Cystathionine ketimine (BioDeep_00000027740)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(5R)-2,5,6,7-tetrahydro-1,4-Thiazepine-3,5-dicarboxylic acid

化学式: C7H9NO4S (203.0252274)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 9.52%

分子结构信息

SMILES: C1CSCC(=NC1C(=O)O)C(=O)O
InChI: InChI=1S/C7H9NO4S/c9-6(10)4-1-2-13-3-5(8-4)7(11)12/h4H,1-3H2,(H,9,10)(H,11,12)/t4-/m1/s1

描述信息

D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner. D-Cystathionine Ketimine enhanced seryl phosphorylation of 16. 5-kDa protein in human neutrophils, while L-Cystathionine Ketimine enhanced tyrosyl phosphorylation of 45-kDa protein.(PMID: 10049498). Among the cystathionine metabolites, cystathionine ketimine and N-acetyl-S-(3-oxo-3-carboxy-n-propyl) cysteine (NAc-OCPC) significantly enhanced the N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide generation, but cystathionine, NAc-cystathionine, and cyclothionine did not enhance the superoxide generation. Cystathionine ketimine and NAc-OCPC also enhanced superoxide generation induced by opsonized zymosan (OZ) but not that induced by arachidonic acid (AA) and phorbol 12-myristate 13-acetate (PMA). Superoxide generation induced by cystathionine ketimine and NAc-OCPC was inhibited by genistein, an inhibitor of tyrosine kinase, and was enhanced by 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase C.(PMID: 10708546) [HMDB]
Cystathionine ketimine (CT) is a cyclic amino acid that was found to have a priming effect on superoxide generation in human neutrophils (PMID: 10708546). D-Cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in two different manners. D-Cystathionine ketimine enhanced seryl phosphorylation of 16.5-kDa protein in human neutrophils, while L-cystathionine ketimine enhanced tyrosyl phosphorylation of 45-kDa protein (PMID: 10049498). Cystathionine ketimine was found in the urine of a cystathioninuria patient (PMID: 8373176).

同义名列表

8 个代谢物同义名

(5R)-2,5,6,7-tetrahydro-1,4-Thiazepine-3,5-dicarboxylic acid; (R)-2,5,6,7-Tetrahydro-1,4-thiazepine-3,5-dicarboxylic acid; (5R)-2,5,6,7-Tetrahydro-1,4-thiazepine-3,5-dicarboxylate; (R)-2,5,6,7-Tetrahydro-1,4-thiazepine-3,5-dicarboxylate; (5R)-1-Thia-4-azacyclohepta-3-ene-3,5-dicarboxylic acid; (5R)-1-Thia-4-azacyclohepta-3-ene-3,5-dicarboxylate; Cystathionine ketimine; CT



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Han Li, Mu Wang, Qiande Liang, Shuna Jin, Xiaojie Sun, Yangqian Jiang, Xingyun Pan, Yanqiu Zhou, Yang Peng, Bin Zhang, Aifen Zhou, Yiming Zhang, Zhong Chen, Jiangxia Cao, Hongling Zhang, Wei Xia, Tongzhang Zheng, Zongwei Cai, Yuanyuan Li, Shunqing Xu. Urinary metabolomics revealed arsenic exposure related to metabolic alterations in general Chinese pregnant women. Journal of chromatography. A. 2017 Jan; 1479(?):145-152. doi: 10.1016/j.chroma.2016.12.007. [PMID: 27988079]
  • S Yu, K Sugahara, K Nakayama, S Awata, H Kodama. Accumulation of cystathionine, cystathionine ketimine, and perhydro-1,4-thiazepine-3,5-dicarboxylic acid in whole brain and various regions of the brain of D, L-propargylglycine-treated rats. Metabolism: clinical and experimental. 2000 Aug; 49(8):1025-9. doi: 10.1053/meta.2000.7705. [PMID: 10954021]
  • H Kodama, J Zhang, K Sugahara. Novel priming compounds of cystathionine metabolites on superoxide generation in human neutrophils. Biochemical and biophysical research communications. 2000 Mar; 269(2):297-301. doi: 10.1006/bbrc.1999.1970. [PMID: 10708546]
  • J Zhang, M Zhang, D Ma, K Sugahara, H Kodama. Metabolism of cystathionine, N-monoacetylcystathionine, perhydro-1,4-thiazepine-3,5-dicarboxylic acid, and cystathionine ketimine in the liver and kidney of D,L-propargylglycine-treated rats. Metabolism: clinical and experimental. 1998 Oct; 47(10):1233-8. doi: 10.1016/s0026-0495(98)90329-8. [PMID: 9781627]
  • J Zhang, K Sugahara, Y Sagara, M Fontana, S Duprè, H Kodama. Effect of cystathionine ketimine on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors. Biochemical and biophysical research communications. 1996 Jan; 218(1):371-6. doi: 10.1006/bbrc.1996.0065. [PMID: 8573164]
  • A Antonucci, L Pecci, M Fontana, D Cavallini. Influence of diet on cystathionine ketimine and lanthionine ketimine content in human urine. The Italian journal of biochemistry. 1990 Mar; 39(2):100-5. doi: NULL. [PMID: 2361849]
  • L Pecci, A Antonucci, M Nardini, D Cavallini. Detection of cystathionine and lanthionine ketimines in human urine. Biochemistry international. 1988 Nov; 17(5):877-83. doi: NULL. [PMID: 3254164]