N1-methylinosine (BioDeep_00000027844)

 

Secondary id: BioDeep_00000595682

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1H-purin-6-one

化学式: C11H14N4O5 (282.0964154)
中文名称: 1-甲基肌苷, 7-甲基肌苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.36%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

N1-methylinosine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/n1-methylinosine (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000027844). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN1C=NC2=C(C1=O)N=CN2C3C(C(C(O3)CO)O)O
InChI: InChI=1S/C11H14N4O5/c1-14-3-13-9-6(10(14)19)12-4-15(9)11-8(18)7(17)5(2-16)20-11/h3-5,7-8,11,16-18H,2H2,1H3/t5-,7-,8-,11-/m1/s1

描述信息

1-methylinosine is inosine carrying a methyl substituent at position 1 on the hypoxanthine ring. It has a role as a metabolite. It derives from an inosine. It is a modified nucleotide found at position 37 in tRNA 3 to the anticodon of eukaryotic tRNA. Shown that sequences are forced to adopt a hairpin conformation if one of the central 6 nt is replaced by the corresponding methylated nucleotide, such as 1-methylguanosine. In Vivo synthesis: Inosine-37 in tRNA is synthesised by a hydrolytic deamination-type reaction, catalysed by distinct tRNA:adenosine deaminases.
Modified nucleotide found at position 37 in tRNA 3 to the anticodon of eukaryotic tRNA. Shown that sequences are forced to adopt a hairpin conformation if one of the central 6 nt is replaced by the corresponding methylated nucleotide, such as 1-methylguanosine.
1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA[1].
1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA[1].

同义名列表

5 个代谢物同义名

9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1H-purin-6-one; 1-Methyl-inosine; N1-Methylinosine; 1-Methylinosine; m(1)I



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaohuan Jin, Zhengyi Lv, Junbao Gao, Rui Zhang, Ting Zheng, Ping Yin, Dongqin Li, Liangcai Peng, Xintao Cao, Yan Qin, Staffan Persson, Bo Zheng, Peng Chen. AtTrm5a catalyses 1-methylguanosine and 1-methylinosine formation on tRNAs and is important for vegetative and reproductive growth in Arabidopsis thaliana. Nucleic acids research. 2019 01; 47(2):883-898. doi: 10.1093/nar/gky1205. [PMID: 30508117]
  • Daniel G Beach, Wojciech Gabryelski. Linear and nonlinear regimes of electrospray signal response in analysis of urine by electrospray ionization-high field asymmetric waveform ion mobility spectrometry-MS and implications for nontarget quantification. Analytical chemistry. 2013 Feb; 85(4):2127-34. doi: 10.1021/ac3027542. [PMID: 23297652]
  • J G Tebib, C Reynaud, J P Cedoz, M C Letroublon, A Niveleau. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. British journal of rheumatology. 1997 Sep; 36(9):990-5. doi: 10.1093/rheumatology/36.9.990. [PMID: 9376997]
  • H Grosjean, S Auxilien, F Constantinesco, C Simon, Y Corda, H F Becker, D Foiret, A Morin, Y X Jin, M Fournier, J L Fourrey. Enzymatic conversion of adenosine to inosine and to N1-methylinosine in transfer RNAs: a review. Biochimie. 1996; 78(6):488-501. doi: 10.1016/0300-9084(96)84755-9. [PMID: 8915538]
  • J I Langridge, T D McClure, S el-Shakawi, A Fielding, K H Schram, R P Newton. Gas chromatography/mass spectrometric analysis of urinary nucleosides in cancer patients; potential of modified nucleosides as tumour markers. Rapid communications in mass spectrometry : RCM. 1993 Jun; 7(6):427-34. doi: 10.1002/rcm.1290070605. [PMID: 8329765]
  • S M D'Ambrosio, R E Gibson-D'Ambrosio, R W Trewyn. An enzyme-linked immunosorbent assay (ELISA) for the detection and quantitation of the tumor marker 1-methylinosine in human urine. Clinica chimica acta; international journal of clinical chemistry. 1991 Jun; 199(2):119-28. doi: 10.1016/0009-8981(91)90103-j. [PMID: 1873911]
  • K Koshida, J Harmenberg, U Stendahl, B Wahren, E Borgström, L Helström, L Andersson. Urinary modified nucleosides as tumor markers in cancer of the urinary organs or female genital tract. Urological research. 1985; 13(5):213-8. doi: 10.1007/bf00261578. [PMID: 4060364]
  • L D Szabo, P Keresztes, J P Pallos, E Csato, T Predmerszky. Study of nucleic acid metabolism in two astronauts. Advances in space research : the official journal of the Committee on Space Research (COSPAR). 1984; 4(10):15-8. doi: 10.1016/0273-1177(84)90219-9. [PMID: 11539621]
  • D A Heldman, M R Grever, J S Miser, R W Trewyn. Relationship of urinary excretion of modified nucleosides to disease status in childhood acute lymphoblastic leukemia. Journal of the National Cancer Institute. 1983 Aug; 71(2):269-73. doi: . [PMID: 6576186]
  • D A Heldman, M R Grever, C E Speicher, R W Trewyn. Urinary excretion of modified nucleosides in chronic myelogenous leukemia. The Journal of laboratory and clinical medicine. 1983 May; 101(5):783-92. doi: NULL. [PMID: 6572681]
  • D A Heldman, M R Grever, R W Trewyn. Differential excretion of modified nucleosides in adult acute leukemia. Blood. 1983 Feb; 61(2):291-6. doi: NULL. [PMID: 6571786]
  • P Clemens, G Schöch, G Ziemer, J Altenhoff, N Erb, H Lorenz, J Müller, R Grüttner. [Excretion of methylated nucleosides in the initial therapy phase in a case of anorexia nervosa]. Padiatrie und Padologie. 1982; 17(2):157-63. doi: NULL. [PMID: 7099674]
  • D C Tormey, T P Waalkes, C W Gehrke. Biological markers in breast carcinoma--clinical correlations with pseudouridine, N2,N2-dimethylguanosine, and 1-methylinosine. Journal of surgical oncology. 1980; 14(3):267-73. doi: 10.1002/jso.2930140313. [PMID: 7392649]
  • A M Krstulovic, R A Hartwick, P R Brown. High performance liquid chromatographic determination of serum UV profiles of normal subjects and patients with breast cancer and benign fibrocystic changes. Clinica chimica acta; international journal of clinical chemistry. 1979 Oct; 97(2-3):159-70. doi: 10.1016/0009-8981(79)90412-1. [PMID: 487602]
  • K B Woo, T P Waalkes, D L Ahmann, D C Tormey, C W Gehrke, V T Oliverio. A quantitative approach to determining disease response during therapy using multiple biologic markers: application to carcinoma of the breast. Cancer. 1978 May; 41(5):1685-703. doi: 10.1002/1097-0142(197805)41:5<1685::aid-cncr2820410507>3.0.co;2-9. [PMID: 348295]