zabala, Ayub Darji, Ursula Dietrich, Eugenia Panou-Pomonis, Maria Sakarellos-Daitsiotis. Sialic acid and sialyl-lactose glyco-conjugates: design, synthesis and binding assays to lectins and swine influenza H1N1 virus. Journal of peptide science : an official publication of the European Peptide Society. 2012 Jan; 18(1):52-8. doi: 10.1002/psc.1415. [PMID: 22052803]
  • Tomohisa Kato, Atsushi Kawaguchi, Kyosuke Nagata, Kenichi Hatanaka. Development of tetraphenylethylene-based fluorescent oligosaccharide probes for detection of influenza virus. Biochemical and biophysical research communications. 2010 Mar; 394(1):200-4. doi: 10.1016/j.bbrc.2010.02.155. [PMID: 20188703]
  • Alexandra S Gambaryan, Alexander I Karasin, Alexander B Tuzikov, Alexander A Chinarev, Galina V Pazynina, Nicolai V Bovin, Mikhail N Matrosovich, Christopher W Olsen, Alexander I Klimov. Receptor-binding properties of swine influenza viruses isolated and propagated in MDCK cells. Virus research. 2005 Dec; 114(1-2):15-22. doi: 10.1016/j.virusres.2005.05.005. [PMID: 15996787]
  • Larisa Mochalova, Alexandra Gambaryan, Julia Romanova, Alexander Tuzikov, Alexander Chinarev, Dietmar Katinger, Herman Katinger, Andrej Egorov, Nicolai Bovin. Receptor-binding properties of modern human influenza viruses primarily isolated in Vero and MDCK cells and chicken embryonated eggs. Virology. 2003 Sep; 313(2):473-80. doi: 10.1016/s0042-6822(03)00377-5. [PMID: 12954214]
  • Q K Huynh, K Shailubhai, H Boddupalli, H H Yu, K O Broschat, G S Jacob. Isolation and characterization from porcine serum of a soluble sulfotransferase responsible for 6-O-sulfation of the galactose residue in 2'-fucosyllactose: implications in the synthesis of the ligand for L-selectin. Glycoconjugate journal. 1999 Jul; 16(7):357-63. doi: 10.1023/a:1007052228230. [PMID: 10619708]