4-Nitrophenyl sulfate (BioDeep_00000028216)

   

human metabolite Endogenous Chemicals and Drugs


代谢物信息卡片


Sulphuric acid mono(4-nitrophenyl) ester

化学式: C6H5NO6S (218.983759)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1[N+](=O)[O-])OS(=O)(=O)O
InChI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)

描述信息

4-Nitrophenyl sulfate is a minor metabolic byproduct of parathion metabolism that is excreted in the urine (PMID: 1956875). Parathion is an organophosphate compound developed in the 1940s. It is a potent insecticide and acaricide. It is highly toxic to non-target organisms, including humans. 4-Nitrophenyl sulfate is also used as a model substrate to investigate the influence of drug therapy, disease, nutrient deficiencies and other physiologically altered conditions on conjugative drug metabolism in animal studies.(PMID: 16844228) [HMDB]
4-Nitrophenyl sulfate is a minor metabolic byproduct of parathion metabolism that is excreted in the urine (PMID: 1956875). Parathion is an organophosphate compound developed in the 1940s. It is a potent insecticide and acaricide. It is highly toxic to non-target organisms, including humans. 4-Nitrophenyl sulfate is also used as a model substrate to investigate the influence of drug therapy, disease, nutrient deficiencies and other physiologically altered conditions on conjugative drug metabolism in animal studies.(PMID: 16844228).

同义名列表

31 个代谢物同义名

Sulphuric acid mono(4-nitrophenyl) ester; Sulfuric acid mono(4-nitrophenyl) ester; 4-Nitrophenyl sulfate, potassium salt; 4-Nitrophenyl hydrogen sulphuric acid; 4-Nitrophenyl hydrogen sulfuric acid; (4-nitrophenyl)oxidanesulfonic acid; Sulphate mono(4-nitrophenyl) ester; 4-Nitrophenyl sulfate, sodium salt; Sulfate mono(4-nitrophenyl) ester; Para-nitrophenyl sulphuric acid; 4-Nitrophenyl hydrogen sulphate; 4-Nitrophenyl sulfate, ion (1-); Para-nitrophenyl sulfuric acid; mono (4-Nitrophenyl)-sulphate; 4-Nitrophenyl sulphuric acid; p-Nitrophenyl sulphuric acid; p-Nitrophenol sulphuric acid; mono (4-Nitrophenyl)-sulfate; p-Nitrophenyl sulfuric acid; p-Nitrophenol sulfuric acid; 4-Nitrophenyl sulfuric acid; Para-nitrophenyl sulphate; Para-nitrophenyl sulfate; 4-Nitrophenyl sulphate; p-Nitrophenol sulphate; p-Nitrophenyl sulphate; p-Nitrophenyl sulfate; p-Nitrophenol sulfate; 4-Nitrophenyl sulfate; P-nitro-Phenol; 4-Nitrophenyl



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

52 个相关的代谢反应过程信息。

Reactome(52)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • John W Nichols, Alex D Hoffman, Patrick N Fitzsimmons, Gregory J Lien. Quantification of phenol, phenyl glucuronide, and phenyl sulfate in blood of unanesthetized rainbow trout by online microdialysis sampling. Toxicology mechanisms and methods. 2008; 18(5):405-12. doi: 10.1080/15376510701511935. [PMID: 20020864]
  • Jin-Oh Kwak, Hyun-Woo Kim, Kwang-Jin Oh, Chang-Bo Ko, Hwayong Park, Seok Ho Cha. Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter. The Journal of steroid biochemistry and molecular biology. 2005 Dec; 97(4):369-75. doi: 10.1016/j.jsbmb.2005.06.028. [PMID: 16150593]
  • Henriette de Loor, Bert Bammens, Pieter Evenepoel, Vicky De Preter, Kristin Verbeke. Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum. Clinical chemistry. 2005 Aug; 51(8):1535-8. doi: 10.1373/clinchem.2005.050781. [PMID: 16040852]
  • F Hernández, J V Sancho, O J Pozo. An estimation of the exposure to organophosphorus pesticides through the simultaneous determination of their main metabolites in urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Sep; 808(2):229-39. doi: 10.1016/j.jchromb.2004.05.019. [PMID: 15261816]
  • Vadim V Mozhaev, Yuri L Khmelnitsky, Fernando Sanchez-Riera, Julie Maurina-Brunker, Reinhardt A Rosson, Alan D Grund. Arylsulfotransferase from Clostridium innocuum-A new enzyme catalyst for sulfation of phenol-containing compounds. Biotechnology and bioengineering. 2002 Jun; 78(5):567-75. doi: 10.1002/bit.10229. [PMID: 12115126]
  • A W Abu-Qare, A A Abdel-Rahman, H Ahmad, A M Kishk, M B Abou-Donia. Absorption, distribution, metabolism and excretion of daily oral doses of [14C]methyl parathion in hens. Toxicology letters. 2001 Dec; 125(1-3):1-10. doi: 10.1016/s0378-4274(01)00409-x. [PMID: 11701217]
  • S H Cha, T Sekine, H Kusuhara, E Yu, J Y Kim, D K Kim, Y Sugiyama, Y Kanai, H Endou. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. The Journal of biological chemistry. 2000 Feb; 275(6):4507-12. doi: 10.1074/jbc.275.6.4507. [PMID: 10660625]
  • S W Toennes, H H Maurer. Efficient cleavage of conjugates of drugs or poisons by immobilized beta-glucuronidase and arylsulfatase in columns. Clinical chemistry. 1999 Dec; 45(12):2173-82. doi: 10.1093/clinchem/45.12.2173. [PMID: 10585350]
  • M E Morris, S B Hansel. High-performance liquid chromatographic analysis of p-nitrophenol and its conjugates in biological samples. Journal of chromatography. 1990 Nov; 532(2):285-93. doi: 10.1016/s0378-4347(00)83779-2. [PMID: 2084126]
  • M P Kung, S W Spaulding, J A Roth. Desulfation of 3,5,3'-triiodothyronine sulfate by microsomes from human and rat tissues. Endocrinology. 1988 Apr; 122(4):1195-200. doi: 10.1210/endo-122-4-1195. [PMID: 2964360]
  • H Iwabuchi, A Nakagawa, K Nakamura. Application of molecular-secondary-ion mass spectrometry for drug metabolism studies. I. Direct analysis of conjugates by thin-layer chromatography-secondary-ion mass spectrometry. Journal of chromatography. 1987 Feb; 414(1):139-48. doi: 10.1016/0378-4347(87)80032-4. [PMID: 3571378]
  • S Partanen. Simultaneous azo-coupling method for an estrogen sulfatase in human tissues. Histochemistry. 1983; 78(2):241-9. doi: 10.1007/bf00489502. [PMID: 6874424]
  • P Michalke. [Quantification of p-nitrophenolglucuronide and sulfate in blood and urine using enzyme hydrolysis and HPLC following E 605-poisoning]. Beitrage zur gerichtlichen Medizin. 1983; 41(?):103-7. doi: NULL. [PMID: 6639573]
  • G Diamond, A J Quebbemann. Rapid separation of p-nitrophenol and its glucuronide and sulfate conjugates by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1979 Sep; 177(2):368-71. doi: 10.1016/s0021-9673(01)96336-8. [PMID: 528645]