4-Chloromethandienone (BioDeep_00000027906)

   

human metabolite


代谢物信息卡片


(1S,2R,10R,11S,14S,15S)-6-chloro-14-hydroxy-2,14,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one

化学式: C20H27ClO2 (334.1699)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 0.98%

分子结构信息

SMILES: CC12CCC3C(C1CCC2(C)O)CCC4=C(C(=O)C=CC34C)Cl
InChI: InChI=1S/C20H27ClO2/c1-18-9-8-16(22)17(21)15(18)5-4-12-13(18)6-10-19(2)14(12)7-11-20(19,3)23/h8-9,12-14,23H,4-7,10-11H2,1-3H3/t12-,13+,14+,18-,19+,20+/m1/s1

描述信息

4-Chloromethandienone is a synthetic anabolic steroid, suspected of misuse in sports. Although the widespread use of androgenic anabolic steroids might be implicated in the development of hormone-sensitive tumors, there are few reports regarding a possible causal relation between doping and cancer; however, there is one reported case of a 32-year-old man that underwent right radical orchiectomy for a tumor (identified as an intratesticular leiomyosarcoma) of the upper pole of the right testicle where the patient reported a 5-year history of systematic use of high dose of 4-Chloromethandienone. (PMID: 10526287) [HMDB]
4-Chloromethandienone is a synthetic anabolic steroid, suspected of misuse in sports. Although the widespread use of androgenic anabolic steroids might be implicated in the development of hormone-sensitive tumors, there are few reports regarding a possible causal relation between doping and cancer; however, there is one reported case of a 32-year-old man that underwent right radical orchiectomy for a tumor (identified as an intratesticular leiomyosarcoma) of the upper pole of the right testicle where the patient reported a 5-year history of systematic use of high dose of 4-Chloromethandienone. (PMID: 10526287).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

20 个代谢物同义名

(1S,2R,10R,11S,14S,15S)-6-chloro-14-hydroxy-2,14,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one; D-4-Chloro-17 beta-hydroxy-3-oxo-17 alpha-methylandrosta-1,4-diene; (17b)-4-chloro-17-Hydroxy-17-methyl-androsta-1,4-dien-3-one; 4-chloro-17b-Hydroxy-17a-methyl-5a-androsta-1,4-dien-3-one; 4-chloro-17b-Hydroxy-17-methyl-androsta-1,4-dien-3-one; 4-chloro-17a-Methyl-17b-hydroxyandrosta-1,4-dien-3-one; 4-chloro-1,2-dehydro-17a-Methyltestosterone; 1-dehydro-4-chloro-17a-Methyltestosterone; 4-chloro-1-dehydro-17-Methyltestosterone; 1-dehydro-4-chloro-17-Methyltestosterone; 4-chloro-1-Dehydromethyltestosterone; 4-Chlorodehydromethyltestosterone; Dehydrochlormethyltestosterone; 4-Chloro-methandienone; 4-Chloromethandienone; 4-Chlorodianabol; Oral turinabol; Turinabol-oral; Oral-turinabol; CDMT



数据库引用编号

7 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Christian Görgens, Anja Patricia Ramme, Sven Guddat, Yvonne Schrader, Annika Winter, Eva-Maria Dehne, Reyk Horland, Mario Thevis. Organ-on-a-chip: Determine feasibility of a human liver microphysiological model to assess long-term steroid metabolites in sports drug testing. Drug testing and analysis. 2021 Nov; 13(11-12):1921-1928. doi: 10.1002/dta.3161. [PMID: 34505743]
  • Steffen Loke, Xavier de la Torre, Michele Iannone, Giuseppe La Piana, Nils Schlörer, Francesco Botrè, Matthias Bureik, Maria Kristina Parr. Controlled administration of dehydrochloromethyltestosterone in humans: Urinary excretion and long-term detection of metabolites for anti-doping purpose. The Journal of steroid biochemistry and molecular biology. 2021 11; 214(?):105978. doi: 10.1016/j.jsbmb.2021.105978. [PMID: 34418529]
  • Jiaxin Liu, Lei Chen, Jan Felix Joseph, Alexandra Naß, Anna Stoll, Xavier de la Torre, Francesco Botrè, Gerhard Wolber, Maria Kristina Parr, Matthias Bureik. Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT). Journal of inorganic biochemistry. 2018 06; 183(?):165-171. doi: 10.1016/j.jinorgbio.2018.02.020. [PMID: 29544993]
  • Tim Sobolevsky, Grigory Rodchenkov. Detection and mass spectrometric characterization of novel long-term dehydrochloromethyltestosterone metabolites in human urine. The Journal of steroid biochemistry and molecular biology. 2012 Feb; 128(3-5):121-7. doi: 10.1016/j.jsbmb.2011.11.004. [PMID: 22142641]
  • W Schumann. [The pharmacokinetics of Oral-Turinabol in humans]. Die Pharmazie. 1991 Sep; 46(9):650-4. doi: NULL. [PMID: 1798729]
  • C S Liu, J Zhang, T H Zhou. [Investigation on the metabolism of dehydrochloromethyltestosterone in man]. Yao xue xue bao = Acta pharmaceutica Sinica. 1991; 26(9):682-7. doi: NULL. [PMID: 1821088]
  • J Schulze, U Julius, W Leonhardt, H Haller. [Metabolism kinetic characterization of hypertriglyceridemias in drug therapy variations]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. 1987 Sep; 42(18):506-11. doi: ". [PMID: 3687141]
  • A Hoffmann, H P Klöcking, F Markwardt. [Activation of the fibrinolytic system with dehydrochlormethyltestosterone]. Folia haematologica (Leipzig, Germany : 1928). 1984; 111(4):556-62. doi: NULL. [PMID: 6083926]
  • H P Klöcking, F Markwardt, A Hoffmann. Animal experiments on the enhancement of fibrinolytic potential by anabolic steroids. Biomedica biochimica acta. 1984; 43(4):501-7. doi: NULL. [PMID: 6548376]
  • H W Dürbeck, I Büker, B Scheulen, B Telin. GC and capillary column GC/MS determination of synthetic anabolic steroids. II. 4-chloro-methandienone (oral turinabol) and its metabolites. Journal of chromatographic science. 1983 Sep; 21(9):405-10. doi: 10.1093/chromsci/21.9.405. [PMID: 6630400]
  • A Brock. Binding of digitoxin to human serum albumin: influence of ionic strength and ionic medium on the digitoxin-albumin complex formation. Acta pharmacologica et toxicologica. 1975 Nov; 37(5):361-8. doi: 10.1111/j.1600-0773.1975.tb00854.x. [PMID: 887]