Retinoyl CoA (BioDeep_00000028220)

   

human metabolite Endogenous


代谢物信息卡片


4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-N-{2-[(2-{[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]sulphanyl}ethyl)-C-hydroxycarbonimidoyl]ethyl}-2-hydroxy-3,3-dimethylbutanimidic acid

化学式: C41H62N7O17P3S (1049.3136)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O)O)O)C)C
InChI: InChI=1S/C41H62N7O17P3S/c1-25(13-14-28-27(3)12-9-16-40(28,4)5)10-8-11-26(2)20-31(50)69-19-18-43-30(49)15-17-44-38(53)35(52)41(6,7)22-62-68(59,60)65-67(57,58)61-21-29-34(64-66(54,55)56)33(51)39(63-29)48-24-47-32-36(42)45-23-46-37(32)48/h8,10-11,13-14,20,23-24,29,33-35,39,51-52H,9,12,15-19,21-22H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b11-8+,14-13+,25-10+,26-20+/t29-,33-,34-,35?,39-/m1/s1

描述信息

Retinoyl coenzyme A is an intermediate in vitamin A metabolism. The formation of retinoyl-CoA from retinoic acid, as the first step of retinoylation (acylation of proteins by retinoic acid in cells), required ATP, CoA and MgCl2. [HMDB]
Retinoyl coenzyme A is an intermediate in vitamin A metabolism. The formation of retinoyl-CoA from retinoic acid, as the first step of retinoylation (acylation of proteins by retinoic acid in cells), required ATP, CoA and MgCl2.

同义名列表

34 个代谢物同义名

4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-N-{2-[(2-{[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]sulphanyl}ethyl)-C-hydroxycarbonimidoyl]ethyl}-2-hydroxy-3,3-dimethylbutanimidic acid; 4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-N-{2-[(2-{[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]sulphanyl}ethyl)-C-hydroxycarbonimidoyl]ethyl}-2-hydroxy-3,3-dimethylbutanimidate; 4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-N-{2-[(2-{[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]sulfanyl}ethyl)-C-hydroxycarbonimidoyl]ethyl}-2-hydroxy-3,3-dimethylbutanimidate; {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[3-({2-[(2-{[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid; [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-[({[3-({2-[(2-{[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)-3-hydroxy-2,2-dimethylpropoxy(hydroxy)phosphoryl]oxy(hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxyphosphonic acid; Fatty acyl coenzyme A retinol acyltransferase; Fatty acyl coenzyme A-retinol acyltransferase; Acyl-coenzyme A-retinol acyltransferase.; Acyl-coenzyme A-retinol acyltransferase; Acyl-CoA-retinol acyltransferase.; Acyltransferase, acyl CoA-retinol; CoA-Retinol acyltransferase, acyl; O-Fatty-acyltransferase, retinol; Acyl CoA retinol acyltransferase; Acyl-CoA-retinol acyltransferase; Acyl CoA-retinol acyltransferase; Retinol O fatty acyltransferase; Retinol O-fatty-acyltransferase; Fatty-acyltransferase, retinol; Retinol fatty-acyltransferase; Retinol fatty acyltransferase; Synthetase, retinol-palmitate; Retinol palmitate synthetase; Stearate synthetase, retinol; Retinol-palmitate synthetase; Synthetase, retinol stearate; Retinol stearate synthetase; Retinol O-acyltransferase; Ester synthetase, retinol; Synthetase, retinol ester; Retinol ester synthetase; Retinol acyltransferase; Retinoyl coenzyme A; Retinoyl CoA



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • R K Randolph, A C Ross. Vitamin A status regulates hepatic lecithin: retinol acyltransferase activity in rats. The Journal of biological chemistry. 1991 Sep; 266(25):16453-7. doi: 10.1016/s0021-9258(18)55321-7. [PMID: 1885578]
  • S Mobarhan, H K Seitz, R M Russell, R Mehta, J Hupert, H Friedman, T J Layden, M Meydani, P Langenberg. Age-related effects of chronic ethanol intake on vitamin A status in Fisher 344 rats. The Journal of nutrition. 1991 Apr; 121(4):510-7. doi: 10.1093/jn/121.4.510. [PMID: 2007903]
  • R B Edwards, A J Adler, R C Claycomb. Requirement of insulin or IGF-1 for the maintenance of retinyl ester synthetase activity by cultured retinal pigment epithelial cells. Experimental eye research. 1991 Jan; 52(1):51-7. doi: 10.1016/0014-4835(91)90127-z. [PMID: 1868886]
  • M A Jurek, R H Powers, L G Gilbert, S D Aust. The effect of TCDD on acyl CoA:retinol acyltransferase activity and vitamin A accumulation in the kidney of male Sprague-Dawley rats. Journal of biochemical toxicology. 1990; 5(3):155-60. doi: 10.1002/jbt.2570050304. [PMID: 2283665]
  • P V Bhat, A Lacroix. Metabolism of retinol and retinoic acid in N-methyl-N-nitrosourea-induced mammary carcinomas in rats. Cancer research. 1989 Jan; 49(1):139-44. doi: NULL. [PMID: 2908841]
  • B Berne, H Törmä, B Staberg, S Mikkelsen, A Vahlquist. Decreased retinyl ester concentrations in UV-induced murine squamous cell carcinomas. Acta dermato-venereologica. 1989; 69(6):503-8. doi: NULL. [PMID: 2575323]
  • B Boron, J Hupert, D H Barch, C C Fox, H Friedman, T J Layden, S Mobarhan. Effect of zinc deficiency on hepatic enzymes regulating vitamin A status. The Journal of nutrition. 1988 Aug; 118(8):995-1001. doi: 10.1093/jn/118.8.995. [PMID: 3404291]
  • K O Wathne, R Blomhoff, K R Norum. Effect of cytostatics on liver retinol store in rat. Medical oncology and tumor pharmacotherapy. 1988; 5(2):107-12. doi: 10.1007/bf02985447. [PMID: 3412034]
  • H Törmä, B Berne, A Vahlquist. UV irradiation and topical vitamin A modulate retinol esterification in hairless mouse epidermis. Acta dermato-venereologica. 1988; 68(4):291-9. doi: NULL. [PMID: 2459873]
  • R K Jensen, M E Cullum, J Deyo, M H Zile. Vitamin A metabolism in rats chronically treated with 3,3',4,4',5,5'-hexabromobiphenyl. Biochimica et biophysica acta. 1987 Dec; 926(3):310-20. doi: 10.1016/0304-4165(87)90217-0. [PMID: 2825801]
  • L R Chaudhary, E C Nelson. Some properties and subcellular distribution of acyl-coenzyme A: retinol acyltransferase activity in rat testes. Biochimica et biophysica acta. 1987 Jan; 917(1):24-32. doi: 10.1016/0005-2760(87)90279-7. [PMID: 3790609]
  • M Rasmussen, H Michalsen, S O Lie, A Nilsson, L B Petersen, K R Norum. Intestinal retinol esterification and serum retinol in children with cystic fibrosis. Journal of pediatric gastroenterology and nutrition. 1986 May; 5(3):397-403. doi: 10.1097/00005176-198605000-00011. [PMID: 3723258]
  • M D Ball, H C Furr, J A Olson. Acyl coenzyme A:retinol acyltransferase activity and the vitamin A content of polar bear (Ursus maritimus) liver. Comparative biochemistry and physiology. B, Comparative biochemistry. 1986; 84(4):513-7. doi: 10.1016/0305-0491(86)90115-x. [PMID: 3757481]
  • M Rasmussen, R Blomhoff, P Helgerud, L A Solberg, T Berg, K R Norum. Retinol and retinyl esters in parenchymal and nonparenchymal rat liver cell fractions after long-term administration of ethanol. Journal of lipid research. 1985 Sep; 26(9):1112-9. doi: 10.1016/s0022-2275(20)34284-x. [PMID: 4067432]
  • M Rasmussen, L B Petersen, K R Norum. The activity of acyl CoA: retinol acyltransferase in the rat: variation with vitamin A status. The British journal of nutrition. 1984 Mar; 51(2):245-53. doi: 10.1079/bjn19840029. [PMID: 6704372]