Ferrugin (BioDeep_00000280647)

   

PANOMIX_OTCML-2023


代谢物信息卡片


8bH-Cyclopenta[b]benzofuran-1,8b-diol, 1,2,3,3a-tetrahydro-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,3S,3aR,8bS)-

化学式: C26H26O6 (434.1729)
中文名称: 洛克米兰醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=C(C=C1)C23C(CC(C2(C4=C(O3)C=C(C=C4OC)OC)O)O)C5=CC=CC=C5
InChI: InChI=1S/C26H26O6/c1-29-18-11-9-17(10-12-18)26-20(16-7-5-4-6-8-16)15-23(27)25(26,28)24-21(31-3)13-19(30-2)14-22(24)32-26/h4-14,20,23,27-28H,15H2,1-3H3/t20-,23+,25+,26-/m0/s1

描述信息

Rocaglaol is a natural product found in Aglaia ferruginea, Aglaia laxiflora, and other organisms with data available.

同义名列表

6 个代谢物同义名

8bH-Cyclopenta[b]benzofuran-1,8b-diol, 1,2,3,3a-tetrahydro-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,3S,3aR,8bS)-; (1R,3S,3aR,8bS)-6,8-Dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-1,8b-diol; (1R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-1,8b-diol; (+/-)-Rocaglaol; Rocaglaol; Ferrugin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Wei Ge, Weikang Ming, Zhenkun Li, Yunyan Tang, Ya-Nan Li, Jue Yang, Xiaojiang Hao, Chunmao Yuan. Design and Synthesis of Cytotoxic Water-Soluble Rocaglaol Derivatives against HEL Cells by Inhibiting Fli-1. Journal of natural products. 2024 02; 87(2):276-285. doi: 10.1021/acs.jnatprod.3c00948. [PMID: 38253024]
  • Yanan Li, Jie Qiu, Ping Yi, Jue Yang, Wei Gu, Yanmei Li, Chunmao Yuan, Xiaojiang Hao. Isolation and synthesis of rocaglaol derivatives by inhibiting Wnt/β-catenin and MAPK signaling pathways against colorectal cancer. Bioorganic chemistry. 2022 Dec; 129(?):106149. doi: 10.1016/j.bioorg.2022.106149. [PMID: 36116324]
  • Hao-Jie Yang, Ya-Nan Li, Chen Yan, Jue Yang, Yan-Rong Zeng, Ping Yi, Yan-Mei Li, Xiao-Jiang Hao, Chun-Mao Yuan. Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway. Fitoterapia. 2021 Jun; 151(?):104876. doi: 10.1016/j.fitote.2021.104876. [PMID: 33675885]
  • Jialei Song, Chunmao Yuan, Jue Yang, Tangjingjun Liu, Yao Yao, Xiao Xiao, Babu Gajendran, Dahai Xu, You-Jun Li, Chunlin Wang, Wuling Liu, Min Wen, David Spaner, Jorge Filmus, Eldad Zacksenhaus, Yiguo Zhang, Xiaojiang Hao, Yaacov Ben-David. Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia. The FEBS journal. 2018 12; 285(24):4631-4645. doi: 10.1111/febs.14690. [PMID: 30387554]
  • Hisashi Kato-Noguchi, Masahiko Suzuki, Kazutaka Noguchi, Osamu Ohno, Kiyotake Suenaga, Chamroon Laosinwattana. A Potent Phytotoxic Substance in Aglaia odorata Lour. Chemistry & biodiversity. 2016 May; 13(5):549-54. doi: 10.1002/cbdv.201500175. [PMID: 27088639]
  • Soyoung Kim, Angela A Salim, Steven M Swanson, A Douglas Kinghorn. Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy. Anti-cancer agents in medicinal chemistry. 2006 Jul; 6(4):319-45. doi: 10.2174/187152006777698123. [PMID: 16842234]
  • Qiuwen Mi, Bao-Ning Su, Heebyung Chai, Geoffrey A Cordell, Norman R Farnsworth, A Douglas Kinghorn, Steven M Swanson. Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells. Anticancer research. 2006 Mar; 26(2A):947-52. doi: ". [PMID: 16619491]
  • D Engelmeier, F Hadacek, T Pacher, S Vajrodaya, H Greger. Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea). Journal of agricultural and food chemistry. 2000 Apr; 48(4):1400-4. doi: 10.1021/jf990509h. [PMID: 10775404]
  • Y J Xu, X H Wu, B K Tan, Y H Lai, J J Vittal, Z Imiyabir, L Madani, K S Khozirah, S H Goh. Flavonol-cinnamate cycloadducts and diamide derivatives from Aglaia laxiflora. Journal of natural products. 2000 Apr; 63(4):473-6. doi: 10.1021/np990454d. [PMID: 10785416]
  • T Ohse, S Ohba, T Yamamoto, T Koyano, K Umezawa. Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata. Journal of natural products. 1996 Jul; 59(7):650-2. doi: 10.1021/np960346g. [PMID: 8759160]